The absolute delay caused by equipment of radio navigation satellite service (RNSS) signal channel must be calibrated in the application of positioning. The measurement accuracy of absolute delay will affect the posit...The absolute delay caused by equipment of radio navigation satellite service (RNSS) signal channel must be calibrated in the application of positioning. The measurement accuracy of absolute delay will affect the positioning precision of RNSS user. An absolute delay measurement technique using digital envelope detection was developed for RNSS signal transmission channel. The RNSS transmission signal of navigation satellite and the one pulse per second (1PPS)generated by satellite time keeping system were sampled synchronously. With sampling data of 1PPS,the reference point of the absolute delay can be decided at first,and then sampling data of RNSS transmission signal were truncated. The truncated data were processed using digital envelop detection algorithm to search the phase converting points of RNSS signal. Finally,the absolute delay of RNSS signal transmitting channel was calculated. Uncertainty of measurement with proposed technique is lower than 0. 2 ns as the sampling frequency is 10 GHz.展开更多
The module for function electrical stimulation (FES) of neurons is designed for the research of the neural function regeneration microelectronic system, which is an in-body embedded micro module. It is implemented b...The module for function electrical stimulation (FES) of neurons is designed for the research of the neural function regeneration microelectronic system, which is an in-body embedded micro module. It is implemented by using discrete devices at first and characterized in vitro. The module is used to stimulate sciatic nerve and spinal cord of rats and rabbits for in-vivo real-time experiments of the neural function regeneration system. Based on the module, a four channel module for the FES of neurons is designed for 12 sites cuff electrode or 10 sites shaft electrode. Three animal experiments with total five rats and two rabbits were made. In the in-vivo experiment, the neural signals including spontaneous and imitated were regenerated by the module. The stimulating signal was used to drive sciatic nerve and spinal cord of rats and rabbits, successfully caused them twitch in different parts of their bodies, such as legs, tails, and fingers. This testifies that the neural function regeneration system can regenerate the neural signals.展开更多
Synthesis of ultra-wideband (UWB) linear frequency modulation radar signals is a very important technology for microwave imaging, target identification and detection of low radar-cross-section (RCS) targets. A new...Synthesis of ultra-wideband (UWB) linear frequency modulation radar signals is a very important technology for microwave imaging, target identification and detection of low radar-cross-section (RCS) targets. A new method of UWB radar signals generation with two-channel signal generator is presented. The realization structure is given; the principle and errors of signal synthesis are analyzed. At the same time, an automatic .adjustment measure of signal phase is proposed because of phase discontinuity of waveform in this method. The simulation experiment and analysis results indicate that radar signals with large instantaneous bandwidth can be generated by means of this method on the condition that the high-speed digital devices are limited.展开更多
A Bayesian estimation method to separate multicomponent signals with single channel observation is presented in this paper. By using the basis function projection, the component separation becomes a problem of limited...A Bayesian estimation method to separate multicomponent signals with single channel observation is presented in this paper. By using the basis function projection, the component separation becomes a problem of limited parameter estimation. Then, a Bayesian model for estimating parameters is set up. The reversible jump MCMC (Monte Carlo Markov Chain) algorithmis adopted to perform the Bayesian computation. The method can jointly estimate the parameters of each component and the component number. Simulation results demonstrate that the method has low SNR threshold and better performance.展开更多
The through silicon via (TSV) technology has proven to be the critical enabler to realize a three-dimensional (3D) gigscale system with higher performance but shorter interconnect length. However, the received dig...The through silicon via (TSV) technology has proven to be the critical enabler to realize a three-dimensional (3D) gigscale system with higher performance but shorter interconnect length. However, the received digital signal after trans- mission through a TSV channel, composed of redistribution layers (RDLs), TSVs, and bumps, is degraded at a high data-rate due to the non-idealities of the channel. We propose the Chebyshev multisection transformers to reduce the signal reflec- tion of TSV channel when operating frequency goes up to 20 GHz, by which signal reflection coefficient ($11) and signal transmission coefficient ($21) are improved remarkably by 150% and 73.3%, respectively. Both the time delay and power dissipation are also reduced by 4% and 13.3%, respectively. The resistance-inductance-conductance-capacitance (RLGC) elements of the TSV channel are iterated from scattering (S)-parameters, and the proposed method of weakening the signal reflection is verified using high frequency simulator structure (HFSS) simulation software by Ansoft.展开更多
