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A Shared Natural Neighbors Based-Hierarchical Clustering Algorithm for Discovering Arbitrary-Shaped Clusters
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作者 Zhongshang Chen Ji Feng +1 位作者 Fapeng Cai Degang Yang 《Computers, Materials & Continua》 SCIE EI 2024年第8期2031-2048,共18页
In clustering algorithms,the selection of neighbors significantly affects the quality of the final clustering results.While various neighbor relationships exist,such as K-nearest neighbors,natural neighbors,and shared... In clustering algorithms,the selection of neighbors significantly affects the quality of the final clustering results.While various neighbor relationships exist,such as K-nearest neighbors,natural neighbors,and shared neighbors,most neighbor relationships can only handle single structural relationships,and the identification accuracy is low for datasets with multiple structures.In life,people’s first instinct for complex things is to divide them into multiple parts to complete.Partitioning the dataset into more sub-graphs is a good idea approach to identifying complex structures.Taking inspiration from this,we propose a novel neighbor method:Shared Natural Neighbors(SNaN).To demonstrate the superiority of this neighbor method,we propose a shared natural neighbors-based hierarchical clustering algorithm for discovering arbitrary-shaped clusters(HC-SNaN).Our algorithm excels in identifying both spherical clusters and manifold clusters.Tested on synthetic datasets and real-world datasets,HC-SNaN demonstrates significant advantages over existing clustering algorithms,particularly when dealing with datasets containing arbitrary shapes. 展开更多
关键词 Cluster analysis shared natural neighbor hierarchical clustering
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Shared-nothing并行事务数据库系统中规则的挖掘与更新算法 被引量:3
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作者 朱玉全 陈耿 +1 位作者 宋余庆 孙志挥 《小型微型计算机系统》 CSCD 北大核心 2003年第8期1499-1502,共4页
关联规则是数据挖掘中的一个重要研究内容 .本文提出了 Shared- nothing并行事务数据库系统 (简称SNPDBS)中一种快速的关联规则挖掘算法 SNPMAR,并考虑当最小支持度发生变化后 SNPDBS中关联规则的高效更新问题 ,提出了一种有效的关联规... 关联规则是数据挖掘中的一个重要研究内容 .本文提出了 Shared- nothing并行事务数据库系统 (简称SNPDBS)中一种快速的关联规则挖掘算法 SNPMAR,并考虑当最小支持度发生变化后 SNPDBS中关联规则的高效更新问题 ,提出了一种有效的关联规则更新算法 SNPIUA. 展开更多
关键词 数据挖掘 关联规则 shared—nothing 并行事务数据库系统 增量式更新
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Bi-level model for shared parking decision-making based on parking lot assignment simulation 被引量:7
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作者 冉江宇 过秀成 +1 位作者 唐亮 张晔 《Journal of Southeast University(English Edition)》 EI CAS 2011年第3期322-327,共6页
