Wireless sensor networks (WSNs) operate in complex and harshenvironments;thus, node faults are inevitable. Therefore, fault diagnosis ofthe WSNs node is essential. Affected by the harsh working environment ofWSNs and ...Wireless sensor networks (WSNs) operate in complex and harshenvironments;thus, node faults are inevitable. Therefore, fault diagnosis ofthe WSNs node is essential. Affected by the harsh working environment ofWSNs and wireless data transmission, the data collected by WSNs containnoisy data, leading to unreliable data among the data features extracted duringfault diagnosis. To reduce the influence of unreliable data features on faultdiagnosis accuracy, this paper proposes a belief rule base (BRB) with a selfadaptivequality factor (BRB-SAQF) fault diagnosis model. First, the datafeatures required for WSN node fault diagnosis are extracted. Second, thequality factors of input attributes are introduced and calculated. Third, themodel inference process with an attribute quality factor is designed. Fourth,the projection covariance matrix adaptation evolution strategy (P-CMA-ES)algorithm is used to optimize the model’s initial parameters. Finally, the effectivenessof the proposed model is verified by comparing the commonly usedfault diagnosis methods for WSN nodes with the BRB method consideringstatic attribute reliability (BRB-Sr). The experimental results show that BRBSAQFcan reduce the influence of unreliable data features. The self-adaptivequality factor calculation method is more reasonable and accurate than thestatic attribute reliability method.展开更多
This study established a dog model of acute multiple cauda equina constriction by experimental constriction injury （48 hours） of the lumbosacral central processes in dorsal root ganglia neurons. The repair effect of...This study established a dog model of acute multiple cauda equina constriction by experimental constriction injury （48 hours） of the lumbosacral central processes in dorsal root ganglia neurons. The repair effect of intrathecal injection of brain-derived neurotrophic factor with 15 mg encapsulated biodegradable poly（lactide-co-glycolide） nanoparticles on this injury was then analyzed. Dorsal root ganglion cells （LT） of all experimental dogs were analyzed using hematoxylin-eosin staining and immunohistochemistry at 1,2 and 4 weeks following model induction. Intrathecal injection of brain-derived neurotrophic factor can relieve degeneration and inflammation, and elevate the expression of brain-derived neurotrophic factor in sensory neurons of compressed dorsal root ganglion Simultaneously, intrathecal injection of brain-derived neurotrophic factor obviously improved neurological function in the dog model of acute multiple cauda equina constriction. Results verified that sustained intraspinal delivery of brain-derived neurotrophic factor encapsulated in biodegradable nanoparticles promoted the repair of histomorphology and function of neurons within the dorsal root ganglia in dogs with acute and severe cauda equina syndrome.展开更多
Objective To evaluate platelet activating factor (PAF) induced aqueous liare, corneai edema, pupillary constriction and btphasic intraocular pressure (IOP) changes in the rabbit eyes. Methods PAF was delivered into an...Objective To evaluate platelet activating factor (PAF) induced aqueous liare, corneai edema, pupillary constriction and btphasic intraocular pressure (IOP) changes in the rabbit eyes. Methods PAF was delivered into anterior chamber by intracameral injection, other antagonists were administered systemically. Results PAF induced responses in a dose - dependent manner. All of the responses to PAF were inhibited by the PAF receptor antagonist, BN 52021 (20mg/kg, i.p.). The cyclooxygenase inhibitor, indomethacin (30mg/kg, i.P.) caused signofcant inhibition of the early phase PAF- induced aqueous flare, pupillary constriction and intraocular hypertension, but did not alfect PAF- induced corneal edema or intraocular hypotension. Nordihydroguaiaretic acid (NDGA) (10mg/kg, ip.), a lipoxygenase inhibitor, did not inhibit the inflammatory effects of PAF. Conclusion These data suggest that PAF may be an important mediator of intraocular inllammation and that some PAF- induced effects are prostaglandin dependent, while others may be independent of eicosanoid synthesis and release.展开更多
