Photovoltaic(PV) power generation is characterized by randomness and intermittency due to weather changes.Consequently, large-scale PV power connections to the grid can threaten the stable operation of the power syste...Photovoltaic(PV) power generation is characterized by randomness and intermittency due to weather changes.Consequently, large-scale PV power connections to the grid can threaten the stable operation of the power system. An effective method to resolve this problem is to accurately predict PV power. In this study, an innovative short-term hybrid prediction model(i.e., HKSL) of PV power is established. The model combines K-means++, optimal similar day approach,and long short-term memory(LSTM) network. Historical power data and meteorological factors are utilized. This model searches for the best similar day based on the results of classifying weather types. Then, the data of similar day are inputted into the LSTM network to predict PV power. The validity of the hybrid model is verified based on the datasets from a PV power station in Shandong Province, China. Four evaluation indices, mean absolute error, root mean square error(RMSE),normalized RMSE, and mean absolute deviation, are employed to assess the performance of the HKSL model. The RMSE of the proposed model compared with those of Elman, LSTM, HSE(hybrid model combining similar day approach and Elman), HSL(hybrid model combining similar day approach and LSTM), and HKSE(hybrid model combining K-means++,similar day approach, and LSTM) decreases by 66.73%, 70.22%, 65.59%, 70.51%, and 18.40%, respectively. This proves the reliability and excellent performance of the proposed hybrid model in predicting power.展开更多
As social networks become increasingly complex, contemporary fake news often includes textual descriptionsof events accompanied by corresponding images or videos. Fake news in multiple modalities is more likely tocrea...As social networks become increasingly complex, contemporary fake news often includes textual descriptionsof events accompanied by corresponding images or videos. Fake news in multiple modalities is more likely tocreate a misleading perception among users. While early research primarily focused on text-based features forfake news detection mechanisms, there has been relatively limited exploration of learning shared representationsin multimodal (text and visual) contexts. To address these limitations, this paper introduces a multimodal modelfor detecting fake news, which relies on similarity reasoning and adversarial networks. The model employsBidirectional Encoder Representation from Transformers (BERT) and Text Convolutional Neural Network (Text-CNN) for extracting textual features while utilizing the pre-trained Visual Geometry Group 19-layer (VGG-19) toextract visual features. Subsequently, the model establishes similarity representations between the textual featuresextracted by Text-CNN and visual features through similarity learning and reasoning. Finally, these features arefused to enhance the accuracy of fake news detection, and adversarial networks have been employed to investigatethe relationship between fake news and events. This paper validates the proposed model using publicly availablemultimodal datasets from Weibo and Twitter. Experimental results demonstrate that our proposed approachachieves superior performance on Twitter, with an accuracy of 86%, surpassing traditional unimodalmodalmodelsand existing multimodal models. In contrast, the overall better performance of our model on the Weibo datasetsurpasses the benchmark models across multiple metrics. The application of similarity reasoning and adversarialnetworks in multimodal fake news detection significantly enhances detection effectiveness in this paper. However,current research is limited to the fusion of only text and image modalities. Future research directions should aimto further integrate features fromadditionalmodalities to comprehensively represent themultifaceted informationof fake news.展开更多
Text Summarization models facilitate biomedical clinicians and researchers in acquiring informative data from enormous domain-specific literature within less time and effort.Evaluating and selecting the most informati...Text Summarization models facilitate biomedical clinicians and researchers in acquiring informative data from enormous domain-specific literature within less time and effort.Evaluating and selecting the most informative sentences from biomedical articles is always challenging.This study aims to develop a dual-mode biomedical text summarization model to achieve enhanced coverage and information.The research also includes checking the fitment of appropriate graph ranking techniques for improved performance of the summarization model.The input biomedical text is mapped as a graph where meaningful sentences are evaluated as the central node and the critical associations between them.The proposed framework utilizes the top k similarity technique in a combination of UMLS and a sampled probability-based clustering method which aids in unearthing relevant meanings of the biomedical domain-specific word vectors and finding the best possible associations between crucial sentences.The quality of the framework is assessed via different parameters like information retention,coverage,readability,cohesion,and ROUGE scores in clustering and non-clustering modes.The significant benefits of the suggested technique are capturing crucial biomedical information with increased coverage and reasonable memory consumption.The configurable settings of combined parameters reduce execution time,enhance memory utilization,and extract relevant information outperforming other biomedical baseline models.An improvement of 17%is achieved when the proposed model is checked against similar biomedical text summarizers.展开更多
