Alzheimer’s Disease Diagnosis Based on a Semantic Rule-Based Modeling and Reasoning Approach

Alzheimer’s disease(AD)is a very complex disease that causes brain failure,then eventually,dementia ensues.It is a global health problem.99%of clinical trials have failed to limit the progression of this disease.The risks and barriers to detecting AD are huge as pathological events begin decades before appearing clinical symptoms.Therapies for AD are likely to be more helpful if the diagnosis is determined early before the final stage of neurological dysfunction.In this regard,the need becomes more urgent for biomarker-based detection.A key issue in understanding AD is the need to solve complex and high-dimensional datasets and heterogeneous biomarkers,such as genetics,magnetic resonance imaging(MRI),cerebrospinal fluid(CSF),and cognitive scores.Establishing an interpretable reasoning system and performing interoperability that achieves in terms of a semantic model is potentially very useful.Thus,our aim in this work is to propose an interpretable approach to detect AD based on Alzheimer’s disease diagnosis ontology(ADDO)and the expression of semantic web rule language(SWRL).This work implements an ontology-based application that exploits three different machine learning models.These models are random forest(RF),JRip,and J48,which have been used along with the voting ensemble.ADNI dataset was used for this study.The proposed classifier’s result with the voting ensemble achieves a higher accuracy of 94.1%and precision of 94.3%.Our approach provides effective inference rules.Besides,it contributes to a real,accurate,and interpretable classifier model based on various AD biomarkers for inferring whether the subject is a normal cognitive(NC),significant memory concern(SMC),early mild cognitive impairment(EMCI),late mild cognitive impairment(LMCI),or AD.

τSQWRL:A TSQL2-Like Query Language for Temporal Ontologies Generated from JSON Big Data

Temporal ontologies allow to represent not only concepts,their properties,and their relationships,but also time-varying information through explicit versioning of definitions or through the four-dimensional perdurantist view.They are widely used to formally represent temporal data semantics in several applications belonging to different fields(e.g.,Semantic Web,expert systems,knowledge bases,big data,and artificial intelligence).They facilitate temporal knowledge representation and discovery,with the support of temporal data querying and reasoning.However,there is no standard or consensual temporal ontology query language.In a previous work,we have proposed an approach namedτJOWL(temporal OWL 2 from temporal JSON,where OWL 2 stands for"OWL 2 Web Ontology Language"and JSON stands for"JavaScript Object Notation").τJOWL allows(1)to automatically build a temporal OWL 2 ontology of data,following the Closed World Assumption(CWA),from temporal JSON-based big data,and(2)to manage its incremental maintenance accommodating their evolution,in a temporal and multi-schema-version environment.In this paper,we propose a temporal ontology query language forτJOWL,namedτSQWRL(temporal SQWRL),designed as a temporal extension of the ontology query language—Semantic Query-enhanced Web Rule Language(SQWRL).The new language has been inspired by the features of the consensual temporal query language TSQL2(Temporal SQL2),well known in the temporal(relational)database community.The aim of the proposal is to enable and simplify the task of retrieving any desired ontology version or of specifying any(complex)temporal query on time-varying ontologies generated from time-varying big data.Some examples,in the Internet of Healthcare Things(IoHT)domain,are provided to motivate and illustrate our proposal.

Detecting Vicious Cycles in Urban Problem Knowledge Graph using Inference Rules

Urban areas have many problems,including homelessness,graffiti,and littering.These problems are influenced by various factors and are linked to each other;thus,an understanding of the problem structure is required in order to detect and solve the root problems that generate vicious cycles.Moreover,before implementing action plans to solve these problems,local governments need to estimate cost-effectiveness when the plans are carried out.Therefore,this paper proposed constructing an urban problem knowledge graph that would include urban problems’causality and the related cost information in budget sheets.In addition,this paper proposed a method for detecting vicious cycles of urban problems using SPARQL queries with inference rules from the knowledge graph.Finally,several root problems that led to vicious cycles were detected.Urban-problem experts evaluated the extracted causal relations.

A Multiple Feature Approach for Disorder Normalization in Clinical Notes

In this paper we propose a multiple feature approach for the normalization task which can map each disorder mention in the text to a unique unified medical language system（UMLS）concept unique identifier（CUI）. We develop a two-step method to acquire a list of candidate CUIs and their associated preferred names using UMLS API and to choose the closest CUI by calculating the similarity between the input disorder mention and each candidate. The similarity calculation step is formulated as a classification problem and multiple features（string features,ranking features,similarity features,and contextual features） are used to normalize the disorder mentions. The results show that the multiple feature approach improves the accuracy of the normalization task from 32.99% to 67.08% compared with the Meta Map baseline.