Description Cellular membranes present natural borders for signal transduction between cells and their environment. Nature developed different strategies to enable signals to cross the membrane barrier. The goal of th...Description Cellular membranes present natural borders for signal transduction between cells and their environment. Nature developed different strategies to enable signals to cross the membrane barrier. The goal of this meeting is to discuss the molecular mechanisms of transmembrane signaling on the basis of three protein classes, i.e.展开更多
The single ion channel signal is an ionic current that can be recorded by the patch clamp technique. Hidden Markov model (HMM) algorithm has been used to convert the low signal noise ratio (SNR) noisy recording into a...The single ion channel signal is an ionic current that can be recorded by the patch clamp technique. Hidden Markov model (HMM) algorithm has been used to convert the low signal noise ratio (SNR) noisy recording into an idealized quantal one in the case of white background noise. The traditional HMM algorithm is extended and adapted to the colored background noise. A new algorithm called EHMM (Extended HMM) algorithm is proposed, and mainly validated by simulation. Results show that it’s effective.展开更多
A new method based on phase difference analysis is proposed for the single-channel mixed signal separation of single-channel radar fuze.This method is used to estimate the mixing coefficients of de-noised signals thro...A new method based on phase difference analysis is proposed for the single-channel mixed signal separation of single-channel radar fuze.This method is used to estimate the mixing coefficients of de-noised signals through the cumulants of mixed signals,solve the candidate data set by the mixing coefficients and signal analytical form,and resolve the problem of vector ambiguity by analyzing the phase differences.The signal separation is realized by exchanging data of the solutions.The waveform similarity coefficients are calculated,and the time鈥攆requency distributions of separated signals are analyzed.The results show that the proposed method is effective.展开更多
A novel read channel for signal waveform modulation multi-level disc is presented in this paper. This read channel employs timing recovery system and partial response maximum likelihood detector. Compared to the previ...A novel read channel for signal waveform modulation multi-level disc is presented in this paper. This read channel employs timing recovery system and partial response maximum likelihood detector. Compared to the previous read channel composed of level detection and run-length detection, the present read channel shows superiority in capacity increase and robust performance. Especially, relying on the partial response maximum likelihood detection, lower bit error rate can be obtained.展开更多
BACKGROUND: The onset of focal cerebral ischemia activates extracellular signal-regulated kinases 1 and 2, regulates cell cycle, promotes cell proliferation and differentiation, and affects the normal stage and funct...BACKGROUND: The onset of focal cerebral ischemia activates extracellular signal-regulated kinases 1 and 2, regulates cell cycle, promotes cell proliferation and differentiation, and affects the normal stage and function of brain cells. OBJECTIVE: To observe the effects of electroacupuncture at the Ren channel on extracellular signal-regulated kinases 1/2 expression in the lateral cerebral ventricle wall of rats with focal cerebral ischemia. The effects were analyzed at different time points after intervention. DESIGN: Randomized controlled study. SETTING: Department of Anatomy, Sun Yat-Sen University. MATERIALS: A total of 60 healthy adult male Wistar rats weighing (250±10) g were provided by the Experimental Animal Center, Medical College of Sun Yat-Sen University. The animal experiment was conducted with confirmed consent by the local ethics committee. The GB6805-Ⅱ electric acupuncture apparatus was provided by Shanghai Medical Equipment High-techno Company. METHODS: The experiment was performed at the Laboratory of Anatomy, Sun Yat-Sen University, from February to July 2007. All experimental animals were randomly divided into the following groups: normal group (n = 6), sham operation group (n = 18), model group (n = 18), and electroacupuncture group (n = 18). Middle cerebral artery occlusion (MCAO) was performed in the model group and electroacupuncture group. Zea Longa's grading standard was used to assess neurological impairment after reperfusion; animals whose grades were between l and 4 were included in this study. The normal control group was not exposed to MCAO. In sham operation animals, the right common carotid artery (CCA) was isolated, and the external carotid artery (ECA) was damaged, but no embolism was induced. The electroacupuncture group was given acupuncture on the second day after surgery. The acupoint locations were chosen according to Experimental Acupuncture (People's Publishing House; 1997; First Edition). The Chengjiang, Qihai, and Guanyuan acupoints were labeled and connected to a G6805 electroacupuncture apparatus with sparse-dense waves (sparse waves were 30 Hz, dense waves were 100 Hz), with a frequency of 6-15 V. The duration was 20 minutes. Two days after surgery, the model and sham operation groups were placed with their backs on the operating table, but they received no acupuncture. However, the normal group received acupuncture. The experimental animals under anesthesia were sacrificed on days 7, 14, and 28 post-surgery. Western blot analysis was used to measure expression of extracellular signal-regulated kinases 1/2 in the inferior region of the lateral cerebral ventricle wall. Expression was measured in the normal group at time points corresponding to the sham operation group. MAIN OUTCOME MEASURES: Expression of extracellular signal-regulated kinases 1/2 in the inferior region of the lateral cerebral ventricle wall at different time points after intervention. RESULTS: All 60 rats were included in the final analysis, without any loss. Seven days after MCAO, there was no significant difference in extracellular signal-regulated kinases 1/2 expression in the electroacupuncture group compared to the model group (P 〉 0.05). However, extracellular signal-regulated kinases 1/2 expression significantly increased in the model group at 14 and 28 days after treatment (P 〈 0.05). CONCLUSION: Electroacupuncture at the Ren channel can enhance extracellular signal-regulated kinasesl/2 expression in the inferior region of the lateral cerebral ventricle wall of rats with focal cerebral ischemia. However, this effect is not apparent until 14 days after electroacupuncture intervention.展开更多
