BACKGROUND Perihilar cholangiocarcinoma(pCCA)is a highly malignant tumor arising from the biliary tree.Radical surgery is the only treatment offering a chance of long-term survival.However,limited by the tumor’s anat...BACKGROUND Perihilar cholangiocarcinoma(pCCA)is a highly malignant tumor arising from the biliary tree.Radical surgery is the only treatment offering a chance of long-term survival.However,limited by the tumor’s anatomic location and peri-vascular invasion,most patients lose the chance for curative treatment.Therefore,more methods to increase the resectability of tumors as well as to improve outcomes are needed.CASE SUMMARY A 68-year-old female patient had a hepatic hilar mass without obvious symptoms.Laboratory results showed hepatitis B positivity.Magnetic resonance imaging indicated that the mass(maximum diameter:41 mm)invaded the left and right branches of the main portal vein,as well as the middle,left and right hepatic veins;enlarged lymph nodes were also detected in the hilum.The patient was diagnosed with pCCA,and the clinical stage was determined to be T4N1M0(stage IIIC).Considering the tumor’s anatomic location and vascular invasion,systematic conversion therapy followed by ex vivo liver resection and autotrans-plantation(ELRA)was determined as personalized treatment for this patient.Our original systemic sequential therapeutic strategy(lenvatinib and tislelizumab in combination with gemcitabine and cisplatin)was successfully adopted as conversion therapy because she achieved partial response after three cycles of treatment,without severe toxicity.ELRA,anastomotic reconstruction of the middle hepatic vein,right hepatic vein,root of portal vein,inferior vena cava and right hepatic artery,and lymph node dissection were performed at one month after systemic therapy.Pathological and immunohistochemical examination confirmed the diagnosis of pCCA with lymph node metastasis.Although the middle hepatic vein was partially obstructed four months later,hepatic vein stent implantation successfully addressed this problem.The patient has survived for 22 mo after the diagnosis,with no evidence of recurrence or metastasis.CONCLUSION An effective therapeutic strategy for conversion therapy greatly increases the feasibility and efficiency of ELRA.展开更多
A Bayesian sequential testing method is proposed to evaluate system reliability index with reliability growth during development.The method develops a reliability growth model of repairable systems for failure censore...A Bayesian sequential testing method is proposed to evaluate system reliability index with reliability growth during development.The method develops a reliability growth model of repairable systems for failure censored test,and figures out the approach to determine the prior distribution of the system failure rate by applying the reliability growth model to incorporate the multistage test data collected from system development.Furthermore,the procedure for the Bayesian sequential testing is derived for the failure rate of the exponential life system,which enables the decision to terminate or continue development test.Finally,a numerical example is given to illustrate the efficiency of the proposed model and procedure.展开更多
In this article, we discuss the existence and uniqueness of solutions for a coupled two-parameter system of sequential fractional integro-differential equations supplemented with nonlocal integro-multipoint boundary c...In this article, we discuss the existence and uniqueness of solutions for a coupled two-parameter system of sequential fractional integro-differential equations supplemented with nonlocal integro-multipoint boundary conditions. The standard tools of the fixed-point theory are employed to obtain the main results. We emphasize that our results are not only new in the given configuration, but also correspond to several new special cases for specific values of the parameters involved in the problem at hand.展开更多
A sequential injection analysis (SIA) system for the determination of total calcium in blood has been implemented. The assay principle is based on the arsenazo III method, in which the indicator’s complex with calciu...A sequential injection analysis (SIA) system for the determination of total calcium in blood has been implemented. The assay principle is based on the arsenazo III method, in which the indicator’s complex with calcium forms a blue-purple colour. The absorbance peak height at 650 nm was proportional to the calcium content in samples. A linear range was obtained from 2.5 - 15 mg?dL–1 (r2 = 0.999), with a detection limit of 0.430 mg?dL–1 (3σ). Magnesium, glucose, hae-moglobin, and bilirubin at 123, 1,000, 50, and 0.5 mg?dL–1, respectively, were not found to interfere with the proposed system significantly (recovery 99.1% - 104.4%). The sampling frequency was 30 h–1, in which the carry-over effect was negligible (0.69%). The proposed SIA system was successfully applied to the determination of calcium from serum samples (r2 = 0.970;n = 30).展开更多
