To improve the limiting current interruption capability and minimizing vacuum interrupter with axial magnetic field (AMF) electrodes, it is significant to investigate the vacuum arc behaviours between the contacts. ...To improve the limiting current interruption capability and minimizing vacuum interrupter with axial magnetic field (AMF) electrodes, it is significant to investigate the vacuum arc behaviours between the contacts. AMF distributions of the slot type electrodes were studied by both numerical analysis and experiments. Furthermore, the behaviours of vacuum arcs for different parameters of the slot type AMF electrodes were investigated by using high-speed CCD camera. The influences of gap distance, contact diameter and phase shift time between AMF and arc current on the vacuum arc were investigated. The results provide a reference for research and development of vacuum interrupters with slot type or other types of AMF electrode.展开更多
The use of vacuum interrupters(VIs)as the current interruption component for switches,circuit breakers,reclosers and contactors operating at distribution voltages has escalated since their introduction in the mid-1950...The use of vacuum interrupters(VIs)as the current interruption component for switches,circuit breakers,reclosers and contactors operating at distribution voltages has escalated since their introduction in the mid-1950’s.This electrical product has developed a dominating position for switching and protecting distribution circuits.VIs are even being introduced into switching products operating at transmission voltages.Among the reasons for the VI’s popularity are its compactness,its range of application,its low cost,its superb electrical and mechanical life and its ease of application.Its major advantage is its well-established reliability.In this paper we show how this reliability has been achieved by design,by mechanical life testing and by electrical performance testing.We introduce the“sealed for life”concept for the VI’s integrity.We discuss this in terms of what is meant by a practical leak rate for VIs with a life of over 30 years.We show that a simple high voltage withstand test is an easy and effective method for monitoring the long-term vacuum integrity.Finally we evaluate the need for routine inspection of this electrical product when it is used in adverse ambient environments.展开更多
The greenhouse effect of SFe is a great concern today. The development of high voltage vacuum circuit breakers becomes more important. The vacuum circuit breaker has minimum pollution to the environment. The vacuum in...The greenhouse effect of SFe is a great concern today. The development of high voltage vacuum circuit breakers becomes more important. The vacuum circuit breaker has minimum pollution to the environment. The vacuum interrupter is the key part of a vacuum circuit breaker. The interrupting characteristics in vacuum and arc-controlling techniue are the main problems to be solved for a longer gap distance in developing high voltage vacuum interrupters. To understand the vacuum arc characteristics and provide effective technique to control vacuum arc in a long gap distance, the arc mode transition of a cup-type axial magnetic field electrode is observed by a high-speed charge coupled device (CGD) video camera under different gap distances while the arc voltage and arc current are recorded. The controlling ability of the axial magnetic field on vacuum arc obviously decreases when the gap distance is longer than 40 ram. The noise components and mean value of the arc voltage significantly increase. The effective method for controlling the vacuum arc characteristics is provided by long gap distances based on the test results. The test results can be used as a reference to develop high voltage and large capacity vacuum interrupters.展开更多
When subjected to high voltages between opened contacts, vacuum interrupters may emit X-rays. In order to ensure that these are of an acceptable level, vacuum interrupters should comply with the limits for X-ray emiss...When subjected to high voltages between opened contacts, vacuum interrupters may emit X-rays. In order to ensure that these are of an acceptable level, vacuum interrupters should comply with the limits for X-ray emission and the test procedures to be carried out to verify this based on relevant standards and specifications. In this paper, a comprehensive experimental study has been performed for 126 kV vacuum interrupters used in a transmission system to understand the X-radiation level and its influence by three main parameters, namely applied power-frequency voltage, contact gap and power=frequency voltage conditioning. The radiation instrument is an FJ347 radiometer and the X-radiation dose was measured at the power-frequency test voltage. These tests demonstrated that the X-radiation emission level for a 126 kV vacuum interrupter did not exceed the following: 5 μSv per hour at a rated voltage of 126 kV and 150 μSv per hour at a power-frequency voltage of 230 kV at 1 m distance. The X-radiation dose increased with the applied power-frequency voltage increasing and decreased with the contact gap increasing. The X- radiation dose for 126 kV vacuum interrupters decreased by 57% after the conditioning procedure with a certain power-frequency voltage. During the conditioning procedure, the average value of the X-radiation dose was 4.49 mSv, which means if a professional conditions 180 interrupters per year, it will be safe at the 6.4 m distance.展开更多
