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A pilot study on combination of cryosurgery and ^(125)iodine seed implantation for treatment of locally advanced pancreatic cancer 被引量:38
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作者 Ke-Cheng Xu Li-Zhi Niu +4 位作者 Yi-Ze Hu Wei-Bing He Yi-Song He Ying-Fei Li Jian-Sheng Zuo 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第10期1603-1611,共9页
AIM: To study the therapeutic value of combination o cryosurgery and 125iodine seed implantation for locally advanced pancreatic cancer. METHODS: Forty-nine patients with locally advanced pancreatic cancer (males 36, ... AIM: To study the therapeutic value of combination o cryosurgery and 125iodine seed implantation for locally advanced pancreatic cancer. METHODS: Forty-nine patients with locally advanced pancreatic cancer (males 36, females 13), with a median age of 59 years, were enrolled in the study. Twelve patients had liver metastases. In all cases the tumors were considered unresectable after a comprehensive evaluation. Patients were treated with cryosurgery, which was performed intraoperatively or percutaneously unde guidance of ultrasound and/or computed tomography (CT), and 125iodine seed implantation, which was performed during cryosurgery or post-cryosurgery under guidance of ultrasound and/or CT. A few patients received regional celiac artery chemotherapy. RESULTS: Thirteen patients received intraoperative cryosurgery and 36 received percutaneous cryosurgery Some patients underwent repeat cryosurgery. 125Iodine seed implantation was performed during freezing procedure in 35 patients and 3-9 d after cryosurgery in 14 cases. Twenty patients, 10 of whom had hepaticmetastases received regional chemotherapy. At 3 mo after therapy, CT was repeated to estimate tumor response to therapy. Most patients showed varying degrees of tumor necrosis. Complete response (CR) of tumor was seen in 20.4% patients, partial response (PR), in 38.8%, stable disease (SD), in 30.6%, and progressive disease (PD), in 10.2%. Adverse effects associated with cryosurgery included upper abdomen pain and increased serum amylase. Acute pancreatitis was seen in 6 patients one of whom developed severe pancreatitis. All adverse effects were controlled by medical management with no poor outcome. There was no therapy-related mortality. During a median follow-up of 18 mo (range of 5-40), the median survival was 16.2 mo, with 26 patients (53.1%) surviving for 12 mo or more. Overall, the 6-, 12-, 24- and 36-mo survival rates were 94.9%, 63.1%, 22.8% and 9.5%, respectively. Eight patients had survival of 24 mo or more. The patient with the longest survival (40 mo) is still living without evidence of tumor recurrence. CONCLUSION: Cryosurgery, which is far less invasive than conventional pancreatic resection, and is associated with a low rate of adverse effects, should be the treatment of choice for patients with locally advanced pancreatic cancer. 125Iodine seed implantation can destroy the residual surviving cancer cells after cryosurgery. Hence, a combination of both modalities has a complementary effect. 展开更多
关键词 Pancreatic cancer CRYOSURGERY CRYOABLATION ^125Iodine seed implantation
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Intraoperative radiofrequency ablation combined with ^(125)iodine seed implantation for unresectable pancreatic cancer 被引量:22
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作者 Yi-Ping Zou Wei-Min Li +4 位作者 Fang Zheng Fu-Cheng Li Hui Huang Ji-Dong Du Hao-Run Liu 《World Journal of Gastroenterology》 SCIE CAS CSCD 2010年第40期5104-5110,共7页