In this paper we will investigate some non-asymptotic properties of the modified least squares estimates for the non-linear function f(λ*) by observations that nonlinearly depend on the parameter λ*. Non-asymptotic ...In this paper we will investigate some non-asymptotic properties of the modified least squares estimates for the non-linear function f(λ*) by observations that nonlinearly depend on the parameter λ*. Non-asymptotic confidence regions with fixed sizes for the modified least squares estimate are used. The obtained confidence region is valid for a finite number of data points when the distributions of the observations are unknown. Asymptotically the suggested estimates represent usual estimates of the least squares. The paper presents the results of practical applications of the proposed method in C-OTDR monitoring systems.展开更多
针对电网电压不平衡下电流平衡及功率恒定问题,提出改进型光储虚拟同步发电机(virtual synchronous generator,VSG)控制策略,该策略通过引入虚拟阻抗技术和双二阶广义积分器(double second order generalized integrator,DSOGI)实现正...针对电网电压不平衡下电流平衡及功率恒定问题,提出改进型光储虚拟同步发电机(virtual synchronous generator,VSG)控制策略,该策略通过引入虚拟阻抗技术和双二阶广义积分器(double second order generalized integrator,DSOGI)实现正负序分量的有效分离,并基于瞬时功率理论优化电流和功率的协调控制,显著提高了系统在不平衡电网条件下的电流平衡性和功率稳定性。首先,构建基于电机瞬态模型的光伏储能VSG系统的数学模型,以深入理解和模拟VSG在实际电网中的动态行为。通过应用双二阶广义积分器技术,实现了正序与负序分量的有效分离,并基于瞬时功率理论和负序虚拟复阻抗技术,进一步实现电流和功率的协调控制,确保电流平衡及功率恒定。最后,利用MATLA/Simulink软件构建仿真模型,模拟光伏储能系统在不平衡电网状态下的运行情况,仿真结果表明所提控制策略显著提高了控制策略的精度和响应速度,可确保动态电网环境中的操作效率和可靠性。展开更多
Sequential diagnosis is a very useful strategy for system-level fault identification because of its lower cost of hardware.In this paper,the characterization of sequentially t-diagnosable system is given,and a tmivers...Sequential diagnosis is a very useful strategy for system-level fault identification because of its lower cost of hardware.In this paper,the characterization of sequentially t-diagnosable system is given,and a tmiversal algorithm to seek faulty units in the system is developed.展开更多
文摘BACKGROUND Perihilar cholangiocarcinoma(pCCA)is a highly malignant tumor arising from the biliary tree.Radical surgery is the only treatment offering a chance of long-term survival.However,limited by the tumor’s anatomic location and peri-vascular invasion,most patients lose the chance for curative treatment.Therefore,more methods to increase the resectability of tumors as well as to improve outcomes are needed.CASE SUMMARY A 68-year-old female patient had a hepatic hilar mass without obvious symptoms.Laboratory results showed hepatitis B positivity.Magnetic resonance imaging indicated that the mass(maximum diameter:41 mm)invaded the left and right branches of the main portal vein,as well as the middle,left and right hepatic veins;enlarged lymph nodes were also detected in the hilum.The patient was diagnosed with pCCA,and the clinical stage was determined to be T4N1M0(stage IIIC).Considering the tumor’s anatomic location and vascular invasion,systematic conversion therapy followed by ex vivo liver resection and autotrans-plantation(ELRA)was determined as personalized treatment for this patient.Our original systemic sequential therapeutic strategy(lenvatinib and tislelizumab in combination with gemcitabine and cisplatin)was successfully adopted as conversion therapy because she achieved partial response after three cycles of treatment,without severe toxicity.ELRA,anastomotic reconstruction of the middle hepatic vein,right hepatic vein,root of portal vein,inferior vena cava and right hepatic artery,and lymph node dissection were performed at one month after systemic therapy.Pathological and immunohistochemical examination confirmed the diagnosis of pCCA with lymph node metastasis.Although the middle hepatic vein was partially obstructed four months later,hepatic vein stent implantation successfully addressed this problem.The patient has survived for 22 mo after the diagnosis,with no evidence of recurrence or metastasis.CONCLUSION An effective therapeutic strategy for conversion therapy greatly increases the feasibility and efficiency of ELRA.
