Charcot-Marie-Tooth disease(CMT)is a hereditary peripheral neuropathy causing muscle weakness/wasting and sensory dysfunction predominantly in limb extremities.CMT patients display gait abnormalities,foot deformities,...Charcot-Marie-Tooth disease(CMT)is a hereditary peripheral neuropathy causing muscle weakness/wasting and sensory dysfunction predominantly in limb extremities.CMT patients display gait abnormalities,foot deformities,loss of sensation and decreased/absent deep tendon reflexes,with motor symptoms usually being more prominent than sensory.展开更多
The adult mammalian central nervous system(CNS) coordinates essential functions such as sensation,movement,autonomic control,thought processes,and communication.Consequently,injuries or diseases of the CNS are often a...The adult mammalian central nervous system(CNS) coordinates essential functions such as sensation,movement,autonomic control,thought processes,and communication.Consequently,injuries or diseases of the CNS are often associated with devastating and permanent functional impairments because damaged axons normally fail to regenerate.An insufficient neuron-intrinsic growth capacity and an inhibitory environment at the injury site are the leading causes of this regenerative failure.展开更多
Neurodegenerative diseases(NDDs)are a class of disorders characterized by the gradual loss or malfunction of specific cell populations in the nervous system,which can be triggered by genetic or environmental factors.A...Neurodegenerative diseases(NDDs)are a class of disorders characterized by the gradual loss or malfunction of specific cell populations in the nervous system,which can be triggered by genetic or environmental factors.As a result,patients often experience a decline in mobility,sensation,memory,and cognition,which can ultimately lead to a fatal outcome.The global incidence of NDDs,including Alzheimer’s disease,Parkinson’s disease,Huntington’s disease,amyotrophic lateral sclerosis(ALS),and multiple sclerosis,is increasing.展开更多
Dear Editor,We present a case of ruptured renal angiomyolipoma(AML)and bilateral renal staghorn calculi.We discuss about the management of this patient by angioembolization,partial nephrectomy,and pyelolithotomy,follo...Dear Editor,We present a case of ruptured renal angiomyolipoma(AML)and bilateral renal staghorn calculi.We discuss about the management of this patient by angioembolization,partial nephrectomy,and pyelolithotomy,followed by contralateral interval percutaneous nephrolithotomy(PCNL).Our case is a 40-year-old male who presented with history of dull aching and dragging sensation in bilateral flanks of 6-month duration.He was admitted and evaluated at other hospital for dizziness,sweating,and loss of consciousness.He was found to have bilateral staghorn calculi and left AML and was referred to our institute for further management after initial stabilization.The proper written and informed consent was taken from the patient for management as well as publication of the report and images,maintaining the patient’s anonymity.展开更多
At present,air handling units are usually used indoors to improve the indoor environment quality.However,while introducing fresh air to improve air quality,air velocity has a certain impact on the occupants’thermal c...At present,air handling units are usually used indoors to improve the indoor environment quality.However,while introducing fresh air to improve air quality,air velocity has a certain impact on the occupants’thermal comfort.Therefore,it is necessary to explore the optimization of air-fluid-body interaction dynamics.In this study,the indoor air flow was changed by changing the opening and closing degree of the blower,and the thermal manikin is introduced to objectively evaluate the human thermal comfort under different air velocities.The main experimental results show that the air change rate increases with the increase of the opening and closing degree of the blower considering an ACH(air changes per hour)range between 3.8 and 10.For a better prediction,a linear correlation with a coefficient of 0.995 is proposed.As the blower’s opening is adjusted to 20%,25%,30%,35%,and 40%,the air velocity sensor positioned directly beneath the air inlet records average velocities of 0.19,0.20,0.21,0.28,and 0.34 m/s over four hours,respectively.Observations on thermal comfort and the average sensation experienced by individuals indicate an initial increase followed by a decline when the blower’s operation begins,with optimal conditions achieved at a 35%opening.These findings offer valuable insights for future indoor air ventilation and heat transfer design strategies.展开更多
viral dance sensation and the debate it sparks.EMERGING f rom a festive wedding ceremony,a dance colloquially known as Kemusan or Subject Three has achieved a meteoric rise to fame across digital platforms in recent w...viral dance sensation and the debate it sparks.EMERGING f rom a festive wedding ceremony,a dance colloquially known as Kemusan or Subject Three has achieved a meteoric rise to fame across digital platforms in recent weeks.In the realm of social media,where trends emerge and vanish like fleeting sparks,the dance craze is currently at the zenith of popularity.展开更多
