Objective To study the effect of oral vitamin D （VD） supplementation on VD status and serum lipid in Chinese obese and healthy normal-weight men. Methods Twenty-one obese men with their body mass index （BMI）〉28 k...Objective To study the effect of oral vitamin D （VD） supplementation on VD status and serum lipid in Chinese obese and healthy normal-weight men. Methods Twenty-one obese men with their body mass index （BMI）〉28 kg/m2 served as an obese group and 22 healthy normal-weight men with their BMI〈24 kg/m2 served as a control group in this study. After they were given 50 000 IU of oral VD, once a week for 8 weeks, the serum 25-hydroxyvitamin D [25（OH）D] concentration was measured with an enzyme-immunoassay kit. Results After oral VD supplementation, the serum 25（OH）D concentration significantly increased from 46.1＋9.1 nmol/L to 116.7_＋20.3 nmol/L in the obese subjects （P〈O.01） and from 52.8_＋17.8 nmol/L to 181.3_＋30.2 nmol/L in the control ones （P=0.13）. The serum high-density lipoprotein cholesterol （HDL-C） level was reduced within the normal reference range in the obese group. However, no significant change was observed in the level of other serum lipids （triglycerides, total cholesterol, and low-density lipoprotein cholesterol） in either of the two groups. Conclusion The effect of high-dose oral VD supplementation is weaker on VD status in the obese group than in the control group. High-dose oral VD supplementation has no side effect on serum lipid level in obese and control groups.展开更多
Background: Vitamin D plays a pivotal role in supporting the immune system, helping to reduce the risk of infections and certain autoimmune diseases. Adequate vitamin D levels may be associated with a reduced risk of ...Background: Vitamin D plays a pivotal role in supporting the immune system, helping to reduce the risk of infections and certain autoimmune diseases. Adequate vitamin D levels may be associated with a reduced risk of certain health conditions like pre-eclampsia, gestational diabetes, and postpartum depression. Brittle bones, osteoporosis in the elderly, and osteomalacia in young children are all symptoms of vitamin D insufficiency. Additionally, it contributes to problems linked to gum disease, including an increase in dental cavities, alveolar bone loss around the teeth, and other problems. It could lead to depression, tiredness, and a loss of appetite. In this study, urban children and adolescents in Dhaka city, Bangladesh are examined for vitamin D deficiency, insufficiency, and sufficiency. Methods: The Study was a cross-sectional study conducted under Dhaka National Medical College and Hospital, Dhaka and additionally included two other health centers Medinova Medical Services and Monoara General Hospital Service Golap bag, Dhaka from October 2020 to November 2021. The study location was at the 3 (Three) different hospitals which was located in Dhaka City. In this cross-sectional study, Participants will be selected purposively and conveniently based on the age categories from 0 - 19 years of age at the outdoor department of the hospital. The study included the secondary dataset of ambulatory individuals who came to the 3 (three) hospitals, randomly to evaluate serum vitamin D levels on referral from a general out-patient-department (OPD). They were examined for laboratory findings of serum 25 hydroxyvitamin D levels to determine vitamin D deficiency, insufficiency, and sufficiency among children and adolescent groups of both male and female Sex. Results: A total of 6394 individuals with a diverse age group were statistically examined for laboratory findings of serum vitamin D levels. Vitamin D deficiency was observed in 40.58% of individuals with a mean log of 1.01 ± 0.18 ng/ml serum vitamin D levels, vitamin D