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Comprehensive evaluation and spatial-temporal evolution characteristics of urban resilience in Chengdu-Chongqing Economic Circle
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作者 Xin Li Shuyi Zhang +1 位作者 Rongxi Ren Yafei Wang 《Chinese Journal of Population,Resources and Environment》 2024年第1期58-67,共10页
To clarify the connotations and extensions of urban resilience,this study focuses on the Chengdu-Chongqing Economic Circle with 16 cities as research subjects.A comprehensive evaluation index system was constructed to... To clarify the connotations and extensions of urban resilience,this study focuses on the Chengdu-Chongqing Economic Circle with 16 cities as research subjects.A comprehensive evaluation index system was constructed to measure the resilience of each city from 2003 to 2020.The spatial-temporal evolution characteristics were analyzed using Kernel density estimation,standard deviation ellipse,and spatial Markov chain analysis,and the spatial Tobit model was introduced to discover the influencing factors.The results indicate the following:①Urban resilience in the Chengdu-Chongqing Economic Circle displays an upward trend,with the center of gravity moving to the southwest,and the polarization phenomenon intensifying.②The urban resilience level in a region has certain spatial and geographical dependence,while the probability of urban resilience transfer differs in adjacent cities with different resilience levels.③Urban centrality,economic scale,openness level,and financial development promote urban resilience,whereas government scale significantly inhibits it.Finally,this paper proposes countermeasures and suggestions to improve the urban resilience of the Chengdu-Chongqing Economic Circle. 展开更多
关键词 Chengdu-chongqing Economic circle Urban resilience Spatial-temporal evolution Driving factor
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The Impact of Digital Finance on High-Quality Development of the Chengdu-Chongqing Economic Circle
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作者 Wei Liangyi Bai Xiaobo Li Qin 《Contemporary Social Sciences》 2024年第2期1-15,共15页
This paper developed a comprehensive evaluation system that was able to quantify the levels of high-quality development across the cities within the Chengdu-Chongqing economic circle,and investigate the impact that di... This paper developed a comprehensive evaluation system that was able to quantify the levels of high-quality development across the cities within the Chengdu-Chongqing economic circle,and investigate the impact that digital finance had on the cities’high-quality development and the underlying mechanisms through which it achieved this.This comprehensive evaluation system was constructed using statistical data from these cities for the period 2014 to 2020 while also taking China’s high-quality development philosophy into account.The key findings revealed that:(a)Digital finance was able to significantly promote high-quality development in the Chengdu-Chongqing economic circle;(b)Digital finance had a significant positive effect in promoting innovative,coordinated,green,open,and shared development;(c)Digital finance was able to stimulate the high-quality development in the Chengdu-Chongqing economic circle by boosting entrepreneurial dynamism;(d)Digital finance had a significant impact on the high-quality development of the axis areas,while its impact was less discernible in non-axis areas.The insights from this research offer a deeper understanding of the factors that drive high-quality development,the role digital finance plays,and the mechanisms through which digital finance is able to propel high-quality development at the city cluster scale. 展开更多
