Introduction: Coronary artery disease (CAD) is one of the most common causes of death worldwide. In 2010, about 7 out of total 53 million deaths were due to ischemic heart disease. The aim of this study is to evaluate...Introduction: Coronary artery disease (CAD) is one of the most common causes of death worldwide. In 2010, about 7 out of total 53 million deaths were due to ischemic heart disease. The aim of this study is to evaluate the relationship of serum bilirubin level with the severity and complexity of coronary artery disease (CAD) in the patients undergoing primary percutaneous coronary intervention (PCI). Materials and Methods: 70 patients with STEMI who were undergoing primary PCI were included in the study. All the patients included in the study were subjected to full routine investigations and standard coronary angiographic projections. Total bilirubin level was measured and the patients were divided into two groups. Group 1 was with serum TB (and Group 2 was with serum TB (>1 mg/dl). Severity and complexity of coronary artery lesions will be assessed using Gensini score. Results: After PCI, the two studied groups were compared regarding the number of vessels affected by one and more than one vessel disease. Single vessel disease was frequent in Group 2 (71%) with significant p value (0.003). Cardiac enzymes (troponin I) was more in Group 1 (S. Bil value (0.02). Also (ALT, AST) were more in Group 1 (p value = 0.01). By comparing the 2 groups, there was a significant difference regarding (EF) between both which was less in Group 1 (S.TB 1), p value significance (0, 0001). Also GENSENI was more in Group 1 (S.TB 1) with mean (80.35 vs 34.71) and significant pvalue (0.0001). There was a highly significant negative correlation between serum bilirubin & GENSENI score (r = -0.762, p value 0.0001). Regarding the incidence of complications, incidence was more in Group 1 (S.TB 1), which means a significant difference between both groups with significant p value (0.0001). There was a significant negative correlation between serum bilirubin & incidence of complications (R = -0.38, pvalue 0.001). Also, there was a significant negative correlation between GENSINI score, complication and bilirubin among both groups (r: -0.762\-0.38) with p value (0.0001\0.001) respectively. Conclusion: In conclusion, our results suggested that the Serum Bilirubin level is inversely correlated with the severity of CAD. Also, the SB level is an independent predictor of cardiovascular events in CAD patients. Understandably, our findings need further verification by large-scale, multicenter clinical trials in the future.展开更多
Background: The antioxidant effects of bilirubin in Parkinson’s disease (PD) have recently gained much attention from the research community. However, results from these studies have been conflicting. This meta-analy...Background: The antioxidant effects of bilirubin in Parkinson’s disease (PD) have recently gained much attention from the research community. However, results from these studies have been conflicting. This meta-analysis is conducted to assess the relationship between the serum bilirubin concentration and the risk of PD.Methods: Two reviewers performed a systematic literature search across five databases (MEDLINE, PubMed, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials). The case-control studies regarding bilirubin levels in PD patients published up to April 2020 were included. These studies were subjected to rigorous scrutiny and data extraction to determine the standard mean difference (SMD) and the 95% confidence interval (CI), which were analyzed using the Stata V.12.0 statistical software.Results: A total of eight studies which included 1463 PD cases and 1490 controls were incorporated into our meta-analysis. SMD analysis showed that there was a higher total bilirubin (TBIL) and direct bilirubin (DBIL) levels in PD patients compared with controls (for TBIL, SMD: 0.300, 95% CI: 0.050-0.549,P = 0.018;for DBIL, SMD: 0.395, 95% CI: 0.102-0.688,P = 0.008). However, no significant relationship was found between the serum indirect bilirubin and PD patients (SMD: -0.223, 95% CI: -0.952-0.505,P = 0.548). A subgroup analysis based on ethnicity indicated that the serum TBIL was higher in PD patients of Caucasian descent in contrast to matched healthy controls (SMD: 0.511, 95% CI: 0.324-0.698,P = 0.000,I2 = 58.0%).Conclusion: Higher serum bilirubin levels in PD patients suggest that bilirubin might play a role in the pathogenesis of PD and have the potential to be utilized as a biochemical marker for PD diagnosis and treatment.展开更多
目的探究双歧杆菌联合光疗对黄疸患儿血清胆红素水平的影响。方法采用横断面法,选取2020年10月—2023年6月江苏省启东市妇幼保健院接收的86例黄疸患儿为研究对象,利用统计学方法对其进行随机编号并分为对照组(43例)及观察组(43例)。对...目的探究双歧杆菌联合光疗对黄疸患儿血清胆红素水平的影响。方法采用横断面法,选取2020年10月—2023年6月江苏省启东市妇幼保健院接收的86例黄疸患儿为研究对象,利用统计学方法对其进行随机编号并分为对照组(43例)及观察组(43例)。对照组单纯使用蓝光治疗法,观察组予以双歧杆菌联合蓝光照射治疗。对比两组患儿血清胆红素水平、免疫功能及心功能。结果观察组总胆红素(123.12±26.47)μmol/L、间接胆红素(112.36±22.49)μmol/L、直接胆红素(8.56±2.17)μmol/L水平均低于对照组,差异有统计学意义(t=2.437、2.514、3.380,P均<0.05)。观察组T淋巴细胞(TLymphocytes,CD3+)、辅助T细胞(HelperTCells,CD4+)、CD4+/细胞毒性T细胞(Cytotoxic T Cells,CD8+)均高于对照组,且CD8+低于对照组,差异有统计学意义(P均<0.05)。观察组肌酸激酶、肌酸激酶同工酶MB型、乳酸脱氢酶、天冬氨酸氨基转移酶水平均低于对照组,差异有统计学意义(P均<0.05)。结论针对黄疸患儿采取蓝光照射治疗联合双歧杆菌治疗,有助于降低血清胆红素水平,并改善细胞免疫功能及心功能。展开更多
