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The coordinated evolution of ecological environment,public service,and tourism economy along the Silk Road Economic Belt,using the Dual-Carbon Targets
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作者 Shuo Yang Wei Guo +1 位作者 Tianjun Xu Tongtong Liu 《Chinese Journal of Population,Resources and Environment》 2024年第1期34-47,共14页
Carbon peak and carbon neutrality(dual-carbon)are important targets for the international response to climate change.The Silk Road Economic Belt is a strategic resource region and is important for future ecological en... Carbon peak and carbon neutrality(dual-carbon)are important targets for the international response to climate change.The Silk Road Economic Belt is a strategic resource region and is important for future ecological environment and tourism development.Based on the“dual-carbon”targets,the Single index quantification,Multiple index synthesis,and Poly-criteria integration evaluation model were used in this study to measure the coordinated development index of the ecological environment,public service,and tourism economy along the Silk Road Economic Belt and to analyze its spatial and temporal evolution.Further,it explores the dynamic evolution and development trend of the three systems using the Kernel Density and Grey Markov Prediction Model.The results show that the coordinated development index along this region needs to be improved during the study period.Furthermore,the coordinated development index of the Southwest region is relatively higher than that of the Northwest region.From the development trend of the three systems,all of them develop in a stable manner;however,the tourism economy system is easily affected by external disturbances.The coordinated development index of the three systems changes dynamically and tends to be in a good state of coordination.There is a certain spatial and temporal heterogeneity.The gravity center of the coordinated development index has been in the Southwest region.During the forecast period,the coordinated development index along this region will improve significantly,while insufficient and unbalanced development will continue. 展开更多
关键词 Dual-carbon Ecological environment Public services Tourist economy silk Road Economic Belt
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Synergistic effects of three traditional herbs green tea,mulberry leaf and corn silk on glucose uptake level of L6 myoblasts and the hypoglycemic mechanism
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作者 Jing-Na Zhou Ming-Yue Li +4 位作者 Ting-Ting Zhang Jing-Yang Lu Min Zhang Peng-Wei Zhuang Hai-Xia Chen 《Traditional Medicine Research》 2024年第7期1-12,共12页
Background:Green tea,mulberry leaf and corn silk are traditional herbs used in the prevention and treatment of diabetes in China for a long time,but their synergistic hypoglycemic effects and mechanisms remain unclear... Background:Green tea,mulberry leaf and corn silk are traditional herbs used in the prevention and treatment of diabetes in China for a long time,but their synergistic hypoglycemic effects and mechanisms remain unclear.Methods:The effective components of green tea,mulberry leaf and corn silk were extracted and enriched.Mixture design of experiments was used to study the influences of different combinations on the cell viability and glucose uptake level of L6 myoblasts,so as to determine the optimal