AIM: To evaluate the feasibility, efficacy and safety of intraoperative radiofrequency ablation (RFA) combined with 125 iodine seed implantation for unresectable pancreatic cancer. METHODS: Thirty-two patients (21 mal... AIM: To evaluate the feasibility, efficacy and safety of intraoperative radiofrequency ablation (RFA) combined with 125 iodine seed implantation for unresectable pancreatic cancer. METHODS: Thirty-two patients (21 males and 11 females) at the age of 68 years (range 48-90 years) with unresectable locally advanced pancreatic cancer admitted to our hospital from January 2006 to May 2008 were enrolled in this study. The tumor, 4-12 cm in diameter, located in pancreatic head of 23 patients and in pancreatic body and tail of 9 patients, was found to be unresectable during operation. Diagnosis of pancreatic cancer was made through intraoperative biopsy. Patients were treated with FRA combined with 125 iodine seed implantation. In brief, a RFA needle was placed, which was confirmed by intraoperative ultrasound to decrease the potential injury of surrounding vital structures, a 125 iodine seed was implanted near the blood vessels and around the tumor border followed by bypass palliative procedure (cholangio-jejunostomy and/or gastrojejunostomy) in 29 patients.RESULTS: The serum CA 19-9 level was decreased from 512 ± 86 U/mL before operation to 176 ± 64 U/mL, 108 ± 42 U/mL and 114 ± 48 U/mL, respectively, 1, 3 and 6 mo after operation (P < 0.05). The pain score on day 7 after operation, 1 and 3 mo after combined therapy was decreased from 5.86 ± 1.92 before operation to 2.65 ± 1.04, 1.65 ± 0.88 and 2.03 ± 1.16, respectively, after operation (P < 0.05). The rate of complete response (CR), partial response (PR), stable disease (SD), progressive disease (PD) in 32 patients was 21.8% (7/32), 56.3% (18/32), 15.6% (5/32) and 6.3% (2/32), respectively, 6 mo after operation, with a median overall survival time of 17. 5 mo. The median survival time of patients at stage Ⅲ was longer than that of those at stage Ⅳ (19 mo vs 10 mo, P = 0.0026). The median survival time of patients who received and did not receive chemotherapy after operation was 20 mo and 16 mo, respectively (P = 0.0176). Of the 32 patients, 3 (10.6%) experienced postoperative complications including transient biliary leaks in 2 patients and acute pancreatitis in 1 patient. All the patients recovered well after conservative support treatment. CONCLUSION: Intraoperative RFA combined with 125 iodine seed implantation is a feasible and safe procedure for unresectable pancreatic cancer with acceptable minor complications, and can prolong the survival time of patients, especially those at stage Ⅲ. 展开更多
关键词 Unresectable pancreatic cancer Radiofrequency ablation 125 iodine seed implantation
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Relationship between miR-7-5p expression and ^(125)I seed implantation efficacy in pancreatic cancer and functional analysis of target genes 被引量:1
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作者 Tingting Hao Chaoqi Wang +3 位作者 Yingjie Song Wanyan Wu Xuetao Li Tao Fan 《Oncology and Translational Medicine》 CAS 2021年第4期177-182,共6页
Objective The aim of this study was to investigate the relationship between miR-7-5p expression and intertissue-^(125)I irradiation sensitivity in pancreatic cancer tissues and to analyze the function of target genes.... Objective The aim of this study was to investigate the relationship between miR-7-5p expression and intertissue-^(125)I irradiation sensitivity in pancreatic cancer tissues and to analyze the function of target genes.Methods Thirty-seven patients with unresectable pancreatic ductal adenocarcinoma(PDAC)treated with radioactive ^(125)I seed implantation were enrolled.RT-PCR was used to detect the expression level of miR-7-5p in cancer tissues and analyze