Elevated plasma or serum total homocysteine (tHcy) level has been established as a risk factor for cardiovascular disease[1], as well as dementia and cognitive decline[2]. Plasma or serum folate and vitamin B12 influe...Elevated plasma or serum total homocysteine (tHcy) level has been established as a risk factor for cardiovascular disease[1], as well as dementia and cognitive decline[2]. Plasma or serum folate and vitamin B12 influence homocysteine (Hcy) metabolism as a co-substrate and cofactor respectively, so that low concentrations of folate and vitamin B12 are also associated with high Hcy levels[1]. However, not much information is available describing serum tHcy, folate, and vitamin B12 status in Shanghai adults, especially in a healthy population. Therefore, we hypothesize that low serum folate and vitamin B12 is associated with high Hcy in healthy adults in Shanghai. The aim of this study was to determine the status of serum tHcy, folate, and vitamin B12, and the prevalence and factors contributing to HHcy, folate deficiency, and vitamin B12 deficiency among healthy adults in Shanghai, China.展开更多
Objective: To investigate the changes and significance of serum inflammatory factors, uric acid (UA), homocysteine (Hcy) and small dense low-density lipoprotein (sdLDL-C) levels in patients with coronary heart disease...Objective: To investigate the changes and significance of serum inflammatory factors, uric acid (UA), homocysteine (Hcy) and small dense low-density lipoprotein (sdLDL-C) levels in patients with coronary heart disease (CHD). Methods: A total of 152 patients with CHD were selected as the CHD group, including stable angina pectoris (SAP group, n=48), unstable angina pectoris (UAP group, n=55), and acute myocardial infarction (AMI group, n=49), according to the Gensinis score, it can be divided into mild group (n=88), moderate group (n=43) and severe group (n=21), at the same time 55 healthy people were selected as control group. The serum inflammatory factors [hypersensitivity C reactive protein (hs-CRP), tumor necrosis factor -α (TNF-α)], UA, Hcy and sdLDL-C levels were compared between patients with different CHD and different degree of coronary artery lesions. Results: The levels of hs-CRP, TNF-α, UA, Hcy and sdLDL-C in the CHD group were significantly higher than those in the control group;In the CHD group, the levels of hs-CRP, TNF-α, UA, Hcy and sdLDL-C in the UAP group and AMI group were significantly higher than those off the SAP group, and the level of AMI group [(7.96±1.49) mg/L, (92.87±14.50) ng/L, (417.75±43.88) mol/L, (23.25±7.33) and mol/L (1.31±0.53) mmol/L] was significantly higher than that of UAP group [(6.15±0.97) mg/L, (73.88±9.27) ng/L, (393.63±68.29) mol/L, (19.67±7.26) mol/L and (1.08±0.44) mmol/L];Compared with mild group hs-CRP, TNF-α, UA, Hcy and sdLDL-C levels, the levels of the moderate group and severe group were significantly increased, and the level of severe group was significantly higher than that of moderate group. Conclusion: The levels of serum inflammatory factors, UA, Hcy and sdLDL-C in patients with coronary heart disease are significantly increased, and the detection of the levels has a great significance for the diagnosis of coronary heart disease and the assessment of the severity of coronary heart disease.展开更多
文摘Elevated plasma or serum total homocysteine (tHcy) level has been established as a risk factor for cardiovascular disease[1], as well as dementia and cognitive decline[2]. Plasma or serum folate and vitamin B12 influence homocysteine (Hcy) metabolism as a co-substrate and cofactor respectively, so that low concentrations of folate and vitamin B12 are also associated with high Hcy levels[1]. However, not much information is available describing serum tHcy, folate, and vitamin B12 status in Shanghai adults, especially in a healthy population. Therefore, we hypothesize that low serum folate and vitamin B12 is associated with high Hcy in healthy adults in Shanghai. The aim of this study was to determine the status of serum tHcy, folate, and vitamin B12, and the prevalence and factors contributing to HHcy, folate deficiency, and vitamin B12 deficiency among healthy adults in Shanghai, China.
文摘Objective: To investigate the changes and significance of serum inflammatory factors, uric acid (UA), homocysteine (Hcy) and small dense low-density lipoprotein (sdLDL-C) levels in patients with coronary heart disease (CHD). Methods: A total of 152 patients with CHD were selected as the CHD group, including stable angina pectoris (SAP group, n=48), unstable angina pectoris (UAP group, n=55), and acute myocardial infarction (AMI group, n=49), according to the Gensinis score, it can be divided into mild group (n=88), moderate group (n=43) and severe group (n=21), at the same time 55 healthy people were selected as control group. The serum inflammatory factors [hypersensitivity C reactive protein (hs-CRP), tumor necrosis factor -α (TNF-α)], UA, Hcy and sdLDL-C levels were compared between patients with different CHD and different degree of coronary artery lesions. Results: The levels of hs-CRP, TNF-α, UA, Hcy and sdLDL-C in the CHD group were significantly higher than those in the control group;In the CHD group, the levels of hs-CRP, TNF-α, UA, Hcy and sdLDL-C in the UAP group and AMI group were significantly higher than those off the SAP group, and the level of AMI group [(7.96±1.49) mg/L, (92.87±14.50) ng/L, (417.75±43.88) mol/L, (23.25±7.33) and mol/L (1.31±0.53) mmol/L] was significantly higher than that of UAP group [(6.15±0.97) mg/L, (73.88±9.27) ng/L, (393.63±68.29) mol/L, (19.67±7.26) mol/L and (1.08±0.44) mmol/L];Compared with mild group hs-CRP, TNF-α, UA, Hcy and sdLDL-C levels, the levels of the moderate group and severe group were significantly increased, and the level of severe group was significantly higher than that of moderate group. Conclusion: The levels of serum inflammatory factors, UA, Hcy and sdLDL-C in patients with coronary heart disease are significantly increased, and the detection of the levels has a great significance for the diagnosis of coronary heart disease and the assessment of the severity of coronary heart disease.