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Selective harmonic elimination method for wide range of modulation indexes in multilevel inverters using ICA
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作者 Ali Ajami Mohammad Reza Jannati Oskuee +1 位作者 Ataollah Mokhberdoran Hossein Shokri 《Journal of Central South University》 SCIE EI CAS 2014年第4期1329-1338,共10页
Selective harmonic elimination(SHE) in multilevel inverters is an intricate optimization problem that involves a set of nonlinear transcendental equations which have multiple local minima. A new advanced objective fun... Selective harmonic elimination(SHE) in multilevel inverters is an intricate optimization problem that involves a set of nonlinear transcendental equations which have multiple local minima. A new advanced objective function with proper weighting is proposed and also its efficiency is compared with the objective function which is more similar to the proposed one. To enhance the ability of the SHE in eliminating high number of selected harmonics, at each level of the output voltage, one slot is created. The SHE problem is solved by imperialist competitive algorithm(ICA). The conventional SHE methods cannot eliminate the selected harmonics and satisfy the fundamental component in some ranges of modulation indexes. So, to surmount the SHE defect, a DC-DC converter is applied. Theoretical results are substantiated by simulations and experimental results for a 9-level multilevel inverter. The obtained results illustrate that the proposed method successfully minimizes a large number of identified harmonics which consequences very low total harmonic distortion of output voltage. 展开更多
关键词 selective harmonic elimination DC-DC converter imperialist competitive algorithm(ICA)
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Harmonic Minimization in Seven Level Cascaded Multilevel Inverter Using Selective Harmonic Elimination PWM Techniques
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作者 V. R. Velmurugan Jeyabharath Rajaiah Veena Parasunath 《Circuits and Systems》 2016年第14期4322-4330,共10页
This paper concentrates on enhancing the productivity of the multilevel inverter and nature of yield voltage waveform. Seven level lessened switches topology has been actualized with just seven switches. Essential Swi... This paper concentrates on enhancing the productivity of the multilevel inverter and nature of yield voltage waveform. Seven level lessened switches topology has been actualized with just seven switches. Essential Switching plan and Selective Harmonics Elimination were executed to diminish the Total Harmonics Distortion (THD) esteem. Selective Harmonics Elimination Stepped Waveform (SHESW) strategy is executed to dispense with the lower order harmonics. Fundamental switching plan is utilized to control the switches in the inverter. The proposed topology is reasonable for any number of levels. The harmonic lessening is accomplished by selecting fitting switching angles. It indicates would like to decrease starting expense and unpredictability consequently it is able for modern applications. In this paper, third and fifth level harmonics have been disposed of. Simulation work is done utilizing the MATLAB/Simulink programming results have been displayed to accept the hypothesis. 展开更多
关键词 Multilevel Inverter PSIM Fundamental Switching Scheme selective harmonics elimination
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The General Technique of Selected Harmonics Elimination for Multilevel Converters
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作者 BOBao-zhong SUYan-min 《西安石油学院学报(自然科学版)》 2001年第2期55-58,共4页
