Profound hemorrhagic shock was produced in thirty rabbits by exsanguination via the carotid artery until blood pressure (BP) reached 5.3 kPa (40 mmHg) and was sustained for a period of 90 minutes. The rabbits were equ...Profound hemorrhagic shock was produced in thirty rabbits by exsanguination via the carotid artery until blood pressure (BP) reached 5.3 kPa (40 mmHg) and was sustained for a period of 90 minutes. The rabbits were equally divided into cyproheptadine (Cyp) treated group and control group. Blood samples 30 minutes after liquid and blood infusion and administration of Cyp (10 mg / kg) were collected from the carotid artery, and the plasma superoxide dismutase (SOD) activity and malondialdehyde (MDA) content measured. The results showed that Cyp remarkebly enhanced the plasma SOD activity (2462 338 vs 1955- 596, P<0.01) and reduced MDA content (2.68- 0.24 vs 3.20-0.49, P<0.01). We believe that the in crease of O2 production plays an important role in the develop-ment of shock, the single blood and liquid infusion can not significantly improve the shock conditions. Scavenging oxygen free radicals and alleviating cellular damage and multiple or gan failure are the possible mechanisms of cyproheptadine anti-shock effect.展开更多
文摘Profound hemorrhagic shock was produced in thirty rabbits by exsanguination via the carotid artery until blood pressure (BP) reached 5.3 kPa (40 mmHg) and was sustained for a period of 90 minutes. The rabbits were equally divided into cyproheptadine (Cyp) treated group and control group. Blood samples 30 minutes after liquid and blood infusion and administration of Cyp (10 mg / kg) were collected from the carotid artery, and the plasma superoxide dismutase (SOD) activity and malondialdehyde (MDA) content measured. The results showed that Cyp remarkebly enhanced the plasma SOD activity (2462 338 vs 1955- 596, P<0.01) and reduced MDA content (2.68- 0.24 vs 3.20-0.49, P<0.01). We believe that the in crease of O2 production plays an important role in the develop-ment of shock, the single blood and liquid infusion can not significantly improve the shock conditions. Scavenging oxygen free radicals and alleviating cellular damage and multiple or gan failure are the possible mechanisms of cyproheptadine anti-shock effect.
