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SETD5介导AKT1磷酸化调控结肠癌细胞的迁移和5-FU敏感性
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作者 黄开禹 史建国 程勇 《中国肿瘤生物治疗杂志》 CAS CSCD 北大核心 2024年第6期586-591,共6页
目的:探讨含SET结构域蛋白5(SETD5)对结肠癌细胞增殖、迁移和对5-氟尿嘧啶(5-FU)药物敏感性的影响及机制。方法:常规培养结肠癌细胞,用Lipofectamine 2000将siSETD5-NC、si-SETD5-1~3质粒转染至HT-29细胞中,将其分为对照组(未处理)、si-... 目的:探讨含SET结构域蛋白5(SETD5)对结肠癌细胞增殖、迁移和对5-氟尿嘧啶(5-FU)药物敏感性的影响及机制。方法:常规培养结肠癌细胞,用Lipofectamine 2000将siSETD5-NC、si-SETD5-1~3质粒转染至HT-29细胞中,将其分为对照组(未处理)、si-SETD5-NC组、si-SETD5组和si-SETD5+SC79组,si-SETD5+SC79组HT-29细胞转染质粒的同时用10µmol/L SC79处理。qPCR法检测NCM460、HT-29和LoVo细胞中SETD5 mRNA表达,流式细胞术、细胞划痕法、WB法和CCK-8法分别检测各组HT-29细胞的凋亡情况、迁移能力、相关蛋白的表达,以及对5-FU的敏感性。结果:SETD5 mRNA在HT-29、LoVo细胞中均呈高表达(均P<0.01)。在HT-29细胞中成功地敲减了SETD5 mRNA(P<0.01)。敲减SETD5 mRNA可明显抑制HT-29细胞的增殖活性(P<0.01)、迁移能力(P<0.01)、相关蛋白(SETD5、p-PI3K、p-AKT1、p-mTOR蛋白)的表达(均P<0.01)、促进细胞凋亡(P<0.01),且提高其对5-FU的敏感性(P<0.01),这些作用均可被AKT激活剂SC79部分阻挡(P<0.05或P<0.01)。结论:SETD5在HT-29、LoVo细胞中高表达,SETD5通过PI3K/AKT1通路促进结肠癌HT-29细胞的增殖、迁移,且降低其对5-FU的敏感性,SETD5是结肠癌临床诊断、治疗的潜在靶点。 展开更多
关键词 结肠癌 含有set结构域蛋白5 蛋白激酶B磷酸化 增殖 迁移 5-氟尿嘧啶 耐药
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miR-127-3p靶向调节SETD8对胃癌细胞增殖、迁移和侵袭的影响
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作者 冯丽萍 张辉洁 +1 位作者 欧雯婷 余盈 《中国老年学杂志》 CAS 北大核心 2024年第4期957-962,共6页
目的探讨微小RNA(miR)-127-3p对胃癌细胞增殖、迁移及侵袭的影响及其作用机制。方法采用qRT-聚合酶链反应(PCR)检测150例胃癌患者胃癌组织、癌旁组织及人胃上皮细胞GES1、人胃癌细胞SGC7901、AGS、MKN-45、MGC-803中miR-127-3p表达水平... 目的探讨微小RNA(miR)-127-3p对胃癌细胞增殖、迁移及侵袭的影响及其作用机制。方法采用qRT-聚合酶链反应(PCR)检测150例胃癌患者胃癌组织、癌旁组织及人胃上皮细胞GES1、人胃癌细胞SGC7901、AGS、MKN-45、MGC-803中miR-127-3p表达水平。双荧光素酶报告基因检测miR-127-3p与含SET结构域赖氨酸甲基转移酶(SETD)8的靶向调控关系。将SGC7901细胞分为对照(Control)组、miR-127-3p模拟物(miR-127-3p mimics)组及miR-NC组、沉默SETD8表达(si-SETD8)组、si-NC组、miR-127-3p mimics+SETD8过表达(miR-127-3p mimics+SETD8)组及空载质粒(miR-127-3p mimics+pcDNA)组。噻唑蓝(MTT)法、划痕愈合实验、Transwell小室实验分别检测SGC7901细胞增殖、迁移与侵袭;Western印迹检测SGC7901细胞SETD8、基质金属蛋白酶(MMP)-2、MMP-9蛋白表达;裸鼠成瘤实验检测过表达miR-127-3p对裸鼠胃癌移植瘤生长的影响。结果miR-127-3p在胃癌组织与细胞中较癌旁组织和正常细胞显著下调(P<0.05),SETD8 mRNA在胃癌组织中较癌旁组织显著上调(P<0.05);胃癌组织中miR-127-3p、SETD8 mRNA表达水平呈负相关(r=-0.553,P<0.05);双荧光素酶实验证实miR-127-3p与SETD8存在靶向调控关系(P<0.05);过表达miR-127-3p或抑制SETD8表达显著抑制SGC7901细胞增殖、迁移与侵袭(P<0.05);过表达SETD8可部分逆转过表达miR-127-3p对SGC7901细胞增殖、迁移与侵袭的抑制作用(P<0.05);裸鼠成瘤实验表明过表达miR-127-3p可显著抑制胃癌移植瘤生长(P<0.05)。结论miR-127-3p在胃癌组织与细胞中表达下调,过表达miR-127-3p可靶向抑制SETD8表达而抑制胃癌肿瘤生长。 展开更多
关键词 微小RNA-127-3p set结构域赖氨酸甲基转移酶8 胃癌细胞 增殖 迁移 侵袭
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Self-calibration and Compensation of Setting Errors for Surface Profile Measurement of a Microstructured Roll Workpiece 被引量:3
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作者 GAO Wei XU Bin +2 位作者 TAKEISHI Toshiki SHIMIZU Yuki ITO So 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2014年第1期14-22,共9页