Statistical Signal Transmission(SST)is a technique based on orthogonal frequency-division multiplexing(OFDM)and adopts cyclostationary features,which can transmit extra information without additional bandwidth.However...Statistical Signal Transmission(SST)is a technique based on orthogonal frequency-division multiplexing(OFDM)and adopts cyclostationary features,which can transmit extra information without additional bandwidth.However,the more complicated environment in 5G communication systems,especially the fast time-varying scenarios,will dramatically degrade the performance of the SST.In this paper,we propose a fragmental weight-conservation combining(FWCC)scheme for SST,to overcome its performance degradation under fast time-varying channels.The proposed FWCC scheme consists of three phases:1、incise the received OFDM stream into pieces;2、endue different weights for fine and contaminated pieces,respectively;3、combine cyclic autocorrelation function energies of all the pieces;and 4、compute the final feature and demodulate data of SST.Through these procedures above,the detection accuracy of SST will be theoretically refined under fast time-varying channels.Such an inference is confirmed through numerical results in this paper.It is demonstrated that the BER performance of proposed scheme outperforms that of the original scheme both in ideal channel estimation conditions and in imperfect channel estimation conditions.In addition,we also find the experiential optimal weight distribution strategy for the proposed FWCC scheme,which facilitates practical applications.展开更多
The transports of the dynamic biochemical signals in the non-reversing pulsatile flows in the mixing microchannel of a Y-shaped microfluidic device are ana- lyzed. The results show that the mixing micro-channel acts a...The transports of the dynamic biochemical signals in the non-reversing pulsatile flows in the mixing microchannel of a Y-shaped microfluidic device are ana- lyzed. The results show that the mixing micro-channel acts as a low-pass filter, and the biochemical signals are nonlinearly modulated by the pulsatile flows, which depend on the biochemical signal frequency, the flow signal frequency, and the biochemical signal transporting distance. It is concluded that, the transfer characteristics of the dynamic biochemical signals, which are transported in the time-varying flows, should be carefully considered for better loading biochemical signals on the cells cultured on the bottom of the microfluidic channel.展开更多
This paper presents an analysis of dispersion of dynamic biochemical signals in steady flow in a shallow Y-type microfluidic channel. A method is presented to control the flow widths of two steady flows in the Y-type ...This paper presents an analysis of dispersion of dynamic biochemical signals in steady flow in a shallow Y-type microfluidic channel. A method is presented to control the flow widths of two steady flows in the Y-type microchannel from two inlets.The transfer function for the Y-type microchannel is given by solving the governing equation for the Taylor-Aris dispersion in the microchannel. The amplitude-frequency and phase-frequency relations are provided which show that a shallow Y-type microchannel acts as a low-pass filter. The transports of different dynamic biochemical signals are investigated. In comparison with a fully mixing microfluidic channel, the magnitudes of the dynamic signals at the outlets in a Y-type microchannel are much smaller than those in a fully mixing microchannel, which demonstrates that the amplitude attenuation in a Y-type microchannel is larger than that of a fully mixing microchannel due to the transverse molecular diffusion. In order to control the desired signal in a microchannel, the solution of the inverse problem for the channel is also presented.展开更多
In the future the fifth generation( 5 G) communication systems,channel models may be very complicated and it is difficult to calculate equivalent signal to interference plus noise ratio( SINR)of a random fading channe...In the future the fifth generation( 5 G) communication systems,channel models may be very complicated and it is difficult to calculate equivalent signal to interference plus noise ratio( SINR)of a random fading channel. Therefore,methods for the calculation of equivalent SINR of a random fading channel are very necessary.In this paper,an enhanced algorithm on the exponential effective SINR mapping( EESM) model for random fading channels was proposed. First, the optimal adjustment parameters of typical channel fading models including extended pedestrian A( EPA)model,extended vehicular A( EVA) model and extended typical urban( ETU) model were obtained by simulation. Then the proposed solution was used to actualize channel classification according to the maximum multipath delay and the average power of the random channel. The solution can determine the typical channel closest to random channel for obtaining the optimal adjustment value of EESM. The evaluation results indicate that the proposed one can improve the whole system throughput significantly and meanwhile the accuracy of the link prediction algorithm is also guaranteed.展开更多