synergistic hypoglycemic combination.The possible hypoglycemic mechanism of the optimal synergistic combination was explored by cytotoxicity assay,glucose uptake assay,and western blot.Results:Three polyphenol enrichment fractions of the herbs,30%ethanol elution fraction of green tea(GT),50%ethanol elution fraction of mulberry leaf(ML)and 60%ethanol elution fraction of corn silk(CS)were obtained.The antioxidant activities of GT-30%,ML-50%and CS-60%were superior to those of crude extracts,and showed strong potential inα-amylase andα-glucosidase inhibition activities.The optimal synergistic combination of crude extracts G7(crude extract of green tea:crude extract of mulberry leaf:crude extract of corn silk=1:5:3),polyphenol enrichment fractions R3(GT-30%:ML-50%:CS-60%=1:7:1)and monomers X2(epigallocatechin gallate:morusin:formononetin=3:1:2)were selected,respectively.G7,R3,and X2 showed promoting effects on the cell viability and glucose uptake of L6 myoblasts within the detected concentration range.In addition,G7,R3,and X2 could increase the expression levels of p-PI3K/PI3K and p-Akt/Akt in L6 myoblasts,and promote the translocation of Glut4,but G7 and R3 showed more significant effects.Conclusion:The synergistic hypoglycemic effects of green tea,mulberry leaf and corn silk had the characteristics of multiple-components and multiple-targets with p-PI3K/PI3K,p-Akt/Akt and the translocation of Glut4 signal pathways involved.The three traditional herbs might have the potential to be combined used for the prevention and treatment of diabetes based on the synergistic hypoglycemic effects. 展开更多
关键词 green tea mulberry leaf corn silk synergistic effect type 2 diabetes mellitus mechanism
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皖南伏岭A型花岗岩的成因——地球化学、锆石U-Pb年龄及Lu—Hf同位素特征
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作者 郑伟 陈天虎 +3 位作者 杜建国 陈芳 丁宁 张舒 《地质论评》 CAS CSCD 北大核心 2024年第1期189-206,共18页
伏岭花岗岩体,位于江南造山带东段的皖浙相邻区,岩浆岩沿着近北东向的宁国—绩溪深大断裂断分布。笔者等对伏岭岩体鱼龙川(γ_(5)^(3-2))单元花岗岩开展了系统的全岩岩石地球化学、LA-ICPMS锆石U-Pb同位素年龄和锆石原位Lu—Hf同位素地... 伏岭花岗岩体,位于江南造山带东段的皖浙相邻区,岩浆岩沿着近北东向的宁国—绩溪深大断裂断分布。笔者等对伏岭岩体鱼龙川(γ_(5)^(3-2))单元花岗岩开展了系统的全岩岩石地球化学、LA-ICPMS锆石U-Pb同位素年龄和锆石原位Lu—Hf同位素地球化学研究,结果表明,花岗岩的侵位年龄为131.8±0.9 Ma,富硅、富碱、贫钙、贫铁,具有较高的Rb、Th、U、Ga、Zr和Y含量,较低的Sr、Ba和Nb含量,稀土配分曲线呈现典型的“海鸥式”分布特征,显示强烈的负Eu异常;微量元素原始地幔标准化蛛网图显示明显的Ba、Sr、Nb的负异常。其高SiO_(2)含量和Rb/Sr值、低Ba、Sr含量具备江南造山带东段皖南地区A型花岗岩的典型特征。岩体具有同源岩浆演化特征,源区可能存在磷灰石、钛铁矿的分离结晶作用,而辉石类的分离较少。伏岭岩体主要来源于地壳中镁铁质岩石的部分熔融,其地球化学特征继承于源岩。锆石ε_(Hf)(t)变化范围较小,均在-7.0~-4.6之间,二阶段模式年龄(TDM2)为1478~1630 Ma,伏岭花岗岩可能由中元古代古老下地壳部分熔融形成。伏岭岩体的形成可能受到碰撞作用的影响,岩体形成于后碰撞期,中元古代的基底岩石被大范围的熔融,从而产生了伏岭A型花岗岩。 展开更多
关键词 伏岭 A型花岗岩 岩石地球化学 锆石U-PB年龄 lu—Hf同位素 构造环境 江南造山带 皖南
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国产无载体镥[^(177)Lu]的制备及标记DOTA⁃TOC在神经内分泌肿瘤中的初步临床应用探讨
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作者 姚晓晨 张朋俊 +4 位作者 陈正国 杨宇川 田瑞 俞飞 王峰 《南京医科大学学报(自然科学版)》 CAS 北大核心 2024年第2期235-241,共7页
目的:阐述国产无载体镥[^(177)Lu]制备工艺及^(177)Lu标记1,4,7,10⁃四氮杂环十二烷⁃1,4,7,10⁃四乙酸⁃酪氨酸3⁃奥曲肽(1,4,7,10⁃tetraazacyclododecane⁃1,4,7,10⁃tetraacetic acid conjugated Tyr3⁃octreotide,DOTA⁃TOC)的方法,探讨国产^... 目的:阐述国产无载体镥[^(177)Lu]制备工艺及^(177)Lu标记1,4,7,10⁃四氮杂环十二烷⁃1,4,7,10⁃四乙酸⁃酪氨酸3⁃奥曲肽(1,4,7,10⁃tetraazacyclododecane⁃1,4,7,10⁃tetraacetic acid conjugated Tyr3⁃octreotide,DOTA⁃TOC)的方法,探讨国产^(177)Lu⁃DO⁃TA⁃TOC初步临床应用的安全性及有效性。方法:采用多级连续分离纯化制备国产无载体镥[^(177)Lu],全自动化模块标记合成^(177)Lu⁃DOTA⁃TOC,回顾分析南京医科大学附属南京医院4例仅接受了国产无载体镥[^(177)Lu]标记DOTA⁃TOC的肽受体放射性核素靶向治疗(peptide receptor radionuclide therapy,PRRT)神经内分泌肿瘤(neuroendocrine neoplasm,NEN)患者资料。结果:国产无载体镥[^(177)Lu]质控良好,铜<0.01,锌<0.01,铁<0.01,铅<0.15,镱未检出,放化纯>99%,细菌内毒素<2 EU/mL。国产^(177)Lu⁃DOTA⁃TOC自动化标记产率为(98.85±0.97)%,产品比活度为(80.96±7.47)GBq/μmol,无菌和内毒素检测均符合规定标准,标记产物中乙醇含量为0,放化纯大于99%。仅接受国产^(177)Lu⁃DOTA⁃TOC治疗的4例患者中,1例仅1次治疗后原发灶及转移灶几乎完全消失,1例治疗后1个月出现3级骨髓毒性,治疗后3个月恢复至正常,所有患者均未出现肾毒性。结论:国产无载体镥[^(177)Lu]标记DOTA⁃TOC质控合格,产率高,安全、耐受性好,对于无法手术切除的NEN患者具有较好疗效。无载体镥[^(177)Lu]的国产化和批量化生产将推动我国核医学诊疗一体化的发展。 展开更多