关键词 digital finance Chengdu-Chongqing economic circle high-quality development
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Enhancing Women's Well-being and Self-Confidence through Fragrance Cosmetics:Perceptions within Close and Broader Social Circles
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作者 Yang Fan Guo Miao +1 位作者 Zhou Ziyan Abriat Anne 《China Detergent & Cosmetics》 CAS 2024年第2期69-78,共10页
Mental and physical stress can affect people's self-confidence and happiness.The primary objective of this study is to develop an active fragrance that has been proved to have a positive effect on happiness and se... Mental and physical stress can affect people's self-confidence and happiness.The primary objective of this study is to develop an active fragrance that has been proved to have a positive effect on happiness and self-confidence based on the latest research results of aroma components and fragrance innovation.The active fragrance is applied to the cream formula to study the emotions it brings to the user and extend the research scope of the active emotion to the close and extensive social circle of users to see whether it can perceive it.This study provides a reference cosmetic solution for emotional regulating active fragrance. 展开更多
关键词 FRAGRANCE emotion CREAM social circle
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Spatial Distribution Characteristics and Coverage Rate of Commercial Facilities in 15-minute Radius Livelihood Service Circles of Chunshu Street
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作者 HAN Qiqi YANG Kaitai 《Journal of Landscape Research》 2024年第1期17-21,共5页
Building a 15-minute radius livelihood service circle from the needs of residents is a topdown process of optimizing urban layout and promoting high-quality development implemented by the government.In September 2022,... Building a 15-minute radius livelihood service circle from the needs of residents is a topdown process of optimizing urban layout and promoting high-quality development implemented by the government.In September 2022,Xicheng District of Beijing served as a national pilot of the 15-minute radius livelihood service circle.Based on the data of POI,urban walking network and building outline,this paper studies the coverage of commercial service facilities in the 15-minute radius livelihood service circle of Chunshu Street by using kernel density analysis and urban network analysis tools.The research shows that the commercial facilities are concentrated in Zhuangsheng Square and Dazhalan commercial district.There are large gaps in housekeeping and couriers logistics facilities,which need to be further improved. 展开更多
关键词 Chunshu Street 15-minute radius livelihood service circle POI Historic urban areas Community business
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Research on the Application of Evidence-Based Quality Control Circle to Improve the Implementation Rate of Airway Management Measures in Adult Critically Ill Patients
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作者 Yujiao Yan Jing Wu +4 位作者 Juan Liu Yanting Yuan Lixin Liu Huaxin Ye Juan Ding 《Yangtze Medicine》 2024年第1期8-19,共12页
