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Spatial Protection and Development of Traditional Mountain Settlements from the Perspective of Self-organization : A Case Study of Anju Ancient Town in Tongliang District, Chongqing
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作者 Xin QU 《Meteorological and Environmental Research》 2024年第1期48-56,共9页
Through literature research, field research and urban design analysis methods, based on the self-organization theory, the evolution characteristics of the settlement space of Anju Ancient Town with significant charact... Through literature research, field research and urban design analysis methods, based on the self-organization theory, the evolution characteristics of the settlement space of Anju Ancient Town with significant characteristics of traditional mountain settlements were analyzed, and then its internal and external influencing factors were summarized. Finally, appropriate protection and development strategies were proposed, such as reasonably planning functional zones, breaking through the single structure, and creating a good living cultural environment. The innovation of this study is that it integrates the self-organization theory into the cognition of traditional mountain settlement space, and discusses the connection between the mountain settlement space and the traditional regional context under the modern development concept, so as to seek the benign protection and reasonable development of traditional mountain settlement space. 展开更多
关键词 Traditional mountain settlements self-organization theory Spatial characteristics Protection and development Anju Ancient Town
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Unveiling the brain’s symphony:exploring the necessity and sufficiency of neural networks in behavior control
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作者 Fernando Jose Bustos 《Neural Regeneration Research》 SCIE CAS 2025年第1期186-187,共2页
Since the pioneering work by Broca and Wernicke in the 19th century,who examined individuals with brain lesions to associate them with specific behaviors,it was evident that behaviors are complex and cannot be fully a... Since the pioneering work by Broca and Wernicke in the 19th century,who examined individuals with brain lesions to associate them with specific behaviors,it was evident that behaviors are complex and cannot be fully attributable to specific brain areas alone.Instead,they involve connectivity among brain areas,whether close or distant.At that time,this approach was considered the optimal way to dissect brain circuitry and function.These pioneering efforts opened the field to explore the necessity or sufficiency of brain areas in controlling behavior and hence dissecting brain function.However,the connectivity of the brain and the mechanisms through which various brain regions regulate specific behaviors,either individually or collaboratively,remain largely elusive.Utilizing animal models,researchers have endeavored to unravel the necessity or sufficiency of specific brain areas in influencing behavior;however,no clear associations have been firmly established. 展开更多
关键词 behavior CONNECTIVITY neural
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Increased excitatory amino acid transporter 2 levels in basolateral amygdala astrocytes mediate chronic stress–induced anxiety-like behavior
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作者 Xirong Xu Shoumin Xuan +3 位作者 Shuai Chen Dan Liu Qian Xiao Jie Tu 《Neural Regeneration Research》 SCIE CAS 2025年第6期1721-1734,共14页
The conventional perception of astrocytes as mere supportive cells within the brain has recently been called into question by empirical evidence, which has revealed their active involvement in regulating brain functio... The conventional perception of astrocytes as mere supportive cells within the brain has recently been called into question by empirical evidence, which has revealed their active involvement in regulating brain function and encoding behaviors associated with emotions.Specifically, astrocytes in the basolateral amygdala have been found to play a role in the modulation of anxiety-like behaviors triggered by chronic stress. Nevertheless, the precise molecular mechanisms by which basolateral amygdala astrocytes regulate chronic stress–induced anxiety-like behaviors remain to be fully elucidated. In this study, we found that in a mouse model of anxiety triggered by unpredictable chronic mild stress, the expression of excitatory amino acid transporter 2 was upregulated in the basolateral amygdala. Interestingly, our findings indicate that the targeted knockdown of excitatory amino acid transporter 2 specifically within the basolateral amygdala astrocytes was able to rescue the anxiety-like behavior in mice subjected to stress. Furthermore, we found that the overexpression of excitatory amino acid transporter 2 in the basolateral amygdala, whether achieved through intracranial administration of excitatory amino acid transporter 2agonists or through injection of excitatory amino acid transporter 2-overexpressing viruses with GfaABC1D promoters, evoked anxiety-like behavior in mice. Our single-nucleus RNA sequencing analysis further confirmed that chronic stress induced an upregulation of excitatory amino acid transporter 2 specifically in astrocytes in the basolateral amygdala. Moreover, through in vivo calcium signal recordings, we found that the frequency of calcium activity in the basolateral amygdala of mice subjected to chronic stress was higher compared with normal mice.After knocking down the expression of excitatory amino acid transporter 2 in the basolateral amygdala, the frequency of calcium activity was not significantly increased, and anxiety-like behavior was obviously mitigated. Additionally, administration of an excitatory amino acid transporter 2 inhibitor in the basolateral amygdala yielded a notable reduction in anxiety level among mice subjected to stress. These results suggest that basolateral amygdala astrocytic excitatory amino acid transporter 2 plays a role in in the regulation of unpredictable chronic mild stress-induced anxiety-like behavior by impacting the activity of local glutamatergic neurons, and targeting excitatory amino acid transporter 2 in the basolateral amygdala holds therapeutic promise for addressing anxiety disorders. 展开更多