the relationship between miR-7-5p expression and ^(125)I radiation sensitivity.Bioinformatic software and online tools were used to predict the miR-7-5p target genes and analyze their functional annotation and pathway enrichment.Results Radioactive ^(125)I seed implantation was followed up for 2 months.The objective response rate of the miR-7-5p high expression group was 65.0%(13/20),whereas the objective response rate of the miR-7-5p low expression group was 5.88%(1/17),and the difference between the two groups was statistically significant(χ^(2)=13.654,P<0.001).A total of 187 target genes were predicted using three databases.GO functional annotation showed that target genes were mainly involved in cellular response to insulin stimulus,regulation of gene expression by genetic imprinting,cytosol,peptidyl-serine phosphorylation,bHLH transcription factor binding,cargo loading into vesicles,cellular response to epinephrine stimulus,and nucleoplasm.KEGG pathway enrichment analysis showed that target genes were mainly involved in the ErbB signaling pathway,HIF-1 signaling pathway,axon guidance,longevity regulatory pathway,endocrine resistance,glioma,choline metabolism in cancer,and EGFR tyrosine kinase inhibitor drug resistance.Molecular complex detection analysis by Cytoscape revealed that PIGH,RAF1,EGFR,NXT2,PIK3CD,PIK3R3,ERBB4,TRMT13,and C5orf22 were the key modules of miR-7-5p target gene clustering.Conclusion The expression of miR-7-5p in pancreatic cancer tissues positively correlated with the radiosensitivity of ^(125)I seeds.Via targeted gene regulation,miR-7-5p acts on the network of multiple signaling pathways in PDAC and participates in its occurrence and development.Thus,miR-7-5p may become a predictive index of ^(125)I seed implantation therapy sensitivity in PDAC patients. 展开更多
关键词 miR-7-5p pancreatic cancer ^(125)I radioactive seed implantation
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Treatment of portal vein tumor thrombus using ^(125)Iodine seed implantation brachytherapy 被引量:11
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作者 Lin Zhang Wei Mu +1 位作者 Cun-Fang Hu Xue-Quan Huang 《World Journal of Gastroenterology》 SCIE CAS CSCD 2010年第38期4876-4879,共4页
We reported two cases of liver metastasis with portal vein tumor thrombus that developed after liver transplantation for hepato cellular carcinoma (HCC). Both the patients were women aged 43 and 55 years, who had live... We reported two cases of liver metastasis with portal vein tumor thrombus that developed after liver transplantation for hepato cellular carcinoma (HCC). Both the patients were women aged 43 and 55 years, who had liver metastasis and portal vein tumor thrombus formation after liver transplantations for HCC. 展开更多
关键词 Computed tomography-guided
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Intensity Modulated Proton Therapy as a Boost Treatment after Prostate Seed Implant: A Treatment Planning Study
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作者 Junqing Wu Huanmei Wu Chee-Wai Cheng 《International Journal of Medical Physics, Clinical Engineering and Radiation Oncology》 2015年第1期76-83,共8页
Purpose: Combination of Prostate Seed Implant (PSI) with External Beam Radiation Therapy (EBRT) remains as an attractive option for patients with intermediate or high-risk prostate cancer. One of the most widely used ... Purpose: Combination of Prostate Seed Implant (PSI) with External Beam Radiation Therapy (EBRT) remains as an attractive option for patients with intermediate or high-risk prostate cancer. One of the most widely used approaches is to use external beam radiation therapy (EBRT) to deliver boost doses after permanent prostate seed implant (PSI). In this study, the