关键词 无载体镥[^(177)lu] 神经内分泌肿瘤 肽受体放射性核素治疗 临床应用
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^(177)Lu-前列腺特异性膜抗原放射性配体疗法治疗前列腺癌临床应用专家共识
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作者 刘国兵 卓维海 +43 位作者 顾宇参 杨志 陈跃 樊卫 郭剑明 谭建 朱小华 霍力 兰晓莉 李彪 缪蔚冰 宋少莉 徐浩 田蓉 罗全勇 王峰 王雪梅 杨爱民 戴东 邓智勇 赵晋华 陈晓良 范岩 高再荣 韩星敏 蒋宁一 匡安仁 林岩松 刘甫庚 楼岑 苏新辉 唐立钧 王辉 王欣璐 杨福洲 杨辉 赵新明 杨波 黄晓冬 陈继亮 李思进 汪静 李亚明 石洪成 《中国临床医学》 2024年第5期844-850,F0003,共8页
^(177)Lu标记的前列腺特异性膜抗原(prostate specific membrane antigen,PSMA)放射性配体疗法已在国外获批应用于晚期前列腺癌治疗,且正在国内开展多项临床试验。专家组参考国外经验和观点,并结合国内临床实践和实测数据,形成^(177)Lu-... ^(177)Lu标记的前列腺特异性膜抗原(prostate specific membrane antigen,PSMA)放射性配体疗法已在国外获批应用于晚期前列腺癌治疗,且正在国内开展多项临床试验。专家组参考国外经验和观点,并结合国内临床实践和实测数据,形成^(177)Lu-PSMA放射性配体疗法在前列腺癌临床应用中的专家共识。 展开更多
关键词 ^(177)lu标记的前列腺特异性膜抗原 前列腺癌 放射性配体治疗 专家共识
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基于LU分解的安全外包求解线性代数方程组方法
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作者 冯达 周福才 +1 位作者 吴淇毓 李鲍 《东北大学学报(自然科学版)》 EI CAS CSCD 北大核心 2024年第4期457-463,506,共8页
由于现有协议的安全性为基于某种安全假设的计算安全,依赖于敌手的计算能力,因此,本文针对恶意敌手模型,使用矩阵伪装技术对方程的系数矩阵进行隐藏,结合矩阵的LU分解(lower-upper decomposition)算法,提出一种新的信息论安全外包求解... 由于现有协议的安全性为基于某种安全假设的计算安全,依赖于敌手的计算能力,因此,本文针对恶意敌手模型,使用矩阵伪装技术对方程的系数矩阵进行隐藏,结合矩阵的LU分解(lower-upper decomposition)算法,提出一种新的信息论安全外包求解线性代数方程组(information-theoretically secure outsourcing of linear algebraic equations,ITS-OutsLAE)方法 .与之前的研究相比,在保持计算和通信复杂度与现有最优方案保持一致的同时,首次将方程组唯一解的安全性提升至信息论安全(完美保密).给出了形式化的安全性证明,并通过理论分析和实验证明了所提方法的实用性. 展开更多
关键词 线性代数方程组 信息论安全 安全外包 lu分解 恶意敌手模型
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燕辽裂陷槽基底陆壳生长事件——来自长城系碎屑锆石U-Pb年龄和Lu—Hf同位素的启示
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作者 李文奇 刘汇川 +3 位作者 刘小平 于志琪 王艺壬 王莹莹 《地质论评》 CAS CSCD 北大核心 2024年第4期1335-1352,共18页
华北克拉通大陆地壳生长已有大量研究,但对于被巨厚沉积盖层覆盖的燕辽裂陷槽基底地壳生长的问题前人讨论较少。笔者等以燕辽裂陷槽基底之上的长城系沉积岩为研究对象,统计了燕辽裂陷槽内长城系地层中碎屑锆石年龄频谱和Lu—Hf同位素数... 华北克拉通大陆地壳生长已有大量研究,但对于被巨厚沉积盖层覆盖的燕辽裂陷槽基底地壳生长的问题前人讨论较少。笔者等以燕辽裂陷槽基底之上的长城系沉积岩为研究对象,统计了燕辽裂陷槽内长城系地层中碎屑锆石年龄频谱和Lu—Hf同位素数据,探讨长城系地层沉积年龄、碎屑锆石沉积源区和地壳生长事件等科学问题。同位素年龄将燕辽裂陷槽长城系沉积年龄约束为1680 Ma,代表着燕辽裂陷槽的开启时间。燕辽裂陷槽长城系碎屑锆石年龄频谱主要显示为2.7~2.5 Ga和2.2~1.9 Ga两个阶段,Hf同位素ε_(Hf)(t)表现为高的正值区间0.1~34.6。通过对比长城系碎屑锆石与华北克拉通结晶基底的U-Pb定年、Lu—Hf同位素ε_(Hf)(t)和T_(DM2)模式年龄数据,推测燕辽裂陷槽长城系沉积物源为燕辽裂陷槽下伏基底。结合碎屑锆石U-Pb定年、ε_(Hf)(t)值和T_(DM2)模式年龄数据,我们认为燕辽裂陷槽下伏基底中元古代前地壳生长有3个峰值,分别为2.7~2.5 Ga,2.2~1.9 Ga和1.7~1.6 Ga。 展开更多
关键词 燕辽裂陷槽 长城系 长城群 碎屑锆石 U-Pb年龄 lu—Hf同位素 陆壳生长
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^(177)Lu-PSMA放射性配体疗法治疗前列腺癌的临床实践专家共识(2024年版) 被引量:1
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作者 中国抗癌协会肿瘤核医学专业委员会 中国医师协会核医学医师分会 +5 位作者 宋少莉 樊卫 黄钢 徐文贵 赵新明 杨辉 《中国癌症杂志》 CAS CSCD 北大核心 2024年第7期702-714,共13页
镥-177标记前列腺特异性膜抗原放射性配体疗法(^(177)Lu-labeled prostate-specific membrane antigen radioligand therapy,^(177)Lu-PSMA-RLT)是一种通过精准地向前列腺癌细胞递送^(177)Lu释放的β射线,引发肿瘤细胞DNA的辐射损伤从... 镥-177标记前列腺特异性膜抗原放射性配体疗法(^(177)Lu-labeled prostate-specific membrane antigen radioligand therapy,^(177)Lu-PSMA-RLT)是一种通过精准地向前列腺癌细胞递送^(177)Lu释放的β射线,引发肿瘤细胞DNA的辐射损伤从而杀灭肿瘤的创新治疗方法。现阶段国内外多个前列腺癌领域权威指南与共识推荐其用于治疗转移性去势抵抗性前列腺癌(metastatic castrate-resistant prostate cancer,mCRPC),国内尚未见关于^(177)Lu-PSMA-RLT治疗前列腺癌的临床实践路径和用药规范的报道。本共识由中国抗癌协会肿瘤核医学专业委员会和中国医师协会核医学医师分会共同发起,结合现有的^(177)Lu-PSMA-RLT注册研究结果、真实世界数据及国内外放射性核素临床治疗经验,根据牛津循证医学中心临床证据推荐等级和证据级别来评价不同级别的证据,在适应证、患者筛选、用药不良反应、随访和辐射安全等方面给出推荐意见。本共识旨在为临床医师提供^(177)Lu-PSMA-RLT治疗前列腺癌的临床参考,为进一步制订行业相关指南奠定基础。 展开更多
