Substantial evidence has suggested that deep brain stimulation of the cuneiform nucleus has become a remarkable treatment option for intractable pain,but the possible mechanism is poorly understood. Using a melanocort...Substantial evidence has suggested that deep brain stimulation of the cuneiform nucleus has become a remarkable treatment option for intractable pain,but the possible mechanism is poorly understood. Using a melanocortin-4 receptor（MC4R）-green fluorescent protein（GFP） reporter knockin mouse,we showed that a large number of MC4R-GFP-positive neurons were expressed in the cuneiform nucleus. Immunofluorescence revealed that approximately 40%–50% of MC4R-GFP-positive neurons expressed mu opioid receptors,indicating that they were opioidergic signaling. Our findings support the hypothesis that MC4 R expression in the cuneiform nucleus is involved in the modulation of opioidergic signaling.展开更多
OpticallylabeledIM/FSKsignalsaretransmittedover50kmofSMFunderdifferentcompensationschemes.All-optical label swapping based on MZ-SOA and EAM is presented. Transmission followed by label swapping shows a 2dB overall po...OpticallylabeledIM/FSKsignalsaretransmittedover50kmofSMFunderdifferentcompensationschemes.All-optical label swapping based on MZ-SOA and EAM is presented. Transmission followed by label swapping shows a 2dB overall power penalty.展开更多
基金supported by a grant from Health and Family Planning Commission of Hubei Province(No.WJ2015MB008)
文摘Substantial evidence has suggested that deep brain stimulation of the cuneiform nucleus has become a remarkable treatment option for intractable pain,but the possible mechanism is poorly understood. Using a melanocortin-4 receptor（MC4R）-green fluorescent protein（GFP） reporter knockin mouse,we showed that a large number of MC4R-GFP-positive neurons were expressed in the cuneiform nucleus. Immunofluorescence revealed that approximately 40%–50% of MC4R-GFP-positive neurons expressed mu opioid receptors,indicating that they were opioidergic signaling. Our findings support the hypothesis that MC4 R expression in the cuneiform nucleus is involved in the modulation of opioidergic signaling.
文摘OpticallylabeledIM/FSKsignalsaretransmittedover50kmofSMFunderdifferentcompensationschemes.All-optical label swapping based on MZ-SOA and EAM is presented. Transmission followed by label swapping shows a 2dB overall power penalty.