feasibility of using Intensity Modulated Proton Therapy (IMPT) as an alternative EBRT boost treatment for PSI patients was investigated in the presence of a large number of high Z metallic seeds. The dosimetry of IMPT boost plans was compared with that of conventional Intensity Modulated Radiation Therapy (IMRT) boost plans. Methods: Ten post prostate seed implants with seeds of I-125 were randomly selected for this study. Proton treatment plans were created with two lateral opposed proton beams in Eclipse treatment planning system. IMRT boost plans were generated with seven co-planner beams for comparison. Several plan evaluation parameters such as the planning target volume (PTV) dose homogeneity, dose conformity and dose to surrounding normal tissues were evaluated. Results: Compared to conventional IMRT boost plans, IMPT demonstrated better sparing of normal tissues while providing similar satisfactory PTV coverage. The high Z implanted seeds is not a problem for IMPT as boost treatment. Conclusions: PSI with an IMPT boost can be a valuable option for prostate cancer patient treatment. It delivers comparable or better radiation dose distribution in terms of normal tissue sparing compared to IMRT boost plan. 展开更多
关键词 IMPT PROSTATE seed implant IMRT
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CT guided ^125iodine seed implantation for portal vein tumor thrombus in primary hepatocellular carcinoma 被引量:46
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作者 ZHANG Fu-jun LI Chuan-xing +4 位作者 JIAO De-chao ZHANG Nian-hua WU Pei-hong DUAN Guang-feng WU Yue-xia 《Chinese Medical Journal》 SCIE CAS CSCD 2008年第23期2410-2414,共5页
Background This study evaluated the clinical application of CT guided ^125iodine implantation in patients with portal vein tumor thrombus in primary hepatocellular carcinoma. Methods The ten patients (9 males and 1 f... Background This study evaluated the clinical application of CT guided ^125iodine implantation in patients with portal vein tumor thrombus in primary hepatocellular carcinoma. Methods The ten patients (9 males and 1 female, aged from 36 to 72 years) with portal vein tumor thrombus accompanying hepatocellular carcinoma had been treated with comprehensive therapy including surgery, transcatheter arterial chemoembolization, radiotherapy ablation, microwave ablation or percutaneous ethanol injection. The average diameter of each tumor thrombus was 21.5 mm × 30.5 mm. Seeds of 30 MBq ^125I were implanted 5 mm apart within the portal vein tumor thrombus. The follow-up after 4 months included enhanced spiral CT. Results CT screening of the tumours indicated that 4 out of 10 patients showed complete response to the therapy, 5 partial response and 1 stable disease. Adverse effects included aggravated abdominal dropsy and temporarily increased transaminase, which were controlled by medical management. Severe complications such as haemorrhage, biliary fistula hepatic abscess, pancreatic fistula and hepatic function failure were not observed. Implanted seeds migrated to lung and left hepatic lobe in 1 case. Conclusion CT guided implantation of ^125iodine seeds, can effectively treat portal vein tumor thrombus accompanying hepatocellular carcinoma with minimal damage and few complications. 展开更多
关键词 ^125I iodine seed implantation portal vein tumor thrombus BRACHYTHERAPY primary hepatocellular carcinoma
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Implantation of Radioactive ^(125)I Seeds Improves the Prognosis of Locally Advanced Pancreatic Cancer Patients:A Retrospective Study 被引量:12
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作者 李永峰 刘志强 +4 位作者 张禹舜 董黎明 王春友 勾善淼 吴河水 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2016年第2期205-210,共6页