Objective: To explore the effect of evidence-based quality control circle (QCC) in improving the implementation rate of airway management measures in adult critically ill patients. Methods: Based on the Joanna Briggs ... Objective: To explore the effect of evidence-based quality control circle (QCC) in improving the implementation rate of airway management measures in adult critically ill patients. Methods: Based on the Joanna Briggs Institute (JBI) evidence-based health care model, the best evidence of airway management in adult critically ill patients was obtained and applied to the clinic. Results: The total implementation rate of airway management measures in adult critically ill patients increased from 23.62% before the implementation of quality control circle to 88.82%, and the pulmonary infection rate in critically ill patients decreased from 42.31% to 21.74%, with statistical significance between the two groups (P 0.05). Conclusion: Evidence-based quality control circle activities can standardize the practice standards of airway management in critically ill patients, reduce the occurrence of patients’ airway related complications, and improve clinical outcomes. 展开更多
关键词 Critically Ill Patients Airway Management Be Evidence-Based Quality Control circle Intensive Care Unit (ICU)
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Research on Sports Public Service Supply in the Chengdu-Chongqing Twin-City Economic Circle under the Background of Regional Economic Development
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作者 Yiming Yang Yun Liu Yu Huang 《Proceedings of Business and Economic Studies》 2024年第2期106-113,共8页
Using literature,questionnaires,interviews,and mathematical statistics to investigate the current situation of sports public services in the Chengdu-Chongqing Twin-city Economic Circle.The results show that there are ... Using literature,questionnaires,interviews,and mathematical statistics to investigate the current situation of sports public services in the Chengdu-Chongqing Twin-city Economic Circle.The results show that there are some problems in Chengdu-Chongqing sports public services,such as big difference in the development level of supply between urban and rural areas,low supply level,low efficiency,supply mechanism defect,lack of social sports instructors,an outstanding contradiction between the quality of sports public service and residents’demand.To address the problems,government departments should accelerate the transformation of government functions,improve the relevant regulations and systems,increase the investment in sports public services,improve the quality of supply,cultivate the backbone team,integrate resources,and combine the national characteristics with regional characteristics,take into account the personalized needs of the residents,combine the sports public services with intelligence,and build the service system of“Internet+Fitness.” 展开更多
关键词 Regional economy Chengdu-Chongqing Twin-city Economic circle Sports demand Sports public service Current supply situation
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circLRP6调节miR-31-5p/HMGA1轴对高糖诱导的肾小管上皮细胞损伤的影响
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作者 许峥嵘 任卫东 +3 位作者 谷君 张志英 邓文娟 左丽娟 《中国医科大学学报》 CAS 北大核心 2024年第3期246-251,共6页
