Changes in the activities of Δ 5\|3β\|hydroysteroid dehydrogenase(HSD) in testis and adrenal gland, 17β\|hydroxysteroid dehydrogenase in testis, acid and alkaline phosphatase in testis, prostate and seminal vesic...Changes in the activities of Δ 5\|3β\|hydroysteroid dehydrogenase(HSD) in testis and adrenal gland, 17β\|hydroxysteroid dehydrogenase in testis, acid and alkaline phosphatase in testis, prostate and seminal vesicle were observed in noise exposed mature rats at the intensity of 85 dB for 8 h/day for 45 days. The results indicated that noise exposed group showed a significant diminution in the activities of androgenic key enzymes Δ 5\|3β and 17β\|HSD, acid phosphatase in testis, prostate and seminal vesicle. There was a significant elevation in the activities of adrenal Δ 5\|3β\|HSD, alkaline phosphatase in testis and other accessory sex organ in noise exposed group. Gonadosomatic, prostatosomatic and seminal vesiculo\|somatic indexes were decreased significantly in noise exposed group. Therefore, it is evident that noise exposure at 85dB exerts a deleterious effect on testicular and adrenocortical activities.展开更多
impotence=阳痿.而从本文的内容看,此等号并不完全正确。因为本文明明白白地写着: With more than 80 million men and women in the United States sufferingfrom some form of impotence…(注:八千万,这个数字惊人！) 细查词典,发现im...impotence=阳痿.而从本文的内容看,此等号并不完全正确。因为本文明明白白地写着: With more than 80 million men and women in the United States sufferingfrom some form of impotence…(注:八千万,这个数字惊人！) 细查词典,发现impotence的另一含义适用本文:不能性交。 人类已经开始找到了治疗此病的良法: …it may be possible within 25 years to artificially grow penises(阴茎)andvaginas(阴道)that can be implanted as functioning organs in humans. 本文的另一信息是:Viagra could be licensed for use by women in three tofour years. “伟哥”的后续消息告诉读者,这个被人们偶然发现的新药正在不断改进和完善之中。】展开更多
Stones in the seminal vesicles are extremely rare. We present a 62-year-old patient with a stone within a seminal vesicle cyst, who was cured by laparoscopic treatment. The operative time was 80 rnin, and the estimate...Stones in the seminal vesicles are extremely rare. We present a 62-year-old patient with a stone within a seminal vesicle cyst, who was cured by laparoscopic treatment. The operative time was 80 rnin, and the estimated blood loss was 90 mL. Scanning electron microscope examination of the stone showed a compact crystal image externally and sparse spherical crystal structure in kernel. Composition of the stone was calcium fluorophosphate on X-ray diffractometer. The follow-up time was 15 months with no recurrence of cyst or stone. To our knowledge, this case is the first to describe laparoscopic removal of a stone within a seminal vesicle cyst, and the first to describe calcium fluorophosphate as the composition of seminal vesicle stones. （Asian JAndro12008 Mar; 10： 337-340）展开更多
Objective:To investigate the toxicity of excess iodine and perchlorate co-exposure on male reproductive system in rats.Methods:Eighteen male Wistar albino rats were divided into three groups.Group 1 received no treatm...Objective:To investigate the toxicity of excess iodine and perchlorate co-exposure on male reproductive system in rats.Methods:Eighteen male Wistar albino rats were divided into three groups.Group 1 received no treatment and served as the control group.Group 2 received perchlorate alone(130 mg/kg body weight),and group 3 received perchlorate(130 mg/kg body weight)plus excess iodine(0.7 mg potassium iodine/100 g body weight)for 45 days.Urinary perchlorate and iodine excretion pattern,testicular iodine concentration,serum testosterone levels,epididymal sperm count,key enzymes of steroidogenic pathway,reactive oxygen and nitrogen species including total antioxidant profiles in testis with electron microscopic ultrastructure analysis of spermatozoa were evaluated.Results:Co-exposure of perchlorate and excess iodine reduced their excretion pattern,reflecting accumulation with reactive oxygen species generation.It was