This editorial is a commentary on the case report by Furuya et al focusing on the challenging diagnosis of early pancreatic adenocarcinoma and new tools for an earlier diagnosis.Currently,pancreatic cancer still has a...This editorial is a commentary on the case report by Furuya et al focusing on the challenging diagnosis of early pancreatic adenocarcinoma and new tools for an earlier diagnosis.Currently,pancreatic cancer still has a poor prognosis,mainly due to late diagnosis in an advanced stage.Two main precancerous routes have been identified as pathways to pancreatic adenocarcinoma:The first encompasses a large group of mucinous cystic lesions:intraductal papillary mucinous neoplasm and mucinous cystic neoplasm,and the second is pancreatic intraepithelial neoplasia.In the last decade the focus of research has been to identify high-risk patients,using advanced imaging techniques(magnetic resonance cholangiopancreatography or endoscopic ultrasonography)which could be helpful in finding“indirect signs”of early stage pancreatic lesions.Nevertheless,the survival rate still remains poor,and alternative screening methods are under investigation.Endoscopic retrograde cholangiopancreatography followed by serial pancreatic juice aspiration cytology could be a promising tool for identifying precursor lesions such as intraductal papillary mucinous neoplasm,but confirming data are still needed to validate its role.Probably a combination of cross-sectional imaging,endoscopic techniques(old and new ones)and genetic and biological biomarkers also in pancreatic juice)could be the best solution to reach an early diagnosis.Biomarkers could help to predict and follow the progression of early pancreatic lesions.However,further studies are needed to validate their diagnostic reliability and to establish diagnostic algorithms to improve prognosis and survival in patients with pancreatic cancer.展开更多
BACKGROUND Mesenchymal stem cells(MSCs)have been extensively studied for therapeutic potential,due to their regenerative and immunomodulatory properties.Serial passage and stress factors may affect the biological char...BACKGROUND Mesenchymal stem cells(MSCs)have been extensively studied for therapeutic potential,due to their regenerative and immunomodulatory properties.Serial passage and stress factors may affect the biological characteristics of MSCs,but the details of these effects have not been recognized yet.AIM To investigate the effects of stress factors(high glucose and severe hypoxia)on the biological characteristics of MSCs at different passages,in order to optimize the therapeutic applications of MSCs.METHODS In this study,we investigated the impact of two stress conditions;severe hypoxia and high glucose on human adipose-tissue derived MSCs(hAD-MSCs)at passages 6(P6),P8,and P10.Proliferation,senescence and apoptosis were evaluated measuring WST-1,senescence-associated beta-galactosidase,and annexin V,respectively.RESULTS Cells at P6 showed decreased proliferation and increased apoptosis under conditions of high glucose and hypoxia compared to control,while the extent of senescence did not change significantly under stress conditions.At P8 hAD-MSCs cultured in stress conditions had a significant decrease in proliferation and apoptosis and a significant increase in senescence compared to counterpart cells at P6.Cells cultured in high glucose at P10 had lower proliferation and higher senescence than their counterparts in the previous passage,while no change in apoptosis was observed.On the other hand,MSCs cultured under hypoxia showed decreased senescence,increased apoptosis and no significant change in proliferation when compared to the same conditions at P8.CONCLUSION These results indicate that stress factors had distinct effects on the biological processes of MSCs at different passages,and suggest that senescence may be a protective mechanism for MSCs to survive under stress conditions at higher passage numbers.展开更多
The study investigates long-term changes in annual and seasonal rainfall patterns in the Indira Sagar Region of Madhya Pradesh, India, from 1901 to 2010. Agriculture sustainability, food supply, natural resource devel...The study investigates long-term changes in annual and seasonal rainfall patterns in the Indira Sagar Region of Madhya Pradesh, India, from 1901 to 2010. Agriculture sustainability, food supply, natural resource development, and hydropower system reliability in the region rely heavily on monsoon rainfall. Monthly rainfall data from three stations (East Nimar, Barwani, and West Nimar) were analyzed. Initially, the pre-whitening method was applied to eliminate serial correlation effects from the rainfall data series. Subsequently, statistical trends in annual and seasonal rainfall were assessed using both parametric (student-t test) and non-parametric tests [Mann-Kendall, Sen’s slope estimator, and Cumulative Sum (CUSUM)]. The magnitude of the rainfall trend was determined using Theil-Sen’s slope estimator. Spatial analysis of the Mann-Kendall test on an annual basis revealed a statistically insignificant decreasing trend for Barwani and East Nimar and an increasing trend for West Nimar. On a seasonal basis, the monsoon season contributes a significant percentage (88.33%) to the total annual rainfall. The CUSUM test results indicated a shift change detection in annual rainfall data for Barwani in 1997, while shifts were observed in West and East Nimar stations in 1929. These findings offer valuable insights into regional rainfall behavior, aiding in the planning and management of water resources and ecological systems.展开更多