目的分析circLRP6调节miR-31-5p/高迁移率族蛋白A1(HMGA1)轴对高糖诱导的肾小管上皮细胞损伤的影响。方法体外培养人肾小管上皮HK-2细胞,分为对照组、高糖组、高糖+si-NC组、高糖+si-circLRP6组、高糖+si-circLRP6+miR-NC组、高糖+si-ci... 目的分析circLRP6调节miR-31-5p/高迁移率族蛋白A1(HMGA1)轴对高糖诱导的肾小管上皮细胞损伤的影响。方法体外培养人肾小管上皮HK-2细胞,分为对照组、高糖组、高糖+si-NC组、高糖+si-circLRP6组、高糖+si-circLRP6+miR-NC组、高糖+si-circLRP6+miR-31-5p inhibitor组、高糖+si-circLRP6+miR-31-5p inhibitor+si-NC组、高糖+si-circLRP6+miR-31-5p inhibitor+si-HMGA1组,对照组置于含5.5 mmol/L葡萄糖的DMEM培养基内培养,其余各组置于含25 mmol/L葡萄糖的DMEM培养基内培养,并通过Lipofectamine 2000将相应质粒转染至HK-2细胞内,实时定量PCR测定细胞circLRP6、miR-31-5p、HMGA1 mRNA水平,试剂盒测定细胞上清液白细胞介素-6(IL-6)水平、肿瘤坏死因子α(TNF-α)水平、乳酸脱氢酶(LDH)活性以及丙二醛(MDA)含量;流式细胞仪观察细胞凋亡;Western blotting测定细胞HMGA1、Bax、Bcl-2蛋白表达;双荧光素酶报告基因实验分析miR-31-5p与circLRP6、HMGA1的靶向关系。结果与对照组相比,高糖组HK-2细胞circLRP6水平升高,细胞增殖抑制率、IL-6、TNF-α、LDH、MDA、细胞凋亡率、Bax蛋白表达升高,Bcl-2蛋白表达降低(均P<0.05);与高糖组相比,高糖+si-circLRP6组HK-2细胞增殖抑制率、IL-6、TNF-α、LDH、MDA、细胞凋亡率、Bax蛋白表达降低,Bcl-2蛋白表达升高(均P<0.05);与高糖+si-circLRP6组相比,高糖+si-circLRP6+miR-31-5p inhibitor组HK-2细胞增殖抑制率、IL-6、TNF-α、LDH、MDA、细胞凋亡率、Bax蛋白表达升高,Bcl-2蛋白表达降低(均P<0.05);与高糖+si-circLRP6+miR-31-5p inhibitor组相比,高糖+si-circLRP6+miR-31-5p inhibitor+si-HMGA1组HK-2细胞增殖抑制率、IL-6、TNF-α、LDH、MDA、细胞凋亡率、Bax蛋白表达降低,Bcl-2蛋白表达升高(均P<0.05)。miR-31-5p与circLRP6、HMGA1均具有靶向关系。结论沉默circLRP6可能通过上调miR-31-5p,抑制HMGA1表达,对高糖诱导的肾小管上皮细胞损伤发挥保护作用。 展开更多
关键词 高糖 肾小管 circlRP6 miR-31-5p 高迁移率族蛋白A1
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Circle社交网络系统衍生的社区互助模式探究
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作者 黄浩 张华 《工业工程设计》 2024年第4期100-106,共7页
探究Circle社区网络系统衍生的社区互助模式并总结传统设计与协同创新设计对于协同设计者的职能要求。从多元主体、理念衍生与模式思辨三个层次梳理Circle服务系统流程及利益相关者,剖析Circle社区网络系统的设计模式。基于此,文章从行... 探究Circle社区网络系统衍生的社区互助模式并总结传统设计与协同创新设计对于协同设计者的职能要求。从多元主体、理念衍生与模式思辨三个层次梳理Circle服务系统流程及利益相关者,剖析Circle社区网络系统的设计模式。基于此,文章从行为认同、情感互动及体验价值三个层面建构了社区协同互助模式的设计策略,并进一步扩展出协同设计者的四条职能:思辨设计思维、跨学科知识体系、能级导向设计及协调创新。Circle社交网络系统衍生的社区协同互助模式在一定程度上能够引导和优化本土化社区的弹性和韧性,朝着更加有利于社会创新模式的方向不断发展。 展开更多
关键词 协同设计 社区互助模式 circle 协同设计者职能
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基于Circle映射和自适应t分布变异改进的鹈鹕优化算法
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作者 高猛 曾宪文 《计算机与现代化》 2024年第9期69-73,共5页
针对传统鹈鹕优化算法(POA)存在收敛速度慢、易陷入局部最优解等缺陷,提出一种基于Circle映射初始化和自适应t分布变异的改进的鹈鹕优化算法(IPOA)。首先,在种群初始化阶段,采用Circle映射生成具有高度多样性的初始解,并结合反向学习策... 针对传统鹈鹕优化算法(POA)存在收敛速度慢、易陷入局部最优解等缺陷,提出一种基于Circle映射初始化和自适应t分布变异的改进的鹈鹕优化算法(IPOA)。首先,在种群初始化阶段,采用Circle映射生成具有高度多样性的初始解,并结合反向学习策略,提高种群多样性,增强种群的探索能力。其次,在迭代过程中,采用自适应t分布变异操作对个体进行扰动,有助于鹈鹕优化算法跳出局部最优解并提高收敛速度。另外,在鹈鹕优化算法的探索阶段引入自适应因子和改进惯性权重,更好地平衡算法全局探索能力和局部开发能力。最后,在多个测试函数上将IPOA与其他4种经典算法进行比较。实验结果表明,IPOA在收敛速度、全局搜索能力和收敛鲁棒性方面均有显著提升。 展开更多
关键词 鹈鹕优化算法 circle映射 自适应因子 自适应t分布变异
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法舒地尔缓解β-淀粉样蛋白1-42诱导的SH-SY5Y细胞凋亡
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作者 郭敏芳 张慧宇 +3 位作者 章培军 苏琴 贾思玮 尉杰忠 《中国组织工程研究》 CAS 北大核心 2025年第23期4939-4946,共8页
背景:法舒地尔对阿尔茨海默病小鼠脑内的线粒体动力学有调节作用,并且可以抑制神经炎症,但能否调节线粒体自噬和NLRP3炎症小体进而减轻β-淀粉样蛋白毒性尚不清楚。目的:探究法舒地尔对β-淀粉样蛋白1-42诱导的人源神经母细胞瘤细胞株SH... 背景:法舒地尔对阿尔茨海默病小鼠脑内的线粒体动力学有调节作用,并且可以抑制神经炎症,但能否调节线粒体自噬和NLRP3炎症小体进而减轻β-淀粉样蛋白毒性尚不清楚。目的:探究法舒地尔对β-淀粉样蛋白1-42诱导的人源神经母细胞瘤细胞株SH-SY5Y凋亡和线粒体自噬以及NLRP3炎症小体的调节作用。方法:将SH-SY5Y细胞接种于孔板内,细胞贴壁后分3组干预:对照组不加入任何药物,模型组加入20μmol/L β-淀粉样蛋白1-42,法舒地尔组同时加入20μmol/L β-淀粉样蛋白1-42与15 mg/L法舒地尔,干预24 h后,采用MTT法检测细胞活性,TUNEL染色检测细胞凋亡,qRT-PCR和Western blot检测凋亡相关蛋白表达,免疫荧光染色和Western blot检测线粒体自噬相关蛋白表达,免疫荧光染色和Western blot检测NLRP3炎症小体相关蛋白表达。结果与结论:(1)与对照组比较,模型组细胞活性降低、凋亡率升高(P<0.05);与模型组比较,法舒地尔组细胞活性升高、凋亡率降低(P<0.05);(2)qRT-PCR和Western blot检测结果显示,与对照组比较,模型组细胞Bax mRNA与蛋白表达升高(P<0.05),Bcl-2 mRNA与蛋白表达降低(P<0.05);与模型组比较,法舒地尔组细胞Bax mRNA与蛋白表达降低(P<0.05),Bcl-2 mRNA与蛋白表达升高(P<0.05);(3)免疫荧光染色和Western blot检测结果显示,与对照组相比,模型组细胞PINK1、帕金森病蛋白和LC3蛋白表达降低(P<0.05),p62蛋白表达升高(P<0.05);与模型组相比,法舒地尔组细胞PINK1、帕金森病蛋白和LC3蛋白表达升高(P<0.05),p62蛋白表达降低(P<0.05);(4)免疫荧光染色和Western blot检测结果显示,与对照组相比,模型组细胞NLRP3、ASC、Caspase-1和白细胞介素1β蛋白表达升高(P<0.05);与模型组相比,法舒地尔组细胞NLRP3、ASC、Caspase-1和白细胞介素1β蛋白表达降低(P<0.05);(5)结果表明,法舒地尔可以减轻β-淀粉样蛋白1-42诱导的SH-SY5Y细胞凋亡,其机制可能与激活线粒体自噬且抑制NLRP3炎症小体激活有关。 展开更多
关键词 法舒地尔 Β-淀粉样蛋白 神经细胞 细胞凋亡 线粒体自噬 炎症小体
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The Formation Control of Multi-agent Systems on a Circle 被引量:4