The reactive power dispatch （RPD） problem is a very critical optimization problem of power system which minimizes the real power loss of the transmission system. While solving the said problem, generator bus voltage...The reactive power dispatch （RPD） problem is a very critical optimization problem of power system which minimizes the real power loss of the transmission system. While solving the said problem, generator bus voltages and transformer tap settings are kept within a stable operating limit. In connection with the RPD problem, solving reactive power is compensated by incorporating shunt capacitors. The particle swarm optimization （PSO） technique is a swarm intelligence based fast working optimization method which is chosen in this paper as an optimization tool. Additionally, the constriction factor is included with the conventional PSO technique to accelerate the convergence property of the applied optimization tool. In this paper, the RPD problem is solved in the case of the two higher bus systems, i.e., the IEEE 57-bus system and the IEEE ll8-bus system. Furthermore, the result of the present paper is compared with a few optimization technique based results to substantiate the effectiveness of the proposed study.展开更多
目的研究颅内外动脉纡曲狭窄特点与临床表现及相关危险因素。方法2218例45～89岁患者行全脑血管造影术。根据数字减影血管造影（digital subtraction angiography，DSA）影像，将颅内外动脉形态分为动脉纡曲延长和狭窄，临床特点分为头...目的研究颅内外动脉纡曲狭窄特点与临床表现及相关危险因素。方法2218例45～89岁患者行全脑血管造影术。根据数字减影血管造影（digital subtraction angiography，DSA）影像，将颅内外动脉形态分为动脉纡曲延长和狭窄，临床特点分为头痛头昏、短暂性脑缺血发作（transient ischemic attack，TIA）和脑梗死，危险因素包括高齿鬏原发性高血压及糖尿病等。应用Х^2检验，对动脉纡曲延长、狭窄分布及临床特点进行比较。应用Logistic回归分析对颅内外动脉狭窄纡曲的危险因素进行多因素分析。结果2218例造影显示动脉纡曲延长和狭窄1816例，动脉纡曲延长发生率为76．1％，动脉狭窄发生率为23．9％。颈内动脉系统“S”型纡曲和“0”型纡曲临床表现为脑梗死分别为40．0％和47．9％。椎一基底动脉系统“S”型纡曲和“0”型纡曲临床表现为TIA，分别为57．6％和25．0％。颈内动脉系统重度狭窄临床表现为TIA（45．3％）和脑梗死（35．8％）。椎一基底动脉系统中、重度狭窄临床表现为TIA，分别为48．6％和48．4％。年龄（OR=3．28，95％ CI 2．16～4．75）、原发性高血压（OR=3．17，95％ CI 2．12～4．69）、体质指数（body mass index，BMI）（OR=2．95，95％CI 2．02-4．31）和糖尿病（OR=2．82，95％ CI 1．96～3．87）与颅内外动脉狭窄纡曲密切相关。结论颅内外动脉纡曲类型及狭窄程度与临床表现之间有明显相关性，颅内外动脉纡曲狭窄的危险因素主要为年龄、原发性高血压、BMI和糖尿病等。展开更多
基金supported by the Postdoctoral Science Foundation of China under Grant No.2020M683736partly by the Teaching reform project of higher education in Heilongjiang Province under Grant No.SJGY20210456+2 种基金partly by the Natural Science Foundation of Heilongjiang Province of China under Grant No.LH2021F038partly by the Haiyan foundation of Harbin Medical University Cancer Hospital under Grant No.JJMS2021-28partly by the graduate academic innovation project of Harbin Normal University under Grant Nos.HSDSSCX2022-17,HSDSSCX2022-18 and HSDSSCX2022-19.
文摘Wireless sensor networks (WSNs) operate in complex and harshenvironments;thus, node faults are inevitable. Therefore, fault diagnosis ofthe WSNs node is essential. Affected by the harsh working environment ofWSNs and wireless data transmission, the data collected by WSNs containnoisy data, leading to unreliable data among the data features extracted duringfault diagnosis. To reduce the influence of unreliable data features on faultdiagnosis accuracy, this paper proposes a belief rule base (BRB) with a selfadaptivequality factor (BRB-SAQF) fault diagnosis model. First, the datafeatures required for WSN node fault diagnosis are extracted. Second, thequality factors of input attributes are introduced and calculated. Third, themodel inference process with an attribute quality factor is designed. Fourth,the projection covariance matrix adaptation evolution strategy (P-CMA-ES)algorithm is used to optimize the model’s initial parameters. Finally, the effectivenessof the proposed model is verified by comparing the commonly usedfault diagnosis methods for WSN nodes with the BRB method consideringstatic attribute reliability (BRB-Sr). The experimental results show that BRBSAQFcan reduce the influence of unreliable data features. The self-adaptivequality factor calculation method is more reasonable and accurate than thestatic attribute reliability method.