In order to carry out comprehensive decision-making of multi-class shared parking measures within a region, a bilevel model assisting decision-making is proposed. The upper level selects parkers' average satisfaction... In order to carry out comprehensive decision-making of multi-class shared parking measures within a region, a bilevel model assisting decision-making is proposed. The upper level selects parkers' average satisfaction and the violation rate during peak hours as indices in object function, and sets probability distribution models describing dynamic parking demand of each site, the feasibility of shared parking scenarios and occupancy requirements during peak hours of each parking lot as restrictions. The simulation model in the lower level sets up rules to assign each parker in the random parking demand series to the proper parking lot. An iterative method is proposed to confirm the state of each parking lot at the start of formal simulations. Besides, two patterns linking initialization and formal simulation are presented to acquire multiple solutions. The results of the numerical examples indicate the effectiveness of the model and solution methods. 展开更多
关键词 shared parking DECISION-MAKING bi-level model SIMULATION iterative method
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Shared-nothing并行数据库系统查询优化技术 被引量:21
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作者 文继荣 陈红 王珊 《计算机学报》 EI CSCD 北大核心 2000年第1期28-38,共11页
查询优化是并行数据库系统的核心技术 .该文介绍作者自行研制的一个 Shared- nothing并行数据库系统PBA SE/ 2中独特的两阶段优化策略 .为了缩减并行查询优化庞大的搜索空间 ,PBASE/ 2将并行查询优化划分为顺序优化和并行化两个阶段 .... 查询优化是并行数据库系统的核心技术 .该文介绍作者自行研制的一个 Shared- nothing并行数据库系统PBA SE/ 2中独特的两阶段优化策略 .为了缩减并行查询优化庞大的搜索空间 ,PBASE/ 2将并行查询优化划分为顺序优化和并行化两个阶段 .在顺序优化阶段对并行化后的通信代价进行预先估算 ,将通信开销加入顺序优化的代价模型 ,同时对动态规划搜索算法进行了修正和扩展 ,保证了顺序优化阶段得到的最小代价计划在并行化后代价仍然最小 .并行化阶段的优化目标是实现查询工作量在系统内多种资源上的负载平衡 ,提出了资源负载平衡因子的概念 ,并且通过启发式规则、任务调度等机制保证了并行查询执行计划的优化性 . 展开更多
关键词 并行数据库系统 并行查询优化 资源负载平衡
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非暴力沟通联合think-pair-share模式培训在普外科护士在职培训中的应用研究
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作者 陈钧 潘红英 +2 位作者 肖悦 王娅娅 姚林燕 《中国高等医学教育》 2024年第7期132-133,136,共3页
目的:探讨非暴力沟通联合think-pair-share(TPS)模式培训在普外科护士在职培训中的应用效果。方法:2020年10月至2021年10月选取本院普外科的4个护理单元,通过随机抽签法分为试验组和对照组,试验组参加非暴力沟通联合TPS模式培训,对照组... 目的:探讨非暴力沟通联合think-pair-share(TPS)模式培训在普外科护士在职培训中的应用效果。方法:2020年10月至2021年10月选取本院普外科的4个护理单元,通过随机抽签法分为试验组和对照组,试验组参加非暴力沟通联合TPS模式培训,对照组参与常规非暴力沟通培训。对比两组护士临床沟通能力、患者满意度以及教学满意度的差异。结果:试验组护士临床沟通能力、患者满意度、教学满意度调查结果均优于对照组(P<0.001)。结论:非暴力沟通联合TPS模式培训在普外科护士在职培训中能提高普外科护士的护患沟通能力,提升其岗位胜任力。 展开更多
关键词 非暴力沟通 think-pair-share 外科 护士 在职培训
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长三角城市群经济韧性测度与分析——基于Shift-Share的经济韧性分解
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作者 王欢芳 陈素月 《兰州财经大学学报》 2024年第2期48-61,共14页
以长三角城市群27个城市为研究对象,测度2008—2010年抵抗期和2010—2019年恢复期城市群经济韧性水平,并进一步运用Shift-Share分解方法探索长三角城市群经济韧性内在影响机制。研究显示:抵抗期和恢复期中长三角城市群经济韧性均值分别... 以长三角城市群27个城市为研究对象,测度2008—2010年抵抗期和2010—2019年恢复期城市群经济韧性水平,并进一步运用Shift-Share分解方法探索长三角城市群经济韧性内在影响机制。研究显示:抵抗期和恢复期中长三角城市群经济韧性均值分别为0.309和0.301,均强于全国层面经济韧性水平;Shift-Share分解后发现竞争力分量对各城市经济韧性水平提升起到决定性作用,抵抗期阶段主要由第二、三产业共同作用影响经济韧性水平;恢复期阶段则以第二产业竞争力为主导力量,同时以第三产业竞争力作为辅助力量。通过实证探究长三角城市群经济一体化发展的规律和特点,为增强中国经济韧性提出相关建议,助力中国经济高质量发展。 展开更多
关键词 长三角城市群 经济韧性 Shift-share分解 产业结构 竞争力