Neurodegeneration is attributable to metabolic disturbances in the various cell types responsible for this condition, in respect of glucose utilisation and dysfunctional mitochondrial oxidative mechanisms. The propert...Neurodegeneration is attributable to metabolic disturbances in the various cell types responsible for this condition, in respect of glucose utilisation and dysfunctional mitochondrial oxidative mechanisms. The properties of neurotoxins and antagonists that limit their action are well documented in disease models, whereas effective therapy is very limited. Cell apoptosis, a general marker of neurodegeneration, is also of therapeutic interest in the treatment of cancer. cGMP nucleotide influences apoptosis and has a role in maintaining equilibrium within cell redox parameters. The chemical structure of cGMP provides a comparative template for demonstrating relative molecular similarity within the structures of natural and synthetic compounds influencing tumour cell apoptosis. The present study uses computational software to investigate molecular similarity within the structures of cGMP and compounds that modulate cell apoptosis in experimental models of diabetic peripheral neuropathy (DPN), Parkinson’s and multiple sclerosis. Differential molecular similarity demonstrated in neurotoxin and antagonist structures implicate metabolite impairment of cGMP signaling function as a common mechanism in the initial phases of these neurodegenerative conditions.展开更多
Cholesterol and cholesterol oxides impact on the functional properties of cells, in respect of the intracellular and extracellular distribution of compounds across cell membranes, carcinogenesis and drug resistance. A...Cholesterol and cholesterol oxides impact on the functional properties of cells, in respect of the intracellular and extracellular distribution of compounds across cell membranes, carcinogenesis and drug resistance. Abnormal levels of cholesterol oxides and steroids in cancerous tissues promote interest in steroid receptor cross-talk during cell-signalling and the steroid metabolome of cancer patients. The research literature links the cytotoxic properties of oxysterols to interference with the NO/cGMP pathway. cGMP participates in cell-signalling and has a molecular structure that relates to cancer-inducing and cancer-preventing agents. This study uses a molecular modelling approach to compare the structures of cholesterol oxides to cGMP. Cholesterol and cholesterol oxide structures fit to a cGMP structural template in several ways, some of which are replicated by corticosteroids and gonadal steroid hormones. The results of this study support the concept that cholesterol oxides modulate cell apoptosis and autophagy via the NO/cGMP pathway and in conjunction with steroid hormones participate in modulating regulation of cell function by cGMP.展开更多
3D printing is widely adopted to quickly produce rock mass models with complex structures in batches,improving the consistency and repeatability of physical modeling.It is necessary to regulate the mechanical properti...3D printing is widely adopted to quickly produce rock mass models with complex structures in batches,improving the consistency and repeatability of physical modeling.It is necessary to regulate the mechanical properties of 3D-printed specimens to make them proportionally similar to natural rocks.This study investigates mechanical properties of 3D-printed rock analogues prepared by furan resin-bonded silica sand particles.The mechanical property regulation of 3D-printed specimens is realized through quantifying its similarity to sandstone,so that analogous deformation characteristics and failure mode are acquired.Considering similarity conversion,uniaxial compressive strength,cohesion and stress–strain relationship curve of 3D-printed specimen are similar to those of sandstone.In the study ranges,the strength of 3D-printed specimen is positively correlated with the additive content,negatively correlated with the sand particle size,and first increases then decreases with the increase of curing temperature.The regulation scheme with optimal similarity quantification index,that is the sand type of 70/140,additive content of 2.5‰and curing temperature of 81.6℃,is determined for preparing 3D-printed sandstone analogues and models.The effectiveness of mechanical property regulation is proved through uniaxial compression contrast tests.This study provides a reference for preparing rock-like specimens and engineering models using 3D printing technology.展开更多
For accurately identifying the distribution charac-teristic of Gaussian-like noises in unmanned aerial vehicle(UAV)state estimation,this paper proposes a non-parametric scheme based on curve similarity matching.In the...For accurately identifying the distribution charac-teristic of Gaussian-like noises in unmanned aerial vehicle(UAV)state estimation,this paper proposes a non-parametric scheme based on curve similarity matching.In the framework of the pro-posed scheme,a Parzen window(kernel density estimation,KDE)method on sliding window technology is applied for roughly esti-mating the sample probability density,a precise data probability density function(PDF)model is constructed with the least square method on K-fold cross validation,and the testing result based on evaluation method is obtained based on some data characteristic analyses of curve shape,abruptness and symmetry.Some com-parison simulations with classical methods and UAV flight exper-iment shows that the proposed scheme has higher recognition accuracy than classical methods for some kinds of Gaussian-like data,which provides better reference for the design of Kalman filter(KF)in complex water environment.展开更多