Microstructured roll workpieces have been widely used as functional components in the precision industries. Current researches on quality control have focused on surface profile measurement of microstructured roll wor... Microstructured roll workpieces have been widely used as functional components in the precision industries. Current researches on quality control have focused on surface profile measurement of microstructured roll workpieces, and types of measurement systems and measurement methods have been developed. However, low measurement efficiency and low measurement accuracy caused by setting errors are the common disadvantages for surface profile measurement of microstructured roll workpieces. In order to shorten the measurement time and enhance the measurement accuracy, a method for self-calibration and compensation of setting errors is proposed for surface profile measurement of microstructured roll workpieces. A measurement system is constructed for the measurement, in which a precision spindle is employed to rotate the roll workpiece and an air-bearing displacement sensor with a micro-stylus probe is employed to scan the microstructured surface of the roll workpiece. The resolution of the displacement sensor is 0.14 nm and that of the rotary encoder of the spindle was 0.15r~. Geometrical and mathematical models are established for analyzing the influences of the setting errors of the roll workpiece and the displacement sensor with respect to the axis of the spindle, including the eccentric error of the roll workpiece, the offset error of the sensor axis and the zero point error of the sensor output. Measurement experiments are carded out on a roll workpiece on which periodic microstructures are a period of 133 i^m along the circumferential direction. Experimental results demonstrate the feasibility of the self-compensation method. The proposed method can be used to detect and compensate the setting errors without using any additional accurate artifact. 展开更多
关键词 measurement profile setting error SELF-CALIBRATION COMPENSATION microstructure roll workpiece
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Wheel Setting Error Modeling and Compensation for Arc Envelope Grinding of Large-Aperture Aspherical Optics 被引量:2
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作者 Changsheng Li Lin Sun +4 位作者 Zhaoxiang Chen Jianfang Chen Qijing Lin Jianjun Ding Zhuangde Jiang 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2022年第5期87-99,共13页
Precision grinding is a key process for realizing the use of large-aperture aspherical optical elements in laser nuclear fusion devices,large-aperture astronomical telescopes,and high-resolution space cameras.In this ... Precision grinding is a key process for realizing the use of large-aperture aspherical optical elements in laser nuclear fusion devices,large-aperture astronomical telescopes,and high-resolution space cameras.In this study,the arc envelope grinding process of large-aperture aspherical optics is investigated using a CM1500 precision grinding machine with a maximum machinable diameter ofΦ1500 mm.The form error of the aspherical workpiece induced by wheel setting errors is analytically modeled for both parallel and cross grinding.Results show that the form error is more sensitive to the wheel setting error along the feed direction than that along