Network pharmacology and subsequent experimental validation reveal the synergistic myocardial protection mechanism of Salvia miltiorrhiza Bge.and Carthamus tinctorius L.

Objective:To reveal the molecular mechanism underlying the compatibility of Salvia miltiorrhiza Bge(S.miltiorrhiza,Dan Shen)and C.tinctorius L.(C.tinctorius,Hong Hua)as an herb pair through network pharmacology and subsequent experimental validation.Methods:Network pharmacology was applied to construct an active ingredient-efficacy target-disease protein network to reveal the unique regulation pattern of s.miltiorrhiza and C.tinctorius as herb pair.Molecular docking was used to verify the binding of the components of these herbs and their potential targets.An H9c2 glucose hypoxia model was used to evaluate the efficacy of the components and their synergistic effects,which were evaluated using the combination index.Western blot was performed to detect the protein expression of these targets.Results:Network pharmacology analysis revealed 5 pathways and 8 core targets of s.miltiorrhiza and C.tinctorius in myocardial protection.Five of the core targets were enriched in the hypoxia-inducible factor-1(HIF-1)signaling pathway.S.miltiorrhiza-C.tinctorius achieved vascular tone mainly by regulating the target genes of the HIF-1 pathway.As an upstream gene of the HIF-1 pathway,STAT3 can be activated by the active ingredients cryptotanshinone(Ctan),salvianolic acid B(Sal.B),and myricetin(Myric).Cell experiments revealed that Myric,Sal.B,and Ctan also exhibited synergistic myocardial protective activity.Molecular docking verified the strong binding of Myric,Sal.B,and Ctan to STAT3.Western blot further showed that the active ingredients synergistically upregulated the protein expressionof STAT3.Conclusion:The pharmacodynamic transmission analysis revealed that the active ingredients of S.miltiorrhiza and C.tinctorius can synergistically resist ischemia through various targets and pathways.This study provides a methodological reference for interpreting traditional Chinese medicine compatibility.

Research on Monitoring and Early-warning Standards of Ancient and Famous Trees Protection in the Humble Administrator's Garden

Based on the current situation and symptoms of the trees' growth in the Humble Administrator's Garden,this paper put forward corresponding monitoring and early-warning standards and technical measures of the ancient and famous trees protection in the Humble Administrator's Garden specifically.The aim of doing this is to establish a scientific basis for the protection of the ancient and famous trees in the Humble Administrator's Garden by setting up systematic fundamental data,dynamic protection standard grades and technique measures of protecting the trees.The main symptom of trees in the Humble Administrator's Garden is the erosion and decay of the tree trunks.Fifteen tree trunks need technical protection,which holds 65.22% of the total sum of trees in the Humble Administrator's Garden.Therefore,much more emphasis should be paid in strengthening technical protection procedures of monitoring and early warning of the tree trunks in the future protection of the ancient and famous trees in the garden.Besides,the rejuvenation technique of rooting zone and rooting system,tree pruning technique as well as tree supporting measures according to the specific condition and symptom of the trees should be concerned with in order to protect the ancient and famous trees in the Humble Administrator's Garden in a more scientific and effective way.

Detection of Prorocentrum donghaiense using sandwich hybridization integrated with nuclease protection assay

Prorocentrum donghaiense is an important harmful algae bloom （HAB） causing creature in China＇s seas, and the conventional visual detection can not cope with long-term monitoring and highthroughput sampling projects. An assay for P. donghaiense with sandwich hybridization integrated with nuclease protection assay （NPA-SH） was established. Tests with mixed samples and spiked field ones confirmed its good specificity and sensitivity. The cell number of P. donghaiense correlated well with the optical density, and the regression equation is y=4× 10^- 6x＋ 0.694 9, in which x is the cell number, and y is the optical density, with r2=0.953 5. These results show that the NPA-SH method has good feasibility in the detection of P. donghaiense. Results of NPA-SH and microscopy are excellent for each sample. The NPA-SH method was a simple way in quantitative detection of P. donghaiense, and the whole process could be finished in about six hours, which provided a new approach in high-throughput sampling and long-term monitoring of P. donghaiense.