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一种Shared-Nothing分布式数据库的构建方法 被引量:1
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作者 龙源 郑彦 《计算机技术与发展》 2012年第10期79-82,共4页
分布式数据库能够以相对低廉的代价满足海量数据分析处理的性能需求,兼具良好的可扩展性。文中采用Shared-Nothing架构及MySQL数据库来实现分布式数据库访问层的功能架构及模块设计,提出了使用列存储机制提升分布式数据库系统查询性能... 分布式数据库能够以相对低廉的代价满足海量数据分析处理的性能需求,兼具良好的可扩展性。文中采用Shared-Nothing架构及MySQL数据库来实现分布式数据库访问层的功能架构及模块设计,提出了使用列存储机制提升分布式数据库系统查询性能的思路,包括数据存储的方法及策略。对所设计实现的系统进行了基准性能测试及扩展性能测试,结果表明,文中所实现系统相较传统列式数据库具有出色的查询性能表现,同时具有优秀的可扩展性,能够以较低的代价满足海量数据分析处理所带来的额外数据库性能提升要求。 展开更多
关键词 分布式数据库 shared—Nothing MYSQL 列存储
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法舒地尔缓解β-淀粉样蛋白1-42诱导的SH-SY5Y细胞凋亡
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作者 郭敏芳 张慧宇 +3 位作者 章培军 苏琴 贾思玮 尉杰忠 《中国组织工程研究》 CAS 北大核心 2025年第23期4939-4946,共8页
背景:法舒地尔对阿尔茨海默病小鼠脑内的线粒体动力学有调节作用,并且可以抑制神经炎症,但能否调节线粒体自噬和NLRP3炎症小体进而减轻β-淀粉样蛋白毒性尚不清楚。目的:探究法舒地尔对β-淀粉样蛋白1-42诱导的人源神经母细胞瘤细胞株SH... 背景:法舒地尔对阿尔茨海默病小鼠脑内的线粒体动力学有调节作用,并且可以抑制神经炎症,但能否调节线粒体自噬和NLRP3炎症小体进而减轻β-淀粉样蛋白毒性尚不清楚。目的:探究法舒地尔对β-淀粉样蛋白1-42诱导的人源神经母细胞瘤细胞株SH-SY5Y凋亡和线粒体自噬以及NLRP3炎症小体的调节作用。方法:将SH-SY5Y细胞接种于孔板内,细胞贴壁后分3组干预:对照组不加入任何药物,模型组加入20μmol/L β-淀粉样蛋白1-42,法舒地尔组同时加入20μmol/L β-淀粉样蛋白1-42与15 mg/L法舒地尔,干预24 h后,采用MTT法检测细胞活性,TUNEL染色检测细胞凋亡,qRT-PCR和Western blot检测凋亡相关蛋白表达,免疫荧光染色和Western blot检测线粒体自噬相关蛋白表达,免疫荧光染色和Western blot检测NLRP3炎症小体相关蛋白表达。结果与结论:(1)与对照组比较,模型组细胞活性降低、凋亡率升高(P<0.05);与模型组比较,法舒地尔组细胞活性升高、凋亡率降低(P<0.05);(2)qRT-PCR和Western blot检测结果显示,与对照组比较,模型组细胞Bax mRNA与蛋白表达升高(P<0.05),Bcl-2 mRNA与蛋白表达降低(P<0.05);与模型组比较,法舒地尔组细胞Bax mRNA与蛋白表达降低(P<0.05),Bcl-2 mRNA与蛋白表达升高(P<0.05);(3)免疫荧光染色和Western blot检测结果显示,与对照组相比,模型组细胞PINK1、帕金森病蛋白和LC3蛋白表达降低(P<0.05),p62蛋白表达升高(P<0.05);与模型组相比,法舒地尔组细胞PINK1、帕金森病蛋白和LC3蛋白表达升高(P<0.05),p62蛋白表达降低(P<0.05);(4)免疫荧光染色和Western blot检测结果显示,与对照组相比,模型组细胞NLRP3、ASC、Caspase-1和白细胞介素1β蛋白表达升高(P<0.05);与模型组相比,法舒地尔组细胞NLRP3、ASC、Caspase-1和白细胞介素1β蛋白表达降低(P<0.05);(5)结果表明,法舒地尔可以减轻β-淀粉样蛋白1-42诱导的SH-SY5Y细胞凋亡,其机制可能与激活线粒体自噬且抑制NLRP3炎症小体激活有关。 展开更多
关键词 法舒地尔 Β-淀粉样蛋白 神经细胞 细胞凋亡 线粒体自噬 炎症小体
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Shared and Service-oriented CNC Machining System for Intelligent Manufacturing Process 被引量:7
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作者 LI Yao LIU Qiang +1 位作者 TONG Ronglei CUI Xiaohong 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2015年第6期1100-1108,共9页
To improve efficiency, reduce cost, ensure quality effectively, researchers on CNC machining have focused on virtual machine tool, cloud manufacturing, wireless manufacturing. However, low level of information shared ... To improve efficiency, reduce cost, ensure quality effectively, researchers on CNC machining have focused on virtual machine tool, cloud manufacturing, wireless manufacturing. However, low level of information shared among different systems is a common disadvantage. In this paper, a machining database with data evaluation module is set up to ensure integrity and update. An online monitoring system based on internet of things and multi-sensors "feel" a