AIM：To detect the impact of insulin-like growth factor-1（IGF-1）and other risk factors for the early prediction of retinopathy of prematurity（ROP）and to establish a scoring system for ROP prediction by using clini...AIM：To detect the impact of insulin-like growth factor-1（IGF-1）and other risk factors for the early prediction of retinopathy of prematurity（ROP）and to establish a scoring system for ROP prediction by using clinical criteria and serum IGF-1 levels.METHODS：The study was conducted with 127 preterm infants.IGF-1 levels in the 1st day of life,1st,2nd,3rd and4th week of life was analyzed.The score was established after logistic regression analysis,considering the impact of each variable on the occurrences of any stage ROP.A validation cohort containing 107 preterm infants was included in the study and the predictive ability of ROP score was calculated.RESULTS：Birth weights（BW）,gestational weeks（GW）and the prevalence of breast milk consumption were lower,respiratory distress syndrome（RDS）,bronchopulmonarydysplasia（BPD）and necrotizing enterocolitis（NEC）were more frequent,the duration of mechanical ventilation and oxygen supplementation was longer in patients with ROP（P〈0.05）.Initial serum IGF-1 levels tended to be lower in newborns who developed ROP.Logistic regression analysis revealed that low BW（〈1250 g）,presence of intraventricular hemorrhage（IVH）and formula feeding increased the risk of ROP.Afterwards,the scoring system was validated on 107 infants.The negative predictive values of a score less than 4 were 84.3%,74.7%and 79.8%while positive predictive values were 76.3%,65.5%and71.6%respectively.CONCLUSION：In addition to BW〈1250 g and IVH,formula consumption was detected as a risk factor for the development of ROP.Breastfeeding is important for prevention of ROP in preterm infants.展开更多
目的进行维生素D联合门冬胰岛素对妊娠期糖尿病患者血清指标及分娩结局影响分析。方法选取医院2019年8月—2020年7月收治的妊娠期糖尿病患者86例,按照随机法分为两组,对照组43例患者采用门冬胰岛素治疗,观察组43例患者采用门冬胰岛素联...目的进行维生素D联合门冬胰岛素对妊娠期糖尿病患者血清指标及分娩结局影响分析。方法选取医院2019年8月—2020年7月收治的妊娠期糖尿病患者86例,按照随机法分为两组,对照组43例患者采用门冬胰岛素治疗,观察组43例患者采用门冬胰岛素联合维生素D治疗。根据Toll样受体4(TLR4)、血管细胞黏附分子1(VCAM-1)对比两组治疗前后血清指标。根据空腹血糖(FPG)、餐后2 h血糖(2 h PG)及糖化血红蛋白(HbA1c)水平对比两组治疗前后血糖水平。根据巨大儿、呼吸窘迫、黄疸及早产儿发生率对比两组患者妊娠结局。结果治疗前两组患者TLR4、VCAM-1水平的差异无统计学意义(P>0.05),治疗后观察组TLR4、VCAM-1水平显著降低对照组,组间差异有统计学意义(P<0.05)。治疗前两组FPG、2 h PG及HbA1c等水平的差异无统计学意义(P>0.05),治疗后观察组FPG、2 h PG及HbA1c等水平均优于对照组,组间差异有统计学意义(P<0.05)。观察组不良妊娠结局总发生率均低于对照组,组间差异有统计学意义(P<0.05)。结论采用维生素D联合门冬胰岛素对妊娠期糖尿病患者治疗,显著降低患者各项血清指标及血糖水平,改善患者妊娠结局。展开更多
目的探讨急性脑梗死合并阻塞性睡眠呼吸暂停综合征(OSAS)血清胰岛素样生长因子-1(IGF-1)水平与神经功能缺损及预后相关性。方法 2014年9月至2015年6月收治符合标准的急性脑梗死合并OSAS 41例为A组,选择同期收治的单纯急性脑梗死40例为B...目的探讨急性脑梗死合并阻塞性睡眠呼吸暂停综合征(OSAS)血清胰岛素样生长因子-1(IGF-1)水平与神经功能缺损及预后相关性。方法 2014年9月至2015年6月收治符合标准的急性脑梗死合并OSAS 41例为A组,选择同期收治的单纯急性脑梗死40例为B组、单纯OSAS 43例为C组、健康体检者36例为D组。入组后3、14 d采用ELISA方法检测血清IGF-1水平,采用美国国立卫生院卒中量表(NIHSS)评分评价神经功能缺损程度,90 d行改良Rankin量表(m RS)评分判断预后情况。结果入组后3、14 d,A组血清IGF-1水平均明显均低于B、C和、D组(P<0.05),B、C组又明显低于D组(P<0.05),B、C组之间无明显差异(P>0.05)。A组入组后3、14 d NIHSS评分及90 d m RS评分均明显高于B组(P<0.05)。随着脑梗死严重程度增加,A、B两组血清IGF-1水平显著降低(P<0.05),但两组变化趋势无明显差异(P>0.05)。A、B两组入组后3、14 d NIHSS评分和90 d m RS评分均与血清IGF-1水平呈明显负相关(P<0.05)。结论急性脑梗死合并OSAS血清IGF-1水平可用于预测病情轻重及临床预后。展开更多
