Objective This study was undertaken to investigate the influencing factors on serum ALT level and hepatitis C virus(HCV)RNA titer in chronic hepatitis C(CHC)patients.Methods All patients enrolled into this study were ...Objective This study was undertaken to investigate the influencing factors on serum ALT level and hepatitis C virus(HCV)RNA titer in chronic hepatitis C(CHC)patients.Methods All patients enrolled into this study were anti-HCV positive.Retrospective tracing method was applied to detect serum ALT level and HCV RNA titer and to collect general information of the patients such as genders,age groups,interferon medication history,infection pathways,height and weight.Then the multi-factor analysis was adopted with the application of binominal logistic regression mode.Results The abnormal rate of ALT level was positively correlated to HCV RNA and gender while negatively correlated to interferon medication history and age group,with Wald value of the 4 factors as 39.604,11.823,18.991 and 7.389,respectively.The positive rate of HCV RNA was negatively correlated to interferon medication history and gender while positively correlated to ALT level,with corresponding Wald value of the 3 factors as81.394,7.618 and 27.562,respectively.Conclusions The normal ALT level in HCV infected patients was associated with viral load,age,gender and interferon medication history,while the normal rate of HCV RNA titer was closely associated with gender,interferon medication history and ALT level.展开更多
目的:探讨藏族HBsAg阳性者血清标志物组合模式与乙肝病毒载量(HBV-DNA)以及丙氨酸氨基转移酶(ALT)之间的关系。方法:选取815例藏族HBsAg阳性者为研究对象,采用酶联免疫吸附法进行乙肝血清标志物(HBV-M)定性检测、实时荧光定量PCR-荧光...目的:探讨藏族HBsAg阳性者血清标志物组合模式与乙肝病毒载量(HBV-DNA)以及丙氨酸氨基转移酶(ALT)之间的关系。方法:选取815例藏族HBsAg阳性者为研究对象,采用酶联免疫吸附法进行乙肝血清标志物(HBV-M)定性检测、实时荧光定量PCR-荧光探针法检测HBV-DNA、全自动生化分析仪测定ALT;Mann-Whitney U test用于两分组样本之间的比较,Kruskal-Wallis H分析多组非参数连续数据,两变量间的相关性采用Spearman等级相关分析,计数资料用卡方检验,P<0.05为差异有统计学意义。结果:①藏族HBsAg阳性者男性多于女性(1.3:1)且主要分布在11∼60岁,平均年龄(37.16±14.38)岁;②HBV-M组合模式共有7种,以小三阳(42.7%)和大三阳(38.5%)为主,且大三阳模式的HBV-DNA与ALT异常率均显著高于小三阳(P<0.001);③藏族HBsAg阳性者的HBV-DNA载量与ALT水平呈正相关(rs=0.244,P<0.001)、与年龄呈负相关(rs=-0.223,P<0.001);④HBsAg阳性者中不同性别间ALT有统计学意义(P<0.001),而HBVDNA载量间无统计学意义(P>0.05);⑤HBeAg(+)与(-)两组间HBV-DNA、ALT的差异均有统计学意义(P<0.001)。结论:本研究发现的7种HBV-M模式中主要为小三阳、大三阳,HBeAg阳性者的病毒复制水平和ALT异常率最高;HBV-DNA载量与不同的HBV-M模式、年龄以及ALT异常有关,与性别无关。展开更多
基金supported by a grant from National Health Department of China(2008ZX10005-009)Roche company
文摘Objective This study was undertaken to investigate the influencing factors on serum ALT level and hepatitis C virus(HCV)RNA titer in chronic hepatitis C(CHC)patients.Methods All patients enrolled into this study were anti-HCV positive.Retrospective tracing method was applied to detect serum ALT level and HCV RNA titer and to collect general information of the patients such as genders,age groups,interferon medication history,infection pathways,height and weight.Then the multi-factor analysis was adopted with the application of binominal logistic regression mode.Results The abnormal rate of ALT level was positively correlated to HCV RNA and gender while negatively correlated to interferon medication history and age group,with Wald value of the 4 factors as 39.604,11.823,18.991 and 7.389,respectively.The positive rate of HCV RNA was negatively correlated to interferon medication history and gender while positively correlated to ALT level,with corresponding Wald value of the 3 factors as81.394,7.618 and 27.562,respectively.Conclusions The normal ALT level in HCV infected patients was associated with viral load,age,gender and interferon medication history,while the normal rate of HCV RNA titer was closely associated with gender,interferon medication history and ALT level.
文摘目的:探讨藏族HBsAg阳性者血清标志物组合模式与乙肝病毒载量(HBV-DNA)以及丙氨酸氨基转移酶(ALT)之间的关系。方法:选取815例藏族HBsAg阳性者为研究对象,采用酶联免疫吸附法进行乙肝血清标志物(HBV-M)定性检测、实时荧光定量PCR-荧光探针法检测HBV-DNA、全自动生化分析仪测定ALT;Mann-Whitney U test用于两分组样本之间的比较,Kruskal-Wallis H分析多组非参数连续数据,两变量间的相关性采用Spearman等级相关分析,计数资料用卡方检验,P<0.05为差异有统计学意义。结果:①藏族HBsAg阳性者男性多于女性(1.3:1)且主要分布在11∼60岁,平均年龄(37.16±14.38)岁;②HBV-M组合模式共有7种,以小三阳(42.7%)和大三阳(38.5%)为主,且大三阳模式的HBV-DNA与ALT异常率均显著高于小三阳(P<0.001);③藏族HBsAg阳性者的HBV-DNA载量与ALT水平呈正相关(rs=0.244,P<0.001)、与年龄呈负相关(rs=-0.223,P<0.001);④HBsAg阳性者中不同性别间ALT有统计学意义(P<0.001),而HBVDNA载量间无统计学意义(P>0.05);⑤HBeAg(+)与(-)两组间HBV-DNA、ALT的差异均有统计学意义(P<0.001)。结论:本研究发现的7种HBV-M模式中主要为小三阳、大三阳,HBeAg阳性者的病毒复制水平和ALT异常率最高;HBV-DNA载量与不同的HBV-M模式、年龄以及ALT异常有关,与性别无关。