Regulation on the Protection of Fossils Issued by the State Council of the People's Republic of China:Scientists' Researches Protected Legally—Further Explanation

With large-scale engineering projects being carried out in China, a large number of fossil localities have been discovered and excavated by responsible agencies, but still some important fossils of great value have been removed and smuggled into foreign countries. In the last three years, more than 1345 fossil specimens have been intercepted by Customs in Shenzhen, Shanghai, Tianjin, Beijing and elsewhere, and more than 5000 fossils, most of which are listed as key fossils,

A Protection Method of VSC-HVDC Cables Based on Generalized S-Transform

Generalized S-transform is a time-frequency analysis method which has higher resolution than S-transform. It can precisely extract the time-amplitude characteristics of different frequency components in the signal. In this paper, a novel protection method for VSC-HVDC (Voltage source converter based high voltage DC) based on Generalized S-transform is proposed. Firstly, extracting frequency component of fault current by Generalized S-transform and using mutation point of high frequency to determine the fault time. Secondly, using the zero-frequency component of fault current to eliminate disturbances. Finally, the polarity of sudden change currents in the two terminals is employed to discriminate the internal and external faults. Simulations in PSCAD/EMTDC and MATLAB show that the proposed method can distinguish faults accurately and effectively.

THE DEVELOPMENT AND PROTECTION OF WETLANDS IN THE FOUR LAKE AREA OF JIANGHAN PLAIN

This paper summaries the ecological and environmental research works in the Four Lake Area. A great deal of research and developing works have been done, which may be concluded into three kinds of models for a agricultural development. They are Model Ⅰ-d

Designing a Need Based Social Protection Intervention Package for Children and Adolescents Living with HIV and AIDS in Ghana—An Eclectic Perspective on Desired Social Protection Intervention Package/Framework

Background: Designing a need-based social protection intervention for children comes as comprehensive tool for addressing the overall quality of life of HIV positive children. Not much has been examined on what constitute the desired social protection framework for HIV positive children. Methods: This study was informed by a qualitative descriptive exploratory design approach. The study drew insights from the shared perspectives of 27 participants sampled from positive HIV status disclosed children—10 - 17 years, healthcare workers, Social and Development worker, HIV positive caregivers and parents from 7 ART clinics in rural and urban Brong Ahafo and Ashanti regions of Ghana. Data was collected through interviews and two focus group discussions with study participants. Drawing on the emerged themes from the transcripts, thematic content analysis was used to analyze the data using comparative thematic framework approach. Findings: The eclectic perspectives on the type of social protection policy/intervention preferred demonstrated the need for an interrelated and integrated social protection policy. This should not be designed in isolation towards addressing the child vulnerability. The study found that social protection policies aimed at addressing vulnerability levels of children should consider the dual vulnerability situation within which HIV positive children and adolescents are located. A set of unique specific tailored approach and package reflecting minimum combination social protection package to HIV positive children was considered essential for inclusion. The themes that emerged covered social policy/intervention package inclusive of a disease ending/eradication intervention package, cash transfer for children and their caregivers, free comprehensive health insurance integrating all consultancy and laboratory services charges, direct food supplements supply and nutritional support, research, target specified with evidenced-based monitoring. Counseling support and preferential treatment for children visiting ART for treatment were to be included. Conclusion: Combination social protection intervention packages remain the pathway to yielding maximum dividends on any social intervention that seeks to address the vulnerability levels of HIV positive children in Ghana. This should be designed taking into consideration the preference of the main target beneficiaries (HIV positive children) while accounting for the inclusion of the technical expertise of implementing stakeholders in the policy design from conceptualization to evaluation.

A Double-Ended Protection Principle for an LCC-VSC-MTDC System with Strong Anti-Interference Ability

The DC grid technology of multi-power supply and multi-drop-point power reception is an effective solution for large-scale renewable energy integration into the power grid.Line-commutated converter-Voltage source converter(LCC-VSC)power grids are one of the more important developmental directions of the future power grid that have occured in recent years.But the multi-terminal high voltage direct current system has the problems of inconsistent boundary characteristics,inconsistent control,and fault response characteristics,which puts higher requirements on the protection scheme.Thus,a completely new protection principle is proposed in this paper.Firstly,the fault characteristics of distributed capacitance current are analyzed.The reactive power calculated by the distribution parameters of different frequencies is different.Subsequently,the fault characteristics of DC reactive power are analyzed,and a DC reactive power extraction algorithm is proposed.The polarity of the multi-band DC reactive power is used to construct the protection scheme.Finally,the LCC-VSC power grid model verifies the correctness and superiority of the proposed protection scheme.The proposed scheme uses DC reactive power instead of fault current to solve the long delay problem caused by distributed capacitance.Compared with the prior art,the proposed solution is not affected by distributed capacitance and has a stronger anti-interference ability(600Ω+10 dB+1 ms).