Ontologies have been used for several years in life sciences to formally represent concepts and reason about knowledge bases in domains such as the semantic web, information retrieval and artificial intelligence. The ...Ontologies have been used for several years in life sciences to formally represent concepts and reason about knowledge bases in domains such as the semantic web, information retrieval and artificial intelligence. The exploration of these domains for the correspondence of semantic content requires calculation of the measure of semantic similarity between concepts. Semantic similarity is a measure on a set of documents, based on the similarity of their meanings, which refers to the similarity between two concepts belonging to one or more ontologies. The similarity between concepts is also a quantitative measure of information, calculated based on the properties of concepts and their relationships. This study proposes a method for finding similarity between concepts in two different ontologies based on feature, information content and structure. More specifically, this means proposing a hybrid method using two existing measures to find the similarity between two concepts from different ontologies based on information content and the set of common superconcepts, which represents the set of common parent concepts. We simulated our method on datasets. The results show that our measure provides similarity values that are better than those reported in the literature.展开更多
Existing lithospheric velocity models exhibit similar structures typically associated with the first-order tectonic features,with dissimilarities due to different data and methods used in model generation.The quantifi...Existing lithospheric velocity models exhibit similar structures typically associated with the first-order tectonic features,with dissimilarities due to different data and methods used in model generation.The quantification of model structural similarity can help in interpreting the geophysical properties of Earth's interior and establishing unified models crucial in natural hazard assessment and resource exploration.Here we employ the complex wavelet structural similarity index measure(CW-SSIM)active in computer image processing to analyze the structural similarity of four lithospheric velocity models of Chinese mainland published in the past decade.We take advantage of this method in its multiscale definition and insensitivity to slight geometrical distortion like translation and scaling,which is particularly crucial in the structural similarity analysis of velocity models accounting for uncertainty and resolution.Our results show that the CW-SSIM values vary in different model pairs,horizontal locations,and depths.While variations in the inter-model CW-SSIM are partly owing to different databases in the model generation,the difference of tomography methods may significantly impact the similar structural features of models,such as the low similarities between the full-wave based FWEA18 and other three models in northeastern China.We finally suggest potential solutions for the next generation of tomographic modeling in different areas according to corresponding structural similarities of existing models.展开更多
Following the publication,concerns have been raised about a number of figures in this article.An unexpected area of similarity was identified in terms of the cellular data,where the results from differently performed ...Following the publication,concerns have been raised about a number of figures in this article.An unexpected area of similarity was identified in terms of the cellular data,where the results from differently performed experiments were intended to have been shown,although the areas immediately surrounding this area featured comparatively different distributions of cells.In addition,the western blots in this article were presented with atypical,unusually shaped and possibly anomalous protein bands in many cases.The authors were contacted and invited to comment on the concerns raised and to provide the original,unmodified figures,but did not respond.The Editors-in-Chief therefore no longer have confidence in the integrity of the data in this article and decided to retract this article.展开更多
The scientific community faces the challenge of measuring progress toward biodiversity targets and indices have been traditionally used.However,recent inventories in secondary tropical mountain forests using tradition...The scientific community faces the challenge of measuring progress toward biodiversity targets and indices have been traditionally used.However,recent inventories in secondary tropical mountain forests using traditional biodiversity indices have yielded results that are indistinct with primary ones.This shows the need to develop complementary indices that goes beyond species count but integrates the distribution and conservation status of the species.This study developed endemicity and conservation importance index for tropical forest that incorporated the distribution and conservation status of the species.These indices were applied to Mt.Natoo,a remnant primary mossy forest in Buguias,Benguet,Philippines,that resulted to endemicity index of 81.07 and conservation importance index of 42.90.Comparing these with secondary forest sites with comparable Shannon-Wiener,Simpson,Evenness and Margalef’s indices,our endemicity and conservation indices clearly differentiates primary forest(our study site)with higher values from secondary forests with much lower values.Thus,we are proposing these indices for a direct but scientifically-informed identification of specific sites for conservation and protection in tropical forests.Additionally,our study documented a total of 168 vascular plant species(79 endemic and 12 locally threatened species)in Mt.Nato-o.Majority are of tropical elements for both generic and species levels with some temperate elements that could be attributed to the site's high elevation and semi-temperate climate.These are important baseline information for conservation plans and monitoring of tropical mossy forests.展开更多