We review recent work on broadband RF channelizers based on integrated optical frequency Kerr micro-combs combined with passive micro-ring resonator filters,with microcombs having channel spacings of 200 and 49 GHz.Th...We review recent work on broadband RF channelizers based on integrated optical frequency Kerr micro-combs combined with passive micro-ring resonator filters,with microcombs having channel spacings of 200 and 49 GHz.This approach to realizing RF channelizers offers reduced complexity,size,and potential cost for a wide range of applications to microwave signal detection.展开更多
In order to solve the cross-channel signal problem caused by the uniform channelized wideband digital receiver when processing wideband signal and the problem that the sensitivity of the system greatly decreases when ...In order to solve the cross-channel signal problem caused by the uniform channelized wideband digital receiver when processing wideband signal and the problem that the sensitivity of the system greatly decreases when the bandwidth of wideband digital receiver increases,which both decrease the wideband radar signal detection performance,a new wideband digital receiver based on the modulated wideband converter(MWC)discrete compressed sampling structure and an energy detection method based on the new receiver are proposed.Firstly,the proposed receiver utilizes periodic pseudo-random sequences to mix wideband signals with baseband and other sub-bands.Then the mixed signals are low-pass filtered and downsampled to obtain the baseband compressed sampling data,which can increase the sensitivity of the system.Meanwhile,the cross-channel signal will all appear in any subbands,so the cross-channel signal problem can be solved easily by processing the baseband compressed sampling data.Secondly,we establish the signal detection model and formulate the criterion of the energy detection method.And we directly utilize the baseband compressed sampling data to carry out signal detection without signal reconstruction,which decreases the complexity of the algorithm and reduces the computational burden.Finally,simulation experiments demonstrate the effectiveness of the proposed receiver and show that the proposed signal detection method is effective in low signal-to-noise ratio(SNR)compared with the conventional energy detection and the probability of detection increases significantly when SNR increases.展开更多
Calcium ions (Ca2+) act as an intracellular second messenger and affect nearly all aspects of cellular life. They are functioned by interacting with polar auxin transport, and the negative phototropism of plant roo...Calcium ions (Ca2+) act as an intracellular second messenger and affect nearly all aspects of cellular life. They are functioned by interacting with polar auxin transport, and the negative phototropism of plant roots is caused by the transport of auxin from the irradiated side to the shaded side of the roots. To clarify the role of calcium signaling in the modulation of rice root negative phototropism, as well as the relationship between polar auxin transport and calcium signaling, calcium signaling reagents were used to treat rice seminal roots which were cultivated in hydroculture and unilaterally illuminated at an intensity of 100-200 pmol/(m2.s) for 24 h. Negative phototropism curvature and growth rate of rice roots were both promoted by exogenous CaCI2 lower than 100 pmol/L, but inhibited by calcium channel blockers (verapamil and LaCI3), calcineurin inhibitor (chlorpromazine, CPZ), and polar auxin transport inhibitor (N-l-naphthylphthalamic acid, NPA). Roots stopped growing and negative phototropism disappeared when the concentrations increased to 100 pmol/L verapamil, 12.500 ~Jmol/L LaCI3, 60 pmol/L CPZ, and 6 pmol/L NPA. Moreover, 100 pmol/L CaCI2 could relieve the inhibition of LaCI3, verapamil and NPA. The enhanced negative phototropism curvature was caused by the transportation of more auxin from the irradiated side to the shaded side in the presence of exogenous Ca2+. Calcium signaling plays a key role as a second messenger in the process of light signal regulation of rice root growth and negative phototropism.展开更多
In order to improve the efficiency and success rate of the side channel attack,the utility of side channel information of the attack object must be analyzed and evaluated before the attack implementation.Based on the ...In order to improve the efficiency and success rate of the side channel attack,the utility of side channel information of the attack object must be analyzed and evaluated before the attack implementation.Based on the study of side-channel attack techniques,a method is proposed in this paper to analyze and evaluate the utility of side channel information and the evaluation indexes of comentropy,Signal-to-Noise Ratio(SNR)are introduced.On this basis,the side channel information(power and electromagnetic)of a side channel attack experiment board is analyzed and evaluated,and the Data Encryption Standard(DES)cipher algorithm is attacked with the differential power attack method and differential electromagnetic attack method.The attack results show the effectiveness of the analysis and evaluation method proposed in this paper.展开更多
