In sensitivity experiments, the response is binary and each experimental unit has a critical stimulus level that cannot be observed directly. It is often of interest to estimate extreme quantiles of the distribution o...In sensitivity experiments, the response is binary and each experimental unit has a critical stimulus level that cannot be observed directly. It is often of interest to estimate extreme quantiles of the distribution of these critical stimulus levels over the tested products. For this purpose a new sequential scheme is proposed with some commonly used models. By using the bootstrap repeated-sampling principle, reasonable prior distributions based on a historic data set are specified. Then, a Bayesian strategy for the sequential procedure is provided and the estimator is given. Further, a high order approximation for such an estimator is explored and its consistency is proven. A simulation study shows that the proposed method gives superior performances over the existing methods.展开更多
The paper discusses general expressions of the clock signal and the next state equations containing the clock signal for flip-flops, and based on it, a unified theory for designing and analyzing both synchronous and a...The paper discusses general expressions of the clock signal and the next state equations containing the clock signal for flip-flops, and based on it, a unified theory for designing and analyzing both synchronous and asynchronous sequential circuits is proposed. The theory is proved effective by practical examples.展开更多
As a method for testing a sequential circuit efficiently, a scan design is usually used. But, since this design has some drawbacks, a non-scan testable design should be discussed. The testable design can be implemente...As a method for testing a sequential circuit efficiently, a scan design is usually used. But, since this design has some drawbacks, a non-scan testable design should be discussed. The testable design can be implemented by enhancing controllability and observability. This paper discusses a non-scan testable design for a sequential circuit by only focusing the improvement of controllability. The proposed design modifies a circuit so that all the FFs can be directly controlled by primary input lines in a test mode. Experimental results show that we can get a good testability using this method.展开更多
Clinical trials are usually long term studies and it seems impossible to reach all required subjects at the same time. Performing interim analyses and monitoring results may provide early termination of trial after ob...Clinical trials are usually long term studies and it seems impossible to reach all required subjects at the same time. Performing interim analyses and monitoring results may provide early termination of trial after obtaining significant results. The aim of this study is comparing group sequential tests in respect to advantage of sample size reduction and early termination. In this study, 4 test types used in group sequential designs were compared with fixed sample size design test and each other. Comparisons were done according to two-sided tests for comparing two treatments. In this sense, 1080 models were performed. In models, 2 different Type I errors, 2 different powers, 5 different analysis groups, 6 different effect sizes and 9 different variances selections were considered. All test types increased the maximum sample size in different manner, compared with fixed sample size design. Each test had different critical values to reject H0 hypothesis, at the same type I error rate and number of analyses conditions. Selection of test type used in group sequential designs depends on a few characteristics, as reducing sample size, early termination and detecting minimal effect size. Test performance is highly related with selected Type I error rate, power and number of analyses. In addition to these statistical characteristics, researchers should decide test type with respect to other trial conditions as the issue of trial, reaching subjects easy or not and importance of early termination.展开更多
China,recognized as the world’s largest developing nation,displays considerably lower per capita consumption of dietary supplements in comparison to Asian nations such as Japan and South Korea.However,in recent years...China,recognized as the world’s largest developing nation,displays considerably lower per capita consumption of dietary supplements in comparison to Asian nations such as Japan and South Korea.However,in recent years,there has been a substantial surge in health consciousness among the Chinese populace.This trend is not confined to the middle-aged and elderly;even younger consumer demographics are exhibiting increased health awareness.Consequently,the target demographic for dietary supplements is transitioning towards a younger demographic.Within the Chinese dietary supplement industry,vitamin C has consistently held the largest market share,commanding a broad consumer base.This underscores the substantial role of vitamin C in the dietary supplement sector.In response to the trend towards a younger target demographic in the dietary supplement industry,adjustments are required to accommodate the preferences of this younger consumer group.This research,guided by Norman’s emotional design framework,executed a survey of over 200 respondents to investigate the preferences of Generation Z consumers in China.The research encompassed packaging,product forms,and brand imagery,corresponding to the emotional design’s visceral,behavioral,and reflective layers,with a primary focus on optimally meeting the emotional needs of Generation Z.The findings indicated that consumers favor products in capsule form,packaged in zip-lock.The predominant color scheme is clean white,accented by vibrant orange elements,while emphasizing the product’s health and scientific attributes.This study offers valuable insights for the continued evolution of the vitamin C dietary supplement market in China.展开更多
Based on analyzing significance of controlling clock in design of low power sequential circuits, this paper proposes a technique that the gating signal is derived from the master latch in a flip-flop to make the deriv...Based on analyzing significance of controlling clock in design of low power sequential circuits, this paper proposes a technique that the gating signal is derived from the master latch in a flip-flop to make the derived clock having no glitch and no skew. The design of a decimal counter with half-frequency division shows that by using the synchronous derived clock the counter has lower power dissipation as well as simpler combinational logic. Computer simulation shows 20% power saving.展开更多
文摘In sensitivity experiments, the response is binary and each experimental unit has a critical stimulus level that cannot be observed directly. It is often of interest to estimate extreme quantiles of the distribution of these critical stimulus levels over the tested products. For this purpose a new sequential scheme is proposed with some commonly used models. By using the bootstrap repeated-sampling principle, reasonable prior distributions based on a historic data set are specified. Then, a Bayesian strategy for the sequential procedure is provided and the estimator is given. Further, a high order approximation for such an estimator is explored and its consistency is proven. A simulation study shows that the proposed method gives superior performances over the existing methods.