基金supported by grants from the Medical Scientific Fund and Intensive Research of Nanjing Military Area Command of Chinese PLA, No.Nan2007-13 and Nan 08Z003the Medical Scientific Fund and Research of Chinese PLA during the 12th Five-Year Plan Period,No.CWS11J260
文摘This study established a dog model of acute multiple cauda equina constriction by experimental constriction injury （48 hours） of the lumbosacral central processes in dorsal root ganglia neurons. The repair effect of intrathecal injection of brain-derived neurotrophic factor with 15 mg encapsulated biodegradable poly（lactide-co-glycolide） nanoparticles on this injury was then analyzed. Dorsal root ganglion cells （LT） of all experimental dogs were analyzed using hematoxylin-eosin staining and immunohistochemistry at 1,2 and 4 weeks following model induction. Intrathecal injection of brain-derived neurotrophic factor can relieve degeneration and inflammation, and elevate the expression of brain-derived neurotrophic factor in sensory neurons of compressed dorsal root ganglion Simultaneously, intrathecal injection of brain-derived neurotrophic factor obviously improved neurological function in the dog model of acute multiple cauda equina constriction. Results verified that sustained intraspinal delivery of brain-derived neurotrophic factor encapsulated in biodegradable nanoparticles promoted the repair of histomorphology and function of neurons within the dorsal root ganglia in dogs with acute and severe cauda equina syndrome.
文摘Objective To evaluate platelet activating factor (PAF) induced aqueous liare, corneai edema, pupillary constriction and btphasic intraocular pressure (IOP) changes in the rabbit eyes. Methods PAF was delivered into anterior chamber by intracameral injection, other antagonists were administered systemically. Results PAF induced responses in a dose - dependent manner. All of the responses to PAF were inhibited by the PAF receptor antagonist, BN 52021 (20mg/kg, i.p.). The cyclooxygenase inhibitor, indomethacin (30mg/kg, i.P.) caused signofcant inhibition of the early phase PAF- induced aqueous flare, pupillary constriction and intraocular hypertension, but did not alfect PAF- induced corneal edema or intraocular hypotension. Nordihydroguaiaretic acid (NDGA) (10mg/kg, ip.), a lipoxygenase inhibitor, did not inhibit the inflammatory effects of PAF. Conclusion These data suggest that PAF may be an important mediator of intraocular inllammation and that some PAF- induced effects are prostaglandin dependent, while others may be independent of eicosanoid synthesis and release.
文摘The reactive power dispatch （RPD） problem is a very critical optimization problem of power system which minimizes the real power loss of the transmission system. While solving the said problem, generator bus voltages and transformer tap settings are kept within a stable operating limit. In connection with the RPD problem, solving reactive power is compensated by incorporating shunt capacitors. The particle swarm optimization （PSO） technique is a swarm intelligence based fast working optimization method which is chosen in this paper as an optimization tool. Additionally, the constriction factor is included with the conventional PSO technique to accelerate the convergence property of the applied optimization tool. In this paper, the RPD problem is solved in the case of the two higher bus systems, i.e., the IEEE 57-bus system and the IEEE ll8-bus system. Furthermore, the result of the present paper is compared with a few optimization technique based results to substantiate the effectiveness of the proposed study.
文摘目的研究颅内外动脉纡曲狭窄特点与临床表现及相关危险因素。方法2218例45～89岁患者行全脑血管造影术。根据数字减影血管造影（digital subtraction angiography，DSA）影像，将颅内外动脉形态分为动脉纡曲延长和狭窄，临床特点分为头痛头昏、短暂性脑缺血发作（transient ischemic attack，TIA）和脑梗死，危险因素包括高齿鬏原发性高血压及糖尿病等。应用Х^2检验，对动脉纡曲延长、狭窄分布及临床特点进行比较。应用Logistic回归分析对颅内外动脉狭窄纡曲的危险因素进行多因素分析。结果2218例造影显示动脉纡曲延长和狭窄1816例，动脉纡曲延长发生率为76．1％，动脉狭窄发生率为23．9％。颈内动脉系统“S”型纡曲和“0”型纡曲临床表现为脑梗死分别为40．0％和47．9％。椎一基底动脉系统“S”型纡曲和“0”型纡曲临床表现为TIA，分别为57．6％和25．0％。颈内动脉系统重度狭窄临床表现为TIA（45．3％）和脑梗死（35．8％）。椎一基底动脉系统中、重度狭窄临床表现为TIA，分别为48．6％和48．4％。年龄（OR=3．28，95％ CI 2．16～4．75）、原发性高血压（OR=3．17，95％ CI 2．12～4．69）、体质指数（body mass index，BMI）（OR=2．95，95％CI 2．02-4．31）和糖尿病（OR=2．82，95％ CI 1．96～3．87）与颅内外动脉狭窄纡曲密切相关。结论颅内外动脉纡曲类型及狭窄程度与临床表现之间有明显相关性，颅内外动脉纡曲狭窄的危险因素主要为年龄、原发性高血压、BMI和糖尿病等。