the lateral direction.It is a bilinear function of the feed-direction wheel setting error and the distance to the optical axis.Based on the error function above,a method to determine the wheel setting error is proposed.Subsequently,grinding tests are performed with the wheels aligned accurately.Using a newly proposed partial error compensation method with an appropriate compensation factor,a form error of 3.4μm peak-to-valley(PV)for aΦ400 mm elliptical K9 glass surface is achieved. 展开更多
关键词 Aspherical optics Wheel setting Arc envelope grinding Form error Large aperture
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An Evaluation of Inter-Fractional Set-Up Errors in Patients Treated with Distinct Immobilization Equipment for Varying Anatomical Regions
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作者 Sibel Karaca Hamit Başaran +1 位作者 Timur Koca Ferhat Özbayrak 《International Journal of Medical Physics, Clinical Engineering and Radiation Oncology》 2016年第2期121-129,共9页
This study aims to evaluate inter-fractional set-up errors in patients treated with distinct immobilization equipment (thermoplastic mask, knee-fix and feet-fix, wing board and vac-lok) for four anatomical regions inc... This study aims to evaluate inter-fractional set-up errors in patients treated with distinct immobilization equipment (thermoplastic mask, knee-fix and feet-fix, wing board and vac-lok) for four anatomical regions including brain, head and neck (HN), thorax and pelvis. Data of randomly selected 140 patients who were treated for four anatomical regions were obtained using Hi-Art Helical Tomotherapy (HT) system. Pre-treatment planning was based on automatic registration readings of computed tomography (CT) and mega-voltage computed tomography (MVCT) on a daily basis. Distinct immobilization equipment was used for varying anatomical regions. Individual mean set-up error (M), systematic error (Σ), and random error (σ) values were calculated through daily translational and rotational deviation values. The size of translational, systematic and random error was 1.31 - 4.93 mm for brain, 2.28 - 4.88 mm for HN, 4.04 - 9.90 mm for thorax, and 6.34 - 14.68 mm for pelvis. Rotational values were as follows: 0.06&deg - 0.73&deg for brain, 0.42&deg - 0.6&deg for HN, 0.48&deg - 1.14&deg for thorax and 0.65&deg - 1.05&deg for pelvis. The highest translational, systematic and random error value was obtained from the pelvic regional. The highest standard and random error value in pitch and roll was produced in the rotational direction of the pelvis (0.05° and 0.71°), while the highest error value in yaw was (1.14°) produced from thorax. Inter-fractional set-up errors were most commonly produced in the pelvis, followed by thorax. Our study results suggest that the highest systematic and random errors are found for thorax and pelvis. Distinct immobilization equipment was important in these results. Safety margins around the clinical target volume (CTV) are changeable for different anatomical regions. A future work could be developed to new equipment for immobilization because of the reduced margins CTV. 展开更多