The free shrinkage of ceramic or metal is restricted due to solidification of the solder. Hence the shrinkage stress arises and the jointing strength is reduced during the brazing of high-voltage vacuum interrupters ...The free shrinkage of ceramic or metal is restricted due to solidification of the solder. Hence the shrinkage stress arises and the jointing strength is reduced during the brazing of high-voltage vacuum interrupters (HVVIs). The solder bound contour was gained by solved energy bound equation. The finite element model of weld beads was established with Surface Evolver software. Then the stress in two different cooling techniques ( natural cooling and force cooling) was calculated with ANSYS. Comparing the stress, a better cooling technique was selected for HVVIs. Its cooling time is shortened by 3 hours while the jointing stress doesn' t increase and the tensile strength of ceramic to metal seal is not decreased. The stress-rupture tests have validated the calculated results. More important, a method is found, by which the brazing technique could be improved in advance instead of blind experiments.展开更多
Background: An interrupted family history, as is the case after taking someone into care, can complicate collecting family anamnesis data. In addition, the interrupted family history itself could be considered part of...Background: An interrupted family history, as is the case after taking someone into care, can complicate collecting family anamnesis data. In addition, the interrupted family history itself could be considered part of a person’s risk profile. Aim and methods: Literature analysis was conducted to examine whether there are scientific studies on health development after placement in out-of-home-care in order to recognise any existing medical characteristics that may be relevant for internal medical care. Results: There are few scientific publications on the health development of people after being placed in out-of-home-care. Direct reactions to the stress of being taken into custody include nausea and fever. However, effects that go beyond the acute situation and last into adulthood have also been described, such as AD(H)D, asthma, diabetes, cancer, hypertension and cardiovascular diseases (myocardial infarction, stroke), epilepsy and increased overall mortality in adulthood. Studies show that not only previous experience but also the stress of being taken into care is triggers for this. Conclusion: Information about a previous institutionalisation can hence be important for internal medical practice. The available scientific literature shows heterogeneous study methodology and no group of people with experience of out-of-home-placement has yet been scientifically accompanied for a long time period. Further studies on this could help to better weigh up the consequences of omitting and conducting an intervention for child/youth protection as well as to improve the medical care for this group of people.展开更多
The effects of interrupted aging on mechanical properties and corrosion resistance of 7A75 aluminum alloy extruded bar were investigated through various analyses,including electrical conductivity,mechanical properties...The effects of interrupted aging on mechanical properties and corrosion resistance of 7A75 aluminum alloy extruded bar were investigated through various analyses,including electrical conductivity,mechanical properties,local corrosion properties,and slow strain rate tensile stress corrosion tests.Microstructure characterization techniques such as metallographic microscopy,scanning electron microscopy(SEM),and transmission electron microscopy(TEM)were also employed.The results indicate that the tensile strength of the alloy produced by T6I6 aging is similar to that produced by T6I4 aging,and it even exceeds 700 MPa.Furthermore,the yield strength increases by 52.7 MPa,reaching 654.8 MPa after T6I6 aging treatment.The maximum depths of intergranular corrosion(IGC)and exfoliation corrosion(EXCO)decrease from 116.3 and 468.5μm to 89.5 and 324.3μm,respectively.The stress corrosion factor also decreases from 2.1%to 1.6%.These findings suggest that the alloy treated with T6I6 aging exhibits both high strength and excellent stress corrosion cracking resistance.Similarly,when the alloy is treated with T6I4,T6I6 and T6I7 aging,the sizes of grain boundary precipitates(GBPs)are found to be 5.2,18.4,and 32.8 nm,respectively.The sizes of matrix precipitates are 4.8,5.7 and 15.7 nm,respectively.The atomic fractions of Zn in GBPs are 9.92 at.%,8.23 at.%and 6.87 at.%,respectively,while the atomic fractions of Mg are 12.66 at.%,8.43 at.%and 7.00 at.%,respectively.Additionally,the atomic fractions of Cu are 1.83 at.%,2.47 at.%and 3.41 at.%,respectively.展开更多