Forhigh power applications,multilevel converters have many advantages in comparison with other circuit topologies with output transformers. Cascaded inverters are one type of multilevel converters,they are easy to imp... Forhigh power applications,multilevel converters have many advantages in comparison with other circuit topologies with output transformers. Cascaded inverters are one type of multilevel converters,they are easy to implement,very suitable for modularized layout and packaging.Their manufacturing cost is low.A multilevel PWM technique,called as General Technique of Selected Harmonics Elimination (GTSHE) ,is proposed in the paper. A general harmonic elimination equation for N cells,M pulses per half cycle,nth harmonic is derived,and verified by simulation results. 展开更多
关键词 换流器 谐波消除 技术 SHE 逐级变换器
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Genetic Algorithm Based 7-Level Step-Up Inverter with Reduced Harmonics and Switching Devices
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作者 T.Anand Kumar M.Kaliamoorthy I.Gerald Christopher Raj 《Intelligent Automation & Soft Computing》 SCIE 2023年第3期3081-3097,共17页
This paper presents a unique voltage-raising topology for a single-phase seven-level inverter with triple output voltage gain using single input source and two switched capacitors.The output voltage has been boosted u... This paper presents a unique voltage-raising topology for a single-phase seven-level inverter with triple output voltage gain using single input source and two switched capacitors.The output voltage has been boosted up to three times the value of input voltage by configuring the switched capacitors in series and parallel combinations which eliminates the use of additional step-up converters and transformers.The selective harmonic elimination(SHE)approach is used to remove the lower-order harmonics.The optimal switching angles for SHE is determined using the genetic algorithm.These switching angles are com-bined with a level-shifted pulse width modulation(PWM)technique for pulse generation,resulting in reduced total harmonic distortion(THD).A detailed com-parison has been made against other relevant seven-level inverter topologies in terms of the number of switches,drivers,diodes,capacitors,and boosting facil-ities to emphasize the benefits of the proposed model.The proposed topology is simulated using MATLAB/SIMULINK and an experimental prototype has been developed to validate the results.The Digital Signal Processing(DSP)TMS320F2812 board is used to generate the switching pulses for the proposed technique and the experimental results concur with the simulated model outputs. 展开更多
关键词 Genetic algorithm multilevel inverter pulse width modulation selective harmonic elimination switched capacitor
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A phenology-based vegetation index for improving ratoon rice mapping using harmonized Landsat and Sentinel-2 data 被引量:2
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作者 Yunping Chen Jie Hu +6 位作者 Zhiwen Cai Jingya Yang Wei Zhou Qiong Hu Cong Wang Liangzhi You Baodong Xu 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2024年第4期1164-1178,共15页
Ratoon rice,which refers to a second harvest of rice obtained from the regenerated tillers originating from the stubble of the first harvested crop,plays an important role in both food security and agroecology while r... Ratoon rice,which refers to a second harvest of rice obtained from the regenerated tillers originating from the stubble of the first harvested crop,plays an important role in both food security and agroecology while requiring minimal agricultural inputs.However,accurately identifying ratoon rice crops is challenging due to the similarity of its spectral features with other rice cropping systems(e.g.,double