关键词 Hi-Art Helical Tomotherapy IGRT Inter-Fractional set-Up errors Rotational Variation Translational Variation
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Gap Functions and Error Bounds for Set-Valued Vector Quasi Variational Inequality Problems
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作者 Rachana Gupta Aparna Mehra 《Applied Mathematics》 2017年第12期1903-1917,共15页
One of the classical approaches in the analysis of a variational inequality problem is to transform it into an equivalent optimization problem via the notion of gap function. The gap functions are useful tools in deri... One of the classical approaches in the analysis of a variational inequality problem is to transform it into an equivalent optimization problem via the notion of gap function. The gap functions are useful tools in deriving the error bounds which provide an estimated distance between a specific point and the exact solution of variational inequality problem. In this paper, we follow a similar approach for set-valued vector quasi variational inequality problems and define the gap functions based on scalarization scheme as well as the one with no scalar parameter. The error bounds results are obtained under fixed point symmetric and locally α-Holder assumptions on the set-valued map describing the domain of solution space of a set-valued vector quasi variational inequality problem. 展开更多
关键词 set-VALUED VECTOR QUASI Variational Inequality Problem GAP FUNCTION Regularized GAP FUNCTION error Bounds Fixed Point Symmetric MAP α-Holder MAP
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Iterative Approximation with Errors for Generalized Set-Valued Strongly Accretive Mapping in Banach Spaces
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作者 张勇 《Journal of Southwest Jiaotong University(English Edition)》 2007年第1期70-74,共5页
A new concept of generalized set-valued strongly accretive mappings in Banach spaces was given and some strong convergence theorems of Ishikawa and Mann iterative process with errors approximation methods by Huang et ... A new concept of generalized set-valued strongly accretive mappings in Banach spaces was given and some strong convergence theorems of Ishikawa and Mann iterative process with errors approximation methods by Huang et al. was proved. The results presented in this paper improve and extend the earlier results obtained by Huang et al. 展开更多
关键词 Generalized set-valued strongly accretive mappings Ishikawa and Mann iterative processes with errors q-Uniformly Smooth Banach spaces Generalized duality mapping
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Iterative Processes with Errors for Generalized Set-Valued φ-Hemi-contractive Mapping in Banach Spaces
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作者 张勇 《Journal of Southwest Jiaotong University(English Edition)》 2006年第2期194-199,共6页