This paper proposes a desirable method to detect different kinds of low probability of intercept (LPI) radar signals, targeted at the main intra-pulse modulation method of LPI radar signals including the signals of li...This paper proposes a desirable method to detect different kinds of low probability of intercept (LPI) radar signals, targeted at the main intra-pulse modulation method of LPI radar signals including the signals of linear frequency modulation, phase code, and frequency code. Firstly, it improves the coherent integration of LPI radar signals by adding the periodicity of the ambiguity function. Then, it develops a frequency domain detection method based on fast Fourier transform (FFT) and segmented autocorrelation function to detect signals without features of linear frequency modulation by virtue of the distribution characteristics of noise signals in the frequency domain. Finally, this paper gives a verification of the performance of the method for different signal-to-noise ratios by conducting simulation experiments, and compares the method with existing ones. Additionally, this method is characterized by the straightforward calculation and high real-time performance, which is conducive to better detecting all kinds of LPI radar signals.展开更多
基金National Science and Technology Major Project of China(No.DHZX01A02004)
文摘The absolute delay caused by equipment of radio navigation satellite service (RNSS) signal channel must be calibrated in the application of positioning. The measurement accuracy of absolute delay will affect the positioning precision of RNSS user. An absolute delay measurement technique using digital envelope detection was developed for RNSS signal transmission channel. The RNSS transmission signal of navigation satellite and the one pulse per second (1PPS)generated by satellite time keeping system were sampled synchronously. With sampling data of 1PPS,the reference point of the absolute delay can be decided at first,and then sampling data of RNSS transmission signal were truncated. The truncated data were processed using digital envelop detection algorithm to search the phase converting points of RNSS signal. Finally,the absolute delay of RNSS signal transmitting channel was calculated. Uncertainty of measurement with proposed technique is lower than 0. 2 ns as the sampling frequency is 10 GHz.
基金The National Natural Science Foundation of China(No69825101,90377013)
文摘The module for function electrical stimulation (FES) of neurons is designed for the research of the neural function regeneration microelectronic system, which is an in-body embedded micro module. It is implemented by using discrete devices at first and characterized in vitro. The module is used to stimulate sciatic nerve and spinal cord of rats and rabbits for in-vivo real-time experiments of the neural function regeneration system. Based on the module, a four channel module for the FES of neurons is designed for 12 sites cuff electrode or 10 sites shaft electrode. Three animal experiments with total five rats and two rabbits were made. In the in-vivo experiment, the neural signals including spontaneous and imitated were regenerated by the module. The stimulating signal was used to drive sciatic nerve and spinal cord of rats and rabbits, successfully caused them twitch in different parts of their bodies, such as legs, tails, and fingers. This testifies that the neural function regeneration system can regenerate the neural signals.
文摘Synthesis of ultra-wideband (UWB) linear frequency modulation radar signals is a very important technology for microwave imaging, target identification and detection of low radar-cross-section (RCS) targets. A new method of UWB radar signals generation with two-channel signal generator is presented. The realization structure is given; the principle and errors of signal synthesis are analyzed. At the same time, an automatic .adjustment measure of signal phase is proposed because of phase discontinuity of waveform in this method. The simulation experiment and analysis results indicate that radar signals with large instantaneous bandwidth can be generated by means of this method on the condition that the high-speed digital devices are limited.
文摘A Bayesian estimation method to separate multicomponent signals with single channel observation is presented in this paper. By using the basis function projection, the component separation becomes a problem of limited parameter estimation. Then, a Bayesian model for estimating parameters is set up. The reversible jump MCMC (Monte Carlo Markov Chain) algorithmis adopted to perform the Bayesian computation. The method can jointly estimate the parameters of each component and the component number. Simulation results demonstrate that the method has low SNR threshold and better performance.
基金Project supported by the National Natural Science Foundation of China(Grant No.61204044)
文摘The through silicon via (TSV) technology has proven to be the critical enabler to realize a three-dimensional (3D) gigscale system with higher performance but shorter interconnect length. However, the received digital signal after trans- mission through a TSV channel, composed of redistribution layers (RDLs), TSVs, and bumps, is degraded at a high data-rate due to the non-idealities of the channel. We propose the Chebyshev multisection transformers to reduce the signal reflec- tion of TSV channel when operating frequency goes up to 20 GHz, by which signal reflection coefficient ($11) and signal transmission coefficient ($21) are improved remarkably by 150% and 73.3%, respectively. Both the time delay and power dissipation are also reduced by 4% and 13.3%, respectively. The resistance-inductance-conductance-capacitance (RLGC) elements of the TSV channel are iterated from scattering (S)-parameters, and the proposed method of weakening the signal reflection is verified using high frequency simulator structure (HFSS) simulation software by Ansoft.