关键词 镥-177标记前列腺特异性膜抗原放射性配体疗法 前列腺癌 临床实践 专家共识
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A Brief Discussion on the Development of the Silk-Weaving Industry Along the “Southern Silk Road” in Yunnan 被引量:1
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作者 Lin Kaiqiang 《Contemporary Social Sciences》 2024年第1期18-33,共16页
Ancient Yunnan was one of the most significant regions along China’s ancient“Southern Silk Road.”During the Nanzhao period(738–902)of the late Tang Dynasty,Yunnan’s silk-weaving industry underwent a qualitative l... Ancient Yunnan was one of the most significant regions along China’s ancient“Southern Silk Road.”During the Nanzhao period(738–902)of the late Tang Dynasty,Yunnan’s silk-weaving industry underwent a qualitative leap as skilled silk craftsmen from the Bashu area migrated to Yunnan and introduced mulberry planting,silkworm breeding,and advanced silk-weaving techniques from Sichuan to the region.Consequently,people in Yunnan gradually acquired expertise in brocade weaving and embroidery.Many even mastered complex silk-weaving techniques.The development and progress of the silk-weaving industry in the ancient Yunnan region were intricately linked to the economic function and value of silk as both a commodity and currency along the“Southern Silk Road.”The local government in ancient Yunnan was greatly motivated by the economic interests brought by the development of silk-related industries and recognized the significance of developing the local silk industry.They even initiated a campaign to capture skilled silk craftsmen from Sichuan,aiming to foster the growth of the silk-weaving industry in Yunnan.After years of dedicated efforts from the local government in ancient Yunnan,the region emerged as a significant hub for silk production along China’s ancient“Southern Silk Road.”Despite the devastation caused by the wars in other parts of the country,Yunnan’s silk industry continued to thrive and provide ample silk products to sustain trade along this renowned route.In the contemporary era,amidst the decline of the silk-weaving industry in eastern China,Yunnan has proposed an industrial development strategy known as“relocating the silk-weaving industry from east to west.”This involves introducing advanced silk production techniques from the eastern regions into Yunnan to enhance and enrich its local silk industry,thereby establishing it as a traditional national sector and securing a competitive position within the global silk market.The historical experience of Yunnan’s silk industry demonstrated that economic development opportunities can only be seized through proactive endeavors rather than passive anticipation.The modern Yunnan silk industry,which upholds its historical traditions,continues to actively engage in international high-end technical cooperation,thus ensuring the enduring vitality of the ancient“Southern Silk Road.” 展开更多
关键词 Southern silk Road Bashu area YUNNAN silk-weaving technique
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吉南夹皮沟地区变质侵入岩的锆石U-Pb定年、Lu-Hf同位素分析及其构造意义 被引量:1
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作者 徐强 郭佳丽 周喜文 《岩石学报》 SCIE EI CAS CSCD 北大核心 2024年第11期3363-3378,共16页