variety of signal features to "percept" the state in CNC machining process. A high efficiency and green machining parameters optimization system "execute" service-oriented manufacturing, intelligent manufacturing and green manufacturing. The intelligent CNC machining system is applied in production. CNC machining database effectively shares and manages process data among different systems. The prediction accuracy of online monitoring system is up to 98.8% by acquiring acceleration and noise in real time. High efficiency and green machining parameters optimization system optimizes the original processing parameters, and the calculation indicates that optimized processing parameters not only improve production efficiency, but also reduce carbon emissions. The application proves that the shared and service-oriented CNC machining system is reliable and effective. This research presents a shared and service-oriented CNC machining system for intelligent manufacturing process. 展开更多
关键词 INTELLIGENT SERVICE-ORIENTED shared DATABASE MONITOR OPTIMIZATION evaluation
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Core-based Shared Tree Multicast Routing Algorithms for LEO Satellite IP Networks 被引量:6
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作者 Cheng Lianzhen Zhang Jun Liu Kai 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2007年第4期353-361,共9页
A new core-based shared tree algorithm, viz core-cluster combination-based shared tree (CCST) algorithm and the weighted version (i.e. w-CCST algorithm) are proposed in order to resolve the channel resources waste... A new core-based shared tree algorithm, viz core-cluster combination-based shared tree (CCST) algorithm and the weighted version (i.e. w-CCST algorithm) are proposed in order to resolve the channel resources waste problem in typical source-based multicast routing algorithms in low earth orbit (LEO) satellite IP networks. The CCST algorithm includes the dynamic approximate center (DAC) core selection method and the core-cluster combination multicast route construction scheme. Without complicated onboard computation, the DAC method is uniquely developed for highly dynamic networks of periodical and regular movement. The core-cluster combination method takes core node as the initial core-cluster, and expands it stepwise to construct an entire multicast tree at the lowest tree cost by a shortest path scheme between the newly-generated core-cluster and surplus group members, which results in great bandwidth utilization. Moreover, the w-CCST algorithm is able to strike a balance between performance of tree cost and that of end-to-end propagation delay by adjusting the weighted factor to meet strict end-to-end delay requirements of some real-time multicast services at the expense of a slight increase in tree cost. Finally, performance comparison is conducted between the proposed algorithms and typical algorithms in LEO satellite IP networks. Simulation results show that the CCST algorithm significantly decreases the average tree cost against to the others, and also the average end-to-end propagation delay ofw-CCST algorithm is lower than that of the CCST algorithm. 展开更多