insufficiency in 30.93% of individuals with a mean log of 1.38 ± 0.05 ng/ml serum vitamin D levels and vitamin D sufficiency in 19.49% individuals with a mean log of 1.63 ± 0.12 ng/ml serum vitamin D levels. The highest percentage of individuals deficient in vitamin D were children and adolescents of age ranging between 15 to 19 years. Conclusion: The findings of vitamin D deficiency in children and adolescents direct higher authorities in the public health sector to take immediate steps to screen, intervene and educate high-risk populations incorporating vitamin D supplements to establish preventive and therapeutic measures.展开更多
目的观察原发性肝癌(primary hepatocellular carcinoma,PHC)与血清25(OH)维生素D水平的相关性。方法抽取2018年8月—2020年8月莆田市第一医院PHC患者50例作为观察组,抽取同时期健康体检者50例作为对照组。检测两组血清25(OH)D3水平以...目的观察原发性肝癌(primary hepatocellular carcinoma,PHC)与血清25(OH)维生素D水平的相关性。方法抽取2018年8月—2020年8月莆田市第一医院PHC患者50例作为观察组,抽取同时期健康体检者50例作为对照组。检测两组血清25(OH)D3水平以及甲胎蛋白(alpha fetoprotein,AFP)水平。结果观察组血清25(OH)D3水平低于对照组,差异有统计学意义(P<0.05)。观察组AFP水平高于对照组,差异有统计学意义(P<0.05)。PHC血清患者25(OH)D3水平与中国肝癌分期(China live cancer staging,CNLC)、淋巴结转移有关,差异有统计学意义(P<0.05)。结论针对PHC患者,其血清25(OH)D3水平主要相关因素为CNLC分期、淋巴结转移,根据血清25(OH)D3水平可为疾病治疗及其预后评估提供依据。展开更多
目的:探讨妊娠早、中期妇女血清25-羟维生素D-3(25-OHD-3)与妊娠期糖尿病(GDM)的关系。方法:随机选取2018年1月至2021年12月在本院进行常规孕期检查的产妇作为研究对象,孕8~12周检测其空腹血糖(FBG)及糖化血红蛋白(HbAlc)水平,孕13~15...目的:探讨妊娠早、中期妇女血清25-羟维生素D-3(25-OHD-3)与妊娠期糖尿病(GDM)的关系。方法:随机选取2018年1月至2021年12月在本院进行常规孕期检查的产妇作为研究对象,孕8~12周检测其空腹血糖(FBG)及糖化血红蛋白(HbAlc)水平,孕13~15周检测其血清25-OHD-3水平,孕24~28周行75 g口服葡萄糖耐量试验(OGTT),包括FBG、餐后1 h血糖(1 h PBG)、餐后2 h血糖(2 h PBG),并在空腹、服糖水后1 h和2 h均检测血清25-OHD-3。根据OGTT筛查结果,将其分为GDM组(n=100)及对照组(n=100)。比较2组孕早期FBG、HbAlc,孕中期血清25-OHD-3及孕中后期空腹、服糖水后1、2 h的血糖及25-OHD-3等指标的差异,并分析血清25-OHD-3水平与GDM发病的关系。结果:GDM组孕早期FBG、HbAlc及OGTT中FBG、1 h PBG、2 h PBG均高于对照组(P<0.05);GDM组血清25-OHD-3水平低于对照组,差异具有统计学意义(P<0.05);两组孕妇存在孕期血清25-OHD-3不足且缺乏的情况,血清25-OHD-3指标GDM组充足率为6.00%,对照组为7.00%;GDM组不足率为30.00%,对照组为32.00%;GDM组缺乏率为64.00%,对照组为61.00%。综合比较显示,两组血清25-OHD-3充足率、不足率及缺乏率差异无统计学意义(P>0.05);GDM组中FBG正常组的25-OHD-3水平显著高于FBG异常组(P<0.05);而服糖后1 h及2 h,血糖正常组及异常组的25-OHD-3水平比较差异无统计学意义(P>0.05)。结论:随着孕龄的增加,孕妇血清25-OHD-3水平逐渐下降,而妊娠中期较低的血清25-OHD-3水平与GDM的发生存在相关性,增加了GDM发生的风险,对于高危人群需要加强早期监测,积极补充维生素D,以预防及减少GDM的发生。展开更多
基金supported by grants from Danone Institute,China Diet Nutrition Research & Communication (DIC2010-03)National Natural Science Foundation of China (81172669)+1 种基金Medical Scientific Research Foundation of Guangdong Province (A2012581)National Key Technology Research and Development Program of China (2012BAI02B02)
文摘Objective To study the effect of oral vitamin D （VD） supplementation on VD status and serum lipid in Chinese obese and healthy normal-weight men. Methods Twenty-one obese men with their body mass index （BMI）〉28 kg/m2 served as an obese group and 22 healthy normal-weight men with their BMI〈24 kg/m2 served as a control group in this study. After they were given 50 000 IU of oral VD, once a week for 8 weeks, the serum 25-hydroxyvitamin D [25（OH）D] concentration was measured with an enzyme-immunoassay kit. Results After oral VD supplementation, the serum 25（OH）D concentration significantly increased from 46.1＋9.1 nmol/L to 116.7_＋20.3 nmol/L in the obese subjects （P〈O.01） and from 52.8_＋17.8 nmol/L to 181.3_＋30.2 nmol/L in the control ones （P=0.13）. The serum high-density lipoprotein cholesterol （HDL-C） level was reduced within the normal reference range in the obese group. However, no significant change was observed in the level of other serum lipids （triglycerides, total cholesterol, and low-density lipoprotein cholesterol） in either of the two groups. Conclusion The effect of high-dose oral VD supplementation is weaker on VD status in the obese group than in the control group. High-dose oral VD supplementation has no side effect on serum lipid level in obese and control groups.