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作者 Qiang Wang Yuzhen Wang Huaxiang Zhang 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2018年第1期148-154,共7页
This paper investigates the formation control of a class of multi-agent systems moving on a circle, whose topology is a cyclic graph, and presents several new results for the following two cases: Case I, the agents wi... This paper investigates the formation control of a class of multi-agent systems moving on a circle, whose topology is a cyclic graph, and presents several new results for the following two cases: Case I, the agents with single-integrator kinematics,and Case II, the agents with double-integrator kinematics. Firstly,for Case I, two control protocols are proposed under which the multiagent systems keep a uniformly-spaced formation. Secondly,we study Case II, and a control protocol is designed for this case, then the stability of the formation is proved. Finally, three simulations are studied by using our presented results. The study of illustrative examples with simulations shows that our results as well as designed control protocols work very well in studying the formation control of this class of multi-agent systems. 展开更多
关键词 circle cyclic graph formation control multiagent systems uniformly spaced
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Endonuclease-rolling circle amplification-based method for sensitive analysis of DNA-binding protein 被引量:4
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作者 Min Li Li Dong Rui Zhou +2 位作者 Hong Zhao Jin Ke Wang Zu Hong Lu 《Chinese Chemical Letters》 SCIE CAS CSCD 2009年第11期1315-1318,共4页
A sensitive approach for the qualitative detection of DNA-binding protein on the microarray was developed. DNA complexes in which a partial duplex region is formed from a biotin-primer and a circle single strand DNA ... A sensitive approach for the qualitative detection of DNA-binding protein on the microarray was developed. DNA complexes in which a partial duplex region is formed from a biotin-primer and a circle single strand DNA (ssDNA) were spotted on a microarray. The endonuclease recognition site (ERS) and the DNA-binding sites (DBS) were arranged side by side within the duplex region. The working principle of the detection system is described as follows: when the DNA-binding protein capture the DBS, the endonuclease could not attach to the ERS, and the immobilized primer in the DNA complex could be extended along the circle ssDNA by rolling circle amplification (RCA). When no protein protects the DBS, the ERS could be attacked by the endonuclease and subsequently no rolling circle amplification occurs. Thereby we can detect the sequence specific DNA-binding activity with high-sensitivity due to the signal amplification of RCA. 展开更多
关键词 Rolling circle amplification DNA-binding protein MICROARRAY
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ANGPTL4 TSP-1及CyPA与脑卒中后癫痫患者认知功能的关系
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作者 高灵利 方建 +2 位作者 李晓晖 李延红 耿智凡 《中国实用神经疾病杂志》 2025年第1期63-67,共5页
目的探讨血管生成素样蛋白4(ANGPTL4)、凝血酶敏感蛋白-1(TSP-1)、亲环素A(CyPA与脑卒中后癫痫患者认知功能的关系。方法选取2021-01—2022-12河南大学第一附属医院神经内科收治的100例脑卒中后癫痫病例进行观察,按简易精神状态量表(MM... 目的探讨血管生成素样蛋白4(ANGPTL4)、凝血酶敏感蛋白-1(TSP-1)、亲环素A(CyPA与脑卒中后癫痫患者认知功能的关系。方法选取2021-01—2022-12河南大学第一附属医院神经内科收治的100例脑卒中后癫痫病例进行观察,按简易精神状态量表(MMSE)划分认知障碍标准将患者分为认知障碍组(50例)和认知正常组(50例),应用酶联免疫吸附试验(ELISA)检测2组患者的血清ANGPTL4、TSP-1、CyPA水平,MMSE量表测评2组患者的认知功能。结果与认知正常组比较,认知障碍组患者MMSE评分降低,ANGPTL4、TSP-1、CyPA水平升高(P<0.05);与轻度认知障碍患者比较,中度认知障碍患者血清ANGPTL4、TSP-1、CyPA水平升高(P<0.05);与中度认知障碍患者比较,重度认知障碍患者血清ANGPTL4、TSP-1、CyPA水平升高(P<0.05)。在脑卒中后癫痫患者中,血清ANGPTL4、TSP-1、Cy PA与MMSE评分各维度均呈负相关(P<0.05)。结论脑卒中后癫痫会降低MMSE评分,提高患者血清ANGPTL4、TSP-1、CyPA水平。ANGPTL4、TSP-1、CyPA水平越高,患者认知功能障碍越严重。 展开更多