rice).Moreover,images with a high spatiotemporal resolution are essential since ratoon rice is generally cultivated in fragmented croplands within regions that frequently exhibit cloudy and rainy weather.In this study,taking Qichun County in Hubei Province,China as an example,we developed a new phenology-based ratoon rice vegetation index(PRVI)for the purpose of ratoon rice mapping at a 30 m spatial resolution using a robust time series generated from Harmonized Landsat and Sentinel-2(HLS)images.The PRVI that incorporated the red,near-infrared,and shortwave infrared 1 bands was developed based on the analysis of spectro-phenological separability and feature selection.Based on actual field samples,the performance of the PRVI for ratoon rice mapping was carefully evaluated by comparing it to several vegetation indices,including normalized difference vegetation index(NDVI),enhanced vegetation index(EVI)and land surface water index(LSWI).The results suggested that the PRVI could sufficiently capture the specific characteristics of ratoon rice,leading to a favorable separability between ratoon rice and other land cover types.Furthermore,the PRVI showed the best performance for identifying ratoon rice in the phenological phases characterized by grain filling and harvesting to tillering of the ratoon crop(GHS-TS2),indicating that only several images are required to obtain an accurate ratoon rice map.Finally,the PRVI performed better than NDVI,EVI,LSWI and their combination at the GHS-TS2 stages,with producer's accuracy and user's accuracy of 92.22 and 89.30%,respectively.These results demonstrate that the proposed PRVI based on HLS data can effectively identify ratoon rice in fragmented croplands at crucial phenological stages,which is promising for identifying the earliest timing of ratoon rice planting and can provide a fundamental dataset for crop management activities. 展开更多
关键词 ratoon rice phenology-based ratoon rice vegetation index(PRVI) phenological phase feature selection harmonized Landsat Sentinel-2 data
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A novel adaptive harmonic balance method with an asymptotic harmonic selection
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作者 Rongzhou LIN Lei HOU +3 位作者 Yi CHEN Yuhong JIN N.A.SAEED Yushu CHEN 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2023年第11期1887-1910,共24页
The harmonic balance method(HBM)is one of the most widely used methods in solving nonlinear vibration problems,and its accuracy and computational efficiency largely depend on the number of the harmonics selected.The a... The harmonic balance method(HBM)is one of the most widely used methods in solving nonlinear vibration problems,and its accuracy and computational efficiency largely depend on the number of the harmonics selected.The adaptive harmonic balance(AHB)method is an improved HBM method.This paper presents a modified AHB method with the asymptotic harmonic selection(AHS)procedure.This new harmonic selection procedure selects harmonics from the frequency spectra of nonlinear terms instead of estimating the contribution of each harmonic to the whole nonlinear response,by which the additional calculation is avoided.A modified continuation method is proposed to deal with the variable size of nonlinear algebraic equations at different values of path parameters,and then all solution branches of the amplitude-frequency response are obtained.Numerical experiments are carried out to verify the performance of the AHB-AHS method.Five typical nonlinear dynamic equations with different types of nonlinearities and excitations are chosen as the illustrative examples.Compared with the classical HBM and Runge-Kutta methods,the proposed AHB-AHS method is of higher accuracy and better convergence.The AHB-AHS method proposed in this paper has the potential to investigate the nonlinear vibrations of complex high-dimensional nonlinear systems. 展开更多