accompanied by higher lipid peroxidation level with imbalance in the pro-/antioxidant status,inhibiting the activities ofΔ^(5)3β-hydroxysteroid dehydrogenase(HSD)and 17β-HSD rate limiting enzyme activities,and causing reduced synthesis of testosterone,parallel to reduction in testicular and accessory sex organs weight,epididymal sperm-count with deformed ultrastructure of sperm.Perchlorate alone was not a reproductive toxicant;however,in combination with excess-iodine,acute effects were noticed,resulting in a severe deterioration of testicular and spermatozoal structure and function.Conclusions:This study provides a novel insight on the augmentation of the relatively moderate repro-toxic effects of perchlorate to a more severe form in presence of excess iodine on male reproductive physiology,which justifies further investigations.展开更多
We investigated whether DNA fragmentation in two cytometric sperm populations （PIddimmer and PIbriehter） with different biological characteristics and clinical relevance is related to clinical and color-Doppler ultr...We investigated whether DNA fragmentation in two cytometric sperm populations （PIddimmer and PIbriehter） with different biological characteristics and clinical relevance is related to clinical and color-Doppler ultrasound （CDUS） parameters of the male genital tract. One hundred and sixty males of infertile couples without genetic abnormalities were evaluated for clinical, scrotal, and transrectal CDUS characteristics, presence of prostatitis-like symptoms （with the National Institutes of Health-Chronic Prostatitis Symptom Index） and sperm DNA fragmentation （sDF） in PIdimmer and PIbrighter populations （using TUNEIJPI method coupled with flow cytometry）. Data were adjusted for age （Model 1） along with waistline, testosterone levels, smoking habit, and sexual abstinence （Model 2）. According to the statistical Model 2, PIdi sDF was associated with testicular abnormalities, including lower clinical and ultrasound volume （r = -0.21 and r = -0.20, respectively; P 〈 0.05）, higher FSH levels （r = 0.34, P 〈 0.0001） and occurrence of testicular inhomogeneity （P 〈 0.05） and hypoechogenicity （P 〈 0.05）. PIbrighter sDF was associated with prostate-related symptoms and abnormal signs, including higher NIH-CPSI total and subdomain scores, a higher prevalence of prostatitis-like symptoms and of CDUS alterations such as macro-calcifications, severe echo-texture inhomogeneity, hyperemia （all P 〈 0.05）, and higher arterial peak systolic velocity （r = 0.25, P 〈 0.05）. Our results suggest that DNA fragmentation in PIdimmer sperm, which is related to poor semen quality, mainly originates in the testicles, likely due to apoptosis. Conversely, DNA fragmentation in PIbrighter sperm appears to mainly originate during or after transit through the prostate, increasing with the presence of an inflammatory status of the organ. These results could lead to new perspectives for the identification of therapeutic targets to reduce sDF.展开更多
文摘Changes in the activities of Δ 5\|3β\|hydroysteroid dehydrogenase(HSD) in testis and adrenal gland, 17β\|hydroxysteroid dehydrogenase in testis, acid and alkaline phosphatase in testis, prostate and seminal vesicle were observed in noise exposed mature rats at the intensity of 85 dB for 8 h/day for 45 days. The results indicated that noise exposed group showed a significant diminution in the activities of androgenic key enzymes Δ 5\|3β and 17β\|HSD, acid phosphatase in testis, prostate and seminal vesicle. There was a significant elevation in the activities of adrenal Δ 5\|3β\|HSD, alkaline phosphatase in testis and other accessory sex organ in noise exposed group. Gonadosomatic, prostatosomatic and seminal vesiculo\|somatic indexes were decreased significantly in noise exposed group. Therefore, it is evident that noise exposure at 85dB exerts a deleterious effect on testicular and adrenocortical activities.