We utilized Raspberry Pi 4B to develop a microbial monitoring system to simplify the microbial image-capturing process and facilitate the informatization of microbial observation results.The Raspberry Pi 4B firmware,d...We utilized Raspberry Pi 4B to develop a microbial monitoring system to simplify the microbial image-capturing process and facilitate the informatization of microbial observation results.The Raspberry Pi 4B firmware,developed under Python on the Linux platform,achieves sum verification of serial data,file upload based on TCP protocol,control of sequence light source and light valve,real-time self-test based on multithreading,and an experiment-oriented file management method.The system demonstrated improved code logic,scheduling,exception handling,and code readability.展开更多
To improve the performance of the short interleaved serial concatenated convolutional code(SCCC) with low decoding iterative times, the structure of Log MAP algorithm is introduced into the conventional SOVA decoder...To improve the performance of the short interleaved serial concatenated convolutional code(SCCC) with low decoding iterative times, the structure of Log MAP algorithm is introduced into the conventional SOVA decoder to improve its performance at short interleaving delay. The combination of Log MAP and SOVA avoids updating the matrices of the maximum path, and also makes a contribution to the requirement of short delay. The simulation results of several SCCCs show that the improved decoder can obtain satisfied performance with short frame interleaver and it is suitable to the high bit rate low delay communication systems.展开更多
为了实时掌握农业机械自动导航时运行状态的相关参数,并根据监测参数作出相应的调整动作,本文以Visual Studio 2008为开发平台,开发了一套高速插秧机自动导航的运行参数远程监测系统软件。该软件功能主要包括信号检测、数据通讯、控制...为了实时掌握农业机械自动导航时运行状态的相关参数,并根据监测参数作出相应的调整动作,本文以Visual Studio 2008为开发平台,开发了一套高速插秧机自动导航的运行参数远程监测系统软件。该软件功能主要包括信号检测、数据通讯、控制决策、数据显示和数据存储。系统采用Visual Studio 2008中Visual Basic.net 2008语言进行开发,将远程采集的各监测数据经由GSM网络进行无线传输到上位机;并采用Serial Port控件来进行串行通讯,完成PC机与GSM模块之间数据的交换,并对相应控制动作进行相应性能仿真。展开更多
U SB( U niversal Serial Bus)经过了 9年发展 ,已经得到了市场的认可 ,其传输速度达到了最大 480 Mb/s的惊人地步 ,而 USB OTG ( On The Go)的推出更是鼓舞人心 ,其双重角色的强大功能可以使 U SB设备摆脱对 PC的完全依赖。 USB OTG是 ...U SB( U niversal Serial Bus)经过了 9年发展 ,已经得到了市场的认可 ,其传输速度达到了最大 480 Mb/s的惊人地步 ,而 USB OTG ( On The Go)的推出更是鼓舞人心 ,其双重角色的强大功能可以使 U SB设备摆脱对 PC的完全依赖。 USB OTG是 U SB 2 .0规范的补充 ,他使外设可以在无主机参与的情况下直接互连进行通信工程。本文简单介绍了 U SB OTG的工作原理 ,并分析了现在 U SB OTG的应用情况 ,重点针对数码相机伴侣存在的问题 。展开更多
文摘This editorial is a commentary on the case report by Furuya et al focusing on the challenging diagnosis of early pancreatic adenocarcinoma and new tools for an earlier diagnosis.Currently,pancreatic cancer still has a poor prognosis,mainly due to late diagnosis in an advanced stage.Two main precancerous routes have been identified as pathways to pancreatic adenocarcinoma:The first encompasses a large group of mucinous cystic lesions:intraductal papillary mucinous neoplasm and mucinous cystic neoplasm,and the second is pancreatic intraepithelial neoplasia.In the last decade the focus of research has been to identify high-risk patients,using advanced imaging techniques(magnetic resonance cholangiopancreatography or endoscopic ultrasonography)which could be helpful in finding“indirect signs”of early stage pancreatic lesions.Nevertheless,the survival rate still remains poor,and alternative screening methods are under investigation.Endoscopic retrograde cholangiopancreatography followed by serial pancreatic juice aspiration cytology could be a promising tool for identifying precursor lesions such as intraductal papillary mucinous neoplasm,but confirming data are still needed to validate its role.Probably a combination of cross-sectional imaging,endoscopic techniques(old and new ones)and genetic and biological biomarkers also in pancreatic juice)could be the best solution to reach an early diagnosis.Biomarkers could help to predict and follow the progression of early pancreatic lesions.However,further studies are needed to validate their diagnostic reliability and to establish diagnostic algorithms to improve prognosis and survival in patients with pancreatic cancer.
基金Supported by the Deanship of Scientific Research,Yarmouk University,Jordan,No.73/2022.