关键词 harmonic balance method(HBM) adaptive harmonic balance(AHB)method harmonic selection nonlinear vibration multi-frequency excitation
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A feature selection method combined with ridge regression and recursive feature elimination in quantitative analysis of laser induced breakdown spectroscopy 被引量:4
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作者 Guodong WANG Lanxiang SUN +3 位作者 Wei WANG Tong CHEN Meiting GUO Peng ZHANG 《Plasma Science and Technology》 SCIE EI CAS CSCD 2020年第7期11-20,共10页
In the spectral analysis of laser-induced breakdown spectroscopy,abundant characteristic spectral lines and severe interference information exist simultaneously in the original spectral data.Here,a feature selection m... In the spectral analysis of laser-induced breakdown spectroscopy,abundant characteristic spectral lines and severe interference information exist simultaneously in the original spectral data.Here,a feature selection method called recursive feature elimination based on ridge regression(Ridge-RFE)for the original spectral data is recommended to make full use of the valid information of spectra.In the Ridge-RFE method,the absolute value of the ridge regression coefficient was used as a criterion to screen spectral characteristic,the feature with the absolute value of minimum weight in the input subset features was removed by recursive feature elimination(RFE),and the selected features were used as inputs of the partial least squares regression(PLS)model.The Ridge-RFE method based PLS model was used to measure the Fe,Si,Mg,Cu,Zn and Mn for 51 aluminum alloy samples,and the results showed that the root mean square error of prediction decreased greatly compared to the PLS model with full spectrum as input.The overall results demonstrate that the Ridge-RFE method is more efficient to extract the redundant features,make PLS model for better quantitative analysis results and improve model generalization ability. 展开更多
关键词 laser-induced breakdown spectroscopy feature selection ridge regression recursive feature elimination quantitative analysis
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Selection of right-circular-polarized harmonics from p orbital of neon atom by two-color bicircular laser fields 被引量:1
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作者 Chang-Long Xia Yue-Yue Lan +1 位作者 Qian-Qian Li Xiang-Yang Miao 《Chinese Physics B》 SCIE EI CAS CSCD 2019年第10期315-320,共6页
The polarization properties of high-order harmonic generation(HHG) in the two-color circularly polarized laser fields are investigated by numerically solving the two-dimensional time-dependent Schr?dinger equation. By... The polarization properties of high-order harmonic generation(HHG) in the two-color circularly polarized laser fields are investigated by numerically solving the two-dimensional time-dependent Schr?dinger equation. By adding a wavelength of 1600-nm right-circular-polarized field to an 800-nm left-circular-polarized field, HHG is simulated from a real model of neon atom with p orbital, but not from a hydrogen-like atom model with s orbital. The orders of 3n + 1 can be selected while the orders of 3n + 2 are suppressed by adjusting the intensities of the two pulses. The physical mechanism is analyzed by time-frequency analysis and semiclassical model. 展开更多
关键词 HIGH-ORDER harmonic generation CIRCULAR POLARIZATION field POLARIZATION selectION
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Programmed PWM Technique and Optimal Harmonic Elimination 被引量:1