文摘Description Cellular membranes present natural borders for signal transduction between cells and their environment. Nature developed different strategies to enable signals to cross the membrane barrier. The goal of this meeting is to discuss the molecular mechanisms of transmembrane signaling on the basis of three protein classes, i.e.
文摘The single ion channel signal is an ionic current that can be recorded by the patch clamp technique. Hidden Markov model (HMM) algorithm has been used to convert the low signal noise ratio (SNR) noisy recording into an idealized quantal one in the case of white background noise. The traditional HMM algorithm is extended and adapted to the colored background noise. A new algorithm called EHMM (Extended HMM) algorithm is proposed, and mainly validated by simulation. Results show that it’s effective.
文摘A new method based on phase difference analysis is proposed for the single-channel mixed signal separation of single-channel radar fuze.This method is used to estimate the mixing coefficients of de-noised signals through the cumulants of mixed signals,solve the candidate data set by the mixing coefficients and signal analytical form,and resolve the problem of vector ambiguity by analyzing the phase differences.The signal separation is realized by exchanging data of the solutions.The waveform similarity coefficients are calculated,and the time鈥攆requency distributions of separated signals are analyzed.The results show that the proposed method is effective.
文摘A novel read channel for signal waveform modulation multi-level disc is presented in this paper. This read channel employs timing recovery system and partial response maximum likelihood detector. Compared to the previous read channel composed of level detection and run-length detection, the present read channel shows superiority in capacity increase and robust performance. Especially, relying on the partial response maximum likelihood detection, lower bit error rate can be obtained.
基金the National Natural Science Foundation of China, No. 30371808Post-doctor's Project of Guangzhou University of Traditional Chinese Medicine, No.106B3YH0411
文摘BACKGROUND: The onset of focal cerebral ischemia activates extracellular signal-regulated kinases 1 and 2, regulates cell cycle, promotes cell proliferation and differentiation, and affects the normal stage and function of brain cells. OBJECTIVE: To observe the effects of electroacupuncture at the Ren channel on extracellular signal-regulated kinases 1/2 expression in the lateral cerebral ventricle wall of rats with focal cerebral ischemia. The effects were analyzed at different time points after intervention. DESIGN: Randomized controlled study. SETTING: Department of Anatomy, Sun Yat-Sen University. MATERIALS: A total of 60 healthy adult male Wistar rats weighing (250±10) g were provided by the Experimental Animal Center, Medical College of Sun Yat-Sen University. The animal experiment was conducted with confirmed consent by the local ethics committee. The GB6805-Ⅱ electric acupuncture apparatus was provided by Shanghai Medical Equipment High-techno Company. METHODS: The experiment was performed at the Laboratory of Anatomy, Sun Yat-Sen University, from February to July 2007. All experimental animals were randomly divided into the following groups: normal group (n = 6), sham operation group (n = 18), model group (n = 18), and electroacupuncture group (n = 18). Middle cerebral artery occlusion (MCAO) was performed in the model group and electroacupuncture group. Zea Longa's grading standard was used to assess neurological impairment after reperfusion; animals whose grades were between l and 4 were included in this study. The normal control group was not exposed to MCAO. In sham operation animals, the right common carotid artery (CCA) was isolated, and the external carotid artery (ECA) was damaged, but no embolism was induced. The electroacupuncture group was given acupuncture on the second day after surgery. The acupoint locations were chosen according to Experimental Acupuncture (People's Publishing House; 1997; First Edition). The Chengjiang, Qihai, and Guanyuan acupoints were labeled and connected to a G6805 electroacupuncture apparatus with sparse-dense waves (sparse waves were 30 Hz, dense waves were 100 Hz), with a frequency of 6-15 V. The duration was 20 minutes. Two days after surgery, the model and sham operation groups were placed with their backs on the operating table, but they received no acupuncture. However, the normal group received acupuncture. The experimental animals under anesthesia were sacrificed on days 7, 14, and 28 post-surgery. Western blot analysis was used to measure expression of extracellular signal-regulated kinases 1/2 in the inferior region of the lateral cerebral ventricle wall. Expression was measured in the normal group at time points corresponding to the sham operation group. MAIN OUTCOME MEASURES: Expression of extracellular signal-regulated kinases 1/2 in the inferior region of the lateral cerebral ventricle wall at different time points after intervention. RESULTS: All 60 rats were included in the final analysis, without any loss. Seven days after MCAO, there was no significant difference in extracellular signal-regulated kinases 1/2 expression in the electroacupuncture group compared to the model group (P 〉 0.05). However, extracellular signal-regulated kinases 1/2 expression significantly increased in the model group at 14 and 28 days after treatment (P 〈 0.05). CONCLUSION: Electroacupuncture at the Ren channel can enhance extracellular signal-regulated kinasesl/2 expression in the inferior region of the lateral cerebral ventricle wall of rats with focal cerebral ischemia. However, this effect is not apparent until 14 days after electroacupuncture intervention.