A new conception of generalized set-valued Ф-hemi-contractive mapping in Banach spaces is presented. Some strong convergence theorems of Ishikawa and Mann iterative approximation with errors is proved. The results in... A new conception of generalized set-valued Ф-hemi-contractive mapping in Banach spaces is presented. Some strong convergence theorems of Ishikawa and Mann iterative approximation with errors is proved. The results in this paper improve and extend the earlier results. 展开更多
关键词 Generalized set-valued Ф-hemi-contractive mapping Ishikawa and Mann iterative processes with errors q-uniformlysmooth Banach space Hausdorff metric Generalized duality mapping
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LEVEL SET输运方程的求解方法及其对气-液两相流运动界面数值模拟的影响 被引量:10
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作者 李会雄 邓晟 +2 位作者 赵建福 陈听宽 王飞 《核动力工程》 EI CAS CSCD 北大核心 2005年第3期242-248,267,共8页
用数值模拟方法来研究气-液两相流动与传热现象是当今多相流领域的一个热门课题。由于两相流固有的复杂性,气-液两相流界面迁移现象的数值模拟一直是两相流研究中的一大难点。本文介绍了捕捉气-液两相流相界面运动的水平集方法(LevelSet... 用数值模拟方法来研究气-液两相流动与传热现象是当今多相流领域的一个热门课题。由于两相流固有的复杂性,气-液两相流界面迁移现象的数值模拟一直是两相流研究中的一大难点。本文介绍了捕捉气-液两相流相界面运动的水平集方法(LevelSet)及其研究进展,介绍了求解LevelSet输运方程的3种方法,即一般差分格式、Superbee-TVD格式和Runge-Kutta法-5阶WENO组合格式。结合主流场的求解,分别用这3种方法对4种典型相界面在5种流场中的迁移特性进行了模拟计算,并对计算结果进行了比较和分析。结果表明,Runge-Kutta法-5阶WENO组合格式求解LevelSet输运方程的效果最好,在以后的计算中将主要采用这种组合格式来进行气-液相界面输运方程的求解。 展开更多
关键词 运动界面 LEVEL set方法 -液两相流 5阶WENO格式 Superbee-TVD格式
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高磷通过SET8-shRNA调控AKT/Caspase-3通路促进血管平滑肌细胞凋亡 被引量:7
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作者 刘兰 张东雪 +3 位作者 朱荣芳 梁向楠 李晖 张胜雷 《山西医科大学学报》 CAS 2021年第10期1312-1318,共7页
目的探讨高磷通过SET8-shRNA调控AKT/Caspase-3通路促进大鼠血管平滑肌细胞(vascular smooth muscle cells,VSMCs)发生钙化的机制。方法将血管平滑肌细胞随机分为两组:正常组和高磷组(10 mmol/Lβ-甘油磷酸)。采用茜素红染色及钙含量检... 目的探讨高磷通过SET8-shRNA调控AKT/Caspase-3通路促进大鼠血管平滑肌细胞(vascular smooth muscle cells,VSMCs)发生钙化的机制。方法将血管平滑肌细胞随机分为两组:正常组和高磷组(10 mmol/Lβ-甘油磷酸)。采用茜素红染色及钙含量检测血管平滑肌细胞钙化,采用实时荧光定量及Western blot检测SET8、AKT、Caspase-3 mRAN和蛋白表达情况。为验证SET8在细胞钙化中的作用,将大鼠VSMCs分为6组:正常组、空质粒组、SET8低表达组(转染SET8-shRNA质粒)、高磷组(10 mmol/Lβ-甘油磷酸)、空质粒+高磷组(高磷基础上转染SET8过表达的对照质粒)、SET8过表达+高磷组(高磷基础上转染SET8过表达质粒)。检测各组血管平滑肌细胞的钙化、凋亡及AKT、Caspase-3表达情况。为进一步验证AKT在VSMCs钙化中的作用,将血管平滑肌细胞分为3组:AKT抑制剂组(1μl DMSO+AKT抑制剂LY294002)、对照组(1μl DMSO)和正常组,检测AKT、Caspase-3 mRAN和蛋白表达。结果与正常组比较,高磷组细胞钙化结节增多,钙含量增加(P<0.05),STE8和AKT表达降低,Caspase-3表达升高(P<0.05)。与正常组和空质粒组比较,SET8-shRNA组细胞钙化和凋亡增多,AKT表达降低,Caspase-3表达升高(P<0.05);与高磷组和空质粒+高磷组比较,SET8过表达+高磷组细胞钙化和凋亡减少,AKT表达升高,Caspase-3表达降低(P<0.05)。与正常组和对照组比较,AKT抑制剂组AKT表达显著降低,Caspase-3表达显著升高(P<0.05)。结论高磷通过SET8-shRNA抑制AKT活化,进而促进Caspase-3表达,增加VSMCs凋亡,从而影响细胞钙化的发生。 展开更多
关键词 血管平滑肌细胞 set8 AKT Caspase-3 β-甘油磷酸
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B7-H3、葡萄糖6-磷酸脱氢酶及SET8蛋白在肾透明细胞癌中的表达及与预后的关系分析 被引量:1
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作者 程波 黄连饴 张海芳 《癌症进展》 2021年第10期1047-1049,1065,共4页
目的分析B7-H3、葡萄糖6-磷酸脱氢酶(G6PD)及SET8蛋白在肾透明细胞癌中的表达及与预后的关系。方法收集81例肾透明细胞癌患者的肾透明细胞癌组织及正常组织,比较不同组织中B7-H3、G6PD及SET8蛋白阳性表达情况,随访2年分析肾透明细胞癌... 目的分析B7-H3、葡萄糖6-磷酸脱氢酶(G6PD)及SET8蛋白在肾透明细胞癌中的表达及与预后的关系。方法收集81例肾透明细胞癌患者的肾透明细胞癌组织及正常组织,比较不同组织中B7-H3、G6PD及SET8蛋白阳性表达情况,随访2年分析肾透明细胞癌预后的影响因素。结果肾透明细胞癌组织中B7-H3、G6PD及SET8蛋白阳性表达率均明显高于正常组织,差异均有统计学意义(P﹤0.01)。多因素分析结果显示,肿瘤直径≥5 cm、TNM分期为Ⅲ-Ⅳ期、有淋巴结转移、细胞分级为G2-3级、B7-H3阳性、G6PD阳性、SET8阳性均为影响肾透明细胞癌患者预后的独立危险因素(P﹤0.05)。结论B7-H3、G6PD及SET8蛋白在肾透明细胞癌中均高表达,在临床中检测三者表达情况对患者预后评估有重要参考价值。 展开更多