A Research on the Relationship of Charismatic Leadership Behaviors of Agricultural Cooperative Managers With Cooperative Shareholders＇ Performance and Satisfaction

In this study, the cooperative shareholders＇ performance and satisfaction were investigated as antecedent. Charismatic leadership of cooperative managers has been identified as antecedent. In addition, shareholders＇ age, education, land size, and duration of membership in the cooperative were investigated to have effect on the shareholder＇s performance and satisfaction. Charismatic leadership of cooperative managers is the subject of research on the effects of performance and satisfaction of the cooperative shareholders. A field survey was conducted. This study has been applied to Cukobirlik, an agricultural sale cooperative in East Mediterranean of Turkey. The researchers collected data by random questionnaire method. The research data were collected from 155 cooperative shareholders. For the data, exploratory factor, correlation, and regression were analyzed. The results of this analysis show that there is a meaningful relationship between charismatic leaders and the performance and satisfaction of shareholders for these cooperatives. Another result, there is significant relation between land size of cooperative shareholders and the performance and satisfaction of cooperative shareholders.

China's Labor and Social Security Protection under the Globle Financial Crisis

Against the background of economic globalization, the economy of many countries has been inevitably affected by the globle financial crisis. But the impact varies. China, as one of the leading countries in globalization, the direct or indirect impact it suffered can be imagined. The Chinese government adopted a series of measures to deal with the financial crisis.

Protection of Women's Rights Means Human Rights Protection——Marking the 30th anniversary of the Convention on the Elimination of All Forms of Discrimination against Women

On December 18, 1979, the 34th General Assembly of the United Nations adopted the Convention on the Elimination of All Forms of Discrimination against Women with an overwhelming majority of the votes in its favor. Over the past 30 years, the Convention has come to be known by increasing numbers of governments and people, particularly women＇s organizations. It has played an increasingly great role in protecting women＇s rights and enhancing women＇s status in society.

Expropriation of Big Shareholders——Research Review on the Domestic Literature

It is tangible that big shareholders infringe the interests of small and medium shareholders in China's listed companies,and such behaviors of big shareholders influence not only the normal production and business operation of companies but also the sound development of the capital market. At the same time,the economic order of society is also disturbed. Therefore,expropriation of big shareholders shall be governed effectively in time. This paper tries to analyze related research findings on expropriation and make conclusion from three aspects—the ways of expropriation,economic consequences of expropriation and the management effects of expropriation,pointing out the limitation of present research and the direction for the future.

Legislative Protection for Women's Rights and Interests after the Founding of the People's Republic of China

The process of legislative protection for women’s rights and interests of the new China can be divided into two phases: The first phase is from the establishment of the People’s Republic of China to the adoption of the policy of reform and opening up to the outside

PROGRESS OF CHINA'S ENVIRONMENT PROTECTION

SincethelastAsia-PacificParliamentarian'sConferenceonEnvironmentandDevelopment,theChinesegovernmenthaskeptontheimplementingthesustainabledevelopmentstrategy.Thenationaleconomyhasenjoyedanincreasinggrowthmomentumwiththeadoptionofpositivefiscalpolicies...

The Core of the Chinese Democracy Is to Respect and Protect Human Rights——A Summary of the Academic Seminar on Chinese Democracy and Human Rights Protection

On March 26,2023,a Seminar on Chinese Democracy and Human Rights Protection was held,jointly organized by the National Human Rights Education and Training Base and the Human Rights Research Center of Central South University under the guidance of the Chinese Society for Human Rights Studies.The event adopted a combination of online and offline channels.Over 30 experts and scholars from universities,research institutions,and practical departments across the country participated in extensive discussions on“Theoretical and Practical Aspects of Chinese Democracy and Protection of Human Rights.”The seminar aimed to focused on the essence,characteristics,advantages,and human rights implications of Chinese democracy and interpreted the concept of Chinese democracy and the protection of human rights through academic and theoretical methods.

BEIJING'S JUDICIAL PROTECTION OF INTELLECTUAL PROPERTY

With legislation on intellectualproperty being perfectedcontinuously,"no law to follow"inChina’s intellectual property protectionhas become a phenomenon of thepast.Legislation is the prerequisitefor law enforcement,whereas thelatter is the aim of the former,and aguarantee for safeguarding people’slegitimate rights and interests.Thejudicial organs at various levels inBeijing have strictly implemented theintellectual property laws,safeguarded the legitimate rights andinterests of intellectual propertyproprietors,and enhanced the judicialprotection of intellectual property.

Song Jian on China's Intellectual Property Protection

On June 29 this year, Mr. Song Jian, State Councillor and Minister of the State Scientific and Technology Commission, was elected chairman at the 1995 Annual Meeting of the Chinese Group of the Association for the International Protection of Industrial Property (AIPPI). A leader in China’s scientific field and world-renowned expert, Mr. Song fully recognizes the positive role played by the Chinese Group of the AIPPI in promoting the establishment and development of China’s intellectual property system, expanding relations