吉南夹皮沟变质地体作为华北克拉通东北部太古宙基底的重要组成部分,其新太古代到古元古代的构造演化过程一直存在争议。为此,在详细野外地质调查基础上,选择三种代表性变质侵入岩,开展了锆石稀土微量元素、锆石U-Pb定年与Lu-Hf同位素... 吉南夹皮沟变质地体作为华北克拉通东北部太古宙基底的重要组成部分,其新太古代到古元古代的构造演化过程一直存在争议。为此,在详细野外地质调查基础上,选择三种代表性变质侵入岩,开展了锆石稀土微量元素、锆石U-Pb定年与Lu-Hf同位素分析工作。结果显示:夹皮沟地区紫苏花岗岩的侵位年龄为2504±8Ma,并记录有2476±13Ma的变质年龄;其锆石Hf模式年龄介于2.82~2.66Ga之间,εHf(t)值介于1.72~5.1之间,反映为新生地壳物质再循环的产物。变辉长岩体(斜长角闪岩)的侵位年龄为2529±14Ma,并记录有2484±23Ma的变质年龄。变基性岩墙(石榴角闪岩)的侵位年龄为2214±18Ma,并记录有1930±16Ma的变质年龄;其岩浆锆石具有异常高的εHf(t)值(7~15),并存在明显的重稀土亏损现象,推测其母岩浆来源于富含石榴石的岩石圈地幔。综合多种信息,认为吉南地区新太古代末期(2.50~2.48Ga)构造热事件受大规模地幔柱活动控制,古元古代中晚期(2.2~1.84Ga)构造热事件可能源于克拉通边缘板块俯冲引起的碰撞造山作用。 展开更多
关键词 变质侵入体 锆石U-PB定年 锆石lu-Hf同位素 夹皮沟 吉林南部
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基于鲲鹏处理器的LU并行分解优化算法
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作者 徐鹤 周涛 +2 位作者 李鹏 秦芳芳 季一木 《计算机科学》 CSCD 北大核心 2024年第9期51-58,共8页
ScaLAPACK(Scalable Linear Algebra PACKage)是并行计算软件包,适用于分布式存储的MIMD(Multiple Instruction,Multiple Data)并行计算机,被广泛应用于基于线性代数运算的并行应用程序开发。然而在进行LU分解过程中,ScaLAPACK库中的例... ScaLAPACK(Scalable Linear Algebra PACKage)是并行计算软件包,适用于分布式存储的MIMD(Multiple Instruction,Multiple Data)并行计算机,被广泛应用于基于线性代数运算的并行应用程序开发。然而在进行LU分解过程中,ScaLAPACK库中的例程并不是通信最优的,没有充分利用当前的并行架构。针对上述问题,提出一种基于鲲鹏处理器的LU并行分解优化算法(Parallel LU Factorization,PLF),实现了负载均衡,适配国产鲲鹏环境。PLF对不同进程的不同分区的数据进行差异化处理,并将每个进程所拥有的部分数据分配给根进程进行计算,之后再由根进程散播回各个子进程,这有利于充分利用CPU资源,实现负载均衡。在单节点Intel 9320R处理器以及鲲鹏(Kunpeng)920处理器环境中进行测试,其中,Intel平台下使用Intel MKL(Math Kernel Library),Kunpeng平台下使用PLF算法。对比两个平台关于不同规模的方程组求解的性能发现,Kunpeng平台的求解性能有显著优势。在NUMA数进程和单线程的情况下,优化后的计算效率在小规模平均达到4.35%,相比Intel的1.38%提升了215%;中规模平均达到4.24%,相比Intel平台的1.86%提升了118%;大规模平均达到4.24%,相比Intel的1.99%提升了113%。 展开更多
关键词 SCALAPACK lu分解 并行计算 MKL
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氢溴酸伏硫西汀片杂质Lu AF39904的合成
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作者 曹雪丽 郭晓 王建强 《化学研究与应用》 CAS 北大核心 2024年第8期1956-1960,共5页
本文报道了氢溴酸伏硫西汀片杂质Lu AF39904的合成方法。以2-溴碘苯、2,4-二甲基苯硫酚和哌嗪为原料,经“一锅法”反应制得氢溴酸伏硫西汀,氢溴酸伏硫西汀碱化游离后与溴乙酰氯缩合经一步反应即可制得杂质Lu AF39904。杂质Lu AF39904的... 本文报道了氢溴酸伏硫西汀片杂质Lu AF39904的合成方法。以2-溴碘苯、2,4-二甲基苯硫酚和哌嗪为原料,经“一锅法”反应制得氢溴酸伏硫西汀,氢溴酸伏硫西汀碱化游离后与溴乙酰氯缩合经一步反应即可制得杂质Lu AF39904。杂质Lu AF39904的结构经^(1)H-NMR、^(13)C-NMR和HR-MS(ESI)确证。该合成路线反应条件温和、原料廉价易得、操作简便。合成的杂质Lu AF39904为氢溴酸伏硫西汀片的质量控制提供了标准对照品。 展开更多
关键词 氢溴酸伏硫西汀 lu AF39904 合成
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Research on the Development of Fibroin and Nano-Fiber from Silk Cocoons for Regenerated Tissue Engineering Applications by Electro-Spinning
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作者 Md Kamrul Hasan Xinbo Ding 《Advances in Nanoparticles》 CAS 2024年第1期1-9,共9页
In this paper, the main goal is to prepare silk fibroin nano-fiber, which is used for regenerated tissue applications. Silk scaffold nano-fibers made by electro-spinning technology can be used in regenerated tissue ap... In this paper, the main goal is to prepare silk fibroin nano-fiber, which is used for regenerated tissue applications. Silk scaffold nano-fibers made by electro-spinning technology can be used in regenerated tissue applications. The purpose of the research is to prepare a silk-fibroin nano-fiber solution for potential applications in tissue engineering. Using a degumming process, pure silk fibroin protein is extracted from silk cocoons. The protein solution for fibroin is purified, and the protein content is determined. The precise chemical composition, exact temperature, time, voltage, distance, ratio, and humidity all have a huge impact on degumming, solubility, and electro-spinning nano-fibers. The SEM investigates the morphology of silk fibroin nano-fibres at different magnifications. It also reveals the surface condition, fiber orientation, and fiber thickness of the silk fibroin nano-fiber. The results show that regenerated silk fibroin and nano-fiber can be used in silk fibroin scaffolds for various tissue engineering applications. 展开更多