文摘Background: Vitamin D plays a pivotal role in supporting the immune system, helping to reduce the risk of infections and certain autoimmune diseases. Adequate vitamin D levels may be associated with a reduced risk of certain health conditions like pre-eclampsia, gestational diabetes, and postpartum depression. Brittle bones, osteoporosis in the elderly, and osteomalacia in young children are all symptoms of vitamin D insufficiency. Additionally, it contributes to problems linked to gum disease, including an increase in dental cavities, alveolar bone loss around the teeth, and other problems. It could lead to depression, tiredness, and a loss of appetite. In this study, urban children and adolescents in Dhaka city, Bangladesh are examined for vitamin D deficiency, insufficiency, and sufficiency. Methods: The Study was a cross-sectional study conducted under Dhaka National Medical College and Hospital, Dhaka and additionally included two other health centers Medinova Medical Services and Monoara General Hospital Service Golap bag, Dhaka from October 2020 to November 2021. The study location was at the 3 (Three) different hospitals which was located in Dhaka City. In this cross-sectional study, Participants will be selected purposively and conveniently based on the age categories from 0 - 19 years of age at the outdoor department of the hospital. The study included the secondary dataset of ambulatory individuals who came to the 3 (three) hospitals, randomly to evaluate serum vitamin D levels on referral from a general out-patient-department (OPD). They were examined for laboratory findings of serum 25 hydroxyvitamin D levels to determine vitamin D deficiency, insufficiency, and sufficiency among children and adolescent groups of both male and female Sex. Results: A total of 6394 individuals with a diverse age group were statistically examined for laboratory findings of serum vitamin D levels. Vitamin D deficiency was observed in 40.58% of individuals with a mean log of 1.01 ± 0.18 ng/ml serum vitamin D levels, vitamin D insufficiency in 30.93% of individuals with a mean log of 1.38 ± 0.05 ng/ml serum vitamin D levels and vitamin D sufficiency in 19.49% individuals with a mean log of 1.63 ± 0.12 ng/ml serum vitamin D levels. The highest percentage of individuals deficient in vitamin D were children and adolescents of age ranging between 15 to 19 years. Conclusion: The findings of vitamin D deficiency in children and adolescents direct higher authorities in the public health sector to take immediate steps to screen, intervene and educate high-risk populations incorporating vitamin D supplements to establish preventive and therapeutic measures.
文摘目的观察原发性肝癌(primary hepatocellular carcinoma,PHC)与血清25(OH)维生素D水平的相关性。方法抽取2018年8月—2020年8月莆田市第一医院PHC患者50例作为观察组,抽取同时期健康体检者50例作为对照组。检测两组血清25(OH)D3水平以及甲胎蛋白(alpha fetoprotein,AFP)水平。结果观察组血清25(OH)D3水平低于对照组,差异有统计学意义(P<0.05)。观察组AFP水平高于对照组,差异有统计学意义(P<0.05)。PHC血清患者25(OH)D3水平与中国肝癌分期(China live cancer staging,CNLC)、淋巴结转移有关,差异有统计学意义(P<0.05)。结论针对PHC患者,其血清25(OH)D3水平主要相关因素为CNLC分期、淋巴结转移,根据血清25(OH)D3水平可为疾病治疗及其预后评估提供依据。
文摘目的:探讨妊娠早、中期妇女血清25-羟维生素D-3(25-OHD-3)与妊娠期糖尿病(GDM)的关系。方法:随机选取2018年1月至2021年12月在本院进行常规孕期检查的产妇作为研究对象,孕8~12周检测其空腹血糖(FBG)及糖化血红蛋白(HbAlc)水平,孕13~15周检测其血清25-OHD-3水平,孕24~28周行75 g口服葡萄糖耐量试验(OGTT),包括FBG、餐后1 h血糖(1 h PBG)、餐后2 h血糖(2 h PBG),并在空腹、服糖水后1 h和2 h均检测血清25-OHD-3。根据OGTT筛查结果,将其分为GDM组(n=100)及对照组(n=100)。比较2组孕早期FBG、HbAlc,孕中期血清25-OHD-3及孕中后期空腹、服糖水后1、2 h的血糖及25-OHD-3等指标的差异,并分析血清25-OHD-3水平与GDM发病的关系。结果:GDM组孕早期FBG、HbAlc及OGTT中FBG、1 h PBG、2 h PBG均高于对照组(P<0.05);GDM组血清25-OHD-3水平低于对照组,差异具有统计学意义(P<0.05);两组孕妇存在孕期血清25-OHD-3不足且缺乏的情况,血清25-OHD-3指标GDM组充足率为6.00%,对照组为7.00%;GDM组不足率为30.00%,对照组为32.00%;GDM组缺乏率为64.00%,对照组为61.00%。综合比较显示,两组血清25-OHD-3充足率、不足率及缺乏率差异无统计学意义(P>0.05);GDM组中FBG正常组的25-OHD-3水平显著高于FBG异常组(P<0.05);而服糖后1 h及2 h,血糖正常组及异常组的25-OHD-3水平比较差异无统计学意义(P>0.05)。结论:随着孕龄的增加,孕妇血清25-OHD-3水平逐渐下降,而妊娠中期较低的血清25-OHD-3水平与GDM的发生存在相关性,增加了GDM发生的风险,对于高危人群需要加强早期监测,积极补充维生素D,以预防及减少GDM的发生。