Locally advanced pancreatic cancer is associated with a very poor prognosis. This study was performed to evaluate whether patients with locally advanced pancreatic cancer benefit from 125 ^I seed implantation. This re... Locally advanced pancreatic cancer is associated with a very poor prognosis. This study was performed to evaluate whether patients with locally advanced pancreatic cancer benefit from 125 ^I seed implantation. This retrospective study included 224 patients with locally advanced pancreatic cancer, with 137 patients(61.2%) in the implantation(IP) group and 87(38.9%) in the non-implantation(NIP) group. The survival status, complications and objective curative effects were compared between the groups. The average operative time in the IP group was significantly longer than that in the NIP group(243±51 vs. 214±77 min). The tumor response rates were 9.5% and 0 at the 2nd month after surgery in the IP and NIP groups, respectively(P〈0.05). The IP group exhibited a trend toward pain relief at the 6th month after surgery. The global health status scores of the IP group were higher than those of the NIP group at the 3rd and 6th month after surgery. The median survival time in the IP group was significantly longer than that in the NIP group. In conclusion, patients with locally advanced pancreatic cancer can benefit from 125 I seed implantation in terms of local tumor control, survival time, pain relief and quality of life. 展开更多
关键词 125I seed implantation locally advanced pancreatic cancer pain relief quality of life
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CT guidance ^(125)I seed implantation for pelvic recurrent rectal cancer assisted by 3D printing individual non-coplanar template 被引量:1
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作者 王皓 《China Medical Abstracts(Internal Medicine)》 2017年第1期44-45,共2页
Objective To analyze the difference of dosimetric parameters between pre-plan and post-plan of 125I radioactive seed implantation assisted by 3D printing individual non-coplanar template(3D printing template)for loc... Objective To analyze the difference of dosimetric parameters between pre-plan and post-plan of 125I radioactive seed implantation assisted by 3D printing individual non-coplanar template(3D printing template)for locally recurrent rectal cancer(LRRC).Methods From February 2016 to April 2016,a total of 10 patients with locally recurrent rectal cancer received 125I seeds implan- 展开更多
关键词 CT guidance I seed implantation for pelvic recurrent rectal cancer assisted by 3D printing individual non-coplanar template
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In vitro antimicrobial effects of grape seed extract on peri-implantitis microflora in craniofacial implants 被引量:1
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作者 Binit Shrestha M.L.Srithavaj Theerathavaj +1 位作者 Sroisiri Thaweboon Boonyanit Thaweboon 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2012年第10期822-825,共4页
Objective:To determine the antimicrobial effects of grape seed on peri-implantitis microflora.Methods:The grape seed extract was tested against peri-implantitis microflora most commonly found in craniofacial implants ... Objective:To determine the antimicrobial effects of grape seed on peri-implantitis microflora.Methods:The grape seed extract was tested against peri-implantitis microflora most commonly found in craniofacial implants including reference strains of Staphylococcus aureus(S.aureus),Escherichia coli(E.coli),Candida albicans(C.albicans)and clinical strains of S.aureus,Klebsiella pneumonia(K.pneumonia)and Candida parapsilosis(C.parapsilosis)by disk diffusion test.Minimum inhibitory concentrations(MIC)and minimum cidal