关键词 脑卒中后癫痫 血管生成素样蛋白4 凝血酶敏感蛋白-1 亲环素A 认知功能
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Study on the Layout of 15-Minute Community-Life Circle in Third-Tier Cities Based on POI: Baoding City of Hebei Province 被引量:7
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作者 Zeqin Li Jie Zheng Yukun Zhang 《Engineering(科研)》 2019年第9期592-603,共12页
At present, the planning of 15-minute community-life circle is being actively promoted in China. Taking Baoding City as an example, the status quo of service facilities layout was analyzed based on the POI data. Using... At present, the planning of 15-minute community-life circle is being actively promoted in China. Taking Baoding City as an example, the status quo of service facilities layout was analyzed based on the POI data. Using the spatial accessibility algorithm, the ranges of 15-minute life circle of more than 1000 communities in Baoding were determined. By calculating the up-to-standard rates of public service facilities in each district, it is found that the allocation of medical facilities and commercial facilities in urban community life circle is relatively perfect, but the allocation of public cultural facilities and pension facilities is obviously inadequate. Based on this, optimization suggestions on the layout of public service facilities in the 15-minute life circle were put forward from three aspects: facilities sharing, function mixing and population structure and activity characteristics differentiation. It not only provides data and technical support for the planning and construction of community life circle in Baoding city, but also provides referable examples and promotable models for the community planning of third-tier cities. 展开更多
关键词 COMMUNITY LIFE circle ACCESSIBILITY Up-to-Standard Rate Planning Strategy
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Closed circle DNA algorithm of change positive-weighted Hamilton circuit problem 被引量:5
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作者 Zhou Kang Tong Xiaojun Xu Jin 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2009年第3期636-642,共7页
Chain length of closed circle DNA is equal. The same closed circle DNA's position corresponds to different recognition sequence, and the same recognition sequence corresponds to different foreign DNA segment, so clos... Chain length of closed circle DNA is equal. The same closed circle DNA's position corresponds to different recognition sequence, and the same recognition sequence corresponds to different foreign DNA segment, so closed circle DNA computing model is generalized. For change positive-weighted Hamilton circuit problem, closed circle DNA algorithm is put forward. First, three groups of DNA encoding are encoded for all arcs, and deck groups are designed for all vertices. All possible solutions are composed. Then, the feasible solutions are filtered out by using group detect experiment, and the optimization solutions are obtained by using group insert experiment and electrophoresis experiment. Finally, all optimization solutions are found by using detect experiment. Complexity of algorithm is concluded and validity of DNA algorithm is explained by an example. Three dominances of the closed circle DNA algorithm are analyzed, and characteristics and dominances of group delete experiment are discussed. 展开更多
关键词 closed circle DNA computing model change positive-weighted Hamilton circuit problem group insert experiment group delete experiment.
