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Highly Pathogenic H5N1 Influenza Virus Infection in Migratory Birds 被引量:114
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作者 Jinhua Liu et al.College of Veterinary Medicine, China Agricultural University, Beijing 100094, China. 《中国实验动物学报》 CAS CSCD 2005年第S1期11-12,共2页
关键词 Highly Pathogenic H5n1 influenza virus infection in Migratory Birds
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Clinical characteristics of critical patients with pandemic influenza A(H1N1) virus infection in Chengdu,China 被引量:4
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作者 Li-hui DENG1,2,Yi-lan ZENG3,Ping FENG1,Ya-ling LIU3,Li-chun WANG1,2,Yun BAI3,Hong TANG1,2(1Center of Infectious Diseases,West China Hospital of Sichuan University,Chengdu 610041,China)(2Division of Infectious Diseases,State Key Laboratory of Biotherapy,Sichuan University,Chengdu 610041,China)(3Chengdu Infectious Disease Hospital,Chengdu 610041,China) 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2012年第1期49-55,共7页
Objective: The critical illness of pandemic influenza A (H1N1) virus infection may be associated with relatively poor outcomes. The objective of this study is to describe clinical features and factors associated wi... Objective: The critical illness of pandemic influenza A (H1N1) virus infection may be associated with relatively poor outcomes. The objective of this study is to describe clinical features and factors associated with the deaths of critical patients. Methods: Medical records of 26 critical patients with H1N1 infection admitted from Sept. 1 to Dec. 31, 2009, were retrospectively reviewed. Diagnosis was established by real-time reverse transcdptase- polymerase chain reaction (RT-PCR) assay. Results: The mean age of the patients was (40.4+18.4) years and 73.1% of them were male. Clinical manifestations included fever, cough, and sputum production. The laboratory findings included leukocytosis, lymphopenia, C-reaction protein, and lactic dehydrogenase elevation. In this series, 17 subjects survived and 9 died. The parameters between the deaths and survivors were compared, which included acute physiology and chronic health evaluation II (APACHE II) scores (23.8+10.1 vs. 14.3_+6.6, P〈0.05), sequential organ failure assessment (SOFA) scores (13.3_+3.0 vs. 6.6_+3.3, P〈0.05), and multiple organ dysfunction syndrome (MODS) scores (7.4+2.5 vs. 3.3+1.7, P〈0.05). The cases of deaths had higher incidences of cardiovascular failure (100% vs. 41.2%, P〈0.05), renal failure (55.6% vs. 11.7%, P〈0.05), encephalopathy (44.4% vs. 5.9%, P〈0.05), hepatic failure (33.3% vs. 5.9%, P〈0.05), and septic shock (33.3% vs. 17.6%, P〈0.05). Conclusions: The critical patients with H1 N1 infection have high APACHE II, SOFA, and MODS scores, which may be associated with an increased risk of death and complex clinical courses. 展开更多
关键词 critical illness h1n1 infection influenza A virus MORTALITY
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Sixty-two severe and critical patients with 2009 influenza A (H1N1) in Shanghai, China 被引量:1
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作者 LIU Li ZHANG Ren-fang +5 位作者 LU Hong-zhou LU Shui-hua HUANG Qin XIONG Yan-ying XI Xiu-hong ZHANG Zhi-yong 《Chinese Medical Journal》 SCIE CAS CSCD 2011年第11期1662-1666,共5页
Background Pandemic influenza A (H1N1) emerged rapidly in China in May 2009. Preliminary comparisons with seasonal influenza suggest that pandemic 2009 influenza A (HIN1) disproportionately affects younger ages an... Background Pandemic influenza A (H1N1) emerged rapidly in China in May 2009. Preliminary comparisons with seasonal influenza suggest that pandemic 2009 influenza A (HIN1) disproportionately affects younger ages and causes generally mild disease. To characterize disease progress, comorbidities, and treatment outcomes among consecutive severe and critically ill patients in a hospital served as a reference center for the care of patients with HIN1 in Shanghai, China.Methods A retrospective study on 62 severe and critically ill patients with 2009 influenza A (H1N1) was conducted in Shanghai Public Health Clinical Center. Demographic data, symptoms, comorbidities, disease progression, treatments, and clinical outcomes were collected for analysis. 展开更多
