Cannabinoid receptor antagonist SR141716A decreases operant ethanol self administration in rats exposed to ethanol-vapor chambers

AIM:To study the potential role of dependence statuson CB_(1)-mediated blockade of ethanol self-administra-tion.METHODS:We examined the effects of thecannabinoid antagonist SR141716A(0,0.03,0.3,and 3 mg/kg)on pperant ethanol(10%v/v)self-administration in male Wistar rats that were madeethanol-dependent by chronic(14 d)exposure toethanol vapor-chambers or exposed to air in identicalvapor chambers.RESULTS:Dependent animalsresponded more for ethanol than did air controlnondependent tats.The acute administration of a 3mg/kg dose of SR141716A almost suppressed ethanolself-administration ouly in ethanol dependent animals.However,operant responses for food were not afected by the administration of SR141716A.CONCLU.SION:These results further support that cannabinoid CB_(1) receptor blockade may have a potential utility for the treatment of alcobolism.

中加两国大学管理模式的差异比较及其启示

通过对加拿大大学管理模式的分析比较,发现加拿大在大学管理突出表现在办学经营理念方面,具有明确的产业意识、市场观念和成本核算理念;严谨的治理策略——依法治校,保证了学校在国家、省法律法规的框架内能够独立自主的发展;灵活的运行模式——公立性、独立性与国际化,使高等教育面向社会、公众全方位开放,实现教育的公平公开、多样性和多元化。中国大学经过百年发展,管理模式经过几次重大调整,逐步形成政府管理模式、教育行政化的特点,学习和借鉴加方管理经验,提升中国大学管理水平,扩大大学办学自主权,明确大学法人地位;深化学校内部管理体制改革,平衡行政权力与学术权力;注重大学与社会的关系,建立多元化的办学格局。