目的:唾液酸广泛存在于多种生物组织中,有50多种存在形式,其中,N-乙酰神经氨酸(Neu5Ac)和N-羟乙酰神经氨酸(Neu5Gc)是最主要的2种存在形式。唾液酸具有抗炎、抗病毒和抗肿瘤等多种生物活性,并能有效促进婴儿的认知发育、增强学习和记忆...目的:唾液酸广泛存在于多种生物组织中,有50多种存在形式,其中,N-乙酰神经氨酸(Neu5Ac)和N-羟乙酰神经氨酸(Neu5Gc)是最主要的2种存在形式。唾液酸具有抗炎、抗病毒和抗肿瘤等多种生物活性,并能有效促进婴儿的认知发育、增强学习和记忆能力。目前中国食物成分表中无唾液酸含量数据,本研究旨在总结和分析各类食物中唾液酸分布及含量,并推测每日膳食中可能的唾液酸摄入量。方法:在PubMed、Embase、Web of Science、中国知网、万方数据库、维普检索自建库至2022年6月国内外公开发表的相关研究文献。纳入测定食物中唾液酸分布与含量的定性与定量研究,包括一手研究数据、综述、系统综述等非一手研究数据,语言限定为中英文、意大利语;排除与主题无关、重复、数据不完整、无法获得全文的文章。结果:共检索出文献11187篇,本文共纳入35篇文献作为本综述的主要证据,其中,奶及奶制品、动物性食物、蔬菜类、水果类、谷薯类、其他食物文献各15、9、3、2、4、4篇。研究显示,燕窝中唾液酸含量最高,可高达116.2 mg/g。其次是动物性食物、奶及奶制品。动物性食物中唾液酸含量在0~4574.298μg/g、奶及奶制品中唾液酸含量在28~1596 mg/L。谷类、蔬菜类、水果类食物中含有微量或不含唾液酸,油、薯类中不含唾液酸。总结:动物性食物、奶及奶制品含有唾液酸,大豆及坚果类、蔬菜类、水果类、谷类中含有微量或不含唾液酸。展开更多
Abstract Objective To conduct a screening survey of glycophorin (GP) variants and observe the content changes of sialic acid (SA) and total sulfhydryl (SH) groups on the erythrocyte membranes among residents in a...Abstract Objective To conduct a screening survey of glycophorin (GP) variants and observe the content changes of sialic acid (SA) and total sulfhydryl (SH) groups on the erythrocyte membranes among residents in a tertian malaria hyperendemic area of Guizhou Province. Methods GP variants were detected in the erythrocyte hemolysates of 173 local residents at two villages of Libo County by SDS PAGE on 10% to 15% gradients gel and Western immunoblotting. Their SA and total SH group contents were estimated in erythrocyte membranes by spectrophotometric methods. 114 healthy subjects in Changsha and 49 individuals at a neighbouring village of the above area showing low morbidity of malaria served as normal and endemic controls respectively. Results Three distinct types of GP variants were found among 19 propositi in this hyperendemic area. The incidence of GP variants was 7.9% (8/101) at Yaolu Village whose population was mainly composed of Yao ethnic group;while that of Buyi ethnic group at Maolan Village was higher (15.3%; 11/72).The erythrocyte membrane contents of SA in residents at both villages exhibited a very significant tendency of decline (P<0.01), whereas those of total SH groups increased prominently in residents of Yaolu Village only (P<0.05). Conclusions The frequency of GP variants in this hyperendemic area does not depend upon the severity of malarial prevalence. The evident reduction of SA contents in the residents may be related to the breaking down of the SA residues on membrane GPs by the invasion of Plasmodium vivax.展开更多
文摘目的:唾液酸广泛存在于多种生物组织中,有50多种存在形式,其中,N-乙酰神经氨酸(Neu5Ac)和N-羟乙酰神经氨酸(Neu5Gc)是最主要的2种存在形式。唾液酸具有抗炎、抗病毒和抗肿瘤等多种生物活性,并能有效促进婴儿的认知发育、增强学习和记忆能力。目前中国食物成分表中无唾液酸含量数据,本研究旨在总结和分析各类食物中唾液酸分布及含量,并推测每日膳食中可能的唾液酸摄入量。方法:在PubMed、Embase、Web of Science、中国知网、万方数据库、维普检索自建库至2022年6月国内外公开发表的相关研究文献。纳入测定食物中唾液酸分布与含量的定性与定量研究,包括一手研究数据、综述、系统综述等非一手研究数据,语言限定为中英文、意大利语;排除与主题无关、重复、数据不完整、无法获得全文的文章。结果:共检索出文献11187篇,本文共纳入35篇文献作为本综述的主要证据,其中,奶及奶制品、动物性食物、蔬菜类、水果类、谷薯类、其他食物文献各15、9、3、2、4、4篇。研究显示,燕窝中唾液酸含量最高,可高达116.2 mg/g。其次是动物性食物、奶及奶制品。动物性食物中唾液酸含量在0~4574.298μg/g、奶及奶制品中唾液酸含量在28~1596 mg/L。谷类、蔬菜类、水果类食物中含有微量或不含唾液酸,油、薯类中不含唾液酸。总结:动物性食物、奶及奶制品含有唾液酸,大豆及坚果类、蔬菜类、水果类、谷类中含有微量或不含唾液酸。
文摘Abstract Objective To conduct a screening survey of glycophorin (GP) variants and observe the content changes of sialic acid (SA) and total sulfhydryl (SH) groups on the erythrocyte membranes among residents in a tertian malaria hyperendemic area of Guizhou Province. Methods GP variants were detected in the erythrocyte hemolysates of 173 local residents at two villages of Libo County by SDS PAGE on 10% to 15% gradients gel and Western immunoblotting. Their SA and total SH group contents were estimated in erythrocyte membranes by spectrophotometric methods. 114 healthy subjects in Changsha and 49 individuals at a neighbouring village of the above area showing low morbidity of malaria served as normal and endemic controls respectively. Results Three distinct types of GP variants were found among 19 propositi in this hyperendemic area. The incidence of GP variants was 7.9% (8/101) at Yaolu Village whose population was mainly composed of Yao ethnic group;while that of Buyi ethnic group at Maolan Village was higher (15.3%; 11/72).The erythrocyte membrane contents of SA in residents at both villages exhibited a very significant tendency of decline (P<0.01), whereas those of total SH groups increased prominently in residents of Yaolu Village only (P<0.05). Conclusions The frequency of GP variants in this hyperendemic area does not depend upon the severity of malarial prevalence. The evident reduction of SA contents in the residents may be related to the breaking down of the SA residues on membrane GPs by the invasion of Plasmodium vivax.