You may think the scent of coffee or roses hits your nose as one seamless sensation.A new study shatters that notion,revealing our brain doesn’t perceive smells as whole molecules.Instead,it deconstructs odor molecul...You may think the scent of coffee or roses hits your nose as one seamless sensation.A new study shatters that notion,revealing our brain doesn’t perceive smells as whole molecules.Instead,it deconstructs odor molecules into substructures before reassembling them into unified scents we recognize.This counterintuitive finding flips our understanding of how we process the invisible world of smells around us.展开更多
In order to find out how the climatic characteristics affect people＇s adaptability to thermal environments,experimental studies in a climate chamber are conducted on the effects of transition seasons（from spring to ...In order to find out how the climatic characteristics affect people＇s adaptability to thermal environments,experimental studies in a climate chamber are conducted on the effects of transition seasons（from spring to summer）and the occupants＇ native areas on indoor thermal sensations.Results reveal that people＇s tolerances to cool and warm indoor environments are different in the transition season.When the outdoor temperature is higher,the occupants have a weaker tolerance to a cool indoor environment,but a stronger tolerance to a warm indoor environment.Besides,it is found that the occupants＇ thermal sensations depend on both the climatic characteristics of the season and their native areas.The people from southern China present a greater tolerance to both warm and cool indoor environments than those from northern China.The reason can be explained according to the occupants＇ adaptability to the climatic characteristics and the indoor thermal environments of their native areas in different climate zones.展开更多
To reveal the principles of human thermal responses and find out the effects of body parts on whole-body thermal sensation,through a subjective survey,experimental investigations on human responses are carried out whe...To reveal the principles of human thermal responses and find out the effects of body parts on whole-body thermal sensation,through a subjective survey,experimental investigations on human responses are carried out when a single body part is thermally stimulated.Cooling airflow is sent to seven body parts,respectively.Totally 94 samples are tested.To eliminate the obvious multicollinearity of thermal sensation among different body parts,the principal component regression approach is adopted to obtain the principal components for the body parts under different experimental conditions.Through regression and analysis of principal components,the weighting factors of the seven body parts are obtained.A predictive model on whole-body thermal sensation is obtained based on the weighting factors.The results show that the different characteristics of trunk and limbs are clearly seen.The weighting factors of local thermal sensation are integrated values,and there is little difference among values of different body parts.展开更多
To study the draft sensation distribution of an air jet supply system in a large space building in summer,experiments are conducted in a large laboratory.The temperature,velocity and draft sensation distributions at a...To study the draft sensation distribution of an air jet supply system in a large space building in summer,experiments are conducted in a large laboratory.The temperature,velocity and draft sensation distributions at a nozzle height of 4 m in the occupied zone are obtained.Then,the numerical simulation under the test condition is carried out by the computational fluid dynamics（CFD）method.The calculation results of the indoor vertical temperature and the draft sensation distribution are validated by the test data.Simulations with different nozzle heights are conducted.The satisfactory air supply condition is determined by analyzing the draft sensations and the temperatures in the occupied zone under three conditions.The simulation results show that the optimal draft sensation distribution and the uniform temperature and velocity fields can be obtained at a nozzle height of 5 m.展开更多
Tourist's satisfaction degree is one of the important indexes to evaluate the service quality of scenic spot.Taking Xi'an Dongda Hot Spring Resort Area for an example,with the expectation difference theory and...Tourist's satisfaction degree is one of the important indexes to evaluate the service quality of scenic spot.Taking Xi'an Dongda Hot Spring Resort Area for an example,with the expectation difference theory and customers' satisfaction evaluation model as the theoretical basis of the research,the overall satisfaction degree of tourists to hot spring resort area,and the actual sensation accomplishments and the expectation difference of each service index were analyzed by using regression analysis and paired sample t test method.The results showed:① The overall satisfaction degree of tourists to the resort area was higher.There were remarkable correlation among three variables:the sensation value,the overall satisfaction degree,and the tourist's loyalty degree;② Generally,the sensation actual accomplishments of 15 service appraisal factors were higher than the expectation value.According to the characteristics,these 15 service appraisal factors were divided into 5 groups.Some unsatisfactory aspects were found out,and the corrective measures were put forward.展开更多