关键词 silk fibroin SCAFFOLD electro-spinning nano-fiber Tissue Engineering
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Lu-Mg和Lu-Al合金热力学性质的理论分析
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作者 纪凡 何荧 +1 位作者 向金秋 罗立平 《世界有色金属》 2024年第6期20-23,共4页
文章利用Miedema生成热模型计算Lu-Mg和Lu-Al二元合金的混合焓、过剩熵、过剩吉布斯自由能以及各组元的活度。结合Butler方程,计算Lu-Mg和Lu-Al合金熔体的表面张力以及表面相中各元素含量。研究结果表明,Lu-Mg和Lu-Al合金熔体的混合焓... 文章利用Miedema生成热模型计算Lu-Mg和Lu-Al二元合金的混合焓、过剩熵、过剩吉布斯自由能以及各组元的活度。结合Butler方程,计算Lu-Mg和Lu-Al合金熔体的表面张力以及表面相中各元素含量。研究结果表明,Lu-Mg和Lu-Al合金熔体的混合焓、过剩熵以及过剩吉布斯自由能都为负值,同时各组分活度较理想熔体有着一定负偏差,说明Lu与Mg和Al原子之间存在显著的相互作用力。Lu-Mg和Lu-Al合金熔体表面张力随Mg和Al含量的增加而减小,Mg和Al元素均会向熔体表面富集。 展开更多
关键词 MIEDEMA模型 Butler方程 活度 表面张力 lu-Mg lu-Al
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^(177)Lu-DOTATATE治疗GEP-NEN的体外辐射剂量学研究
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作者 戚鸣 张建平 +7 位作者 陈峙昊 杨洪星 乔莹 黄正文 唐亦睿 刘菲 徐俊彦 宋少莉 《肿瘤影像学》 2024年第5期501-507,共7页
目的:探讨^(177)Lu-DOTATATE治疗胃肠胰神经内分泌肿瘤(gastroenteropancreatic neuroendocrine neoplasm,GEP-NEN)后不同时间点患者体外辐射水平,为辐射安全及患者管理提供参考依据。方法:选择2023年5—11月在复旦大学附属肿瘤医院接受... 目的:探讨^(177)Lu-DOTATATE治疗胃肠胰神经内分泌肿瘤(gastroenteropancreatic neuroendocrine neoplasm,GEP-NEN)后不同时间点患者体外辐射水平,为辐射安全及患者管理提供参考依据。方法:选择2023年5—11月在复旦大学附属肿瘤医院接受^(177)Lu-DOTATATE住院治疗的GEP-NEN患者作为研究对象,单次静脉给予(7618.5±241.9)MBq的^(177)Lu-DOTATATE治疗,在给药后不同时间点,测量其正前方1 m处的周围剂量当量率,分析周围剂量当量率随时间的变化规律。结果:纳入的30例GEP-NEN患者共行78次^(177)Lu-DOTATATE治疗,给药结束后即刻其正前1 m处的平均剂量当量率为20.0μSv/h。周围剂量当量率随时间呈指数衰减,其降至10μSv/h的平均时间为3.95 h,95%CI上限时间为4.6 h。24 h内周围剂量当量率的有效半衰期为1.42 h。结论:在每次^(177)Lu-DOTATATE治疗后,其周围剂量当量率随时间快速降低,平均3.95 h时其在1 m处的周围剂量当量率降至10μSv/h。在4.6 h时,95%的患者可降至10μSv/h以下。本研究为中国制定^(177)Lu-DOTATATE治疗时患者的出院标准或患者的管理提供试验数据和依据。 展开更多
关键词 ^(177)lu-DOTATATE 肽受体放射性核素治疗 周围剂量当量率 辐射剂量
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Piezoelectric fibers based on silk fibroin with excellent output performance
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作者 甄文强 陈杰 +1 位作者 范苏娜 张耀鹏 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第8期128-135,共8页
The self-powered tissue engineering scaffold with good biocompatibility is of great significance for stimulating nerve cell growth.In this study,silk fibroin(SF)-based fibers with regulatable structure and piezoelectr... The self-powered tissue engineering scaffold with good biocompatibility is of great significance for stimulating nerve cell growth.In this study,silk fibroin(SF)-based fibers with regulatable structure and piezoelectric performance are fabricated by dry-spinning and post-treatment.The concentration of SF and calcium ion in spinning dope and the post-treatment affect the conformation transition and crystallinity of SF.As a result,the SF fibers exhibit high piezoelectric coefficient d_(33)(3.24 pm/V)and output voltage(~27 V).Furthermore,these piezoelectric fibers promote the growth of PC-12 cells,demonstrating the promising potential for nerve repair and other energy harvester. 展开更多
关键词 silk fibroin piezoelectric fiber DRY-SPINNING conformation transition