BACKGROUND Pituitary stalk interruption syndrome(PSIS)is a rare anatomical defect of the pituitary gland falling under the spectrum of holoprosencephaly phenotypes.It is characterized by a deficiency in anterior pitui...BACKGROUND Pituitary stalk interruption syndrome(PSIS)is a rare anatomical defect of the pituitary gland falling under the spectrum of holoprosencephaly phenotypes.It is characterized by a deficiency in anterior pituitary hormones,such as growth hormone,gonadotropins,and thyroid hormones.Due to the syndrome's rarity and nonspecific manifestations,there is a lack of standardized treatment strategies.Consequently,early diagnosis through imaging and on-time intervention are crucial for improving patients’outcomes.CASE SUMMARY A 30-year-old man presented with absent secondary sexual characteristics and azoospermia.Laboratory evaluation revealed a deficiency in gonadotropins,while thyroid function was mostly within normal ranges.Magnetic resonance imaging of the pituitary gland showed pituitary stalk agenesis,hypoplasia of the anterior pituitary,and ectopic posterior pituitary,leading to the diagnosis of PSIS.Initially,the patient underwent 6 mo of gonadotropin therapy without significant changes in hormone levels and secondary sexual characteristics.Pulsatile gonadotropin-releasing hormone therapy was then administered,resulting in the detection of sperm in the semen analysis within 3 mo.After 6 mo,routine semen tests showed normal semen quality.The couple faced challenges in conceiving due to abstinence and underwent three cycles of artificial insemination,which was unsuccessful.They also attempted in vitro fertilization,but unfortunately,the woman experienced a miscarriage 10 wk after the embryo transfer.CONCLUSION Early detection,accurate diagnosis,and timely treatment are crucial in improving the quality of life and fertility of PSIS patients.展开更多
BACKGROUND Pituitary stalk interruption syndrome(PSIS)is a rare disorder,often characterized by delayed growth and development,short stature,and hypogonadism as the main clinical manifestations.It is not clear whether...BACKGROUND Pituitary stalk interruption syndrome(PSIS)is a rare disorder,often characterized by delayed growth and development,short stature,and hypogonadism as the main clinical manifestations.It is not clear whether PSIS can lead to liver cirrhosis.CASE SUMMARY This paper reported a case of liver cirrhosis of unknown origin.The patient was admitted to Beijing Ditan Hospital Affiliated to Capital Medical University in November 2023.The diagnosis of PSIS complicated with liver cirrhosis was established after a series of blood tests and pituitary magnetic resonance imaging examination.CONCLUSION We also reviewed the literature from both domestic and international sources to deepen the clinical understanding of PSIS in conjunction with liver cirrhosis among medical practitioners.展开更多
To study the congestion of interrupted flow on urban roads, a comprehensive evaluation method is proposed. First, based on the results of correlation analysis between different parameters of interrupted flow, the traf...To study the congestion of interrupted flow on urban roads, a comprehensive evaluation method is proposed. First, based on the results of correlation analysis between different parameters of interrupted flow, the traffic parameters of interrupted traffic flow are divided into two categories: the basic parameters and the operation parameters. Polynomial regression is used to formulize the nonlinear relationships between the basic parameters and the operation parameters. Then, the congestion model incorporating both operational and volume characteristics of traffic flow is proposed. The inputs of the model are the basic parameters, while the output is a dimensionless index value between 0 and 1. Finally, the proposed methods are compared with existing evaluation measures of congestion. Results show that the proposed indices can capture the variation of both the basic parameters and the operation parameters, which is more balanced compared with the existing evaluation measures.展开更多
Background:To investigate SCL/TAL 1 interrupting locus(STIL)’s role and prognostic significance in lung adenocarcinoma(LUAD)progression,we examined STIL and E2 promoter binding factor 1(E2F1)expression and their impa...Background:To investigate SCL/TAL 1 interrupting locus(STIL)’s role and prognostic significance in lung adenocarcinoma(LUAD)progression,we examined STIL and E2 promoter binding factor 1(E2F1)expression and their impacts on LUAD prognosis using Gene Expression Profiling Interactive Analysis(GEPIA).Methods:Functional assays including CCK-8,wound-healing,5-ethynyl-2-deoxyuridine(EdU),Transwell assays,and flow cytometry,elucidated STIL and E2F1’s effects on cell viability,proliferation,apoptosis,and migration.Gene set enrichment analysis(GSEA)identified potential pathways,while metabolic assays assessed glucose metabolism.Results:Our findings reveal that STIL and E2F1 are overexpressed in LUAD,correlating with adverse outcomes.It enhances cell proliferation,migration,and invasion,and suppresses apoptosis,activating downstream of E2F1.Silencing E2F1 reversed the promotion effect of the STIL overexpression on cell viability and invasiveness.Importantly,STIL modulates glycolysis,influencing glucose consumption,lactate production,and energy balance in LUAD cells.Conclusion:Our model,incorporating STIL,age,and disease stage,robustly predicts patient prognosis,underscored STIL’s pivotal role in LUAD pathogenesis through metabolic reprogramming.This comprehensive approach not only confirms STIL’s prognostic value but also highlights its potential as a therapeutic target in LUAD.展开更多