关键词 satellite IP networks LEO multicast routing shared tree CORE
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PSA-based prostate cancer screening: the role of active surveillance and informed and shared decision making 被引量:6
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作者 Lionne D F Venderbos Monique J Roobol 《Asian Journal of Andrology》 SCIE CAS CSCD 2011年第2期219-224,共6页
Since the first publication describing the identification of prostate-specific antigen (PSA) in the 1960s, much progress has been made. The PSA test changed from being initially a monitoring tool to being also used ... Since the first publication describing the identification of prostate-specific antigen (PSA) in the 1960s, much progress has been made. The PSA test changed from being initially a monitoring tool to being also used as a diagnostic tool. Over time, the test has been heavily debated due to its lack of sensitivity and specificity. However, up to now the PSA test is still the only biomarker for the detection and monitoring of prostate cancer. PSA-based screening for prostate cancer is associated with a high proportion of unnecessary testing and overdiagnosis with subsequent overtreatment. In the early years of screening for prostate cancer, high rates of uptake were very important. However, over time the opinion on PSA-based screening has shifted towards the notion of informed choice. Nowadays, it is thought to be unethical to screen men without them being aware of the pros and cons of PSA testing, as well as the fact that an informed choice is related to better patient outcomes. Now, as the results of three major screening studies have been presented and the downsides of screening are becoming better understood, informed choice is becoming more relevant. 展开更多
关键词 active surveillance informed decision making PSA testing shared decision making
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ANGPTL4 TSP-1及CyPA与脑卒中后癫痫患者认知功能的关系
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作者 高灵利 方建 +2 位作者 李晓晖 李延红 耿智凡 《中国实用神经疾病杂志》 2025年第1期63-67,共5页
目的探讨血管生成素样蛋白4(ANGPTL4)、凝血酶敏感蛋白-1(TSP-1)、亲环素A(CyPA与脑卒中后癫痫患者认知功能的关系。方法选取2021-01—2022-12河南大学第一附属医院神经内科收治的100例脑卒中后癫痫病例进行观察,按简易精神状态量表(MM... 目的探讨血管生成素样蛋白4(ANGPTL4)、凝血酶敏感蛋白-1(TSP-1)、亲环素A(CyPA与脑卒中后癫痫患者认知功能的关系。方法选取2021-01—2022-12河南大学第一附属医院神经内科收治的100例脑卒中后癫痫病例进行观察,按简易精神状态量表(MMSE)划分认知障碍标准将患者分为认知障碍组(50例)和认知正常组(50例),应用酶联免疫吸附试验(ELISA)检测2组患者的血清ANGPTL4、TSP-1、CyPA水平,MMSE量表测评2组患者的认知功能。结果与认知正常组比较,认知障碍组患者MMSE评分降低,ANGPTL4、TSP-1、CyPA水平升高(P<0.05);与轻度认知障碍患者比较,中度认知障碍患者血清ANGPTL4、TSP-1、CyPA水平升高(P<0.05);与中度认知障碍患者比较,重度认知障碍患者血清ANGPTL4、TSP-1、CyPA水平升高(P<0.05)。在脑卒中后癫痫患者中,血清ANGPTL4、TSP-1、Cy PA与MMSE评分各维度均呈负相关(P<0.05)。结论脑卒中后癫痫会降低MMSE评分,提高患者血清ANGPTL4、TSP-1、CyPA水平。ANGPTL4、TSP-1、CyPA水平越高,患者认知功能障碍越严重。 展开更多