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A Review on Silk Fibroin as a Biomaterial in Tissue Engineering
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作者 Tkhu Chang Le Qian Zhang +3 位作者 Qingdi Qu Wentong Ding Sergej Anatolyevich Lazarev Shuang Pan 《Journal of Biosciences and Medicines》 2024年第3期275-290,共16页
Regenerative medicine progress is based on the development of cell and tissue bioengineering. One of the aims of tissue engineering is the development of scaffolds, which should substitute the functions of the replace... Regenerative medicine progress is based on the development of cell and tissue bioengineering. One of the aims of tissue engineering is the development of scaffolds, which should substitute the functions of the replaced organ after their implantation into the body. The tissue engineering material must meet a range of requirements, including biocompatibility, mechanical strength, and elasticity. Furthermore, the materials have to be attractive for cell growth: stimulate cell adhesion, migration, proliferation and differentiation. One of the natural biomaterials is silk and its component (silk fibroin). An increasing number of scientists in the world are studying silk and silk fibroin. The purpose of this review article is to provide information about the properties of natural silk (silk fibroin), as well as its manufacture and clinical application of each configuration of silk fibroin in medicine. Materials and research methods. Actual publications of foreign authors on resources PubMed, Medline, E-library have been analyzed. The selection criteria were materials containing information about the structure and components of silk, methods of its production in nature. This article placed strong emphasis on silk fibroin, the ways of artificial modification of it for use in various sphere of medicine. 展开更多
关键词 Tissue Engineering Biomaterial SCAFFOLD silk Fibroin
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Structural analysis of silk using solid-state NMR
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作者 Tetsuo Asakura 《Magnetic Resonance Letters》 2024年第3期19-34,共16页
Silkworms and spiders are capable of generating fibers that are both highly durable and elastic in a short span of time,using a silk solution stored within their bodies at room temperature and normal atmospheric press... Silkworms and spiders are capable of generating fibers that are both highly durable and elastic in a short span of time,using a silk solution stored within their bodies at room temperature and normal atmospheric pressure.The dragline silk fiber,which is essentially a spider's lifeline,surpasses the strength of a steel wire of equivalent thickness.Regrettably,humans have yet to replicate this process to produce fibers with similar high strength and elasticity in an eco-friendly manner.Therefore,it is of utmost importance to thoroughly comprehend the extraordinary structure and fibrillation mechanism of silk,and leverage this understanding in the manufacturing of high-strength,high-elasticity fibers.This review will delve into the recent progress in comprehending the structure of silks derived from silkworms and spiders,emphasizing the distinctive attributes of solidstate NMR. 展开更多
关键词 silk Bombyx mori SPIDER Solid-state NMR STRUCTURE
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The NAC transcription factor LuNAC61 negatively regulates fiber development in flax (Linum usitatissimum L.)