To determine the feasibility and practicability of interrupt continuous wave (CW) approach proposed for real time simulating radar intermediate frequency(IF) video signal, theoretical analysis and computer simulation...To determine the feasibility and practicability of interrupt continuous wave (CW) approach proposed for real time simulating radar intermediate frequency(IF) video signal, theoretical analysis and computer simulation were used. Phases at two linked points between the end and beginning of adjoined frames are always consistent; the bias Doppler frequency for the time delay of A/D sampling start responds to that for target acceleration. No digital phase compensation is required at continuous points, and the interrupt CW approach has apparently practical values.展开更多
文摘To improve the limiting current interruption capability and minimizing vacuum interrupter with axial magnetic field (AMF) electrodes, it is significant to investigate the vacuum arc behaviours between the contacts. AMF distributions of the slot type electrodes were studied by both numerical analysis and experiments. Furthermore, the behaviours of vacuum arcs for different parameters of the slot type AMF electrodes were investigated by using high-speed CCD camera. The influences of gap distance, contact diameter and phase shift time between AMF and arc current on the vacuum arc were investigated. The results provide a reference for research and development of vacuum interrupters with slot type or other types of AMF electrode.
文摘The use of vacuum interrupters(VIs)as the current interruption component for switches,circuit breakers,reclosers and contactors operating at distribution voltages has escalated since their introduction in the mid-1950’s.This electrical product has developed a dominating position for switching and protecting distribution circuits.VIs are even being introduced into switching products operating at transmission voltages.Among the reasons for the VI’s popularity are its compactness,its range of application,its low cost,its superb electrical and mechanical life and its ease of application.Its major advantage is its well-established reliability.In this paper we show how this reliability has been achieved by design,by mechanical life testing and by electrical performance testing.We introduce the“sealed for life”concept for the VI’s integrity.We discuss this in terms of what is meant by a practical leak rate for VIs with a life of over 30 years.We show that a simple high voltage withstand test is an easy and effective method for monitoring the long-term vacuum integrity.Finally we evaluate the need for routine inspection of this electrical product when it is used in adverse ambient environments.
基金supported by National Natural Science Foundation of China(No.50477024)
文摘The greenhouse effect of SFe is a great concern today. The development of high voltage vacuum circuit breakers becomes more important. The vacuum circuit breaker has minimum pollution to the environment. The vacuum interrupter is the key part of a vacuum circuit breaker. The interrupting characteristics in vacuum and arc-controlling techniue are the main problems to be solved for a longer gap distance in developing high voltage vacuum interrupters. To understand the vacuum arc characteristics and provide effective technique to control vacuum arc in a long gap distance, the arc mode transition of a cup-type axial magnetic field electrode is observed by a high-speed charge coupled device (CGD) video camera under different gap distances while the arc voltage and arc current are recorded. The controlling ability of the axial magnetic field on vacuum arc obviously decreases when the gap distance is longer than 40 ram. The noise components and mean value of the arc voltage significantly increase. The effective method for controlling the vacuum arc characteristics is provided by long gap distances based on the test results. The test results can be used as a reference to develop high voltage and large capacity vacuum interrupters.
基金supported by National Key Basic Research Program of China(973 Program)(No.2015CB251002)
文摘When subjected to high voltages between opened contacts, vacuum interrupters may emit X-rays. In order to ensure that these are of an acceptable level, vacuum interrupters should comply with the limits for X-ray emission and the test procedures to be carried out to verify this based on relevant standards and specifications. In this paper, a comprehensive experimental study has been performed for 126 kV vacuum interrupters used in a transmission system to understand the X-radiation level and its influence by three main parameters, namely applied power-frequency voltage, contact gap and power=frequency voltage conditioning. The radiation instrument is an FJ347 radiometer and the X-radiation dose was measured at the power-frequency test voltage. These tests demonstrated that the X-radiation emission level for a 126 kV vacuum interrupter did not exceed the following: 5 μSv per hour at a rated voltage of 126 kV and 150 μSv per hour at a power-frequency voltage of 230 kV at 1 m distance. The X-radiation dose increased with the applied power-frequency voltage increasing and decreased with the contact gap increasing. The X- radiation dose for 126 kV vacuum interrupters decreased by 57% after the conditioning procedure with a certain power-frequency voltage. During the conditioning procedure, the average value of the X-radiation dose was 4.49 mSv, which means if a professional conditions 180 interrupters per year, it will be safe at the 6.4 m distance.