关键词 脑卒中后癫痫 血管生成素样蛋白4 凝血酶敏感蛋白-1 亲环素A 认知功能
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Decision-Making in Driver-Automation Shared Control:A Review and Perspectives 被引量:20
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作者 Wenshuo Wang Xiaoxiang Na +4 位作者 Dongpu Cao Jianwei Gong Junqiang Xi Yang Xing Fei-Yue Wang 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2020年第5期1289-1307,共19页
Shared control schemes allow a human driver to work with an automated driving agent in driver-vehicle systems while retaining the driver’s abilities to control.The human driver,as an essential agent in the driver-veh... Shared control schemes allow a human driver to work with an automated driving agent in driver-vehicle systems while retaining the driver’s abilities to control.The human driver,as an essential agent in the driver-vehicle shared control systems,should be precisely modeled regarding their cognitive processes,control strategies,and decision-making processes.The interactive strategy design between drivers and automated driving agents brings an excellent challenge for human-centric driver assistance systems due to the inherent characteristics of humans.Many open-ended questions arise,such as what proper role of human drivers should act in a shared control scheme?How to make an intelligent decision capable of balancing the benefits of agents in shared control systems?Due to the advent of these attentions and questions,it is desirable to present a survey on the decision making between human drivers and highly automated vehicles,to understand their architectures,human driver modeling,and interaction strategies under the driver-vehicle shared schemes.Finally,we give a further discussion on the key future challenges and opportunities.They are likely to shape new potential research directions. 展开更多
关键词 Automated vehicle DECISION-MAKING human driver human-vehicle interaction shared control
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Multi-proxy quantum group signature scheme with threshold shared verification 被引量:4
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作者 杨宇光 《Chinese Physics B》 SCIE EI CAS CSCD 2008年第2期415-418,共4页
A multi-proxy quantum group signature scheme with threshold shared verification is proposed. An original signer may authorize a proxy group as his proxy agent. Then only the cooperation of all the signers in the proxy... A multi-proxy quantum group signature scheme with threshold shared verification is proposed. An original signer may authorize a proxy group as his proxy agent. Then only the cooperation of all the signers in the proxy group can generate the proxy signature on behalf of the original signer. In the scheme, any t or more of n receivers can verify the message and any t - 1 or fewer receivers cannot verify the validity of the proxy signature. 展开更多
关键词 quantum signature multi-proxy quantum group signature threshold shared verification