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作者 李力 纪延超 柳焯 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 1995年第3期41-44,共4页
A method for the preestimation of the iterative initial value in solving a system of nonlinear transcendental equations is described. It can guarantee the convergerce of a solution and decrase the number of iteratioon... A method for the preestimation of the iterative initial value in solving a system of nonlinear transcendental equations is described. It can guarantee the convergerce of a solution and decrase the number of iteratioon cycles. A novel concept, expanded programmed PWM technique, is proposed. The conclusion has important theoretical and practical significance in improving the comprehensive performance index of the generalized active filter (GAF). 展开更多
关键词 ss:Programmed PWM harmonIC elimination GAF
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Study and Design of a DC/AC Energy Converter for PV System Connected to the Grid Using Harmonic Selected Eliminated (HSE) Approach 被引量:1
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作者 Dominique Bonkoungou Éric Korsaga +3 位作者 Toussaint Guingané Sosthène Tassembédo Zacharie Koalaga François Zougmoré 《Open Journal of Applied Sciences》 2022年第3期301-316,共16页
Nowadays, distributing network-connected photovoltaic (PV) systems are expanded by merging a PV system and a Direct Current (DC)/Alternating Current (AC) energy converter. DC/AC conversion of PV energy is in great dem... Nowadays, distributing network-connected photovoltaic (PV) systems are expanded by merging a PV system and a Direct Current (DC)/Alternating Current (AC) energy converter. DC/AC conversion of PV energy is in great demand for AC applications. The supply of electrical machines and transfer energy to the distribution network is a typical case. In this work, we study and design a DC/AC energy converter using harmonic selective eliminated (HSE) method. To this end, we have combined two power stages connected in derivation. Each power stage is constituted of transistors and transformers. The connection by switching of the two rectangular waves, delivered by each of the stages, makes it possible to create a quasi-sinusoidal output voltage of the inverter. Mathematical equations based on the current-voltage characteristics of the inverter have been developed. The simulation model was validated using experimental data from a 25.2 kWp grid-coupled (PV) system, connected to Gridfit type inverters. The data were exported and implemented in programming software. A good agreement was observed and this shows all the robustness and the technical performances of the energy converter device. It emerges from this analysis that the inverter output voltage and the phase angle thus simulated are very important to control in order to orientate the transfer of the power flow from the continuous cell to cell to the alternating part. Simulated and field-testing results also show that increases in the value of the modulation factor (m) for low power output are highly significant. This study is an important tool for DC/AC inverter designers during initial planning stages. A short presentation of the design model of the inverter has been proposed in this article. 展开更多
关键词 Inverter Modulation Index TRANSISTORS Power Stage harmonic selective eliminated Photovoltaic (PV) System
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Double-phase-shift filtering method for harmonic elimination based on AR2U-Net
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作者 Li Bo-Lin Wang Yan-Chun +1 位作者 Yuan Hang Liu Xue-Qing 《Applied Geophysics》 SCIE CSCD 2022年第2期271-283,309,共14页