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作者 Dongwei Xie Jing Li +5 位作者 Wan Li Lijun Sun Zhigang Dai Wenzhi Zhou Jianguang Su Jian Sun 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2024年第3期795-805,共11页
Flax is a crucial fiber crop that exhibits excellent textile properties and serves as a model plant for investigating phloem fiber development. The regulation of multiple genes significantly influences fiber developme... Flax is a crucial fiber crop that exhibits excellent textile properties and serves as a model plant for investigating phloem fiber development. The regulation of multiple genes significantly influences fiber development, notably involving NAC(NAM, ATAF1/2, CUC2) transcription factors in forming the fiber secondary cell wall(SCW).Overexpression of LuNAC61 in flax resulted in sparse top meristematic zone leaves and significantly reduced stem cellulose content. Scanning electron microscopy and staining observations revealed a significant reduction in fiber bundles. β-Glucuronidase(GUS) staining analysis demonstrated high activity of the LuNAC61 promoter in the bast fibers of the flax stem. Additionally, several members of the LuPLATZ and LuCesA families exhibited significant coexpression with LuNAC61. Subcellular localization indicated the presence of LuPLATZ24 protein in the nucleus and cytoplasm, LuNAC61 protein exclusively in the nucleus, and LuCesA10 in the nucleus and endoplasmic reticulum. LuPLATZ24 positively regulates LuNAC61, whereas LuNAC61 negatively affects LuCesA10, suggesting the involvement of a metabolic network in regulating flax fiber development. In conclusion, this study provides a critical opportunity for a comprehensive and in-depth analysis of the mechanisms governing flax fiber development and the potential use of biotechnology to enhance flax fiber yield. 展开更多
关键词 FLAX fiber development lu NAC61 gene function gene interaction
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Engineering biomimetic silk fibroin hydrogel scaffolds with“organic-inorganic assembly”strategy for rapid bone regeneration
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作者 Renjie Liang Rui Li +10 位作者 Weidong Mo Xianzhu Zhang Jinchun Ye Chang Xie Wenyue Li Zhi Peng Yuqing Gu Yuxuan Huang Shufang Zhang Xiaozhao Wang Hongwei Ouyang 《Bioactive Materials》 SCIE CSCD 2024年第10期541-556,共16页
Although natural polymers have been widely used in constructing bone scaffolds,it still remains challenging to fabricate natural polymer-derived bone scaffolds with biomimetic mechanical properties as well as outstand... Although natural polymers have been widely used in constructing bone scaffolds,it still remains challenging to fabricate natural polymer-derived bone scaffolds with biomimetic mechanical properties as well as outstanding osteogenic properties for large-size and weight-bearing bone defects regeneration.Herein,an“organic-inorganic assembly”strategy is developed to construct silk fibroin(SF)-based bone scaffolds with the aforementioned merits.After secondary structure reshuffling,the 3.3-fold increment ofβ-sheet structures in SF hydrogel resulted in a 100-fold improvement of mineral-assembly efficacy via influencing the ion adsorption process and providing templates for mineral growth.Notably,abundant minerals were deposited within the hydrogel and also on the surface,which indicated entire mineral-assembly,which ensured the biomimetic mechanical properties of the digital light processing 3D printed SF hydrogel scaffolds with haversian-mimicking structure.In vitro experiments proved that the assembly between the mineral and SF results in rapid adhesion and enhanced osteogenic differentiation of human bone marrow-derived mesenchymal stem cells.In vivo experiments further proved that the mineral-assembled SF hydrogel scaffold could significantly enhance integration and bone regeneration at the weight-bearing site within one month.This SF-based“organic-inorganic assembly”strategy sheds light on constructing cell-free,growth factor-free and natural polymer-derived bone scaffolds with biomimetic 3D structure,mechanical properties and excellent osteogenic properties. 展开更多
关键词 silk fibroin Organic-inorganic assembly MINERALIZATION DLP 3D printing Bone regeneration
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