关键词 ANXIETY ASTROCYTES basolateral amygdala behavior dihydrokainic acid excitatory amino acid transporter 2 fiber photometry GLUTAMATE LDN-212320 TRANSPORTER
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Hierarchical Self-organization of Complex Systems 被引量:27
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作者 CHAILi-he WENDong-sheng 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2004年第4期440-445,共6页
Researches on organization and structure in complex systems are academic and industrial fronts in modern sciences. Though many theories are tentatively proposed to analyze complex systems, we still lack a rigorous the... Researches on organization and structure in complex systems are academic and industrial fronts in modern sciences. Though many theories are tentatively proposed to analyze complex systems, we still lack a rigorous theory on them. Complex systems possess various degrees of freedom, which means that they should exhibit all kinds of structures. However, complex systems often show similar patterns and structures. Then the question arises why such similar structures appear in all kinds of complex systems. The paper outlines a theory on freedom degree compression and the existence of hierarchical self-organization for all complex systems is found. It is freedom degree compression and hierarchical self-organization that are responsible for the existence of these similar patterns or structures observed in the complex systems. 展开更多
关键词 Complex systems Degrees of freedom HIERARCHICAL self-organization
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Evolution of technology management system based on self-organization theory 被引量:1
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作者 WU Weiwei MA Qian +2 位作者 LIU Yexin YANG Ying YUE Suzhen 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2021年第6期1439-1449,共11页
Industrial and academic interest in how to effectively manage technology resources is increasing as it becomes more and more important.Effective managing of technology resources depends on technology management system... Industrial and academic interest in how to effectively manage technology resources is increasing as it becomes more and more important.Effective managing of technology resources depends on technology management system,and thus understanding how such system evolves becomes an ongoing research topic.Based on the self-organization theory,this paper constructs an evolution model of technology management system.The simulation results show that the evolution of each of the technology management subsystem is affected by the knowledge growth rate of its own,and it is also affected by the coupling and synergy relationship with other subsystems.Moreover,the coupling and synergy relationship can make the speed of evolution higher than the knowledge growth rate of the subsystem itself. 展开更多
关键词 technology management technology management system self-organization
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Self-Organization Approaches for Optimization in Cognitive Radio Networks 被引量:1
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作者 XU Xu CHAI Xiaomeng ZHANG Zhongshan 《China Communications》 SCIE CSCD 2014年第4期121-129,共9页
Cognitive radio(CR) is regarded as a promising technology for providing a high spectral efficiency to mobile users by using heterogeneous wireless network architectures and dynamic spectrum access techniques.However,c... Cognitive radio(CR) is regarded as a promising technology for providing a high spectral efficiency to mobile users by using heterogeneous wireless network architectures and dynamic spectrum access techniques.However,cognitive radio networks(CRNs)may also impose some challenges due to the ever increasing complexity of network architecture,the increasing complexity with configuration and management of large-scale networks,fluctuating nature of the available spectrum,diverse Quality-of-Service(QoS)requirements of various applications,and the intensifying difficulties of centralized control,etc.Spectrum management functions with self-organization features can be used to address these challenges and realize this new network paradigm.In this paper,fundamentals of CR,including spectrum sensing,spectrum management,spectrum mobility and spectrum sharing,have been surveyed,with their paradigms of self-organization being emphasized.Variant aspects of selforganization paradigms in CRNs,including critical functionalities of Media Access Control(MAC)- and network-layer operations,are surveyed and compared.Furthermore,new directions and open problems in CRNs are also identified in this survey. 展开更多
关键词 cognitive radio self-organized networking heterogeneous machine-to-machine DECENTRALIZED load balancing cooperation.