concentrations(MCC)were determined using modified agar dilution millpore method.The extract was further combined with polyethylene glycol and propylene glycol,and was tested for antimicrobial effects.Results:Grape seed extract showed positive inhibitory effects with S.aureus at MIC of 0.625 mg/mL and MCC of1.25 mg/mL respectively.However the extracts showed minimal or no reactivity against strains of E.coli,K.pneumonia,C.parapsilosis and C.albicans.The use of grape seed extract in combination with polyethylene glycol and propylene glycol also showed dose dependent inhibitory effect on S.aureus.Conclusions:The results of the study showed that grape seed has potential antimicrobial effects which can be further studied and developed to be used in the treatment of infected skinabutment interface of craniofacial implants. 展开更多
关键词 PERI-implantITIS Grape seed extract CRANIOFACIAL implantS STAPHYLOCOCCUS AUREUS
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Biological effects of implantation and penetration of nitrogenion beams on wheat seeds
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作者 李文建 卫增泉 +6 位作者 颉红梅 党秉荣 韩光武 李强 高清祥 杨汉民 汪丽虹 《Nuclear Science and Techniques》 SCIE CAS CSCD 1996年第4期249-252,共4页
BiologicaleffectsofimplantationandpenetrationofnitrogenionbeamsonwheatseedsLiWen-Jian(李文建),WeiZeng-Quan(卫增泉)... BiologicaleffectsofimplantationandpenetrationofnitrogenionbeamsonwheatseedsLiWen-Jian(李文建),WeiZeng-Quan(卫增泉),XieHong-Mei(颉红梅)... 展开更多
关键词 氮离子移植 离子贯穿 生物效应 小麦种子
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Penetration depth and concentration distribution for implanted heavy ions with low energies in plant seeds by SEM and EDS 被引量:2
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作者 WANG Xin-Fu ZHOU Yun-Long +6 位作者 ZHOU Hong-Yu LU Ting Wang Chao SU Ying ZHU Guang-Hua WEN Chen-Lin LI Yong-Liang (Key Laboratory for Beam Technology and Material Modification of Ministry of Education, Institute of Low Energy Nuclear Physics, Beijing Norm 《Nuclear Science and Techniques》 SCIE CAS CSCD 2001年第1期26-31,共6页
The penetration depth and concentration distribution of implanted ions have been studied for low energy heavy ions implanted in the dry seeds of plant, such as peanut, mung beau, sunflower, wheat and radish seeds, etc... The penetration depth and concentration distribution of implanted ions have been studied for low energy heavy ions implanted in the dry seeds of plant, such as peanut, mung beau, sunflower, wheat and radish seeds, etc. by SEM+EDS. The results .how that the maximum penetration depth is about 12μm for V+ with an energy 200 keV implanted in cotyledon of the peanut, 18pm, spin, 20μm for V2+ with 90 keV implanted in sunflower, wheat, radish seeds, respectively. The penetration depth of implanted Cu2+ with 80 keV is about 90μm in the remainder funicle derivative of the mung beau seeds. The experimental result of the maximum penetration depth of implanted V+ in the peanut seeds was compared with the calculated value of the TRIM95. 展开更多
关键词 离子移植 渗透深度 浓度分布 植物种子
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耳穴埋籽在良性前列腺增生临床治疗中的干预作用
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作者 朱勇 葛晓东 +2 位作者 施勇 马亮亮 郭军华 《中国性科学》 2024年第8期115-118,共4页
目的评价分析耳穴埋籽在良性前列腺增生(BPH)患者临床治疗中的干预作用。方法选取2021年1月至2022年10月南京中医药大学附属盐城中医院(盐城市中医院)收治的105例BPH患者作为研究对象,采用随机数字表法分为治疗组(n=55)和对照组(n=50)... 目的评价分析耳穴埋籽在良性前列腺增生(BPH)患者临床治疗中的干预作用。方法选取2021年1月至2022年10月南京中医药大学附属盐城中医院(盐城市中医院)收治的105例BPH患者作为研究对象,采用随机数字表法分为治疗组(n=55)和对照组(n=50)。对照组采用盐酸坦索罗辛缓释胶囊和非那雄胺片治疗,治疗组在对照组治疗基础上联合王不留行籽耳穴(尿道、膀胱、肾、缘中、皮质下)贴压。比较两组治疗前后前列腺体积(PV)、排尿后膀胱残余尿量(PVR)、最大尿流率(Qmax),比较两组治疗前后国际前列腺症状评分(IPSS)和生活质量(QOL)评分。结果治疗后,两组IPSS、QOL评分、Qmax均优于治疗前,且治疗组优于对照组,差异具有统计学意义(P<0.05);治疗后,治疗组PVR小于治疗前(P<0.05),且小于对照组,但差异无统计学意义(P>0.05);治疗后,两组PV与治疗前比较,差异无统计学意义(P>0.05)。结论耳穴埋籽治疗BPH的疗效确切,可有效改善尿动力学指标,缓解前列腺症状,提升生活质量。 展开更多