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Shared Control of Highly Automated Vehicles Using Steer-By-Wire Systems 被引量:10
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作者 Chao Huang Fazel Naghdy +1 位作者 Haiping Du Hailong Huang 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2019年第2期410-423,共14页
A shared control of highly automated Steer-by-Wire system is proposed for cooperative driving between the driver and vehicle in the face of driver's abnormal driving. A fault detection scheme is designed to detect... A shared control of highly automated Steer-by-Wire system is proposed for cooperative driving between the driver and vehicle in the face of driver's abnormal driving. A fault detection scheme is designed to detect the abnormal driving behaviour and transfer the control of the car to the automatic system designed based on a fault tolerant model predictive control(MPC) controller driving the vehicle along an optimal safe path.The proposed concept and control algorithm are tested in a number of scenarios representing intersection, lane change and different types of driver's abnormal behaviour. The simulation results show the feasibility and effectiveness of the proposed method. 展开更多
关键词 Driver behaviour highly automation shared control steer-by-wire system
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自旋-轨道耦合作用下极化激元凝聚中的调制不稳定性
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作者 陈海军 《原子与分子物理学报》 CAS 北大核心 2025年第6期136-143,共8页
利用线性稳定性分析方法,对存在自旋-轨道耦合(SOS)作用的二维极化激元玻色-爱因斯坦凝聚(BEC)系统中的调制不稳定性(MI)进行了研究.分析了组分内部,组分之间以及SOC相互作用对系统调制不稳定性的影响.结果显示,当系统内部不存在SOC作用... 利用线性稳定性分析方法,对存在自旋-轨道耦合(SOS)作用的二维极化激元玻色-爱因斯坦凝聚(BEC)系统中的调制不稳定性(MI)进行了研究.分析了组分内部,组分之间以及SOC相互作用对系统调制不稳定性的影响.结果显示,当系统内部不存在SOC作用,组分之间的相互作用为0,组分内部存在排斥作用时,不会出现调制不稳定性,组分内部存在吸引作用时,会出现调制不稳定性,并且调制不稳定性区间长度随吸引作用的增强而增加;组分之间相互作用不为0时,组分之间的相互作用以平方形式出现,其正负不会对调制不稳定性产生实质性影响.存在SOC相互作用时,SOC相互作用会引起增益谱曲线的不规则振荡,破坏原来的调制不稳定性区间. 展开更多
关键词 极化激元凝聚 调制不稳定性 自旋-轨道耦合 双分量
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双偶氮苯-二苯并[b,i]噻蒽-[2,3-b]苯-5,7,12,14-四酮衍生物分子的二阶非线性光学性质 被引量:1
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作者 张宇红 李博 +4 位作者 陈自然 李渊 徐友辉 张莉萍 何旭东 《原子与分子物理学报》 CAS 北大核心 2025年第2期15-23,共9页
使用密度泛函理论(DFT)M06-2X方法、采用6-311+g(d,p)基组,分别对26个双偶氮-二苯并[b,i]噻蒽-[2,3-b]苯-5,7,12,14-四酮衍生物分子进行结构优化与频率计算;使用含时密度泛函理论(TD-DFT)TD-M06-2X方法计算了a1~d6分子的前线分子轨道与... 使用密度泛函理论(DFT)M06-2X方法、采用6-311+g(d,p)基组,分别对26个双偶氮-二苯并[b,i]噻蒽-[2,3-b]苯-5,7,12,14-四酮衍生物分子进行结构优化与频率计算;使用含时密度泛函理论(TD-DFT)TD-M06-2X方法计算了a1~d6分子的前线分子轨道与电子吸收光谱,采用有效场FF方法研究了二阶非线性光学性质(NLO).研究结果表明,26个噻蒽四酮类衍生物分子的能隙在1.33—2.02 eV范围,归属于有机半导体;最低能量吸收峰波长在601.8~609.5nm范围;在增大分子的二阶非线性光学系数β_(μ)(或β_(0))值方面,含相同偶氮苯基团或含不同偶氮苯基团分别引入到二苯并[b,i]噻蒽-[2,3-b]苯-5,7,12,14-四酮分子两侧的2,10位优于2,9位,在2,10位分别端接含推、拉基团的偶氮苯优于含相同给电子基团的偶氮苯.在偶氮苯苯环对位分别端接强吸电子基(-NO_(2))与强供电子基(如-N(CH_(3))_(2)、-N(Ph)_(3)、-N-苯基咔唑等)可增强体系的二阶非线性光学性能,获得性能良好的非线性光学材料. 展开更多
关键词 双偶氮 二苯并[b i]噻蒽-[2 3-b]苯-5 7 12 14-四酮 密度泛函理论 电子吸收光谱 二阶非线性光学性质