关键词 B7-H3 葡萄糖6-磷酸脱氢酶 set8 肾透明细胞癌 表达 预后
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基于SET/MOS混合结构的4-2编码器设计
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作者 魏榕山 陈锦锋 +1 位作者 陈寿昌 何明华 《南昌大学学报(工科版)》 CAS 2011年第2期190-193,共4页
基于单电子晶体管(SET)的库仑振荡效应、多栅输入特性和相移特性,实现了SET/MOS混合结构的或门逻辑,并利用该或门逻辑实现了4-2编码器。利用HSPICE对所设计电路进行仿真验证,仿真结果表明该电路能够实现4-2编码器的编码功能。与纯CMOS... 基于单电子晶体管(SET)的库仑振荡效应、多栅输入特性和相移特性,实现了SET/MOS混合结构的或门逻辑,并利用该或门逻辑实现了4-2编码器。利用HSPICE对所设计电路进行仿真验证,仿真结果表明该电路能够实现4-2编码器的编码功能。与纯CMOS编码器相比,该SET/MOS混合电路仅由2个PMOS管、2个NMOS管和2个SET构成,具有结构简单、尺寸小、集成度高的优点。 展开更多
关键词 单电子晶体管 set/MOS混合电路 4-2编码器 HSPICE仿真
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细胞自身分化抗原-1—SET家族的新成员
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作者 韩淑华 陈秋惠 迟宝荣 《中国老年学杂志》 CAS CSCD 北大核心 2006年第4期571-573,共3页
关键词 细胞自身分化抗原-1 set家族 转化生长因子Β1
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长链非编码RNA SBF2-AS1通过miR-372-3p/CDK6轴调控肝癌细胞侵袭及增殖
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作者 宋巍 徐蓉 +5 位作者 李玉鹏 李智德 王锦国 马超 孟塬 陈雄 《肿瘤防治研究》 CAS 2023年第7期666-674,共9页
目的探讨长链非编码RNA SET结合因子2反义RNA1(lnc RNA SBF2-AS1)调控mi R-372-3p/细胞分裂蛋白激酶6(CDK6)轴对肝癌细胞侵袭及增殖的影响。方法以Bel7402和SK-hep1细胞为研究对象,上调或下调SBF2-AS1、miR-372-3p及CDK6表达水平,实时... 目的探讨长链非编码RNA SET结合因子2反义RNA1(lnc RNA SBF2-AS1)调控mi R-372-3p/细胞分裂蛋白激酶6(CDK6)轴对肝癌细胞侵袭及增殖的影响。方法以Bel7402和SK-hep1细胞为研究对象,上调或下调SBF2-AS1、miR-372-3p及CDK6表达水平,实时荧光定量PCR及Western blot检测细胞中miR-372-3p及CDK6表达水平。双荧光素酶报告基因实验分别验证SBF2-AS1和miR-372-3p、miR-372-3p和CDK6靶向关系。CCK-8、集落形成实验、Transwell、细胞周期实验及流式细胞术分析细胞增殖、集落形成、迁移/侵袭能力、细胞周期活动及凋亡。结果SBF2-AS1在肝癌细胞中高表达(P<0.05)。敲降SBF2-AS1后,Bel7402和SK-hep1细胞侵袭、增殖能力降低(P<0.05)。敲降miR-372-3p后,Bel7402细胞侵袭、增殖能力升高,同时敲降SBF2-AS1后,可反转上述效应(P<0.05)。miR-372-3p靶向CDK6并抑制后者的表达,过表达SFB2-AS1,可反转上述效应(P<0.05)。过表达CDK6,可以逆转过表达miR-372-3p对Bel7402细胞侵袭及增殖的抑制。结论lncRNA SBF2-AS1通过miR-372-3p正向调控CDK6的表达,改变肝癌细胞的周期活动,影响肝癌细胞的增殖、侵袭能力。 展开更多
关键词 长链非编码RNA set结合因子2反义RNA1 miR-372-3p 细胞分裂蛋白激酶6 肝癌
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S-rough sets and knowledge separation 被引量:104
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作者 Shi Kaiquan 1,21. School of Mathematics and System Sciences, Liaocheng University, Liaocheng 252059, P. R. China 2. School of Mathematics and System Sciences, Shandong University, Jinan 250100, P. R. China 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2005年第2期403-410,共8页
The conceptions of the knowledge screen generated by S-rough sets are given: f- screen and - screen , and then puts forward - filter theorem, - filter theorem of knowledge. At last, the applications of knowledge separ... The conceptions of the knowledge screen generated by S-rough sets are given: f- screen and - screen , and then puts forward - filter theorem, - filter theorem of knowledge. At last, the applications of knowledge separation are given according to - screen and - screen. 展开更多
关键词 S- rough sets f- screen - screen f-filter theorem - filter theorem knowledge separation.