As a literary genre of fiction which enjoyed its great popularity in Britain in the 1860 s and 1870 s when the country had just gone through a series of social changes and a variety of anxieties prevailing the whole s...As a literary genre of fiction which enjoyed its great popularity in Britain in the 1860 s and 1870 s when the country had just gone through a series of social changes and a variety of anxieties prevailing the whole society,the sensation novel presents to readers a wide range of anxieties and gives responds to some of them.The Woman in White by Wilkie Collins(1859),which is generally regarded by critics as a typical representative of the sensation novel,displays diversified anxieties through the depiction of various impressive characters,and especially through their processes of establishing,losing,regaining,strengthening,hiding and faking their identities.This essay will analyze the representative work,exploring and examining the characters’ anxieties revolving their identities in relation to the social backgrounds of that era.展开更多
基金supported by the funding from the Medical Research Council(MR/S006990/1)the Wellcome Trust(103191/A/13/Z)+3 种基金the Rosetrees Trust(M806)the UCL Neurogenetic Therapies Programme funded by The Sigrid Rausing Trustnamed inventor on patent GB2303495.2(patent applicant,UCL Business Ltd.,status pending)which describes and protects AAV-BDNF technology for treatment of CMT。
文摘Charcot-Marie-Tooth disease(CMT)is a hereditary peripheral neuropathy causing muscle weakness/wasting and sensory dysfunction predominantly in limb extremities.CMT patients display gait abnormalities,foot deformities,loss of sensation and decreased/absent deep tendon reflexes,with motor symptoms usually being more prominent than sensory.
文摘The adult mammalian central nervous system(CNS) coordinates essential functions such as sensation,movement,autonomic control,thought processes,and communication.Consequently,injuries or diseases of the CNS are often associated with devastating and permanent functional impairments because damaged axons normally fail to regenerate.An insufficient neuron-intrinsic growth capacity and an inhibitory environment at the injury site are the leading causes of this regenerative failure.
文摘Neurodegenerative diseases(NDDs)are a class of disorders characterized by the gradual loss or malfunction of specific cell populations in the nervous system,which can be triggered by genetic or environmental factors.As a result,patients often experience a decline in mobility,sensation,memory,and cognition,which can ultimately lead to a fatal outcome.The global incidence of NDDs,including Alzheimer’s disease,Parkinson’s disease,Huntington’s disease,amyotrophic lateral sclerosis(ALS),and multiple sclerosis,is increasing.
文摘Dear Editor,We present a case of ruptured renal angiomyolipoma(AML)and bilateral renal staghorn calculi.We discuss about the management of this patient by angioembolization,partial nephrectomy,and pyelolithotomy,followed by contralateral interval percutaneous nephrolithotomy(PCNL).Our case is a 40-year-old male who presented with history of dull aching and dragging sensation in bilateral flanks of 6-month duration.He was admitted and evaluated at other hospital for dizziness,sweating,and loss of consciousness.He was found to have bilateral staghorn calculi and left AML and was referred to our institute for further management after initial stabilization.The proper written and informed consent was taken from the patient for management as well as publication of the report and images,maintaining the patient’s anonymity.
基金supported by the China Scholarship Council(Grant Number 202208120025).
文摘At present,air handling units are usually used indoors to improve the indoor environment quality.However,while introducing fresh air to improve air quality,air velocity has a certain impact on the occupants’thermal comfort.Therefore,it is necessary to explore the optimization of air-fluid-body interaction dynamics.In this study,the indoor air flow was changed by changing the opening and closing degree of the blower,and the thermal manikin is introduced to objectively evaluate the human thermal comfort under different air velocities.The main experimental results show that the air change rate increases with the increase of the opening and closing degree of the blower considering an ACH(air changes per hour)range between 3.8 and 10.For a better prediction,a linear correlation with a coefficient of 0.995 is proposed.As the blower’s opening is adjusted to 20%,25%,30%,35%,and 40%,the air velocity sensor positioned directly beneath the air inlet records average velocities of 0.19,0.20,0.21,0.28,and 0.34 m/s over four hours,respectively.Observations on thermal comfort and the average sensation experienced by individuals indicate an initial increase followed by a decline when the blower’s operation begins,with optimal conditions achieved at a 35%opening.These findings offer valuable insights for future indoor air ventilation and heat transfer design strategies.
文摘viral dance sensation and the debate it sparks.EMERGING f rom a festive wedding ceremony,a dance colloquially known as Kemusan or Subject Three has achieved a meteoric rise to fame across digital platforms in recent weeks.In the realm of social media,where trends emerge and vanish like fleeting sparks,the dance craze is currently at the zenith of popularity.