The double-phase-shift filtering method,which is based on the traditional purephase-shift filtering method,is a novel approach to harmonic elimination that can be applied to more complicated signals such as white nois... The double-phase-shift filtering method,which is based on the traditional purephase-shift filtering method,is a novel approach to harmonic elimination that can be applied to more complicated signals such as white noise and slip-sweep.Nonetheless,any type of phase-shift filtering method necessitates a relationship between the frequency of fundamental sweep and time,which may cost necessitate an enormous amount of human and physical resources to achieve inaccurate results with low efficiency.This paper combines deep learning with harmonic elimination to produce a double-phase-shift filtering method based on AR2UNet,a type of U-Net with attention gates structure and recurrent residual blocks for improving accuracy and function while simplifying computational complexity.The input of the AR2UNet structure in this paper is seismic data of slip-sweep signals in vibroseis,and the output is signal frequency variation with the time of the fundamental waves,which are required to eliminate the harmonic waves and adjacent signals using a double-phase-shift method to obtain the fundamental sweep.The training sets and test sets are formed by forward models,and a Log-Cosh loss function is used to monitor the process,during which the results of AR2U-Net and traditional U-Net are compared to demonstrate the eminent function of AR2UNet.Following that,the outcomes’Log-Cosh loss functions and accuracy are also compared to validate the conclusion.AR2U-Net,when applied to raw data and combined with the doublephase-shift method,tends to polish the filtering effects and is worth promoting. 展开更多
关键词 AR2U-Net harmonic elimination double-phase-shifts deep learning VIBROSEIS
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A type of inverter power supply based on harmonic elimination PWM control
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作者 张开如 邢呈呈 刘相楠 《Journal of Measurement Science and Instrumentation》 CAS 2013年第1期68-73,共6页
In order to output sine wave with small degree of distortion and improve stability,a type of inverter power supply is designed based on harmonic elimination pulse-width modulation(PWM)control.The rectifier and filter ... In order to output sine wave with small degree of distortion and improve stability,a type of inverter power supply is designed based on harmonic elimination pulse-width modulation(PWM)control.The rectifier and filter are added to input circuit of the inverter.Single-phrase full-bridge inverter performs the function of converting direct current into alternating current(DC/AC).In the control circuit,single chip micyoco(SCM)AT89C2051 is used for main control chip to accomplish the hardware design of the control system.A given value of output frequency of the inverter is input in the way of coding.According to the output frequency code which is read,SCM AT89C2051 defined harmonic elimination PWM control data which will be selected.Through internal timing control,the switches are switched under this provision of PWM control data.Then the driving signals of the switches in the inverter are output from I/O of SCM AT89C2051 to realize harmonic elimination PWM control.The results show that adding Newton homotopic algorithm of harmonic elimination PWM control to corresponding software of the control system can make the quality of output voltage of the inverter higher and it will have broad application prospects. 展开更多
关键词 inverter power supply pulse-width modulation(PWM) harmonic elimination PWM control Newton homotopic continuation method