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DCGAN Based Spectrum Sensing Data Enhancement for Behavior Recognition in Self-Organized Communication Network 被引量:4
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作者 Kaixin Cheng Lei Zhu +5 位作者 Changhua Yao Lu Yu Xinrong Wu Xiang Zheng Lei Wang Fandi Lin 《China Communications》 SCIE CSCD 2021年第11期182-196,共15页
Communication behavior recognition is an issue with increasingly importance in the antiterrorism and national defense area.However,the sensing data obtained in actual environment is often not sufficient to accurately ... Communication behavior recognition is an issue with increasingly importance in the antiterrorism and national defense area.However,the sensing data obtained in actual environment is often not sufficient to accurately analyze the communication behavior.Traditional means can hardly utilize the scarce and crude spectrum sensing data captured in a real scene.Thus,communication behavior recognition using raw sensing data under smallsample condition has become a new challenge.In this paper,a data enhanced communication behavior recognition(DECBR)scheme is proposed to meet this challenge.Firstly,a preprocessing method is designed to make the raw spectrum data suitable for the proposed scheme.Then,an adaptive convolutional neural network structure is exploited to carry out communication behavior recognition.Moreover,DCGAN is applied to support data enhancement,which realize communication behavior recognition under small-sample condition.Finally,the scheme is verified by experiments under different data size.The results show that the DECBR scheme can greatly improve the accuracy and efficiency of behavior recognition under smallsample condition. 展开更多
关键词 spectrum sensing communication behavior recognition small-sample data enhancement selforganized network
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Self-organized search-attack mission planning for UAV swarm based on wolf pack hunting behavior 被引量:14
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作者 HU Jinqiang WU Husheng +2 位作者 ZHAN Renjun MENASSEL Rafik ZHOU Xuanwu 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2021年第6期1463-1476,共14页
Cooperative search-attack is an important application of unmanned aerial vehicle(UAV)swarm in military field.The coupling between path planning and task allocation,the heterogeneity of UAVs,and the dynamic nature of t... Cooperative search-attack is an important application of unmanned aerial vehicle(UAV)swarm in military field.The coupling between path planning and task allocation,the heterogeneity of UAVs,and the dynamic nature of task environment greatly increase the complexity and difficulty of the UAV swarm cooperative search-attack mission planning problem.Inspired by the collaborative hunting behavior of wolf pack,a distributed selforganizing method for UAV swarm search-attack mission planning is proposed.First,to solve the multi-target search problem in unknown environments,a wolf scouting behavior-inspired cooperative search algorithm for UAV swarm is designed.Second,a distributed self-organizing task allocation algorithm for UAV swarm cooperative attacking of targets is proposed by analyzing the flexible labor division behavior of wolves.By abstracting the UAV as a simple artificial wolf agent,the flexible motion planning and group task coordinating for UAV swarm can be realized by self-organizing.The effectiveness of the proposed method is verified by a set of simulation experiments,the stability and scalability are evaluated,and the integrated solution for the coupled path planning and task allocation problems for the UAV swarm cooperative search-attack task can be well performed. 展开更多
关键词 search-attack mission planning unmanned aerial vehicle(UAV)swarm wolf pack hunting behavior swarm intelligence labor division
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Self-organization of Reconfigurable Protocol Stack for Networked Control Systems 被引量:1
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作者 Chun-Jie Zhou Hui Chen Yuan-Qing Qin Yu-Feng Shi Guang-Can Yu 《International Journal of Automation and computing》 EI 2011年第2期221-235,共15页