关键词 influenza A virus h1n1 subtype critical cases PNEUMONIA
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甲型H1N1流感的胸部X线和CT对比研究
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作者 王明 胡春洪 胡粟 《中国血液流变学杂志》 CAS 2013年第1期182-184,共3页
目的探讨H1N1流感的胸部常规X线、CT表现,并对两种影像学方法进行比较.方法回顾性对比分析31例H1N1流感患者的X线、多层螺旋CT成像资料.结果 X线及CT检出肺部病变分别为19例和30例,两者病变检出率比较具有高度统计学意义(P〈0.01);甲... 目的探讨H1N1流感的胸部常规X线、CT表现,并对两种影像学方法进行比较.方法回顾性对比分析31例H1N1流感患者的X线、多层螺旋CT成像资料.结果 X线及CT检出肺部病变分别为19例和30例,两者病变检出率比较具有高度统计学意义(P〈0.01);甲型H1N1流感的肺部病变影像学上主要表现为磨玻璃影伴或不伴实变,以两肺中、下叶分布多见,胸膜下分布或沿支气管血管树分布为主.结论 X线及CT作为甲型H1N1流感肺部病变的主要检查手段,能较好地检出肺部病变及对其分布范围、密度特点等进行观察,CT在甲型H1N1流感肺部情况的显示方面明显优于常规X线. 展开更多
关键词 甲型h1n1流感 X线 计算机体层摄影 对比
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A critical role of IL-17 in modulating the B-cell response during H5N1 influenza virus infection 被引量:2
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作者 Xiaohui Wang Chris CS Chan +8 位作者 Min Yang Jun Deng Vincent KM Poon Virtual HC Leung King-Hung Ko Jie Zhou Kwok Yung Yuen Bo-Jian Zheng Liwei Lu 《Cellular & Molecular Immunology》 SCIE CAS CSCD 2011年第6期462-468,共7页
Interleukin-17(IL-17),a member of the IL-17 cytokine family,plays a crucial role in mediating the immune response against extracellular bacteria and fungi in the lung.Although there is increasing evidence that IL-17 i... Interleukin-17(IL-17),a member of the IL-17 cytokine family,plays a crucial role in mediating the immune response against extracellular bacteria and fungi in the lung.Although there is increasing evidence that IL-17 is involved in protective immunity against H1 and H3 influenza virus infections,little is known about the role of IL-17 in the highly pathogenic H5N1 influenza virus infection.In this study,we show that H5N1-infected IL-17 knockout(KO)mice exhibit markedly increased weight loss,more pronounced lung immunopathology and significantly reduced survival rates as compared with infected wild-type controls.Moreover,the frequency of B cells in the lung were substantially decreased in IL-17 KO mice after virus infection,which correlated with reduced CXCR5 expression in B cells and decreased CXCL13 production in the lung tissue of IL-17 KO mice.Consistent with this observation,B cells from IL-17 KO mice exhibited a significant reduction in chemokine-mediated migration in culture.Taken together,these findings demonstrate a critical role for IL-17 in mediating the recruitment of B cells to the site of pulmonary influenza virus infection in mice. 展开更多
关键词 B cell H5n1 influenza virus IL-17 lung infection
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Human avian influenza A (H5N1) virus infection in China 被引量:14
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作者 XU CuiLin, DONG LiBo, XIN Li, LAN Yu, CHEN YongKun, YANG LiMei & SHU YueLong State Key Laboratory for Viral Genetic and Engineering, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing 100052, China 《Science China(Life Sciences)》 SCIE CAS 2009年第5期407-411,共5页
Highly pathogenic influenza A (H5N1) virus causes a widespread poultry deaths worldwide. The first human H5N1 infected case was reported in Hong Kong Special Administrative Region of China in 1997. Since then, the vir... Highly pathogenic influenza A (H5N1) virus causes a widespread poultry deaths worldwide. The first human H5N1 infected case was reported in Hong Kong Special Administrative Region of China in 1997. Since then, the virus re-emerged in 2003 and continues to infect people worldwide. Currently, over 400 human infections have been reported in more than 15 countries and mortality rate is greater than 60%. H5N1 viruses still pose a potential pandemic threat in the future because of the continuing global spread and evolution. Here, we summarize the epidemiological, clinical and virological characteristics of human H5N1 infection in China monitored and identified by our national surveillance systems. 展开更多
关键词 AVIAN influenza H5n1 virus human infection China
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New light shed on global epidemiology of avian influenza A H5N1 virus infection in humans,1997—2015
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《Science Foundation in China》 CAS 2016年第4期51-51,共1页