文摘You may think the scent of coffee or roses hits your nose as one seamless sensation.A new study shatters that notion,revealing our brain doesn’t perceive smells as whole molecules.Instead,it deconstructs odor molecules into substructures before reassembling them into unified scents we recognize.This counterintuitive finding flips our understanding of how we process the invisible world of smells around us.
基金The Major Project of the National Natural Science Foundation of China(No.50838003)the National Key Technology R&D Program of China during the 11th Five-Year Plan Period(No.2006BAJ02A06)
文摘In order to find out how the climatic characteristics affect people＇s adaptability to thermal environments,experimental studies in a climate chamber are conducted on the effects of transition seasons（from spring to summer）and the occupants＇ native areas on indoor thermal sensations.Results reveal that people＇s tolerances to cool and warm indoor environments are different in the transition season.When the outdoor temperature is higher,the occupants have a weaker tolerance to a cool indoor environment,but a stronger tolerance to a warm indoor environment.Besides,it is found that the occupants＇ thermal sensations depend on both the climatic characteristics of the season and their native areas.The people from southern China present a greater tolerance to both warm and cool indoor environments than those from northern China.The reason can be explained according to the occupants＇ adaptability to the climatic characteristics and the indoor thermal environments of their native areas in different climate zones.
基金The National Natural Science Foundation of China(No.50678030)
文摘To reveal the principles of human thermal responses and find out the effects of body parts on whole-body thermal sensation,through a subjective survey,experimental investigations on human responses are carried out when a single body part is thermally stimulated.Cooling airflow is sent to seven body parts,respectively.Totally 94 samples are tested.To eliminate the obvious multicollinearity of thermal sensation among different body parts,the principal component regression approach is adopted to obtain the principal components for the body parts under different experimental conditions.Through regression and analysis of principal components,the weighting factors of the seven body parts are obtained.A predictive model on whole-body thermal sensation is obtained based on the weighting factors.The results show that the different characteristics of trunk and limbs are clearly seen.The weighting factors of local thermal sensation are integrated values,and there is little difference among values of different body parts.
基金The National Natural Science Foundation of China(No.50478113)the Leading Academic Discipline Project of Shanghai Municipal Education Commission(No.J50502)
文摘To study the draft sensation distribution of an air jet supply system in a large space building in summer,experiments are conducted in a large laboratory.The temperature,velocity and draft sensation distributions at a nozzle height of 4 m in the occupied zone are obtained.Then,the numerical simulation under the test condition is carried out by the computational fluid dynamics（CFD）method.The calculation results of the indoor vertical temperature and the draft sensation distribution are validated by the test data.Simulations with different nozzle heights are conducted.The satisfactory air supply condition is determined by analyzing the draft sensations and the temperatures in the occupied zone under three conditions.The simulation results show that the optimal draft sensation distribution and the uniform temperature and velocity fields can be obtained at a nozzle height of 5 m.
文摘Tourist's satisfaction degree is one of the important indexes to evaluate the service quality of scenic spot.Taking Xi'an Dongda Hot Spring Resort Area for an example,with the expectation difference theory and customers' satisfaction evaluation model as the theoretical basis of the research,the overall satisfaction degree of tourists to hot spring resort area,and the actual sensation accomplishments and the expectation difference of each service index were analyzed by using regression analysis and paired sample t test method.The results showed:① The overall satisfaction degree of tourists to the resort area was higher.There were remarkable correlation among three variables:the sensation value,the overall satisfaction degree,and the tourist's loyalty degree;② Generally,the sensation actual accomplishments of 15 service appraisal factors were higher than the expectation value.According to the characteristics,these 15 service appraisal factors were divided into 5 groups.Some unsatisfactory aspects were found out,and the corrective measures were put forward.
文摘As a literary genre of fiction which enjoyed its great popularity in Britain in the 1860 s and 1870 s when the country had just gone through a series of social changes and a variety of anxieties prevailing the whole society,the sensation novel presents to readers a wide range of anxieties and gives responds to some of them.The Woman in White by Wilkie Collins(1859),which is generally regarded by critics as a typical representative of the sensation novel,displays diversified anxieties through the depiction of various impressive characters,and especially through their processes of establishing,losing,regaining,strengthening,hiding and faking their identities.This essay will analyze the representative work,exploring and examining the characters’ anxieties revolving their identities in relation to the social backgrounds of that era.