基金supported by the National Natural Science Foundation of China (70571083)the Research Fund for the Doctoral Program of Higher Education of China (20094307110013)
文摘A Bayesian sequential testing method is proposed to evaluate system reliability index with reliability growth during development.The method develops a reliability growth model of repairable systems for failure censored test,and figures out the approach to determine the prior distribution of the system failure rate by applying the reliability growth model to incorporate the multistage test data collected from system development.Furthermore,the procedure for the Bayesian sequential testing is derived for the failure rate of the exponential life system,which enables the decision to terminate or continue development test.Finally,a numerical example is given to illustrate the efficiency of the proposed model and procedure.
文摘In this article, we discuss the existence and uniqueness of solutions for a coupled two-parameter system of sequential fractional integro-differential equations supplemented with nonlocal integro-multipoint boundary conditions. The standard tools of the fixed-point theory are employed to obtain the main results. We emphasize that our results are not only new in the given configuration, but also correspond to several new special cases for specific values of the parameters involved in the problem at hand.
文摘A sequential injection analysis (SIA) system for the determination of total calcium in blood has been implemented. The assay principle is based on the arsenazo III method, in which the indicator’s complex with calcium forms a blue-purple colour. The absorbance peak height at 650 nm was proportional to the calcium content in samples. A linear range was obtained from 2.5 - 15 mg?dL–1 (r2 = 0.999), with a detection limit of 0.430 mg?dL–1 (3σ). Magnesium, glucose, hae-moglobin, and bilirubin at 123, 1,000, 50, and 0.5 mg?dL–1, respectively, were not found to interfere with the proposed system significantly (recovery 99.1% - 104.4%). The sampling frequency was 30 h–1, in which the carry-over effect was negligible (0.69%). The proposed SIA system was successfully applied to the determination of calcium from serum samples (r2 = 0.970;n = 30).
文摘In this paper we will investigate some non-asymptotic properties of the modified least squares estimates for the non-linear function f(λ*) by observations that nonlinearly depend on the parameter λ*. Non-asymptotic confidence regions with fixed sizes for the modified least squares estimate are used. The obtained confidence region is valid for a finite number of data points when the distributions of the observations are unknown. Asymptotically the suggested estimates represent usual estimates of the least squares. The paper presents the results of practical applications of the proposed method in C-OTDR monitoring systems.
文摘针对电网电压不平衡下电流平衡及功率恒定问题,提出改进型光储虚拟同步发电机(virtual synchronous generator,VSG)控制策略,该策略通过引入虚拟阻抗技术和双二阶广义积分器(double second order generalized integrator,DSOGI)实现正负序分量的有效分离,并基于瞬时功率理论优化电流和功率的协调控制,显著提高了系统在不平衡电网条件下的电流平衡性和功率稳定性。首先,构建基于电机瞬态模型的光伏储能VSG系统的数学模型,以深入理解和模拟VSG在实际电网中的动态行为。通过应用双二阶广义积分器技术,实现了正序与负序分量的有效分离,并基于瞬时功率理论和负序虚拟复阻抗技术,进一步实现电流和功率的协调控制,确保电流平衡及功率恒定。最后,利用MATLA/Simulink软件构建仿真模型,模拟光伏储能系统在不平衡电网状态下的运行情况,仿真结果表明所提控制策略显著提高了控制策略的精度和响应速度,可确保动态电网环境中的操作效率和可靠性。
文摘Sequential diagnosis is a very useful strategy for system-level fault identification because of its lower cost of hardware.In this paper,the characterization of sequentially t-diagnosable system is given,and a tmiversal algorithm to seek faulty units in the system is developed.