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Accelerated Recursive Feature Elimination Based on Support Vector Machine for Key Variable Identification 被引量:4
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作者 毛勇 皮道映 +1 位作者 刘育明 孙优贤 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2006年第1期65-72,共8页
Key variable identification for classifications is related to many trouble-shooting problems in process indus-tries. Recursive feature elimination based on support vector machine (SVM-RFE) has been proposed recently i... Key variable identification for classifications is related to many trouble-shooting problems in process indus-tries. Recursive feature elimination based on support vector machine (SVM-RFE) has been proposed recently in applica-tion for feature selection in cancer diagnosis. In this paper, SVM-RFE is used to the key variable selection in fault diag-nosis, and an accelerated SVM-RFE procedure based on heuristic criterion is proposed. The data from Tennessee East-man process (TEP) simulator is used to evaluate the effectiveness of the key variable selection using accelerated SVM-RFE (A-SVM-RFE). A-SVM-RFE integrates computational rate and algorithm effectiveness into a consistent framework. It not only can correctly identify the key variables, but also has very good computational rate. In comparison with contribution charts combined with principal component aralysis (PCA) and other two SVM-RFE algorithms, A-SVM-RFE performs better. It is more fitting for industrial application. 展开更多
关键词 variable selection support vector machine recursive feature elimination fault diagnosis
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Analysis of space harmonic selectivity of period-varying folded waveguide 被引量:1
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作者 徐朝 王文祥 +1 位作者 魏彦玉 宫玉彬 《Chinese Physics B》 SCIE EI CAS CSCD 2009年第3期1270-1275,共6页
A period-varying folded waveguide is formed by varying the period of a folded waveguide. It has the advantages of the space harmonic selectivity and the wide bandwidth. However, the regularities of the variety of thes... A period-varying folded waveguide is formed by varying the period of a folded waveguide. It has the advantages of the space harmonic selectivity and the wide bandwidth. However, the regularities of the variety of these period-varying folded waveguides are unavailable from the published papers. In order to solve this problem, the principle of the space harmonic selectivity of a period-varying folded waveguide is analysed, and the conditions to select the space harmonic for this slow wave system are obtained. In addition, the space harmonic selectivities for a linear period-varying folded waveguide and a hyperbolic sine-varying period folded waveguide are also analysed as examples. 展开更多
关键词 varying period folded waveguide harmonic selection
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混合级联H桥逆变器的新型SHEPWM功率均衡控制策略
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作者 顾军 丁超 +2 位作者 卜荣荣 蔡润哲 王伟健 《电机与控制学报》 EI CSCD 北大核心 2024年第7期178-186,共9页
对于直流侧电压比为1∶1∶2的混合级联H桥逆变器,传统的指定谐波消除脉宽调制法(SHEPWM)存在各单元间输出功率不均衡问题,因此,提出一种双层功率均衡调制策略。首先,通过对消谐方程组中的基波幅值方程表达式进行等效拆分,使2个低压H桥... 对于直流侧电压比为1∶1∶2的混合级联H桥逆变器,传统的指定谐波消除脉宽调制法(SHEPWM)存在各单元间输出功率不均衡问题,因此,提出一种双层功率均衡调制策略。首先,通过对消谐方程组中的基波幅值方程表达式进行等效拆分,使2个低压H桥单元的输出电压基波幅值之和与高压H桥单元的输出电压基波幅值相等,实现了高低压H桥单元间的功率均衡,即外层功率均衡。其次,利用逻辑运算的方法对低压单元的初始驱动信号进行逻辑重组,实现2个低压单元间的功率均衡,即内层功率均衡;然后使用改进的实数型遗传算法(IRCGA-2)求出消谐方程组的解,消除指定的谐波,得到高质量的输出电压。最后,通过仿真和实验证明了调制策略的正确性与有效性。 展开更多
关键词 混合级联H桥逆变器 指定谐波消除 双层功率均衡 基波幅值 逻辑运算 改进的实数型遗传算法
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改进蛇算法的七电平逆变器SHEPWM研究
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作者 付光杰 李鑫 《微特电机》 2024年第6期49-54,61,共7页
