The expressed proteins were extracted from human benign prostatic hyperplastic tissues obtained with transurethral resection of the prostate before and after their irradiation with radioactive nuclide. The proteins we...The expressed proteins were extracted from human benign prostatic hyperplastic tissues obtained with transurethral resection of the prostate before and after their irradiation with radioactive nuclide. The proteins were separated by two-dimensional gel electrophoresis and analyzed by mass spectrometry. Four proteins were differentially expressed and were identified with a database search. Three were associated with the regulation of cell motion and one was lactate dehydrogenase B, which plays an important role in the process of cell energy metabolism and cell state changes in tissue. The comparative proteomic analysis indicates that after irradiation with radioactive nuclide, changes occur in human benign prostatic hyperplastic cells, and associated proteins are expressed. Analysis of these proteins should help to identify the mechanism involved when human prostatic hyperplasia is treated by irradiation with radioactive nuclide.展开更多
Objective:To design a software to do the complicated and multiple calculations automatically in routine internal radionuclide irradiation therapy to avoid mistakes and shorten patients waiting times. Methods:The softw...Objective:To design a software to do the complicated and multiple calculations automatically in routine internal radionuclide irradiation therapy to avoid mistakes and shorten patients waiting times. Methods:The software is designed on the Microsoft Windows XP operating system. Visual Basic 5.0 and Microsoft Access 2000 are used respectively as the programming language and database system here. The data and DBGrid controls and VB data window guide of Visual Basic were used to control access to and Access database.Results:Not only can the radioactivity of any radionuclide be calculated,but also the administered total iodine dose of therapy for hyperthyroidism or thyroid cancer and the total administered 153Sm-EDTMP solutions for remedy of bone metastasis of malignant tumor can be ciphered out.Conclusion:The work becomes easier,faster,more correct and interesting when the software can make the complicated and multiple calculations automatically. Patients' information,diagnosis and treatment can be recorded for further study.展开更多
基金Supported by the WU Jie-ping Medical Foundation of China(No.32027400501)
文摘The expressed proteins were extracted from human benign prostatic hyperplastic tissues obtained with transurethral resection of the prostate before and after their irradiation with radioactive nuclide. The proteins were separated by two-dimensional gel electrophoresis and analyzed by mass spectrometry. Four proteins were differentially expressed and were identified with a database search. Three were associated with the regulation of cell motion and one was lactate dehydrogenase B, which plays an important role in the process of cell energy metabolism and cell state changes in tissue. The comparative proteomic analysis indicates that after irradiation with radioactive nuclide, changes occur in human benign prostatic hyperplastic cells, and associated proteins are expressed. Analysis of these proteins should help to identify the mechanism involved when human prostatic hyperplasia is treated by irradiation with radioactive nuclide.
文摘Objective:To design a software to do the complicated and multiple calculations automatically in routine internal radionuclide irradiation therapy to avoid mistakes and shorten patients waiting times. Methods:The software is designed on the Microsoft Windows XP operating system. Visual Basic 5.0 and Microsoft Access 2000 are used respectively as the programming language and database system here. The data and DBGrid controls and VB data window guide of Visual Basic were used to control access to and Access database.Results:Not only can the radioactivity of any radionuclide be calculated,but also the administered total iodine dose of therapy for hyperthyroidism or thyroid cancer and the total administered 153Sm-EDTMP solutions for remedy of bone metastasis of malignant tumor can be ciphered out.Conclusion:The work becomes easier,faster,more correct and interesting when the software can make the complicated and multiple calculations automatically. Patients' information,diagnosis and treatment can be recorded for further study.