With the support by the National Natural Science Foundation of China,the research team led by Prof.Yu Hongjie(余宏杰)at the School of Public Health,Fudan University,Key Laboratory of Public Health Safety,Ministry of E... With the support by the National Natural Science Foundation of China,the research team led by Prof.Yu Hongjie(余宏杰)at the School of Public Health,Fudan University,Key Laboratory of Public Health Safety,Ministry of Education,and the Key Laboratory of Surveillance and Early Warning on Infectious Disease,Chinese Center for Disease Control and Prevention,has published the paper entitled“Global epi- 展开更多
关键词 New light shed on global epidemiology of avian influenza A H5n1 virus infection in humans 1997 余宏
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麻黄细辛附子汤对正常小鼠外感及肾阳虚模型小鼠外感影响的比较 被引量:6
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作者 孙启慧 相美容 +3 位作者 王朋展 侯衍豹 容蓉 杨勇 《中国中医急症》 2015年第12期2072-2075,共4页
目的探讨麻黄细辛附子汤(MXF)对正常小鼠外感和肾阳虚模型小鼠外感干预作用效果差异。方法KM小鼠按体质量和肛温随机分成6组,并设空白对照组。腹腔注射苯甲酸雌二醇(8 mg/kg)法复制肾阳虚小鼠模型,流感病毒H1N1鸡胚尿囊液(血凝滴度... 目的探讨麻黄细辛附子汤(MXF)对正常小鼠外感和肾阳虚模型小鼠外感干预作用效果差异。方法KM小鼠按体质量和肛温随机分成6组,并设空白对照组。腹腔注射苯甲酸雌二醇(8 mg/kg)法复制肾阳虚小鼠模型,流感病毒H1N1鸡胚尿囊液(血凝滴度为1∶320)滴鼻感染小鼠,建立肾阳虚小鼠外感模型。感染1 d后给分别给MXF和利巴韦林药物干预,连续给药6 d,每日1次,观察并记录小鼠的体质量、肛温变化,死亡数和死亡时间,比较各脏器指数变化。结果肾阳虚外感模型建立成功,肾阳虚模型建立成功后,小鼠死亡多发生在病毒感染后的2~5 d之内;与正常组比较,其余6组小鼠体质量显著降低(P〈0.01);肾阳虚外感组及肾阳虚外感利巴韦林组的肛温明显降低(P〈0.01),肾阳虚外感组及肾阳虚外感利巴韦林组的肺指数明显升高(P〈0.05)。与肾阳虚外感组比较,肾阳虚外感MXF组小鼠死亡率、肺指数均有所降低,并且小鼠肛温显著回升(P〈0.05);与正常外感组比较,正常外感MXF组小鼠死亡率、肺指数均有所降低,肛温也出现回升趋势;H1N1感染小鼠,对照组无死亡,正常外感组死亡率10%,肾阳虚外感组死亡率20%,利巴韦林分别给药干预后死亡率分别是30%和10%,MXF给药干预后正常外感组和肾阳虚外感组均无死亡现象,与正常组和肾阳虚外感模型组比较,MXF有降低小鼠死亡率的趋势。结论 MXF更适合于肾阳虚外感病证,为临床上方证相关用药提供了一定的实验依据。 展开更多
关键词 肾阳虚模型外感 正常小鼠外感 流感病毒h1n1 MXF
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Viral shedding in Chinese young adults with mild 2009 H1N: influenza
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作者 JIA Ning GAO Yan +5 位作者 SUO Ji-jiang XIE Li-jun YAN Zhong-qiang XING Yu-bin HE Lei LIU Yun-xi 《Chinese Medical Journal》 SCIE CAS CSCD 2011年第10期1576-1579,共4页
Background The duration of viral shedding and the transmission of 2009 H1N1 influenza among individuals, especially among the younger population with mild illness, are not well understood now. The aim of this study wa... Background The duration of viral shedding and the transmission of 2009 H1N1 influenza among individuals, especially among the younger population with mild illness, are not well understood now. The aim of this study was to determine the viral shedding of the young adult patients with mild 2009 H1N1 influenza in China.Methods From September 2009 to January 2010, the clinical data and serial nasopharyngeal swabs of 67 patients with 2009 H1N1 influenza and 37 patients with seasonal influenza aged from 18 years to 35 years were collected. The nasopharyngeal swab samples were detected by real time RT-PCR to determine the viral shedding. All the patients did not receive the antiviral therapy but Chinese medicine for detoxicating.Results Among the patients with H1N1 virus infection, 82.1% (55/67) patients presented with fever symptom, while more patients with high fever (≥39℃) were found in seasonal influenza patients (P〈0.05). For the H1N1 patients, the median interval between the symptom onset and the undetectable RNA was six days (4-10 days). But viral shedding was still found in 31.3% patients after 7 days following illness onset. The median interval between disappearance of fever and an undetectable viral RNA level was three days (2-8 days), and 17.9% patients were found to be viral shedding 6 days later after normalization of body temperature. For the seasonal influenza patients, 94.6% patients were detected out viral RNA within 7 days. The median interval of seasonal influenza between the symptom onset and the undetectable RNA was four days (3-8 days). The median interval between disappearance of fever and an undetectable viral RNA level was three days (2-6 days).Conclusion It suggests that 7 days isolation period from the illness onset or 24 hours after the resolution of fever and respiratory symptoms are not long enough to cut off the transmission among Chinese young adults with mild illness 展开更多
关键词 h1n1 influenza virus infection viral shedding
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