Aiming at the problem of detecting a distributed target when signal mismatch occurs,this paper proposes a tunable detector parameterized by an adjustable parameter.By adjusting the parameter,the tunable detector can a...Aiming at the problem of detecting a distributed target when signal mismatch occurs,this paper proposes a tunable detector parameterized by an adjustable parameter.By adjusting the parameter,the tunable detector can achieve robust or selective detection of mismatched signals.Moreover,the proposed tunable detector,with a proper tunable parameter,can provide higher detection probability compared with existing detectors in the case of no signal mismatch.In addition,the proposed tunable detector possesses the constant false alarm rate property with the unknown noise covariance matrix.展开更多
The problem of adaptive detection in the situation of signal mismatch is considered; that is, the actual signal steering vector is not aligned with the nominal one. Two novel tunable detectors are proposed. They can c...The problem of adaptive detection in the situation of signal mismatch is considered; that is, the actual signal steering vector is not aligned with the nominal one. Two novel tunable detectors are proposed. They can control the degree to which the mismatched signals are rejected. Remarkably, it is found that they both cover existing famous detectors as their special cases. More importantly, they possess the constant false alarm rate（CFAR）property and achieve enhanced mismatched signal rejection or improved robustness than their natural competitors. Besides, they can provide slightly better matched signals detection performance than the existing detectors.展开更多
Colorectal cancer is the second most leading cause of cancer related deaths in the western countries. One of the forms of colorectal cancer is hereditary non-polyposis colorectal cancer (HNPCC), also known as "Ly...Colorectal cancer is the second most leading cause of cancer related deaths in the western countries. One of the forms of colorectal cancer is hereditary non-polyposis colorectal cancer (HNPCC), also known as "Lynch syndrome". It is the most common hereditary form of cancer accounting for 5%-10% of all colon cancers. HNPCC is a dominant autosomal genetic disorder caused by germ line mutations in mismatch repair genes. Human mismatch repair genes play a crucial role in genetic stability of DNA, the inactivation of which results in an increased rate of mutation and often a loss of mismatch repair function. Recent studies have shown that certain mismatch repair genes are involved in the regulation of key cellular processes including apoptosis. Thus, differential expression of mismatch repair genes particularly the contributions of MLH1 and MSH2 play important roles in therapeutic resistance to certain cytotoxic drugs such as cisplatin that is used normally as chemoprevention. An understanding of the role of mismatch repair genes in molecular signaling mechanism of apoptosis and its involvement in HNPCC needs attention for further work into this important area of cancer research, and this review article is intended to accomplish that goal of linkage of apoptosis with HNPCC. The current review was not intended to provide a comprehensive enumeration of the entire body of literature in the area of HNPCC or mismatch repair system or apoptosis; it is rather intended to focus primarily on the current state of knowledge of the role of mismatch repair proteins in molecular signaling mechanism of apoptosis as it relates to understanding of HNPCC.展开更多
针对双通道时间交织模数转换器(ADC)采样系统中的通道间失配问题,提出了一种新的频域纠正补偿算法,即利用单次测量得到的不同频率处的固定补偿系数来实现时间交织ADC频响的部分补偿,并从理论和实验上分别进行了推导和可行性验证。实验...针对双通道时间交织模数转换器(ADC)采样系统中的通道间失配问题,提出了一种新的频域纠正补偿算法,即利用单次测量得到的不同频率处的固定补偿系数来实现时间交织ADC频响的部分补偿,并从理论和实验上分别进行了推导和可行性验证。实验结果表明:在双通道12比特2 Gsample/s时间交织ADC采样系统下,650 MHz带宽范围内的无杂散动态范围(SFDR)可以提高到40 d B。展开更多
基金supported by the National Natural Science Foundation of China(62071482)。
文摘Aiming at the problem of detecting a distributed target when signal mismatch occurs,this paper proposes a tunable detector parameterized by an adjustable parameter.By adjusting the parameter,the tunable detector can achieve robust or selective detection of mismatched signals.Moreover,the proposed tunable detector,with a proper tunable parameter,can provide higher detection probability compared with existing detectors in the case of no signal mismatch.In addition,the proposed tunable detector possesses the constant false alarm rate property with the unknown noise covariance matrix.
基金supported by the National Natural Science Foundation of China(6110216960925005)
文摘The problem of adaptive detection in the situation of signal mismatch is considered; that is, the actual signal steering vector is not aligned with the nominal one. Two novel tunable detectors are proposed. They can control the degree to which the mismatched signals are rejected. Remarkably, it is found that they both cover existing famous detectors as their special cases. More importantly, they possess the constant false alarm rate（CFAR）property and achieve enhanced mismatched signal rejection or improved robustness than their natural competitors. Besides, they can provide slightly better matched signals detection performance than the existing detectors.
基金Supported by NSF-EPSCoR P3 Center and NASA-EOSCoR Research Infrastructure Development Funds to Ali N
文摘Colorectal cancer is the second most leading cause of cancer related deaths in the western countries. One of the forms of colorectal cancer is hereditary non-polyposis colorectal cancer (HNPCC), also known as "Lynch syndrome". It is the most common hereditary form of cancer accounting for 5%-10% of all colon cancers. HNPCC is a dominant autosomal genetic disorder caused by germ line mutations in mismatch repair genes. Human mismatch repair genes play a crucial role in genetic stability of DNA, the inactivation of which results in an increased rate of mutation and often a loss of mismatch repair function. Recent studies have shown that certain mismatch repair genes are involved in the regulation of key cellular processes including apoptosis. Thus, differential expression of mismatch repair genes particularly the contributions of MLH1 and MSH2 play important roles in therapeutic resistance to certain cytotoxic drugs such as cisplatin that is used normally as chemoprevention. An understanding of the role of mismatch repair genes in molecular signaling mechanism of apoptosis and its involvement in HNPCC needs attention for further work into this important area of cancer research, and this review article is intended to accomplish that goal of linkage of apoptosis with HNPCC. The current review was not intended to provide a comprehensive enumeration of the entire body of literature in the area of HNPCC or mismatch repair system or apoptosis; it is rather intended to focus primarily on the current state of knowledge of the role of mismatch repair proteins in molecular signaling mechanism of apoptosis as it relates to understanding of HNPCC.
文摘针对双通道时间交织模数转换器(ADC)采样系统中的通道间失配问题,提出了一种新的频域纠正补偿算法,即利用单次测量得到的不同频率处的固定补偿系数来实现时间交织ADC频响的部分补偿,并从理论和实验上分别进行了推导和可行性验证。实验结果表明:在双通道12比特2 Gsample/s时间交织ADC采样系统下,650 MHz带宽范围内的无杂散动态范围(SFDR)可以提高到40 d B。