In networked control systems (NCS),the control performance depends on not only the control algorithm but also the communication protocol stack.The performance degradation introduced by the heterogeneous and dynamic ... In networked control systems (NCS),the control performance depends on not only the control algorithm but also the communication protocol stack.The performance degradation introduced by the heterogeneous and dynamic communication environment has intensified the need for the reconfigurable protocol stack.In this paper,a novel architecture for the reconfigurable protocol stack is proposed,which is a unified specification of the protocol components and service interfaces supporting both static and dynamic reconfiguration for existing industrial communication standards.Within the architecture,a triple-level self-organization structure is designed to manage the dynamic reconfiguration procedure based on information exchanges inside and outside the protocol stack.Especially,the protocol stack can be self-adaptive to various environment and system requirements through the reconfiguration of working mode,routing and scheduling table.Finally,the study on the protocol of dynamic address management is conducted for the system of controller area network (CAN).The results show the efficiency of our self-organizing architecture for the implementation of a reconfigurable protocol stack. 展开更多
关键词 Networked control system (NCS) communication network self-organization protocol stack RECONFIGURATION
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Improve Fractal Compression Encoding Speed Using Feature Extraction and Self-organization Network 被引量:1
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作者 Berthe Kya, Yang Yang Information Engineering School. University of Science and Technology Beijing. Beijing 100083. China 《Journal of University of Science and Technology Beijing》 CSCD 2001年第4期306-310,共5页
Image compression consists of two main parts: encoding and decoding. One of the important problems of the fractal theory is the long encoding implementation time, which hindered the acceptance of fractal image compres... Image compression consists of two main parts: encoding and decoding. One of the important problems of the fractal theory is the long encoding implementation time, which hindered the acceptance of fractal image compression as a practical method. The long encoding time results from the need to perform a large number of domain-range matches, the total encoding time is the product of the number of matches and the time to perform each match. In order to improve encoding speed, a hybrid method combining features extraction and self-organization network has been provided, which is based on the feature extraction approach the comparison pixels by pixels between the feature of range blocks and domains blocks. The efficiency of the new method was been proved by examples. 展开更多
关键词 image compression fractal theory features extraction self-organization network fractal encoding
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Self-Organization of Charged Particulates in the Presence of External Force 被引量:1
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作者 汪友梅 陈琦 郁明阳 《Chinese Physics Letters》 SCIE CAS CSCD 2017年第3期90-94,共5页
Evolution of spatial distribution of charged particulates under the action of an external force is investigated. It is found that starting from a homogeneous Maxwellian distribution of particulates, clusters can form ... Evolution of spatial distribution of charged particulates under the action of an external force is investigated. It is found that starting from a homogeneous Maxwellian distribution of particulates, clusters can form and aggregate. The evolution process, as well as the asymptotic number and configuration of the clusters formed, depends strongly on the strength of the external force. The particulates in most of the final clusters are in the crystal state, as can also be deduced from the corresponding velocity and auto-correlation functions. 展开更多
关键词 self-organization of Charged Particulates in the Presence of External Force
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On the Mechanism of Evolution for Enterprise's Sustainable Growth Based on the Theory of Self-organization 被引量:1
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作者 Xuejun Tang 《Chinese Business Review》 2005年第3期35-41,共7页
The capabilities of industry, technology, institution and market power form the model of four-capability structure for enterprise's sustainable growth. The firm's system has the characteristics of dissipative struct... The capabilities of industry, technology, institution and market power form the model of four-capability structure for enterprise's sustainable growth. The firm's system has the characteristics of dissipative structure. The process of the formation for the sustainable growth capability is one of self-organization operations. The evolution and development of sustainable growth capability is the result of inter-functions and inter-operations among all the sub-systems. On the whole, the current level of sustainable growth capability, the four-capability structure and the random rise-and-fall elements of the external environment determine the direction, speed