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Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol 被引量:9
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作者 Venkata Muddana Janette Lamb +7 位作者 Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第28期4486-4491,共6页
AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S or alco... AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S or alcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polyrnorphism was significantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a significant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. 展开更多
关键词 Calcium sensing receptor Serine protease inhibitor Kazal llype Chronic pancreatitis ALCOHOL
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Activation of calcium-sensing receptors is associated with apoptosis in a model of simulated cardiomyocytes ischemia/reperfusion 被引量:2
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作者 Ling Yan Tlebing Zhu +5 位作者 Tingting Sun Liansheng Wang Shiyang Pan Zhengxlan Tao Zhijian Yang Kejiang Cao 《The Journal of Biomedical Research》 CAS 2010年第4期301-307,共7页
Objective: Calcium-sensing receptors (CaSRs) are G-protein coupled receptors which maintain systemic calcium homeostasis and participate in hormone secretion, activation of ion channels, cell apoptosis, proliferati... Objective: Calcium-sensing receptors (CaSRs) are G-protein coupled receptors which maintain systemic calcium homeostasis and participate in hormone secretion, activation of ion channels, cell apoptosis, proliferation, and differentiation. Previous studies have shown that CaSRs induce apoptosis in isolated adult rat heart and in normal neonatal rat cardiomyocytes by G-protein-PLC-IP3 signaling transduction. However, little knowledge is presently available concerning the role of CaSRs in the apoptosis induced by ischemia and reperfusion in neonatal cardiomyocytes. Methods: Primary neonatal rat ventricular cardiomyocytes were incubated in ischemiamimetic solution for 2 h, and then re-incubated in normal culture medium for 24 h to establish a model of simu- lated ischemia/reperfusion (I/R). Cardiomyocyte apoptosis was detected by terminal deoxynucleotidyl transferase- mediated dUTP nick end labeling (TUNEL). The expression of CaSRs mRNA was detected by real-time reverse transcription polymerase chain reaction (RT-PCR). In addition, the expressions of caspase-3 and Bcl-2 were analyzed by western blot. Results: The simulated I/R enhanced the expression of CaSRs and cardiomyocyte apoptosis. GdCl3, a specific activator of CaSRs, further increased the expression of CaSRs and cardiomyocyte apoptosis, along with up-regulation of caspase-3 and down-regulation of Bcl-2. Conclusion: CaSRs are associated with UR injury and apoptosis in neonatal rat ventricular cardiomyocytes via suppressing Bcl-2 and promoting caspase-3 expression. 展开更多
关键词 calcium sensing receptors APOPTOSIS CARDIOMYOCYTE ISCHEMIA/REPERFUSION
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The genetic framework for development of nephrolithiasis 被引量:5
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作者 Vinaya Vasudevan Patrick Samson +1 位作者 Arthur D.Smith Zeph Okeke 《Asian Journal of Urology》 2017年第1期18-26,共9页
Over 1%-15% of the population worldwide is affected by nephrolithiasis,which remains the most common and costly disease that urologists manage today.Identification of atrisk individuals remains a theoretical and techn... Over 1%-15% of the population worldwide is affected by nephrolithiasis,which remains the most common and costly disease that urologists manage today.Identification of atrisk individuals remains a theoretical and technological challenge.The search for monogenic causes of stone disease has been largely unfruitful and a technological challenge;however,several candidate genes have been implicated in the development of nephrolithiasis.In this review,we will review current data on the genetic inheritance of stone disease,as well as investigate the evolving role of genetic analysis and counseling in the management of nephrolithiasis. 展开更多
关键词 GENETICS HYPERCALCIURIA NEPHROLITHIASIS UROLITHIASIS Calcium sensing receptor CYSTINURIA Medullary sponge kidney Autosomal dominant polcystic kidney disease Uric acid nephrolithiasis HYPERCALCIURIA
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Involvement of CaSR in Hyperglycemia-induced Macroangiopathy and Related Mechanism 被引量:1
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作者 卢金萍 任江华 +2 位作者 陈玲 李夏 陈慧莉 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2015年第1期42-47,共6页