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中央苏区红色资源整理挖掘的实践与思考--以《闽西革命史珍稀史料集》编辑出版为例
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作者 张芳 《大学图书情报学刊》 2025年第1期130-136,共7页
文章通过梳理总结中共福建省委党校图书馆与该校中央苏区史研究中心联合整理挖掘中央苏区红色资源、编辑出版《闽西革命史珍稀史料集》的实践经历,提出中央苏区红色资源开发与利用的三点建议:一是福建、江西、广东三省文化主管部门加强... 文章通过梳理总结中共福建省委党校图书馆与该校中央苏区史研究中心联合整理挖掘中央苏区红色资源、编辑出版《闽西革命史珍稀史料集》的实践经历,提出中央苏区红色资源开发与利用的三点建议:一是福建、江西、广东三省文化主管部门加强统筹协作,做好顶层设计;二是运用数字技术构建开放共享的中央苏区红色资源知识平台,实现跨地区、跨领域、跨主体的中央苏区红色资源共建共享;三是加强图书馆、档案馆和革命博物馆等红色资源管理部门与党校、高校及其他科研机构之间的联动协作,形成合力,创新红色资源传播形式,搭建全媒体传播平台。 展开更多
关键词 中央苏区 红色资源 整理挖掘 编辑出版 中国革命史 资源共享平台 福建省
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基于TLR4 NF-κB通路-神经相关因子探究依达拉奉对急性脑梗死患者炎症反应与神经损伤的保护机制
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作者 李莉 姜雪 +1 位作者 姜荣格 李恳 《中国实用神经疾病杂志》 2025年第1期47-52,共6页
目的基于Toll样受体4(TLR4)核因子-κB(NF-κB)通路-神经相关因子探究依达拉奉对急性脑梗死(ACI)患者炎症反应与神经损伤的保护机制。方法选取2020-07—2023-07保定市第一中心医院收治的110例ACI患者,以随机数字表法分为观察组、对照组,... 目的基于Toll样受体4(TLR4)核因子-κB(NF-κB)通路-神经相关因子探究依达拉奉对急性脑梗死(ACI)患者炎症反应与神经损伤的保护机制。方法选取2020-07—2023-07保定市第一中心医院收治的110例ACI患者,以随机数字表法分为观察组、对照组,各55例,对照组给予阿替普酶溶栓,观察组给予阿替普酶溶栓联合依达拉奉治疗。比较2组疗效、神经功能[美国国立卫生研究院卒中量表(NIHSS)评分、改良Rankin评分]、TLR4 NF-κB通路指标(TLR4、NF-κB)、神经损伤相关因子[神经元特异性烯醇化酶(NSE)、中枢神经特异性蛋白(S-100β)、脑源性神经营养因子(BDNF)]、TLR4 NF-κB通路相关炎症因子[白介素-1β(IL-1β)、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子(TNF-α)、五聚素3(PTX3)、脂蛋白相关磷脂酶A2(Lp-PLA2)]。结果观察组总有效率96.36%,高于对照组的83.64%(P<0.05)。治疗1、2周观察组NIHSS评分、改良Rankin评分均低于对照组(P<0.05),观察组TLR4、NF-κB均低于对照组(P<0.05)。相较于治疗前,2组治疗1、2周后S-100β、NSE水平明显下降,BDNF水平明显升高,观察组S-100β、NSE水平均低于对照组,BDNF水平高于对照组(P<0.05)。相较于治疗前,2组治疗1、2周后IL-1β、hs-CRP、TNF-α、PTX3、Lp-PLA2水平均明显下降,观察组IL-1β、hs-CRP、TNF-α、PTX3、Lp-PLA2水平均低于对照组(P<0.05)。结论依达拉奉对ACI患者的疗效显著,有利于缓解炎症反应,改善神经损伤,其保护机制可能与TLR4 NF-κB通路调控神经损伤、炎症反应相关因子有关。 展开更多
关键词 急性脑梗死 TOLL样受体4 核因子-ΚB 依达拉奉 TLR4 NF-κB通路
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Shared decision-making in the management of patients with inflammatory bowel disease 被引量:3
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作者 Kai Song Dong Wu 《World Journal of Gastroenterology》 SCIE CAS 2022年第26期3092-3100,共9页
The rapid progress of research into inflammatory bowel disease(IBD)has resulted in increasingly more treatment options.Different options have different advantages and disadvantages,and the preferences of patients may ... The rapid progress of research into inflammatory bowel disease(IBD)has resulted in increasingly more treatment options.Different options have different advantages and disadvantages,and the preferences of patients may also differ.If patients can be invited to the formulation of medical decision-making,their compliance and satisfaction would be improved,thus possibly achieving better therapeutic results.The present review aims to summarize the current literature on shared decision-making(SDM)in the management of IBD,with the goal of promoting the application of SDM. 展开更多
关键词 Inflammatory bowel diseases Decision making shared THERAPEUTICS
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