and level of transition of sustainable growth capability. The self-organization mechanism of the enterprise's sustainable growth can be illustrated by the instability of system evolution, the sequence parameter, the potential function and the nonequilibrium phase transition. Chinese firms must pay attention to industry selecting and positioning, technology innovation, institution reform and cultivation of market power, and accelerate the formation of self-organization and effective operation through the dynamic integration and inter-operation of industry, technology, institution and market power. Only in this way can firms cultivate and develop their sustainable growth capability and realize enterprises' sustainable growth finally. 展开更多
关键词 enterprise's sustainable growth self-organization evolution mechanism
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Influence of heat treatment on microstructure,mechanical and corrosion behavior of WE43 alloy fabricated by laser-beam powder bed fusion 被引量:6
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作者 Chenrong Ling Qiang Li +6 位作者 Zhe Zhang Youwen Yang Wenhao Zhou Wenlong Chen Zhi Dong Chunrong Pan Cijun Shuai 《International Journal of Extreme Manufacturing》 SCIE EI CAS CSCD 2024年第1期258-275,共18页
Magnesium(Mg)alloys are considered to be a new generation of revolutionary medical metals.Laser-beam powder bed fusion(PBF-LB)is suitable for fabricating metal implants withpersonalized and complicated structures.Howe... Magnesium(Mg)alloys are considered to be a new generation of revolutionary medical metals.Laser-beam powder bed fusion(PBF-LB)is suitable for fabricating metal implants withpersonalized and complicated structures.However,the as-built part usually exhibits undesirable microstructure and unsatisfactory performance.In this work,WE43 parts were firstly fabricated by PBF-LB and then subjected to heat treatment.Although a high densification rate of 99.91%was achieved using suitable processes,the as-built parts exhibited anisotropic and layeredmicrostructure with heterogeneously precipitated Nd-rich intermetallic.After heat treatment,fine and nano-scaled Mg24Y5particles were precipitated.Meanwhile,theα-Mg grainsunderwent recrystallization and turned coarsened slightly,which effectively weakened thetexture intensity and reduced the anisotropy.As a consequence,the yield strength and ultimate tensile strength were significantly improved to(250.2±3.5)MPa and(312±3.7)MPa,respectively,while the elongation was still maintained at a high level of 15.2%.Furthermore,the homogenized microstructure reduced the tendency of localized corrosion and favoredthe development of uniform passivation film.Thus,the degradation rate of WE43 parts was decreased by an order of magnitude.Besides,in-vitro cell experiments proved their favorable biocompatibility. 展开更多
关键词 laser-beam powder bed fusion WE43 alloys heat treatment mechanical performance biodegradation behavior
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BCCLR:A Skeleton-Based Action Recognition with Graph Convolutional Network Combining Behavior Dependence and Context Clues 被引量:3
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作者 Yunhe Wang Yuxin Xia Shuai Liu 《Computers, Materials & Continua》 SCIE EI 2024年第3期4489-4507,共19页
In recent years,skeleton-based action recognition has made great achievements in Computer Vision.A graph convolutional network(GCN)is effective for action recognition,modelling the human skeleton as a spatio-temporal ... In recent years,skeleton-based action recognition has made great achievements in Computer Vision.A graph convolutional network(GCN)is effective for action recognition,modelling the human skeleton as a spatio-temporal graph.Most GCNs define the graph topology by physical relations of the human joints.However,this predefined graph ignores the spatial relationship between non-adjacent joint pairs in special actions and the behavior dependence between joint pairs,resulting in a low recognition rate for specific actions with implicit correlation between joint pairs.In addition,existing methods ignore the trend correlation between adjacent frames within an action and context clues,leading to erroneous action recognition with similar poses.Therefore,this study proposes a learnable GCN based on behavior dependence,which considers implicit joint correlation by constructing a dynamic learnable graph with extraction of specific behavior dependence of joint pairs.By using the weight relationship between the joint pairs,an adaptive model is constructed.It also designs a self-attention module to obtain their inter-frame topological relationship for exploring the context of actions.Combining the shared topology and the multi-head self-attention map,the module obtains the context-based clue topology to update the dynamic graph convolution,achieving accurate recognition of different actions with similar poses.Detailed experiments on public datasets demonstrate that the proposed method achieves better results and realizes higher quality representation of actions under various evaluation protocols compared to state-of-the-art methods. 展开更多