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lncRNA-BBOX1-2通过调控成纤维细胞生长因子受体1促进胃癌的发生和发展
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作者 孙颖 顾玮 +1 位作者 王吉 郑雄 《安徽医药》 CAS 2025年第1期57-62,I0002,共7页
目的探讨长链非编码RNA(long non-coding RNA,lncRNA)BBOX1-2通过调控成纤维细胞生长因子受体1(fibroblast growth factor receptor 1,FGFR1)对胃癌的发生发展机制的影响。方法回顾性选取2017年4月至2019年1月于上海交通大学医学院附属... 目的探讨长链非编码RNA(long non-coding RNA,lncRNA)BBOX1-2通过调控成纤维细胞生长因子受体1(fibroblast growth factor receptor 1,FGFR1)对胃癌的发生发展机制的影响。方法回顾性选取2017年4月至2019年1月于上海交通大学医学院附属瑞金医院卢湾分院接受胃癌根治术30例病人肿瘤组织及癌旁相应正常组织作为研究对象,采用实时定量PCT(real-time PCR,RT-PCR)检测lncRNA-BBOX1-2和FGFR1表达;si-linc-BBOX1-2转染SGC-7901细胞后,通过蛋白质印迹法/细胞存活率分析(MTT)、细胞迁移和侵袭(Transwell)实验、细胞划痕、平板克隆一系列生物学功能实验,检测肿瘤细胞生物学功能及FGFR1表达的变化。结果胃癌组织中的lncRNA-BBOX1-2(3.68±0.58比1.15±0.11)和FGFR1(4.26±0.71比1.19±0.18)表达显著高于癌旁正常组织(P<0.05);si-linc-BBOX1-2转染SGC-7901细胞后,FGFR1表达下调,细胞活力、迁移、侵袭和生存能力明显下降。结论LincRNA-BBOX1-2可通过调控FGFR1的表达介导胃癌细胞的增殖、凋亡、迁移和侵袭,可能为胃癌的治疗提供了新的靶点和潜在的生物学标志物。 展开更多
关键词 胃肿瘤 长链非编码RNA BBOX1-2 成纤维细胞生长因子受体1 调控 增殖 凋亡
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自旋-轨道耦合作用下极化激元凝聚中的调制不稳定性
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作者 陈海军 《原子与分子物理学报》 CAS 北大核心 2025年第6期136-143,共8页
利用线性稳定性分析方法,对存在自旋-轨道耦合(SOS)作用的二维极化激元玻色-爱因斯坦凝聚(BEC)系统中的调制不稳定性(MI)进行了研究.分析了组分内部,组分之间以及SOC相互作用对系统调制不稳定性的影响.结果显示,当系统内部不存在SOC作用... 利用线性稳定性分析方法,对存在自旋-轨道耦合(SOS)作用的二维极化激元玻色-爱因斯坦凝聚(BEC)系统中的调制不稳定性(MI)进行了研究.分析了组分内部,组分之间以及SOC相互作用对系统调制不稳定性的影响.结果显示,当系统内部不存在SOC作用,组分之间的相互作用为0,组分内部存在排斥作用时,不会出现调制不稳定性,组分内部存在吸引作用时,会出现调制不稳定性,并且调制不稳定性区间长度随吸引作用的增强而增加;组分之间相互作用不为0时,组分之间的相互作用以平方形式出现,其正负不会对调制不稳定性产生实质性影响.存在SOC相互作用时,SOC相互作用会引起增益谱曲线的不规则振荡,破坏原来的调制不稳定性区间. 展开更多
关键词 极化激元凝聚 调制不稳定性 自旋-轨道耦合 双分量
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双偶氮苯-二苯并[b,i]噻蒽-[2,3-b]苯-5,7,12,14-四酮衍生物分子的二阶非线性光学性质 被引量:1
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作者 张宇红 李博 +4 位作者 陈自然 李渊 徐友辉 张莉萍 何旭东 《原子与分子物理学报》 CAS 北大核心 2025年第2期15-23,共9页
使用密度泛函理论(DFT)M06-2X方法、采用6-311+g(d,p)基组,分别对26个双偶氮-二苯并[b,i]噻蒽-[2,3-b]苯-5,7,12,14-四酮衍生物分子进行结构优化与频率计算;使用含时密度泛函理论(TD-DFT)TD-M06-2X方法计算了a1~d6分子的前线分子轨道与... 使用密度泛函理论(DFT)M06-2X方法、采用6-311+g(d,p)基组,分别对26个双偶氮-二苯并[b,i]噻蒽-[2,3-b]苯-5,7,12,14-四酮衍生物分子进行结构优化与频率计算;使用含时密度泛函理论(TD-DFT)TD-M06-2X方法计算了a1~d6分子的前线分子轨道与电子吸收光谱,采用有效场FF方法研究了二阶非线性光学性质(NLO).研究结果表明,26个噻蒽四酮类衍生物分子的能隙在1.33—2.02 eV范围,归属于有机半导体;最低能量吸收峰波长在601.8~609.5nm范围;在增大分子的二阶非线性光学系数β_(μ)(或β_(0))值方面,含相同偶氮苯基团或含不同偶氮苯基团分别引入到二苯并[b,i]噻蒽-[2,3-b]苯-5,7,12,14-四酮分子两侧的2,10位优于2,9位,在2,10位分别端接含推、拉基团的偶氮苯优于含相同给电子基团的偶氮苯.在偶氮苯苯环对位分别端接强吸电子基(-NO_(2))与强供电子基(如-N(CH_(3))_(2)、-N(Ph)_(3)、-N-苯基咔唑等)可增强体系的二阶非线性光学性能,获得性能良好的非线性光学材料. 展开更多