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Influence of Setting Error of Tool on Tooth Profile and Contact Point of Face Gear Drive 被引量:2
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作者 李晓贞 朱如鹏 +1 位作者 李政民卿 李发家 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI 2014年第4期370-376,共7页
In order to analyze the influence of setting error of tool on both tooth profile and contact characteristic of orthogonal face gear drive,the coordinate systems with and without setting error are established.Moreover,... In order to analyze the influence of setting error of tool on both tooth profile and contact characteristic of orthogonal face gear drive,the coordinate systems with and without setting error are established.Moreover,the equations of tooth profile and contact points of face gear drive are derived by envelope principle.According to the equations,the change of tooth profile and the contact points position on face gear are analyzed.The tooth surface and contact points are obtained by numerical simulation.Results show that the tooth profile and contact characteristic of face gear drive are not sensitive to the setting error of tool. 展开更多
关键词 face gear setting error tooth profile contact characteristic
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Estimation of the Stress-Strength Reliability for Exponentiated Pareto Distribution Using Median and Ranked Set Sampling Methods 被引量:2
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作者 Amer Ibrahim Al-Omari Ibrahim M.Almanjahie +1 位作者 Amal S.Hassan Heba F.Nagy 《Computers, Materials & Continua》 SCIE EI 2020年第8期835-857,共23页
In reliability analysis,the stress-strength model is often used to describe the life of a component which has a random strength(X)and is subjected to a random stress(Y).In this paper,we considered the problem of estim... In reliability analysis,the stress-strength model is often used to describe the life of a component which has a random strength(X)and is subjected to a random stress(Y).In this paper,we considered the problem of estimating the reliability𝑅𝑅=P[Y<X]when the distributions of both stress and strength are independent and follow exponentiated Pareto distribution.The maximum likelihood estimator of the stress strength reliability is calculated under simple random sample,ranked set sampling and median ranked set sampling methods.Four different reliability estimators under median ranked set sampling are derived.Two estimators are obtained when both strength and stress have an odd or an even set size.The two other estimators are obtained when the strength has an odd size and the stress has an even set size and vice versa.The performances of the suggested estimators are compared with their competitors under simple random sample via a simulation study.The simulation study revealed that the stress strength reliability estimates based on ranked set sampling and median ranked set sampling are more efficient than their competitors via simple random sample.In general,the stress strength reliability estimates based on median ranked set sampling are smaller than the corresponding estimates under ranked set sampling and simple random sample methods.Keywords:Stress-Strength model,ranked set sampling,median ranked set sampling,maximum likelihood estimation,mean square error.corresponding estimates under ranked set sampling and simple random sample methods. 展开更多
关键词 Stress-Strength model ranked set sampling median ranked set sampling maximum likelihood estimation mean square error
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Geochemistry of sedimentary rocks from Permian–Triassic boundary sections of Tethys Himalaya: implications for paleo-weathering, provenance, and tectonic setting 被引量:3
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作者 Akhtar R.Mir V.Balaram +2 位作者 Javid A.Ganai Shamim A.Dar A.Keshav Krishna 《Acta Geochimica》 EI CAS CSCD 2016年第4期428-436,共9页