文摘Introduction: Coronary artery disease (CAD) is one of the most common causes of death worldwide. In 2010, about 7 out of total 53 million deaths were due to ischemic heart disease. The aim of this study is to evaluate the relationship of serum bilirubin level with the severity and complexity of coronary artery disease (CAD) in the patients undergoing primary percutaneous coronary intervention (PCI). Materials and Methods: 70 patients with STEMI who were undergoing primary PCI were included in the study. All the patients included in the study were subjected to full routine investigations and standard coronary angiographic projections. Total bilirubin level was measured and the patients were divided into two groups. Group 1 was with serum TB (and Group 2 was with serum TB (>1 mg/dl). Severity and complexity of coronary artery lesions will be assessed using Gensini score. Results: After PCI, the two studied groups were compared regarding the number of vessels affected by one and more than one vessel disease. Single vessel disease was frequent in Group 2 (71%) with significant p value (0.003). Cardiac enzymes (troponin I) was more in Group 1 (S. Bil value (0.02). Also (ALT, AST) were more in Group 1 (p value = 0.01). By comparing the 2 groups, there was a significant difference regarding (EF) between both which was less in Group 1 (S.TB 1), p value significance (0, 0001). Also GENSENI was more in Group 1 (S.TB 1) with mean (80.35 vs 34.71) and significant pvalue (0.0001). There was a highly significant negative correlation between serum bilirubin & GENSENI score (r = -0.762, p value 0.0001). Regarding the incidence of complications, incidence was more in Group 1 (S.TB 1), which means a significant difference between both groups with significant p value (0.0001). There was a significant negative correlation between serum bilirubin & incidence of complications (R = -0.38, pvalue 0.001). Also, there was a significant negative correlation between GENSINI score, complication and bilirubin among both groups (r: -0.762\-0.38) with p value (0.0001\0.001) respectively. Conclusion: In conclusion, our results suggested that the Serum Bilirubin level is inversely correlated with the severity of CAD. Also, the SB level is an independent predictor of cardiovascular events in CAD patients. Understandably, our findings need further verification by large-scale, multicenter clinical trials in the future.
基金National Natural Science Foundation of China(No.81971192)。
文摘Background: The antioxidant effects of bilirubin in Parkinson’s disease (PD) have recently gained much attention from the research community. However, results from these studies have been conflicting. This meta-analysis is conducted to assess the relationship between the serum bilirubin concentration and the risk of PD.Methods: Two reviewers performed a systematic literature search across five databases (MEDLINE, PubMed, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials). The case-control studies regarding bilirubin levels in PD patients published up to April 2020 were included. These studies were subjected to rigorous scrutiny and data extraction to determine the standard mean difference (SMD) and the 95% confidence interval (CI), which were analyzed using the Stata V.12.0 statistical software.Results: A total of eight studies which included 1463 PD cases and 1490 controls were incorporated into our meta-analysis. SMD analysis showed that there was a higher total bilirubin (TBIL) and direct bilirubin (DBIL) levels in PD patients compared with controls (for TBIL, SMD: 0.300, 95% CI: 0.050-0.549,P = 0.018;for DBIL, SMD: 0.395, 95% CI: 0.102-0.688,P = 0.008). However, no significant relationship was found between the serum indirect bilirubin and PD patients (SMD: -0.223, 95% CI: -0.952-0.505,P = 0.548). A subgroup analysis based on ethnicity indicated that the serum TBIL was higher in PD patients of Caucasian descent in contrast to matched healthy controls (SMD: 0.511, 95% CI: 0.324-0.698,P = 0.000,I2 = 58.0%).Conclusion: Higher serum bilirubin levels in PD patients suggest that bilirubin might play a role in the pathogenesis of PD and have the potential to be utilized as a biochemical marker for PD diagnosis and treatment.
文摘目的探究双歧杆菌联合光疗对黄疸患儿血清胆红素水平的影响。方法采用横断面法,选取2020年10月—2023年6月江苏省启东市妇幼保健院接收的86例黄疸患儿为研究对象,利用统计学方法对其进行随机编号并分为对照组(43例)及观察组(43例)。对照组单纯使用蓝光治疗法,观察组予以双歧杆菌联合蓝光照射治疗。对比两组患儿血清胆红素水平、免疫功能及心功能。结果观察组总胆红素(123.12±26.47)μmol/L、间接胆红素(112.36±22.49)μmol/L、直接胆红素(8.56±2.17)μmol/L水平均低于对照组,差异有统计学意义(t=2.437、2.514、3.380,P均<0.05)。观察组T淋巴细胞(TLymphocytes,CD3+)、辅助T细胞(HelperTCells,CD4+)、CD4+/细胞毒性T细胞(Cytotoxic T Cells,CD8+)均高于对照组,且CD8+低于对照组,差异有统计学意义(P均<0.05)。观察组肌酸激酶、肌酸激酶同工酶MB型、乳酸脱氢酶、天冬氨酸氨基转移酶水平均低于对照组,差异有统计学意义(P均<0.05)。结论针对黄疸患儿采取蓝光照射治疗联合双歧杆菌治疗,有助于降低血清胆红素水平,并改善细胞免疫功能及心功能。