关键词 Action recognition deep learning GCN behavior dependence context clue self-attention
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A realistic model for complex networks with local interaction, self-organization and order
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作者 陈飞 陈增强 袁著祉 《Chinese Physics B》 SCIE EI CAS CSCD 2007年第2期287-291,共5页
In this paper, a new mechanism for the emergence of scale-free distribution is proposed. It is more realistic than the existing mechanism. Based on our mechanism, a model responsible for the scale-free distribution wi... In this paper, a new mechanism for the emergence of scale-free distribution is proposed. It is more realistic than the existing mechanism. Based on our mechanism, a model responsible for the scale-free distribution with an exponent in a range of 3-to-5 is given. Moreover, this model could also reproduce the exponential distribution that is discovered in some real networks. Finally, the analytical result of the model is given and the simulation shows the validity of our result, 展开更多
关键词 local interaction self-organization order complex network
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Self-Organization of PbS into Quantum Dots Superlattices
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作者 Lian Zeng YAO Chang Hui YE +2 位作者 Chi Mei MO Ye ZHANG Li De ZHANG(Department of Materials Science and Engineering, University of Science and Technology of China, Hefei 230026 Institute of Solid State Physics, Chinese Academy of Sciences, Hefei 230031) 《Chinese Chemical Letters》 SCIE CAS CSCD 2000年第7期627-630,共4页
Self-organization of PbS into quantum dots superlattices is demonstrated for the first lime, and hexaplanar colloidal crystals 1-10 mu m in size made from PbS quantum dots 4nm in diameter are shown in Transmission Ele... Self-organization of PbS into quantum dots superlattices is demonstrated for the first lime, and hexaplanar colloidal crystals 1-10 mu m in size made from PbS quantum dots 4nm in diameter are shown in Transmission Electron Microscope (TEM) micrograph, and the inner structures of the superlattices can be seen from the High Resolution Transmission Electron Microscope (HRTEM). 展开更多
关键词 self-organization quantum dots PbS superlattices
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Effects of Vertex Activity and Self-organized Criticality Behavior on a Weighted Evolving Network
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作者 ZHANG Gui-Qing YANG Qiu-Ying CHEN Tian-Lun 《Communications in Theoretical Physics》 SCIE CAS CSCD 2008年第8期421-424,共4页
Effects of vertex activity have been analyzed on a weighted evolving network.The network is characterized by the probability distribution of vertex strength,each edge weight and evolution of the strength of vertices w... Effects of vertex activity have been analyzed on a weighted evolving network.The network is characterized by the probability distribution of vertex strength,each edge weight and evolution of the strength of vertices with different vertex activities.The model exhibits self-organized criticality behavior.The probability distribution of avalanche size for different network sizes is also shown.In addition,there is a power law relation between the size and the duration of an avalanche and the average of avalanche size has been studied for different vertex activities. 展开更多
关键词 weighted evolving network vertex activity POWER-LAW self-organized criticality
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Self-organization: the governance of CAO fisheries from perspective of the global commons
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作者 PAN Min WANG Mei 《Advances in Polar Science》 2016年第3期159-162,共4页
The Central Arctic Ocean (CAO) is a global commons, and fishes in the CAO are common property resources. If humanity does not manage this region well, then this will lead to a "Tragedy of the Commons," an old prob... The Central Arctic Ocean (CAO) is a global commons, and fishes in the CAO are common property resources. If humanity does not manage this region well, then this will lead to a "Tragedy of the Commons," an old problem in human society. However, the two existing means of commons governance, privatization and government control, are not appropriate for the CAO. This study's findings indicate that CAO fisheries management will most likely result from a process of self-organization. The openness of the CAO and the imbalance of powers, interests and responsibilities among the states that are involved will lead to a process of self-organized governance of CAO fisheries. There are four stages in this process: competition, synergy, establishment of governing principles and mechanisms, and expansion and evolution of influence. The outcome of CAO fisheries governance will be the result of compromise among the parties as no one actor is in a dominant position. 展开更多