关键词 良性前列腺增生 耳穴埋籽 干预作用
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时辰节律的用药指导联合耳穴埋籽对老年高血压患者遵医行为、睡眠质量和情志状态的影响
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作者 周红霞 刘慧霞 +1 位作者 杨清柯 师卿杰 《中国健康心理学杂志》 2024年第9期1382-1386,共5页
目的:探讨基于时辰节律的用药指导联合耳穴埋籽对老年高血压患者遵医行为、睡眠质量和情志状态的影响。方法:选取2021年3月-2023年12月在某院收治的213例老年高血压患者,根据入院顺序和组间基本资料具可比性的原则分为观察组(2022年12月... 目的:探讨基于时辰节律的用药指导联合耳穴埋籽对老年高血压患者遵医行为、睡眠质量和情志状态的影响。方法:选取2021年3月-2023年12月在某院收治的213例老年高血压患者,根据入院顺序和组间基本资料具可比性的原则分为观察组(2022年12月—2023年12月,n=106)和对照组(2021年3月——2022年11月,n=107),两组患者均予以基于时辰节律的用药指导,观察组联合耳穴埋籽,观察两组患者血压控制、睡眠质量、情志状态、遵医行为和生活质量变化。结果:两组干预后收缩压、舒张压均较干预前有所下降,且观察组血压下降幅度高于对照组(t=7.232,19.046;P<0.05);两组干预后匹兹堡睡眠质量指数(PSQI)评分和抑郁(SDS)、焦虑自评量表(SAS)评分均较干预前下降,且观察组PSQI评分和SAS、SDS评分均低于对照组(t=8.602,7.635,10.045;P<0.05);观察组在用药管理、生活管理和定期复查的遵医行为均优于对照组(χ^(2)=5.357,17.453,8.819;P<0.05)。两组生活质量各维度评分均较干预前均上升,且观察组生活质量各维度评分高于对照组(t=5.648,3.441,3.457,3.971,8.766;P<0.05)。结论:基于时辰节律的用药指导联合耳穴埋籽可有效控制老年高血压患者的血压波动,提升睡眠质量,改善患者情志状态,进一步提高遵医行为,形成良性循环。 展开更多
关键词 高血压 老年 耳穴埋籽 时辰节律 用药指导 遵医行为 睡眠质量 情志状态
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^(125)I粒子植入在难治性甲状腺癌治疗中的应用价值
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作者 龚成鹏 张雅婧 +1 位作者 胡胜清 高再荣 《华中科技大学学报(医学版)》 CAS CSCD 北大核心 2024年第2期269-274,共6页
作为近距离放射治疗的一种,^(125)I粒子植入已广泛应用于各种不可切除或局部复发的恶性肿瘤治疗中,均展现出良好的治疗效果与前景。由于具有疗效确切、安全微创的特点,^(125)I粒子植入为不能再次手术、^(131)I治疗不可控及不适合靶向治... 作为近距离放射治疗的一种,^(125)I粒子植入已广泛应用于各种不可切除或局部复发的恶性肿瘤治疗中,均展现出良好的治疗效果与前景。由于具有疗效确切、安全微创的特点,^(125)I粒子植入为不能再次手术、^(131)I治疗不可控及不适合靶向治疗的持续或复发甲状腺癌提供了一种可选择的手段。该文将简要介绍^(125)I粒子植入在难治性甲状腺癌局部复发灶及其转移灶治疗和病灶术前定位中的应用。 展开更多
关键词 ^(125)I粒子植入 难治性甲状腺癌 近距离放射治疗
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赋能管理模式在^(125)I粒子植入术后放射防护中的效果研究 被引量:1
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作者 刘丽 黄祥忠 +1 位作者 高福磊 朱翠芳 《介入放射学杂志》 CSCD 北大核心 2024年第1期82-85,共4页
目的探讨赋能管理模式在^(125)I粒子植入术后放射防护中的作用。方法选择医院2020年10月至2022年10月首次进行^(125)I粒子植入的患者66例,随机分为对照组和实验组,对照组(n=33)实施传统健康教育;实验组(n=33)在传统健康教育的基础上实... 目的探讨赋能管理模式在^(125)I粒子植入术后放射防护中的作用。方法选择医院2020年10月至2022年10月首次进行^(125)I粒子植入的患者66例,随机分为对照组和实验组,对照组(n=33)实施传统健康教育;实验组(n=33)在传统健康教育的基础上实施赋能管理模式,评价两组患者在自我效能感、健康教育效果及防护依从性等方面的差异。结果实验组患者在自我效能感、健康教育效果及防护依从性等方面均高于对照组,差异有统计学意义(P<0.05)。结论运用赋能管理模式实施健康教育,能够提高^(125)I粒子植入术后健康教育效果,从而让患者更正确地认识^(125)I粒子治疗,使自我效能感加强,有利于提高术后防护依从性,保护周围人群的安全,值得临床推广。 展开更多
关键词 赋能管理 ^(125)I粒子植入 放射防护 延续护理
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正念减压联合纽曼护理模式在恶性肿瘤粒子植入术患者中的应用
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作者 白建玉 仝海燕 +2 位作者 陈芳 姚水丽 邵艳 《护理实践与研究》 2024年第3期421-428,共8页
目的探讨正念减压理论联合纽曼护理模式在恶性肿瘤粒子植入术患者中的应用。方法选择2021年8月—2022年8月在医院进行恶性肿瘤粒子植入术治疗的140例患者为研究对象,按照组间基线资料均衡可比的原则分为观察组和对照组,每组70例,对照组... 目的探讨正念减压理论联合纽曼护理模式在恶性肿瘤粒子植入术患者中的应用。方法选择2021年8月—2022年8月在医院进行恶性肿瘤粒子植入术治疗的140例患者为研究对象,按照组间基线资料均衡可比的原则分为观察组和对照组,每组70例,对照组采用常规护理干预,观察组采用正念减压联合纽曼护理模式干预,比较两组患者的心理弹性[心理弹性量表(CD-RISC)]、尿失禁程度[尿失禁问卷简表(ICIQ-SF)]、术后引流时间、胃肠功能恢复时间、尿失禁持续时间、住院时间、生活质量[癌症患者生活质量量表(EORTC QLQ-C30)]、并发症发生率。结果干预后观察组CD-RISC评分高于对照组,差异有统计学意义(P<0.05)。干预后观察组ICIQ-SF各维度评分均低于对照组,差异有统计学意义(P<0.05)。干预后观察组患者术后引流时间、胃肠功能恢复时间、尿失禁持续时间、住院时间均短于对照组,差异有统计学意义(P<0.05)。干预后观察组EORTC QLQ-C30中功能领域及总体健康领域评分高于对照组,差异有统计学意义(P<0.05),EORTC QLQ-C30中症状领域评分均低于对照组,差异有统计学意义(P<0.05)。干预后观察组患者并发症发生率低于对照组,差异有统计学意义(P<0.05)。结论将正念减压联合纽曼护理模式应用于恶性肿瘤粒子植入术患者的护理中可改善其心理健康,同时降低尿失禁程度,加快术后恢复,并提高其生活质量,减少并发症的发生。 展开更多
关键词 正念减压理论 纽曼护理模式 恶性肿瘤粒子植入术 心理健康 尿失禁
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上海市^(125)I粒子植入治疗技术质量控制研究现状
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作者 单凤玲 楼菁菁 +1 位作者 张锦明 刘兴党 《肿瘤影像学》 2024年第4期384-387,共4页