关键词 双偶氮 二苯并[b i]噻蒽-[2 3-b]苯-5 7 12 14-四酮 密度泛函理论 电子吸收光谱 二阶非线性光学性质
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基于TLR4 NF-κB通路-神经相关因子探究依达拉奉对急性脑梗死患者炎症反应与神经损伤的保护机制
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作者 李莉 姜雪 +1 位作者 姜荣格 李恳 《中国实用神经疾病杂志》 2025年第1期47-52,共6页
目的基于Toll样受体4(TLR4)核因子-κB(NF-κB)通路-神经相关因子探究依达拉奉对急性脑梗死(ACI)患者炎症反应与神经损伤的保护机制。方法选取2020-07—2023-07保定市第一中心医院收治的110例ACI患者,以随机数字表法分为观察组、对照组,... 目的基于Toll样受体4(TLR4)核因子-κB(NF-κB)通路-神经相关因子探究依达拉奉对急性脑梗死(ACI)患者炎症反应与神经损伤的保护机制。方法选取2020-07—2023-07保定市第一中心医院收治的110例ACI患者,以随机数字表法分为观察组、对照组,各55例,对照组给予阿替普酶溶栓,观察组给予阿替普酶溶栓联合依达拉奉治疗。比较2组疗效、神经功能[美国国立卫生研究院卒中量表(NIHSS)评分、改良Rankin评分]、TLR4 NF-κB通路指标(TLR4、NF-κB)、神经损伤相关因子[神经元特异性烯醇化酶(NSE)、中枢神经特异性蛋白(S-100β)、脑源性神经营养因子(BDNF)]、TLR4 NF-κB通路相关炎症因子[白介素-1β(IL-1β)、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子(TNF-α)、五聚素3(PTX3)、脂蛋白相关磷脂酶A2(Lp-PLA2)]。结果观察组总有效率96.36%,高于对照组的83.64%(P<0.05)。治疗1、2周观察组NIHSS评分、改良Rankin评分均低于对照组(P<0.05),观察组TLR4、NF-κB均低于对照组(P<0.05)。相较于治疗前,2组治疗1、2周后S-100β、NSE水平明显下降,BDNF水平明显升高,观察组S-100β、NSE水平均低于对照组,BDNF水平高于对照组(P<0.05)。相较于治疗前,2组治疗1、2周后IL-1β、hs-CRP、TNF-α、PTX3、Lp-PLA2水平均明显下降,观察组IL-1β、hs-CRP、TNF-α、PTX3、Lp-PLA2水平均低于对照组(P<0.05)。结论依达拉奉对ACI患者的疗效显著,有利于缓解炎症反应,改善神经损伤,其保护机制可能与TLR4 NF-κB通路调控神经损伤、炎症反应相关因子有关。 展开更多
关键词 急性脑梗死 TOLL样受体4 核因子-ΚB 依达拉奉 TLR4 NF-κB通路
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Detecting Circles Using a Two-Stage Approach 被引量:1
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作者 Wen-Yen Wu 《Journal of Electronic Science and Technology》 CAS 2014年第3期318-321,共4页
We propose a two-stage method for detecting circular objects in this paper. In the first stage, curves are divided as linear segments or nonlinear segments. A least square estimator is used to find the estimated cente... We propose a two-stage method for detecting circular objects in this paper. In the first stage, curves are divided as linear segments or nonlinear segments. A least square estimator is used to find the estimated centers and radii of the nonlinear segments in the second stage. The found centers and radii are then evaluated to see if there exist circles in the nonlinear segments. Both of the broken and occluded circular objects are evaluated for the proposed method. From the experimental results, it is seen that the proposed method is efficient. 展开更多
关键词 circle detection curve segmentation error estimation FITTING
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