基金Sponsored by the National Natural Science Foundation of China(50377003).
文摘The free shrinkage of ceramic or metal is restricted due to solidification of the solder. Hence the shrinkage stress arises and the jointing strength is reduced during the brazing of high-voltage vacuum interrupters (HVVIs). The solder bound contour was gained by solved energy bound equation. The finite element model of weld beads was established with Surface Evolver software. Then the stress in two different cooling techniques ( natural cooling and force cooling) was calculated with ANSYS. Comparing the stress, a better cooling technique was selected for HVVIs. Its cooling time is shortened by 3 hours while the jointing stress doesn' t increase and the tensile strength of ceramic to metal seal is not decreased. The stress-rupture tests have validated the calculated results. More important, a method is found, by which the brazing technique could be improved in advance instead of blind experiments.
文摘Background: An interrupted family history, as is the case after taking someone into care, can complicate collecting family anamnesis data. In addition, the interrupted family history itself could be considered part of a person’s risk profile. Aim and methods: Literature analysis was conducted to examine whether there are scientific studies on health development after placement in out-of-home-care in order to recognise any existing medical characteristics that may be relevant for internal medical care. Results: There are few scientific publications on the health development of people after being placed in out-of-home-care. Direct reactions to the stress of being taken into custody include nausea and fever. However, effects that go beyond the acute situation and last into adulthood have also been described, such as AD(H)D, asthma, diabetes, cancer, hypertension and cardiovascular diseases (myocardial infarction, stroke), epilepsy and increased overall mortality in adulthood. Studies show that not only previous experience but also the stress of being taken into care is triggers for this. Conclusion: Information about a previous institutionalisation can hence be important for internal medical practice. The available scientific literature shows heterogeneous study methodology and no group of people with experience of out-of-home-placement has yet been scientifically accompanied for a long time period. Further studies on this could help to better weigh up the consequences of omitting and conducting an intervention for child/youth protection as well as to improve the medical care for this group of people.
基金the Tianjin Key Laboratory of Fastening and Connection Technology Enterprises 2022—2023,China(No.TKLF2022-02-C-02)the technical support from the School of Materials Science and Engineering,Central South University,China.
文摘The effects of interrupted aging on mechanical properties and corrosion resistance of 7A75 aluminum alloy extruded bar were investigated through various analyses,including electrical conductivity,mechanical properties,local corrosion properties,and slow strain rate tensile stress corrosion tests.Microstructure characterization techniques such as metallographic microscopy,scanning electron microscopy(SEM),and transmission electron microscopy(TEM)were also employed.The results indicate that the tensile strength of the alloy produced by T6I6 aging is similar to that produced by T6I4 aging,and it even exceeds 700 MPa.Furthermore,the yield strength increases by 52.7 MPa,reaching 654.8 MPa after T6I6 aging treatment.The maximum depths of intergranular corrosion(IGC)and exfoliation corrosion(EXCO)decrease from 116.3 and 468.5μm to 89.5 and 324.3μm,respectively.The stress corrosion factor also decreases from 2.1%to 1.6%.These findings suggest that the alloy treated with T6I6 aging exhibits both high strength and excellent stress corrosion cracking resistance.Similarly,when the alloy is treated with T6I4,T6I6 and T6I7 aging,the sizes of grain boundary precipitates(GBPs)are found to be 5.2,18.4,and 32.8 nm,respectively.The sizes of matrix precipitates are 4.8,5.7 and 15.7 nm,respectively.The atomic fractions of Zn in GBPs are 9.92 at.%,8.23 at.%and 6.87 at.%,respectively,while the atomic fractions of Mg are 12.66 at.%,8.43 at.%and 7.00 at.%,respectively.Additionally,the atomic fractions of Cu are 1.83 at.%,2.47 at.%and 3.41 at.%,respectively.
基金Weifang Fundamental Research Projects,No.WFWSJK-2023-052.