基金supported by the National Natural Science Foundation of China (Nos. 61801461, 61801460)the Strategical Leadership Project of Chinese Academy of Sciences (grant No. XDC02070800)the Shanghai Municipality of Science and Technology Commission Project (Nos. 18XD1404100, 17QA1403800)
文摘Statistical Signal Transmission(SST)is a technique based on orthogonal frequency-division multiplexing(OFDM)and adopts cyclostationary features,which can transmit extra information without additional bandwidth.However,the more complicated environment in 5G communication systems,especially the fast time-varying scenarios,will dramatically degrade the performance of the SST.In this paper,we propose a fragmental weight-conservation combining(FWCC)scheme for SST,to overcome its performance degradation under fast time-varying channels.The proposed FWCC scheme consists of three phases:1、incise the received OFDM stream into pieces;2、endue different weights for fine and contaminated pieces,respectively;3、combine cyclic autocorrelation function energies of all the pieces;and 4、compute the final feature and demodulate data of SST.Through these procedures above,the detection accuracy of SST will be theoretically refined under fast time-varying channels.Such an inference is confirmed through numerical results in this paper.It is demonstrated that the BER performance of proposed scheme outperforms that of the original scheme both in ideal channel estimation conditions and in imperfect channel estimation conditions.In addition,we also find the experiential optimal weight distribution strategy for the proposed FWCC scheme,which facilitates practical applications.
基金Project supported by the National Natural Science Foundation of China(Nos.11172060 and11672065)
文摘The transports of the dynamic biochemical signals in the non-reversing pulsatile flows in the mixing microchannel of a Y-shaped microfluidic device are ana- lyzed. The results show that the mixing micro-channel acts as a low-pass filter, and the biochemical signals are nonlinearly modulated by the pulsatile flows, which depend on the biochemical signal frequency, the flow signal frequency, and the biochemical signal transporting distance. It is concluded that, the transfer characteristics of the dynamic biochemical signals, which are transported in the time-varying flows, should be carefully considered for better loading biochemical signals on the cells cultured on the bottom of the microfluidic channel.
基金National Natural Science Foundation of Chinagrant number:11172060the Fundamental Research Funds for the Central Universities in China
文摘This paper presents an analysis of dispersion of dynamic biochemical signals in steady flow in a shallow Y-type microfluidic channel. A method is presented to control the flow widths of two steady flows in the Y-type microchannel from two inlets.The transfer function for the Y-type microchannel is given by solving the governing equation for the Taylor-Aris dispersion in the microchannel. The amplitude-frequency and phase-frequency relations are provided which show that a shallow Y-type microchannel acts as a low-pass filter. The transports of different dynamic biochemical signals are investigated. In comparison with a fully mixing microfluidic channel, the magnitudes of the dynamic signals at the outlets in a Y-type microchannel are much smaller than those in a fully mixing microchannel, which demonstrates that the amplitude attenuation in a Y-type microchannel is larger than that of a fully mixing microchannel due to the transverse molecular diffusion. In order to control the desired signal in a microchannel, the solution of the inverse problem for the channel is also presented.
基金Institute of Nonlinear Science of Donghua University,China
文摘In the future the fifth generation( 5 G) communication systems,channel models may be very complicated and it is difficult to calculate equivalent signal to interference plus noise ratio( SINR)of a random fading channel. Therefore,methods for the calculation of equivalent SINR of a random fading channel are very necessary.In this paper,an enhanced algorithm on the exponential effective SINR mapping( EESM) model for random fading channels was proposed. First, the optimal adjustment parameters of typical channel fading models including extended pedestrian A( EPA)model,extended vehicular A( EVA) model and extended typical urban( ETU) model were obtained by simulation. Then the proposed solution was used to actualize channel classification according to the maximum multipath delay and the average power of the random channel. The solution can determine the typical channel closest to random channel for obtaining the optimal adjustment value of EESM. The evaluation results indicate that the proposed one can improve the whole system throughput significantly and meanwhile the accuracy of the link prediction algorithm is also guaranteed.
文摘We review recent work on broadband RF channelizers based on integrated optical frequency Kerr micro-combs combined with passive micro-ring resonator filters,with microcombs having channel spacings of 200 and 49 GHz.This approach to realizing RF channelizers offers reduced complexity,size,and potential cost for a wide range of applications to microwave signal detection.