文摘impotence=阳痿.而从本文的内容看,此等号并不完全正确。因为本文明明白白地写着: With more than 80 million men and women in the United States sufferingfrom some form of impotence…(注:八千万,这个数字惊人！) 细查词典,发现impotence的另一含义适用本文:不能性交。 人类已经开始找到了治疗此病的良法: …it may be possible within 25 years to artificially grow penises(阴茎)andvaginas(阴道)that can be implanted as functioning organs in humans. 本文的另一信息是:Viagra could be licensed for use by women in three tofour years. “伟哥”的后续消息告诉读者,这个被人们偶然发现的新药正在不断改进和完善之中。】
文摘Stones in the seminal vesicles are extremely rare. We present a 62-year-old patient with a stone within a seminal vesicle cyst, who was cured by laparoscopic treatment. The operative time was 80 rnin, and the estimated blood loss was 90 mL. Scanning electron microscope examination of the stone showed a compact crystal image externally and sparse spherical crystal structure in kernel. Composition of the stone was calcium fluorophosphate on X-ray diffractometer. The follow-up time was 15 months with no recurrence of cyst or stone. To our knowledge, this case is the first to describe laparoscopic removal of a stone within a seminal vesicle cyst, and the first to describe calcium fluorophosphate as the composition of seminal vesicle stones. （Asian JAndro12008 Mar; 10： 337-340）
基金The author acknowledges the Science and Engineering Research Board,Department of Science and Technology,Government of India for funding this study(Grant No.LS/PDF/2017/001558).
文摘Objective:To investigate the toxicity of excess iodine and perchlorate co-exposure on male reproductive system in rats.Methods:Eighteen male Wistar albino rats were divided into three groups.Group 1 received no treatment and served as the control group.Group 2 received perchlorate alone(130 mg/kg body weight),and group 3 received perchlorate(130 mg/kg body weight)plus excess iodine(0.7 mg potassium iodine/100 g body weight)for 45 days.Urinary perchlorate and iodine excretion pattern,testicular iodine concentration,serum testosterone levels,epididymal sperm count,key enzymes of steroidogenic pathway,reactive oxygen and nitrogen species including total antioxidant profiles in testis with electron microscopic ultrastructure analysis of spermatozoa were evaluated.Results:Co-exposure of perchlorate and excess iodine reduced their excretion pattern,reflecting accumulation with reactive oxygen species generation.It was accompanied by higher lipid peroxidation level with imbalance in the pro-/antioxidant status,inhibiting the activities ofΔ^(5)3β-hydroxysteroid dehydrogenase(HSD)and 17β-HSD rate limiting enzyme activities,and causing reduced synthesis of testosterone,parallel to reduction in testicular and accessory sex organs weight,epididymal sperm-count with deformed ultrastructure of sperm.Perchlorate alone was not a reproductive toxicant;however,in combination with excess-iodine,acute effects were noticed,resulting in a severe deterioration of testicular and spermatozoal structure and function.Conclusions:This study provides a novel insight on the augmentation of the relatively moderate repro-toxic effects of perchlorate to a more severe form in presence of excess iodine on male reproductive physiology,which justifies further investigations.
文摘We investigated whether DNA fragmentation in two cytometric sperm populations （PIddimmer and PIbriehter） with different biological characteristics and clinical relevance is related to clinical and color-Doppler ultrasound （CDUS） parameters of the male genital tract. One hundred and sixty males of infertile couples without genetic abnormalities were evaluated for clinical, scrotal, and transrectal CDUS characteristics, presence of prostatitis-like symptoms （with the National Institutes of Health-Chronic Prostatitis Symptom Index） and sperm DNA fragmentation （sDF） in PIdimmer and PIbrighter populations （using TUNEIJPI method coupled with flow cytometry）. Data were adjusted for age （Model 1） along with waistline, testosterone levels, smoking habit, and sexual abstinence （Model 2）. According to the statistical Model 2, PIdi sDF was associated with testicular abnormalities, including lower clinical and ultrasound volume （r = -0.21 and r = -0.20, respectively; P 〈 0.05）, higher FSH levels （r = 0.34, P 〈 0.0001） and occurrence of testicular inhomogeneity （P 〈 0.05） and hypoechogenicity （P 〈 0.05）. PIbrighter sDF was associated with prostate-related symptoms and abnormal signs, including higher NIH-CPSI total and subdomain scores, a higher prevalence of prostatitis-like symptoms and of CDUS alterations such as macro-calcifications, severe echo-texture inhomogeneity, hyperemia （all P 〈 0.05）, and higher arterial peak systolic velocity （r = 0.25, P 〈 0.05）. Our results suggest that DNA fragmentation in PIdimmer sperm, which is related to poor semen quality, mainly originates in the testicles, likely due to apoptosis. Conversely, DNA fragmentation in PIbrighter sperm appears to mainly originate during or after transit through the prostate, increasing with the presence of an inflammatory status of the organ. These results could lead to new perspectives for the identification of therapeutic targets to reduce sDF.