文摘BACKGROUND Pituitary stalk interruption syndrome(PSIS)is a rare anatomical defect of the pituitary gland falling under the spectrum of holoprosencephaly phenotypes.It is characterized by a deficiency in anterior pituitary hormones,such as growth hormone,gonadotropins,and thyroid hormones.Due to the syndrome's rarity and nonspecific manifestations,there is a lack of standardized treatment strategies.Consequently,early diagnosis through imaging and on-time intervention are crucial for improving patients’outcomes.CASE SUMMARY A 30-year-old man presented with absent secondary sexual characteristics and azoospermia.Laboratory evaluation revealed a deficiency in gonadotropins,while thyroid function was mostly within normal ranges.Magnetic resonance imaging of the pituitary gland showed pituitary stalk agenesis,hypoplasia of the anterior pituitary,and ectopic posterior pituitary,leading to the diagnosis of PSIS.Initially,the patient underwent 6 mo of gonadotropin therapy without significant changes in hormone levels and secondary sexual characteristics.Pulsatile gonadotropin-releasing hormone therapy was then administered,resulting in the detection of sperm in the semen analysis within 3 mo.After 6 mo,routine semen tests showed normal semen quality.The couple faced challenges in conceiving due to abstinence and underwent three cycles of artificial insemination,which was unsuccessful.They also attempted in vitro fertilization,but unfortunately,the woman experienced a miscarriage 10 wk after the embryo transfer.CONCLUSION Early detection,accurate diagnosis,and timely treatment are crucial in improving the quality of life and fertility of PSIS patients.
文摘BACKGROUND Pituitary stalk interruption syndrome(PSIS)is a rare disorder,often characterized by delayed growth and development,short stature,and hypogonadism as the main clinical manifestations.It is not clear whether PSIS can lead to liver cirrhosis.CASE SUMMARY This paper reported a case of liver cirrhosis of unknown origin.The patient was admitted to Beijing Ditan Hospital Affiliated to Capital Medical University in November 2023.The diagnosis of PSIS complicated with liver cirrhosis was established after a series of blood tests and pituitary magnetic resonance imaging examination.CONCLUSION We also reviewed the literature from both domestic and international sources to deepen the clinical understanding of PSIS in conjunction with liver cirrhosis among medical practitioners.
基金The National High Technology Research and Development Program of China(863 Program)(No.2011AA110302-01)
文摘To study the congestion of interrupted flow on urban roads, a comprehensive evaluation method is proposed. First, based on the results of correlation analysis between different parameters of interrupted flow, the traffic parameters of interrupted traffic flow are divided into two categories: the basic parameters and the operation parameters. Polynomial regression is used to formulize the nonlinear relationships between the basic parameters and the operation parameters. Then, the congestion model incorporating both operational and volume characteristics of traffic flow is proposed. The inputs of the model are the basic parameters, while the output is a dimensionless index value between 0 and 1. Finally, the proposed methods are compared with existing evaluation measures of congestion. Results show that the proposed indices can capture the variation of both the basic parameters and the operation parameters, which is more balanced compared with the existing evaluation measures.
文摘Background:To investigate SCL/TAL 1 interrupting locus(STIL)’s role and prognostic significance in lung adenocarcinoma(LUAD)progression,we examined STIL and E2 promoter binding factor 1(E2F1)expression and their impacts on LUAD prognosis using Gene Expression Profiling Interactive Analysis(GEPIA).Methods:Functional assays including CCK-8,wound-healing,5-ethynyl-2-deoxyuridine(EdU),Transwell assays,and flow cytometry,elucidated STIL and E2F1’s effects on cell viability,proliferation,apoptosis,and migration.Gene set enrichment analysis(GSEA)identified potential pathways,while metabolic assays assessed glucose metabolism.Results:Our findings reveal that STIL and E2F1 are overexpressed in LUAD,correlating with adverse outcomes.It enhances cell proliferation,migration,and invasion,and suppresses apoptosis,activating downstream of E2F1.Silencing E2F1 reversed the promotion effect of the STIL overexpression on cell viability and invasiveness.Importantly,STIL modulates glycolysis,influencing glucose consumption,lactate production,and energy balance in LUAD cells.Conclusion:Our model,incorporating STIL,age,and disease stage,robustly predicts patient prognosis,underscored STIL’s pivotal role in LUAD pathogenesis through metabolic reprogramming.This comprehensive approach not only confirms STIL’s prognostic value but also highlights its potential as a therapeutic target in LUAD.
文摘To determine the feasibility and practicability of interrupt continuous wave (CW) approach proposed for real time simulating radar intermediate frequency(IF) video signal, theoretical analysis and computer simulation were used. Phases at two linked points between the end and beginning of adjoined frames are always consistent; the bias Doppler frequency for the time delay of A/D sampling start responds to that for target acceleration. No digital phase compensation is required at continuous points, and the interrupt CW approach has apparently practical values.