Synaptotagmin 7(Syt7), a presynaptic calcium sensor, has a significant role in the facilitation in shortterm synaptic plasticity: Syt7 knock out mice show a significant reduction in the facilitation. The functional im...Synaptotagmin 7(Syt7), a presynaptic calcium sensor, has a significant role in the facilitation in shortterm synaptic plasticity: Syt7 knock out mice show a significant reduction in the facilitation. The functional importance of short-term synaptic plasticity such as facilitation is not well understood. In this study, we attempt to investigate the potential functional relationship between the short-term synaptic plasticity and postsynaptic response by developing a mathematical model that captures the responses of both wild-type and Syt7 knock-out mice. We then studied the model behaviours of wild-type and Syt7 knock-out mice in response to multiple input action potentials. These behaviors could establish functional importance of short-term plasticity in regulating the postsynaptic response and related synaptic properties. In agreement with previous modeling studies, we show that release sites are governed by non-uniform release probabilities of neurotransmitters. The structure of non-uniform release of neurotransmitters makes shortterm synaptic plasticity to act as a high-pass filter. We also propose that Syt7 may be a modulator for the long-term changes of postsynaptic response that helps to train the target frequency of the filter. We have developed a mathematical model of short-term plasticity which explains the experimental data.展开更多
This paper gives a report on borehole bulk-strain data recorded at the seismostation Nanton$ in Jiangsu Province from January 1 , 2003 to December 31 , 2008. While the data at Nantong showed much noise possibly due to...This paper gives a report on borehole bulk-strain data recorded at the seismostation Nanton$ in Jiangsu Province from January 1 , 2003 to December 31 , 2008. While the data at Nantong showed much noise possibly due to site instability and no earthquake-related changes, the data at Liuhe showed anomalous changes that began one to several weeks before three earthquakes of magnitude 4.0 to 6.0 at eplcentral distances up to 400 kin.展开更多
基金supported by a grant from Lincoln University,New Zealand
文摘Synaptotagmin 7(Syt7), a presynaptic calcium sensor, has a significant role in the facilitation in shortterm synaptic plasticity: Syt7 knock out mice show a significant reduction in the facilitation. The functional importance of short-term synaptic plasticity such as facilitation is not well understood. In this study, we attempt to investigate the potential functional relationship between the short-term synaptic plasticity and postsynaptic response by developing a mathematical model that captures the responses of both wild-type and Syt7 knock-out mice. We then studied the model behaviours of wild-type and Syt7 knock-out mice in response to multiple input action potentials. These behaviors could establish functional importance of short-term plasticity in regulating the postsynaptic response and related synaptic properties. In agreement with previous modeling studies, we show that release sites are governed by non-uniform release probabilities of neurotransmitters. The structure of non-uniform release of neurotransmitters makes shortterm synaptic plasticity to act as a high-pass filter. We also propose that Syt7 may be a modulator for the long-term changes of postsynaptic response that helps to train the target frequency of the filter. We have developed a mathematical model of short-term plasticity which explains the experimental data.
基金supported by the National Natural Science Foundation of China( 40901272)Social Development Projects of Science and Technology Department of Jiangsu Province(BS2006085)
文摘This paper gives a report on borehole bulk-strain data recorded at the seismostation Nanton$ in Jiangsu Province from January 1 , 2003 to December 31 , 2008. While the data at Nantong showed much noise possibly due to site instability and no earthquake-related changes, the data at Liuhe showed anomalous changes that began one to several weeks before three earthquakes of magnitude 4.0 to 6.0 at eplcentral distances up to 400 kin.