基金Supported by National Natural Science Foundation of Zhejiang Province
文摘The paper discusses general expressions of the clock signal and the next state equations containing the clock signal for flip-flops, and based on it, a unified theory for designing and analyzing both synchronous and asynchronous sequential circuits is proposed. The theory is proved effective by practical examples.
文摘As a method for testing a sequential circuit efficiently, a scan design is usually used. But, since this design has some drawbacks, a non-scan testable design should be discussed. The testable design can be implemented by enhancing controllability and observability. This paper discusses a non-scan testable design for a sequential circuit by only focusing the improvement of controllability. The proposed design modifies a circuit so that all the FFs can be directly controlled by primary input lines in a test mode. Experimental results show that we can get a good testability using this method.
文摘Clinical trials are usually long term studies and it seems impossible to reach all required subjects at the same time. Performing interim analyses and monitoring results may provide early termination of trial after obtaining significant results. The aim of this study is comparing group sequential tests in respect to advantage of sample size reduction and early termination. In this study, 4 test types used in group sequential designs were compared with fixed sample size design test and each other. Comparisons were done according to two-sided tests for comparing two treatments. In this sense, 1080 models were performed. In models, 2 different Type I errors, 2 different powers, 5 different analysis groups, 6 different effect sizes and 9 different variances selections were considered. All test types increased the maximum sample size in different manner, compared with fixed sample size design. Each test had different critical values to reject H0 hypothesis, at the same type I error rate and number of analyses conditions. Selection of test type used in group sequential designs depends on a few characteristics, as reducing sample size, early termination and detecting minimal effect size. Test performance is highly related with selected Type I error rate, power and number of analyses. In addition to these statistical characteristics, researchers should decide test type with respect to other trial conditions as the issue of trial, reaching subjects easy or not and importance of early termination.
文摘China,recognized as the world’s largest developing nation,displays considerably lower per capita consumption of dietary supplements in comparison to Asian nations such as Japan and South Korea.However,in recent years,there has been a substantial surge in health consciousness among the Chinese populace.This trend is not confined to the middle-aged and elderly;even younger consumer demographics are exhibiting increased health awareness.Consequently,the target demographic for dietary supplements is transitioning towards a younger demographic.Within the Chinese dietary supplement industry,vitamin C has consistently held the largest market share,commanding a broad consumer base.This underscores the substantial role of vitamin C in the dietary supplement sector.In response to the trend towards a younger target demographic in the dietary supplement industry,adjustments are required to accommodate the preferences of this younger consumer group.This research,guided by Norman’s emotional design framework,executed a survey of over 200 respondents to investigate the preferences of Generation Z consumers in China.The research encompassed packaging,product forms,and brand imagery,corresponding to the emotional design’s visceral,behavioral,and reflective layers,with a primary focus on optimally meeting the emotional needs of Generation Z.The findings indicated that consumers favor products in capsule form,packaged in zip-lock.The predominant color scheme is clean white,accented by vibrant orange elements,while emphasizing the product’s health and scientific attributes.This study offers valuable insights for the continued evolution of the vitamin C dietary supplement market in China.
基金Supported by the NSF of China (# 69773034) and DARPA under contract # F33615-95-C-1627
文摘Based on analyzing significance of controlling clock in design of low power sequential circuits, this paper proposes a technique that the gating signal is derived from the master latch in a flip-flop to make the derived clock having no glitch and no skew. The design of a decimal counter with half-frequency division shows that by using the synchronous derived clock the counter has lower power dissipation as well as simpler combinational logic. Computer simulation shows 20% power saving.