Following the publication,concerns have been raised about a number of figures in this article.An unexpected area of similarity was identified in terms of the cellular data,where the results from differently performed ...Following the publication,concerns have been raised about a number of figures in this article.An unexpected area of similarity was identified in terms of the cellular data,where the results from differently performed experiments were intended to have been shown,although the areas immediately surrounding this area featured comparatively different distributions of cells.In addition,the western blots in this article were presented with atypical,unusually shaped and possibly anomalous protein bands in many cases.展开更多
Following the publication,concerns have been raised about a number of figures in this article.An unexpected area of similarity was identified in terms of the cellular data,where the results from differently performed ...Following the publication,concerns have been raised about a number of figures in this article.An unexpected area of similarity was identified in terms of the cellular data,where the results from differently performed experiments were intended to have been shown,although the areas immediately surrounding this area featured comparatively different distributions of cells.In addition,the western blots in this article were presented with atypical,unusually shaped and possibly anomalous protein bands in many cases.展开更多
Following the publication,concerns have been raised about a number of figures in this article.An unexpected area of similarity was identified in terms of the cellular data,where the results from differently performed ...Following the publication,concerns have been raised about a number of figures in this article.An unexpected area of similarity was identified in terms of the cellular data,where the results from differently performed experiments were intended to have been shown,although the areas immediately surrounding this area featured comparatively different distributions of cells.In addition,the western blots in this article were presented with atypical,unusually shaped and possibly anomalous protein bands in many cases.展开更多
Following the publication,concerns have been raised about a number of figures in this article.An unexpected area of similarity was identified in terms of the cellular data,where the results from differently performed ...Following the publication,concerns have been raised about a number of figures in this article.An unexpected area of similarity was identified in terms of the cellular data,where the results from differently performed experiments were intended to have been shown,although the areas immediately surrounding this area featured comparatively different distributions of cells.In addition,the western blots in this article were presented with atypical,unusually shaped and possibly anomalous protein bands in many cases.展开更多
Following the publication,concerns have been raised about a number of figures in this article.An unexpected area of similarity was identified in terms of the cellular data,where the results from differently performed ...Following the publication,concerns have been raised about a number of figures in this article.An unexpected area of similarity was identified in terms of the cellular data,where the results from differently performed experiments were intended to have been shown,although the areas immediately surrounding this area featured comparatively different distributions of cells.In addition,the western blots in this article were presented with atypical,unusually shaped and possibly anomalous protein bands in many cases.展开更多
The settling flux of biodeposition affects the environmental quality of cage culture areas and determines their environmental carrying capacity.Simple and effective simulation of the settling flux of biodeposition is ...The settling flux of biodeposition affects the environmental quality of cage culture areas and determines their environmental carrying capacity.Simple and effective simulation of the settling flux of biodeposition is extremely important for determining the spatial distribution of biodeposition.Theoretically,biodeposition in cage culture areas without specific emission rules can be simplified as point source pollution.Fluent is a fluid simulation software that can simulate the dispersion of particulate matter simply and efficiently.Based on the simplification of pollution sources and bays,the settling flux of biodeposition can be easily and effectively simulated by Fluent fluid software.In the present work,the feasibility of this method was evaluated by simulation of the settling flux of biodeposition in Maniao Bay,Hainan Province,China,and 20 sampling sites were selected for determining the settling fluxes.At sampling sites P1,P2,P3,P4,P5,Z1,Z2,Z3,Z4,A1,A2,A3,A4,B1,B2,C1,C2,C3 and C4,the measured settling fluxes of biodeposition were 26.02,15.78,10.77,58.16,6.57,72.17,12.37,12.11,106.64,150.96,22.59,11.41,18.03,7.90,19.23,7.06,11.84,5.19 and 2.57 g d^(−1)m^(−2),respectively.The simulated settling fluxes of biodeposition at the corresponding sites were 16.03,23.98,8.87,46.90,4.52,104.77,16.03,8.35,180.83,213.06,39.10,17.47,20.98,9.78,23.25,7.84,15.90,6.06 and 1.65 g d^(−1)m^(−2),respectively.There was a positive correlation between the simulated settling fluxes and measured ones(R=0.94,P=2.22×10^(−9)<0.05),which implies that the spatial differentiation of biodeposition flux was well simulated.Moreover,the posterior difference ratio of the simulation was 0.38,and the small error probability was 0.94,which means that the simulated results reached an acceptable level from the perspective of relative error.Thus,if nonpoint source pollution is simplified to point source pollution and open waters are simplified based on similarity theory,the setting flux of biodeposition in the open waters can be simply and effectively simulated by the fluid simulation software Fluent.展开更多