文摘AIM：To detect the impact of insulin-like growth factor-1（IGF-1）and other risk factors for the early prediction of retinopathy of prematurity（ROP）and to establish a scoring system for ROP prediction by using clinical criteria and serum IGF-1 levels.METHODS：The study was conducted with 127 preterm infants.IGF-1 levels in the 1st day of life,1st,2nd,3rd and4th week of life was analyzed.The score was established after logistic regression analysis,considering the impact of each variable on the occurrences of any stage ROP.A validation cohort containing 107 preterm infants was included in the study and the predictive ability of ROP score was calculated.RESULTS：Birth weights（BW）,gestational weeks（GW）and the prevalence of breast milk consumption were lower,respiratory distress syndrome（RDS）,bronchopulmonarydysplasia（BPD）and necrotizing enterocolitis（NEC）were more frequent,the duration of mechanical ventilation and oxygen supplementation was longer in patients with ROP（P〈0.05）.Initial serum IGF-1 levels tended to be lower in newborns who developed ROP.Logistic regression analysis revealed that low BW（〈1250 g）,presence of intraventricular hemorrhage（IVH）and formula feeding increased the risk of ROP.Afterwards,the scoring system was validated on 107 infants.The negative predictive values of a score less than 4 were 84.3%,74.7%and 79.8%while positive predictive values were 76.3%,65.5%and71.6%respectively.CONCLUSION：In addition to BW〈1250 g and IVH,formula consumption was detected as a risk factor for the development of ROP.Breastfeeding is important for prevention of ROP in preterm infants.
文摘目的进行维生素D联合门冬胰岛素对妊娠期糖尿病患者血清指标及分娩结局影响分析。方法选取医院2019年8月—2020年7月收治的妊娠期糖尿病患者86例,按照随机法分为两组,对照组43例患者采用门冬胰岛素治疗,观察组43例患者采用门冬胰岛素联合维生素D治疗。根据Toll样受体4(TLR4)、血管细胞黏附分子1(VCAM-1)对比两组治疗前后血清指标。根据空腹血糖(FPG)、餐后2 h血糖(2 h PG)及糖化血红蛋白(HbA1c)水平对比两组治疗前后血糖水平。根据巨大儿、呼吸窘迫、黄疸及早产儿发生率对比两组患者妊娠结局。结果治疗前两组患者TLR4、VCAM-1水平的差异无统计学意义(P>0.05),治疗后观察组TLR4、VCAM-1水平显著降低对照组,组间差异有统计学意义(P<0.05)。治疗前两组FPG、2 h PG及HbA1c等水平的差异无统计学意义(P>0.05),治疗后观察组FPG、2 h PG及HbA1c等水平均优于对照组,组间差异有统计学意义(P<0.05)。观察组不良妊娠结局总发生率均低于对照组,组间差异有统计学意义(P<0.05)。结论采用维生素D联合门冬胰岛素对妊娠期糖尿病患者治疗,显著降低患者各项血清指标及血糖水平,改善患者妊娠结局。
文摘目的探讨急性脑梗死合并阻塞性睡眠呼吸暂停综合征(OSAS)血清胰岛素样生长因子-1(IGF-1)水平与神经功能缺损及预后相关性。方法 2014年9月至2015年6月收治符合标准的急性脑梗死合并OSAS 41例为A组,选择同期收治的单纯急性脑梗死40例为B组、单纯OSAS 43例为C组、健康体检者36例为D组。入组后3、14 d采用ELISA方法检测血清IGF-1水平,采用美国国立卫生院卒中量表(NIHSS)评分评价神经功能缺损程度,90 d行改良Rankin量表(m RS)评分判断预后情况。结果入组后3、14 d,A组血清IGF-1水平均明显均低于B、C和、D组(P<0.05),B、C组又明显低于D组(P<0.05),B、C组之间无明显差异(P>0.05)。A组入组后3、14 d NIHSS评分及90 d m RS评分均明显高于B组(P<0.05)。随着脑梗死严重程度增加,A、B两组血清IGF-1水平显著降低(P<0.05),但两组变化趋势无明显差异(P>0.05)。A、B两组入组后3、14 d NIHSS评分和90 d m RS评分均与血清IGF-1水平呈明显负相关(P<0.05)。结论急性脑梗死合并OSAS血清IGF-1水平可用于预测病情轻重及临床预后。