目的:分析探讨2022年上海市开展^(125)I粒子植入治疗技术的各医疗中心质量控制现状。方法:根据上海市核医学质量控制中心^(125)I粒子植入治疗技术评估表,对上海市16家医疗机构的20个相关科室的质量控制数据进行分析。结果:对医疗机构基... 目的:分析探讨2022年上海市开展^(125)I粒子植入治疗技术的各医疗中心质量控制现状。方法:根据上海市核医学质量控制中心^(125)I粒子植入治疗技术评估表,对上海市16家医疗机构的20个相关科室的质量控制数据进行分析。结果:对医疗机构基本要求、人员基本要求、技术管理基本要求评估的36项质控内容中,最高符合率为100.00%(36/36),最低符合率为83.33%(30/36),同一家医院不同科室的管理和质量情况也有所不同;对于有关质控各项指标,植入指征正确率(平均)为98.75%,术前制订治疗计划率(平均)为94.74%,粒子活度复测率(平均)为25.13%,术后放射剂量验证率(平均)为83.81%,30 d内穿刺相关主要并发症发生率(平均)为5.67%,30 d内放射性损伤相关主要并发症发生率(平均)为0.85%,粒子植入治疗有效率(平均)为92.2%,30 d内全因死亡率(平均)为0.87%。2个月、4个月、6个月及1年的(平均)随访率分别为97.24%、91.9%、85.31%及71.91%,2个月、4个月、6个月及1年的(平均)生存率分别为96.81%、89.74%、81.31%及66.07%。结论:2022年上海市各医疗中心在^(125)I粒子植入治疗技术的质量控制中仍存在许多问题,各医疗中心应引起重视,按照上海市核医学质量控制中心^(125)I粒子植入治疗技术评估表的要求,完善科室规章制度,完全按照诊疗规范开展该项技术。 展开更多
关键词 ^(125)I粒子植入 质量控制 核医学
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温针灸背俞穴联合耳穴埋籽对老年心力衰竭患者心功能及生活质量的影响
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作者 秦霞 朱帅兵 常文艳 《实用中医内科杂志》 2024年第4期137-139,共3页
目的 探讨温针灸背俞穴联合耳穴埋籽对老年心力衰竭患者心功能及生活质量的影响。方法 选取2021年9月—2022年10月在医院住院治疗的慢性心力衰竭患者88例,按随机数字表法将入组患者分为观察组和对照组,各44例。对照组给予常规抗心力衰... 目的 探讨温针灸背俞穴联合耳穴埋籽对老年心力衰竭患者心功能及生活质量的影响。方法 选取2021年9月—2022年10月在医院住院治疗的慢性心力衰竭患者88例,按随机数字表法将入组患者分为观察组和对照组,各44例。对照组给予常规抗心力衰竭药物治疗及常规护理干预;观察组在对照组基础上给予温针灸背俞穴及耳穴埋籽干预。比较两组干预前后心功能[左室舒张末内径(LVEDD)、左室收缩末内径(LVESD)和左室射血分数(LVEF)]、氨基末端脑钠肽前体(NT-proBNP)、高敏心肌肌钙蛋白I(hs-TNI)水平及生活质量;比较两组干预效果。结果 干预后,观察组LVEDD、LVESD低于对照组,LVEF高于对照组;NT-proBNP、hs-TNI水平及MLHFQ各项评分低于对照组,差异有统计学意义(P<0.05)。观察组总有效率为97.73%,明显高于对照组的81.82%,差异有统计学意义(P<0.05)。结论 温针灸背俞穴联合耳穴埋籽能够有效改善慢性心力衰竭的心功能,降低NT-proBNP、hs-TNI水平,提高临床效果,改善生活质量。 展开更多
关键词 温针灸背俞穴 耳穴埋籽 慢性心力衰竭 心功能 生活质量
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超声引导下放射性^(125)I粒子植入治疗转移性腹膜后去分化脂肪肉瘤1例
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作者 杨天姿 张秉宜 +1 位作者 刘捷 李兴昶 《中国医药科学》 2024年第4期196-198,共3页
去分化脂肪肉瘤(DDLPS)是一种罕见的脂肪肉瘤亚型,预后不良。本病例报告描述了1例65岁中国女性的肝脏及腹膜后DDLPS,临床表现为无痛性腹部肿物。进行计算机断层扫描和超声检查发现瘤体较大且出现部分脏器转移,遂行腹膜后巨大肿瘤切除术... 去分化脂肪肉瘤(DDLPS)是一种罕见的脂肪肉瘤亚型,预后不良。本病例报告描述了1例65岁中国女性的肝脏及腹膜后DDLPS,临床表现为无痛性腹部肿物。进行计算机断层扫描和超声检查发现瘤体较大且出现部分脏器转移,遂行腹膜后巨大肿瘤切除术及肝部分切除术。术后肿瘤免疫组织化学表现为S-100(+),SOX10(-),Desmin(+)。患者愈合良好,为控制转移病灶,术后三个月行超声引导下右侧腹膜后(肝肾间隙)肿瘤放射性^(125)I粒子植入治疗。通过粒子放射治疗,达到稳定病情的治疗目标。本病例报告对该患者的治疗及病例资料进行分析,从DDLPS的临床诊断、治疗和病理特点等方面对文献进行综述,以期提高诊疗水平。 展开更多
关键词 去分化脂肪肉瘤 转移性 放射性粒子 ^(125)I 超声 植入治疗
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Effect of ^(125)I seeds and ^(103)Pd stents on proliferation of vascular smooth muscle cells
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作者 ZHU Jun, LUO Quan-Yong, ZHU Rui-Sen, LU Han-Kui (Shanghai 6th People’s Hospital, Shanghai 200233) 《Nuclear Science and Techniques》 SCIE CAS CSCD 2002年第4期218-223,共6页
This study aims at the theoretical and practical evidence for prevention of restenosis in vitro.Vascular smooth muscle cell(VSMC)model was established using adherent cell culture methods.The proliferation of VSMC was ... This study aims at the theoretical and practical evidence for prevention of restenosis in vitro.Vascular smooth muscle cell(VSMC)model was established using adherent cell culture methods.The proliferation of VSMC was investigated by the cell counting method and 3H-TDR implementation test.The results are as follows.(1) For ^125I-seeds,the inhibition rate was 29.3% at 74B1(P<0.05),35.2% at 148Bq(P<0.05)and 42.4% at 370Bq(P<0.05),For ^103Pd-implanted stents,the inhibition rate was 14.7% at 4.44MBq(P<0.05),24.0% at 5.92MBq(P<0.05) and 38.0%at 7.4MBq(p<0.05),There was no significant difference between the blank tests and non-radioactive tests.(2) 48 hours exposure from ^125I-seeds at 148Bq or ^103Pd-implanted stents at 7.4MBq did not result in VSMC's morphological alteration,but that from ^125I-seeds at 370Bq caused morphological changes,Both ^125I-seeds and ^103Pd0-implanted stents inhibit the VSMC DNA synthesis in vitro.The inhibition effects are significantly related to their exposure duration and doses. 展开更多
关键词 细胞增殖 125I 103Pd 血管肌肉细胞
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