文摘BACKGROUND Mesenchymal stem cells(MSCs)have been extensively studied for therapeutic potential,due to their regenerative and immunomodulatory properties.Serial passage and stress factors may affect the biological characteristics of MSCs,but the details of these effects have not been recognized yet.AIM To investigate the effects of stress factors(high glucose and severe hypoxia)on the biological characteristics of MSCs at different passages,in order to optimize the therapeutic applications of MSCs.METHODS In this study,we investigated the impact of two stress conditions;severe hypoxia and high glucose on human adipose-tissue derived MSCs(hAD-MSCs)at passages 6(P6),P8,and P10.Proliferation,senescence and apoptosis were evaluated measuring WST-1,senescence-associated beta-galactosidase,and annexin V,respectively.RESULTS Cells at P6 showed decreased proliferation and increased apoptosis under conditions of high glucose and hypoxia compared to control,while the extent of senescence did not change significantly under stress conditions.At P8 hAD-MSCs cultured in stress conditions had a significant decrease in proliferation and apoptosis and a significant increase in senescence compared to counterpart cells at P6.Cells cultured in high glucose at P10 had lower proliferation and higher senescence than their counterparts in the previous passage,while no change in apoptosis was observed.On the other hand,MSCs cultured under hypoxia showed decreased senescence,increased apoptosis and no significant change in proliferation when compared to the same conditions at P8.CONCLUSION These results indicate that stress factors had distinct effects on the biological processes of MSCs at different passages,and suggest that senescence may be a protective mechanism for MSCs to survive under stress conditions at higher passage numbers.
文摘The study investigates long-term changes in annual and seasonal rainfall patterns in the Indira Sagar Region of Madhya Pradesh, India, from 1901 to 2010. Agriculture sustainability, food supply, natural resource development, and hydropower system reliability in the region rely heavily on monsoon rainfall. Monthly rainfall data from three stations (East Nimar, Barwani, and West Nimar) were analyzed. Initially, the pre-whitening method was applied to eliminate serial correlation effects from the rainfall data series. Subsequently, statistical trends in annual and seasonal rainfall were assessed using both parametric (student-t test) and non-parametric tests [Mann-Kendall, Sen’s slope estimator, and Cumulative Sum (CUSUM)]. The magnitude of the rainfall trend was determined using Theil-Sen’s slope estimator. Spatial analysis of the Mann-Kendall test on an annual basis revealed a statistically insignificant decreasing trend for Barwani and East Nimar and an increasing trend for West Nimar. On a seasonal basis, the monsoon season contributes a significant percentage (88.33%) to the total annual rainfall. The CUSUM test results indicated a shift change detection in annual rainfall data for Barwani in 1997, while shifts were observed in West and East Nimar stations in 1929. These findings offer valuable insights into regional rainfall behavior, aiding in the planning and management of water resources and ecological systems.
文摘We utilized Raspberry Pi 4B to develop a microbial monitoring system to simplify the microbial image-capturing process and facilitate the informatization of microbial observation results.The Raspberry Pi 4B firmware,developed under Python on the Linux platform,achieves sum verification of serial data,file upload based on TCP protocol,control of sequence light source and light valve,real-time self-test based on multithreading,and an experiment-oriented file management method.The system demonstrated improved code logic,scheduling,exception handling,and code readability.
文摘To improve the performance of the short interleaved serial concatenated convolutional code(SCCC) with low decoding iterative times, the structure of Log MAP algorithm is introduced into the conventional SOVA decoder to improve its performance at short interleaving delay. The combination of Log MAP and SOVA avoids updating the matrices of the maximum path, and also makes a contribution to the requirement of short delay. The simulation results of several SCCCs show that the improved decoder can obtain satisfied performance with short frame interleaver and it is suitable to the high bit rate low delay communication systems.
文摘为了实时掌握农业机械自动导航时运行状态的相关参数,并根据监测参数作出相应的调整动作,本文以Visual Studio 2008为开发平台,开发了一套高速插秧机自动导航的运行参数远程监测系统软件。该软件功能主要包括信号检测、数据通讯、控制决策、数据显示和数据存储。系统采用Visual Studio 2008中Visual Basic.net 2008语言进行开发,将远程采集的各监测数据经由GSM网络进行无线传输到上位机;并采用Serial Port控件来进行串行通讯,完成PC机与GSM模块之间数据的交换,并对相应控制动作进行相应性能仿真。
文摘U SB( U niversal Serial Bus)经过了 9年发展 ,已经得到了市场的认可 ,其传输速度达到了最大 480 Mb/s的惊人地步 ,而 USB OTG ( On The Go)的推出更是鼓舞人心 ,其双重角色的强大功能可以使 U SB设备摆脱对 PC的完全依赖。 USB OTG是 U SB 2 .0规范的补充 ,他使外设可以在无主机参与的情况下直接互连进行通信工程。本文简单介绍了 U SB OTG的工作原理 ,并分析了现在 U SB OTG的应用情况 ,重点针对数码相机伴侣存在的问题 。