In order to clarify the potential role of calcium sensing receptor(Ca SR), a typical G protein coupled receptor(GPCR), in hyperglacemia-induced macroangiopathy, experimental hyperglycemia models in vivo and in vit... In order to clarify the potential role of calcium sensing receptor(Ca SR), a typical G protein coupled receptor(GPCR), in hyperglacemia-induced macroangiopathy, experimental hyperglycemia models in vivo and in vitro were prepared. Firstly, SD rats were divided into control group(n=10) and diabetes group(n=10), and diabetic model was induced via high-fat diet feeding and streptozotocin(STZ, 30 mg/kg) injection. Hydroxyproline level, determined via Choramnie T oxidation method, in vessel wall in diabetic rats was 30% more than that in control group. The gene transcription and expression levels were detected by real-time PCR and Western blotting, respectively. Both of collagen Ⅰ and Ⅲ mR NA levels in diabetic aorta were nearly twice those in normal aorta. The cleaved caspase-3 and-9 were elevated 1.5 and 2.5 times respectively in diabetic vascular cells. As compared with controls, m RNA and protein levels of CaS R in aorta were increased by 3 and 1.5 times in diabetes group. The expression levels of Bax as well as pro-apoptotic kinases(phospho-p38 and phosphor-JNK) were also increased 2, 0.5 and 0.5 times respectively in diabetic rats. To further validate the involvement of Ca SR in cell apoptosis and explore the potential mechanism, the endothelial cell line(human umbilical vascular endothelial cells, HUVECs) was stimulated with high concentration of glucose(33 mmol/L) to mimic hyperglycemia in vitro. Cell-based assays also showed that the Ca SR level and key apoptotic proteins(cleaved caspase-3 and-9, Bax, phospho-p38 and phosphor-JNK) were elevated in response to stimulation, and inhibition of Ca SR by using specific inhibitor(NPS-2143, 10 μmol/L) could protect cells against apoptosis. Our results demonstrated that Ca SR might take important part in the development of diabetic macroangiopathy through promoting cell apoptosis induced by hyperglycemia. 展开更多
关键词 calcium sensing receptor DIABETES HYPERGLYCEMIA MACROANGIOPATHY APOPTOSIS
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Progress in the Clinical Application of Cinacalcet in the Treatment of Secondary Hyperthyroidism
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作者 Yueling ZHU Shengling HUANG +12 位作者 Shuang Cui Lianghong YIN Taksui Wong Xiangnan DONG Bing YAN Baozhang GUAN Bo HU Fanna LIU Yingyan LI Shanshan LI Xin CHEN Berthold Hocher Wolfgang Pommer 《临床医学工程》 2017年第S1期52-54,共3页
Secondary hyperthyroidism(SHPT)is a common complication of maintenance hemodialysis(MHD).In China the prevalence of chronic kidney disease(CKD)is 10.8%and there are about 0.2 million patients treated with maintenance ... Secondary hyperthyroidism(SHPT)is a common complication of maintenance hemodialysis(MHD).In China the prevalence of chronic kidney disease(CKD)is 10.8%and there are about 0.2 million patients treated with maintenance hemodialysis.These number are still increasing.Cinacalcet is a new calcium sensing receptor agonist to treat SHPT and the first calcimimetics be approved by Food and Drug Administration(FDA)to treat human.It can activate the calcium sensing receptor in parathyroid to improving control of parathyroid hormone(PTH),serum calcium,phosphorus,and calcium phosphorus product.Then decrease vascular calcification and parathyroid gland volume and reduce the occurrence of fracture and calcific uremic arteriolopathy(CUA).A better understanding of the clinical evaluation for Cinacalcet will hopefully help us to reduce the incidence of SHPT. 展开更多
关键词 CINACALCET Maintenance hemodialysis(MHD) Secondary hyperthyroidism(SHPT) Calcium sensing receptor(CaSR)
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Amino acid sensing in the gut and its mediation in gut-brain signal transduction 被引量:4
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作者 Jing Liu Kaifan Yu Weiyun Zhu 《Animal Nutrition》 SCIE 2016年第2期69-73,共5页
Animal gastrointestinal tract is not only a digestive organ, but also a nutrient sensing organ which detects luminal nutrient and thus can regulate food intake. There are many amino acid sensing receptors and transpor... Animal gastrointestinal tract is not only a digestive organ, but also a nutrient sensing organ which detects luminal nutrient and thus can regulate food intake. There are many amino acid sensing receptors and transporters in the gut. Amino acids sensing by these receptors and transporters can stimulate the intestinal endocrine cells to release a variety of gut hormones. These hormones trigger a series of physiological effects via the nerve system. This review summarized the recent advance on the amino acid sensing receptors and transporters in the gastrointestinal tract, the gut hormones released from the intestinal endocrine cells and the hormones-induced signal transduction between the gut and brain. A better understanding of these processes may help to gain further insight into the specific role of amino acids in digestion and provide guidelines in developing strategy for the better use of amino acids in the diet. 展开更多
关键词 Amino acid sensing Gut hormones sensing receptor Amino acid transporter Gut-brain signaling
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Expression of the calcium receptor CaR in the parathyroid of secondary hyperparathyroidism patients 被引量:1
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作者 王宁宁 王笑云 +4 位作者 彭韬 吴宏飞 胡建明 赵卫红 俞香宝 《Chinese Medical Journal》 SCIE CAS CSCD 2004年第9期1408-1410,共3页
关键词 calcium sensing receptor · parathyroid · secondary hyperparathyroidism · chronic renal failure
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