多电平逆变器控制策略中的特定谐波消除脉宽调制(SHEPWM)能够以较低的开关频率得到较好的电压输出波形,重点在于开关角的求取。在多电平逆变器SHEPWM调制的开关角求解算法上提出改进蛇优化算法,对传统蛇优化算法采用Tend混沌映射初始种... 多电平逆变器控制策略中的特定谐波消除脉宽调制(SHEPWM)能够以较低的开关频率得到较好的电压输出波形,重点在于开关角的求取。在多电平逆变器SHEPWM调制的开关角求解算法上提出改进蛇优化算法,对传统蛇优化算法采用Tend混沌映射初始种群,使初始种群分布更加均匀;引入Levy飞行策略增强算法的全局搜素能力,能够更加精准快速得到全局开关角的最优解。仿真结果表明,改进蛇优化算法所求的开关角相较于传统算法更好地消除低次谐波,并降低了输出线电压的畸变率,充分验证了该方法的可行性。 展开更多
关键词 特定谐波消除脉宽调制 七电平逆变器 蛇优化算法 开关角求解
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基于SHEPWM的三电平三相逆变器中点电位主动平衡控制策略 被引量:5
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作者 董志强 王琛琛 +2 位作者 周明磊 刘明月 李凯 《电工技术学报》 EI CSCD 北大核心 2024年第4期1147-1158,共12页
在大功率系统中,常采用特定次谐波消除脉宽调制(SHEPWM)以降低系统的开关损耗。针对三电平中点钳位(NPC)型三相逆变器在SHEPWM下的中点电位偏移问题,分析SHEPWM下逆变器输出相电压基波与3次谐波在不同电压相位范围内对中点电位的影响,... 在大功率系统中,常采用特定次谐波消除脉宽调制(SHEPWM)以降低系统的开关损耗。针对三电平中点钳位(NPC)型三相逆变器在SHEPWM下的中点电位偏移问题,分析SHEPWM下逆变器输出相电压基波与3次谐波在不同电压相位范围内对中点电位的影响,设计两种在基波周期内对中点电位总充放电效果相反的开关角组合方案,并提出一种通过测量中点电位偏移值及中点电位滞环控制,选择不同的开关角组合方案进行调制的中点电位主动平衡控制策略。实验结果验证了所提出方法的实用性及有效性。 展开更多
关键词 三电平中点钳位型逆变器 中点电位控制 特定谐波消除脉宽调制 3次谐波
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纤维肌痛综合征生物标记物的筛选及免疫细胞浸润分析
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作者 刘雅妮 杨静欢 +5 位作者 陆慧慧 易玉芳 李智翔 欧阳福 吴璟莉 魏兵 《中国组织工程研究》 CAS 北大核心 2025年第5期1091-1100,共10页
背景:纤维肌痛综合征作为常见风湿病,其发病与中枢敏化及免疫异常有关,但具体过程尚未阐明,缺乏特异性诊断标志物,不断探索该病的发病机制具有重要的临床意义。目的:基于加权基因共表达网络分析(WGCNA)等生物信息学方法和机器学习算法... 背景:纤维肌痛综合征作为常见风湿病,其发病与中枢敏化及免疫异常有关,但具体过程尚未阐明,缺乏特异性诊断标志物,不断探索该病的发病机制具有重要的临床意义。目的:基于加权基因共表达网络分析(WGCNA)等生物信息学方法和机器学习算法筛选纤维肌痛综合征潜在的诊断相关标志基因,并分析其免疫细胞浸润特征。方法:对来自基因表达综合数据库(GEO)的纤维肌痛综合征数据集转录谱进行差异分析和WGCNA分析,整合筛选出差异共表达基因,进一步采用机器学习套索回归(LASSO)算法、支持向量机递归特征消除(SVM-RFE)机器学习算法来识别核心生物标志物,并绘制受试者工作特征(ROC)曲线以评估诊断价值。最后,采用单样本基因集富集分析(ssGSEA)和基因集富集分析(GSEA)评估纤维肌痛综合征的免疫细胞浸润情况及通路富集。结果与结论:①对GSE67311数据集按照log2|(FC)|>0,P<0.05的条件进行差异分析后获得8个下调的差异表达基因;进行WGCNA分析后获得正相关性最高(r=0.22,P=0.04)的模块(MEdarkviolet)内含基因497个,负相关性最高(r=-0.41,P=6×10-5)的模块(MEsalmon2)内含基因19个;将差异表达基因与WGCNA的2个高相关性模块基因取交集,获得7个基因。②对上述7个基因进行LASSO回归算法筛选出4个基因,进行SVM-RFE机器学习算法筛选出5个基因,两者取交集后确定了3个核心基因,分别为重组1号染色体开放阅读框150蛋白(germinal center associated signaling and motility like,GCSAML)、整合素β8(Integrin beta-8,ITGB8)和羧肽酶A3(carboxypeptidase A3,CPA3);绘制3个核心基因的ROC曲线下面积分别为0.744,0.739,0.734,提示均具有很好的诊断价值,可作为纤维肌痛综合征的生物标志物。③免疫浸润分析结果显示,与对照组相比纤维肌痛综合征患者记忆B细胞、CD56 bright NK细胞和肥大细胞显著下调(P<0.05),且与上述3个生物标志物显著正相关(P<0.05)。④富集分析结果提示,纤维肌痛综合征的富集途径包括9条,主要与嗅觉传导、神经活性配体-受体相互作用及感染等通路密切相关。⑤上述结果显示,纤维肌痛综合征的发生发展与多基因参与、免疫调节异常及多个通路失调有关,但这些基因与免疫细胞之间的相互作用,以及它们与各通路之间的关系尚需进一步研究。 展开更多
关键词 纤维肌痛综合征 生物信息学 机器学习 免疫浸润 加权基因共表达网络分析 套索回归 支持向量机递归特征消除算法 单样本基因集富集分析 基因集富集分析
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浅析前胡之推陈致新功用
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作者 王珏 王星栋 薛佳怡 《河南中医》 2024年第3期347-350,共4页
前胡味苦、辛,性微寒,归肺经,《神农本草经》《本草经集注》等均记载其有推陈致新功效,可祛除在表之水饮,解在表之邪气,从而达到“推陈”之功,且其味甘可健中焦,补益胃气,故在祛除病理产物的同时还具有补益之功。柴胡、前胡均能疗伤寒寒... 前胡味苦、辛,性微寒,归肺经,《神农本草经》《本草经集注》等均记载其有推陈致新功效,可祛除在表之水饮,解在表之邪气,从而达到“推陈”之功,且其味甘可健中焦,补益胃气,故在祛除病理产物的同时还具有补益之功。柴胡、前胡均能疗伤寒寒热,发表散风,推陈致新,清里散结,而前胡更偏于除里之痰饮水气,散表之风邪,其与半夏相配能制痰饮痞结,降逆化浊;与黄芩相配可泻厥阴伏火;与桂枝相配能散表之风邪;与生姜相配意在温胃化饮。前胡之推陈致新功用既体现在气机层面,可理气、散气,对不同程度的气机瘀滞、气机凝结等均有效;又表现在活血通脉方面,在理气的基础上,通行血脉,活血化瘀。散气、活血均是“推陈”的体现,“陈”包括机体的病理产物如痰浊、水饮、瘀血、滞气、燥矢等,推出体内陈旧之代谢废物,促使新生之物产生,从而使机体达到气血通畅、五脏安和的状态。 展开更多
关键词 前胡 推陈致新 健中焦 化痰滞 和少阳 降火热 解表邪 祛水饮 散气结 祛瘀血
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基于改进同步解调方式的三级式同步电机无位置传感器起动控制
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作者 蔡正友 魏佳丹 +2 位作者 胡文枝 张卓然 周波 《电工技术学报》 EI CSCD 北大核心 2024年第14期4353-4365,共13页
针对航空三级式同步电机起动控制中存在的转子位置信息获取困难问题,在励磁电压高频谐波自注入方法分析的基础上,该文基于同步解调的基本思路,提出了一种无需极性判断和励磁电流采样环节的同步解耦信号生成方式,并根据主发电机中响应电... 针对航空三级式同步电机起动控制中存在的转子位置信息获取困难问题,在励磁电压高频谐波自注入方法分析的基础上,该文基于同步解调的基本思路,提出了一种无需极性判断和励磁电流采样环节的同步解耦信号生成方式,并根据主发电机中响应电压谐波的频谱特性设计了位置误差信息提取的精准谐波消除滤波器,可以降低转子位置估计闭环系统的阶次,增强系统的稳定性以适应更宽的转速范围。最后通过仿真和实验证明了所述改进同步解调方法能够实现高精度和宽转速范围的三级式同步电机无位置传感器起动控制。 展开更多
关键词 三级式同步电机 谐波自注入 同步解调 精准谐波消除滤波器
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