The geochemical characteristics of two sections—the Permian–Triassic boundary(PTB) Guryul Ravine section, Kashmir Valley, Jammu and Kashmir,India; and the Attargoo section, Spiti Valley, Himachal Pradesh, India—hav... The geochemical characteristics of two sections—the Permian–Triassic boundary(PTB) Guryul Ravine section, Kashmir Valley, Jammu and Kashmir,India; and the Attargoo section, Spiti Valley, Himachal Pradesh, India—have been studied in the context of provenance, paleo-weathering, and plate tectonic setting.These sections represent the siliciclastic sedimentary sequence from the Tethys Himalaya. The PTB siliciclastic sedimentary sequence in these regions primarily consists of sandstones and shales with variable thickness. Present studied sandstones and shales of both sections had chemical index of alteration values between 65 and 74; such values reveal low-to-moderate degree of chemical weathering. The chemical index of weathering in studied samples ranged from 71 to 94, suggesting a minor K-metasomatism effect on these samples. Plagioclase index of alteration in studied sections ranged from 68 to 92, indicating a moderate degree of weathering of plagioclase feldspars. The provenance discriminant function diagram suggests that the detritus involved in the formation of present studied siliciclastic sedimentary rocks fall in quartzose sedimentary and felsic igneous provenances. These sediments were deposited in a passive continental margin plate tectonic setting according to their location on a Si_2 O versus K_2O/Na_2 O tectonic setting diagram. 展开更多
关键词 GEOCHEMISTRY Permian-Triassic boundary - Guryul Ravine Tectonic settings
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A Study Regarding Solution of a Knowledge Model Based on the Containing-Type Error Matrix Equation 被引量:1
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作者 Xilin Min Kaizhong Guo Jize Huang 《Engineering(科研)》 2012年第8期484-492,共9页
An error matrix equation based on error matrix theory was presented in previous research of the error-eliminating theory. The purpose of solving the error matrix equation is to create a decision support on how to swit... An error matrix equation based on error matrix theory was presented in previous research of the error-eliminating theory. The purpose of solving the error matrix equation is to create a decision support on how to switch from bad to good status. A matrix based on error logic is used to express current status u, expectant status u1 and transformation matrix T. It is u, u1, and T that are used to build error matrix equation T (u)= u1. This allows us to find a method whereby bad status “u” changes to good status “u1” by solving the equation. The conversion method that transform from current to expectant status can be obtained from the transformation matrix T. On this basis, this paper proposes a new kind of error matrix equation named “containing-type error matrix equation”. This equation is more suitable for analyzing the realistic question. The method of solving, existence and form of solution for this type of equation have been presented in this paper. This research provides a potential useful new technique for decision analysis. 展开更多
关键词 error MATRIX set EQUATION Containing-Type error MATRIX EQUATION KNOWLEDGE Model
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γ-(α,β)-Open Sets and γ-(α,β)-Ti Spaces 被引量:1
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作者 WU Yao-qiang 《Chinese Quarterly Journal of Mathematics》 2018年第3期324-330,共7页
We introduce the concept of γ-(α, β)-open sets and the concepts of γ-(α, β)-T_i spaces(i = 0, 1, 2, 3, 4) based on the concept of(α, β)-open sets. We obtain some properties of γ-(α, β)-Tispaces. Furthermore... We introduce the concept of γ-(α, β)-open sets and the concepts of γ-(α, β)-T_i spaces(i = 0, 1, 2, 3, 4) based on the concept of(α, β)-open sets. We obtain some properties of γ-(α, β)-Tispaces. Furthermore, we study their essential characterization in topological space. 展开更多
关键词 γ-open setS β)-open setS γ- β)-open setS γ- β)-Tispaces
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