基金supported by the National Natural Science Foundation of China(No.61571146)the Fundamental Research Funds for the Central Universities(HEUCF1608)
文摘In order to solve the cross-channel signal problem caused by the uniform channelized wideband digital receiver when processing wideband signal and the problem that the sensitivity of the system greatly decreases when the bandwidth of wideband digital receiver increases,which both decrease the wideband radar signal detection performance,a new wideband digital receiver based on the modulated wideband converter(MWC)discrete compressed sampling structure and an energy detection method based on the new receiver are proposed.Firstly,the proposed receiver utilizes periodic pseudo-random sequences to mix wideband signals with baseband and other sub-bands.Then the mixed signals are low-pass filtered and downsampled to obtain the baseband compressed sampling data,which can increase the sensitivity of the system.Meanwhile,the cross-channel signal will all appear in any subbands,so the cross-channel signal problem can be solved easily by processing the baseband compressed sampling data.Secondly,we establish the signal detection model and formulate the criterion of the energy detection method.And we directly utilize the baseband compressed sampling data to carry out signal detection without signal reconstruction,which decreases the complexity of the algorithm and reduces the computational burden.Finally,simulation experiments demonstrate the effectiveness of the proposed receiver and show that the proposed signal detection method is effective in low signal-to-noise ratio(SNR)compared with the conventional energy detection and the probability of detection increases significantly when SNR increases.
基金supported by the National Natural Science Foundation of China (Grant No. 31071353) the Open Fund of Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization of Huanggang Normal University, China (Grant Nos. 2013000503 and 2011BLKF243)
文摘Calcium ions (Ca2+) act as an intracellular second messenger and affect nearly all aspects of cellular life. They are functioned by interacting with polar auxin transport, and the negative phototropism of plant roots is caused by the transport of auxin from the irradiated side to the shaded side of the roots. To clarify the role of calcium signaling in the modulation of rice root negative phototropism, as well as the relationship between polar auxin transport and calcium signaling, calcium signaling reagents were used to treat rice seminal roots which were cultivated in hydroculture and unilaterally illuminated at an intensity of 100-200 pmol/(m2.s) for 24 h. Negative phototropism curvature and growth rate of rice roots were both promoted by exogenous CaCI2 lower than 100 pmol/L, but inhibited by calcium channel blockers (verapamil and LaCI3), calcineurin inhibitor (chlorpromazine, CPZ), and polar auxin transport inhibitor (N-l-naphthylphthalamic acid, NPA). Roots stopped growing and negative phototropism disappeared when the concentrations increased to 100 pmol/L verapamil, 12.500 ~Jmol/L LaCI3, 60 pmol/L CPZ, and 6 pmol/L NPA. Moreover, 100 pmol/L CaCI2 could relieve the inhibition of LaCI3, verapamil and NPA. The enhanced negative phototropism curvature was caused by the transportation of more auxin from the irradiated side to the shaded side in the presence of exogenous Ca2+. Calcium signaling plays a key role as a second messenger in the process of light signal regulation of rice root growth and negative phototropism.
文摘In order to improve the efficiency and success rate of the side channel attack,the utility of side channel information of the attack object must be analyzed and evaluated before the attack implementation.Based on the study of side-channel attack techniques,a method is proposed in this paper to analyze and evaluate the utility of side channel information and the evaluation indexes of comentropy,Signal-to-Noise Ratio(SNR)are introduced.On this basis,the side channel information(power and electromagnetic)of a side channel attack experiment board is analyzed and evaluated,and the Data Encryption Standard(DES)cipher algorithm is attacked with the differential power attack method and differential electromagnetic attack method.The attack results show the effectiveness of the analysis and evaluation method proposed in this paper.
基金supported by the National Natural Science Foundation of China(61571462)Weapons and Equipment Exploration Research Project(7131464)
文摘This paper proposes a desirable method to detect different kinds of low probability of intercept (LPI) radar signals, targeted at the main intra-pulse modulation method of LPI radar signals including the signals of linear frequency modulation, phase code, and frequency code. Firstly, it improves the coherent integration of LPI radar signals by adding the periodicity of the ambiguity function. Then, it develops a frequency domain detection method based on fast Fourier transform (FFT) and segmented autocorrelation function to detect signals without features of linear frequency modulation by virtue of the distribution characteristics of noise signals in the frequency domain. Finally, this paper gives a verification of the performance of the method for different signal-to-noise ratios by conducting simulation experiments, and compares the method with existing ones. Additionally, this method is characterized by the straightforward calculation and high real-time performance, which is conducive to better detecting all kinds of LPI radar signals.