关键词 self-organization CAO fisheries global commons
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Integrated ribosome and proteome analyses reveal insights into sevoflurane-induced long-term social behavior and cognitive dysfunctions through ADNP inhibition in neonatal mice 被引量:1
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作者 Li-Rong Liang Bing Liu +9 位作者 Shu-Hui Cao You-Yi Zhao Tian Zeng Mei-Ting Zhai Ze Fan Dan-Yi He San-Xin Ma Xiao-Tong Shi Yao Zhang Hui Zhang 《Zoological Research》 SCIE CSCD 2024年第3期663-678,共16页
A growing number of studies have demonstrated that repeated exposure to sevoflurane during development results in persistent social abnormalities and cognitive impairment.Davunetide,an active fragment of the activity-... A growing number of studies have demonstrated that repeated exposure to sevoflurane during development results in persistent social abnormalities and cognitive impairment.Davunetide,an active fragment of the activity-dependent neuroprotective protein(ADNP),has been implicated in social and cognitive protection.However,the potential of davunetide to attenuate social deficits following sevoflurane exposure and the underlying developmental mechanisms remain poorly understood.In this study,ribosome and proteome profiles were analyzed to investigate the molecular basis of sevoflurane-induced social deficits in neonatal mice.The neuropathological basis was also explored using Golgi staining,morphological analysis,western blotting,electrophysiological analysis,and behavioral analysis.Results indicated that ADNP was significantly down-regulated following developmental exposure to sevoflurane.In adulthood,anterior cingulate cortex(ACC)neurons exposed to sevoflurane exhibited a decrease in dendrite number,total dendrite length,and spine density.Furthermore,the expression levels of Homer,PSD95,synaptophysin,and vglut2 were significantly reduced in the sevoflurane group.Patch-clamp recordings indicated reductions in both the frequency and amplitude of miniature excitatory postsynaptic currents(mEPSCs).Notably,davunetide significantly ameliorated the synaptic defects,social behavior deficits,and cognitive impairments induced by sevoflurane.Mechanistic analysis revealed that loss of ADNP led to dysregulation of Ca^(2+)activity via the Wnt/β-catenin signaling,resulting in decreased expression of synaptic proteins.Suppression of Wnt signaling was restored in the davunetide-treated group.Thus,ADNP was identified as a promising therapeutic target for the prevention and treatment of neurodevelopmental toxicity caused by general anesthetics.This study provides important insights into the mechanisms underlying social and cognitive disturbances caused by sevoflurane exposure in neonatal mice and elucidates the regulatory pathways involved. 展开更多
关键词 Davunetide SEVOFLURANE Abnormal social behaviors ADNP NEUROTOXICITY
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Conditions,Mechanisms and Process within Self-organization Evolution
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作者 祝锦祥 戴昌钧 薛绯 《Journal of Donghua University(English Edition)》 EI CAS 2014年第4期545-550,共6页
Business growth and development are similar to a selforganization evolution system. This paper intends to explore the context, drive and process within enterprise self-organization evolution from a conceptual perspect... Business growth and development are similar to a selforganization evolution system. This paper intends to explore the context, drive and process within enterprise self-organization evolution from a conceptual perspective. And an enterprise evolution model can be applied on the basis of ecological logistic equations to approach the elementary process and the growth stage of organization. Moreover,the influence of diverse variable on the evolution of enterprise growth is discussed. At last, the study concludes that new structures and functions can emerge within organizations and enterprises,which contribute to transformation and upgrade during their self-organization evolution. 展开更多
关键词 enterprise growth process self-organization evolution CONDITIONS complex system
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