Following the publication,concerns have been raised about a number of figures in this article.An unexpected area of similarity was identified in terms of the cellular data,where the results from differently performed ...Following the publication,concerns have been raised about a number of figures in this article.An unexpected area of similarity was identified in terms of the cellular data,where the results from differently performed experiments were intended to have been shown,although the areas immediately surrounding this area featured comparatively different distributions of cells.In addition,the western blots in this article were presented with atypical,unusually shaped and possibly anomalous protein bands in many cases.展开更多
Based on the production curves,changes in hydrocarbon composition and quantities over time,and production systems from key trial production wells in lacustrine shale oil areas in China,fine fraction cutting experiment...Based on the production curves,changes in hydrocarbon composition and quantities over time,and production systems from key trial production wells in lacustrine shale oil areas in China,fine fraction cutting experiments and molecular dynamics numerical simulations were conducted to investigate the effects of changes in shale oil composition on macroscopic fluidity.The concept of“component flow”for shale oil was proposed,and the formation mechanism and conditions of component flow were discussed.The research reveals findings in four aspects.First,a miscible state of light,medium and heavy hydrocarbons form within micropores/nanopores of underground shale according to similarity and intermiscibility principles,which make components with poor fluidity suspended as molecular aggregates in light and medium hydrocarbon solvents,such as heavy hydrocarbons,thereby decreasing shale oil viscosity and enhancing fluidity and outflows.Second,small-molecule aromatic hydrocarbons act as carriers for component flow,and the higher the content of gaseous and light hydrocarbons,the more conducive it is to inhibit the formation of larger aggregates of heavy components such as resin and asphalt,thus increasing their plastic deformation ability and bringing about better component flow efficiency.Third,higher formation temperatures reduce the viscosity of heavy hydrocarbon components,such as wax,thereby improving their fluidity.Fourth,preservation conditions,formation energy,and production system play important roles in controlling the content of light hydrocarbon components,outflow rate,and forming stable“component flow”,which are crucial factors for the optimal compatibility and maximum flow rate of multi-component hydrocarbons in shale oil.The component flow of underground shale oil is significant for improving single-well production and the cumulative ultimate recovery of shale oil.展开更多
基金supported by the No. 4 National Project in 2022 of the Ministry of Emergency Response (2022YJBG04)the International Clean Energy Talent Program (201904100014)。
文摘Photovoltaic(PV) power generation is characterized by randomness and intermittency due to weather changes.Consequently, large-scale PV power connections to the grid can threaten the stable operation of the power system. An effective method to resolve this problem is to accurately predict PV power. In this study, an innovative short-term hybrid prediction model(i.e., HKSL) of PV power is established. The model combines K-means++, optimal similar day approach,and long short-term memory(LSTM) network. Historical power data and meteorological factors are utilized. This model searches for the best similar day based on the results of classifying weather types. Then, the data of similar day are inputted into the LSTM network to predict PV power. The validity of the hybrid model is verified based on the datasets from a PV power station in Shandong Province, China. Four evaluation indices, mean absolute error, root mean square error(RMSE),normalized RMSE, and mean absolute deviation, are employed to assess the performance of the HKSL model. The RMSE of the proposed model compared with those of Elman, LSTM, HSE(hybrid model combining similar day approach and Elman), HSL(hybrid model combining similar day approach and LSTM), and HKSE(hybrid model combining K-means++,similar day approach, and LSTM) decreases by 66.73%, 70.22%, 65.59%, 70.51%, and 18.40%, respectively. This proves the reliability and excellent performance of the proposed hybrid model in predicting power.
基金the National Natural Science Foundation of China(No.62302540)with author F.F.S.For more information,please visit their website at https://www.nsfc.gov.cn/.Additionally,it is also funded by the Open Foundation of Henan Key Laboratory of Cyberspace Situation Awareness(No.HNTS2022020)+1 种基金where F.F.S is an author.Further details can be found at http://xt.hnkjt.gov.cn/data/pingtai/.The research is also supported by the Natural Science Foundation of Henan Province Youth Science Fund Project(No.232300420422)for more information,you can visit https://kjt.henan.gov.cn/2022/09-02/2599082.html.Lastly,it receives funding from the Natural Science Foundation of Zhongyuan University of Technology(No.K2023QN018),where F.F.S is an author.You can find more information at https://www.zut.edu.cn/.
文摘As social networks become increasingly complex, contemporary fake news often includes textual descriptionsof events accompanied by corresponding images or videos. Fake news in multiple modalities is more likely tocreate a misleading perception among users. While early research primarily focused on text-based features forfake news detection mechanisms, there has been relatively limited exploration of learning shared representationsin multimodal (text and visual) contexts. To address these limitations, this paper introduces a multimodal modelfor detecting fake news, which relies on similarity reasoning and adversarial networks. The model employsBidirectional Encoder Representation from Transformers (BERT) and Text Convolutional Neural Network (Text-CNN) for extracting textual features while utilizing the pre-trained Visual Geometry Group 19-layer (VGG-19) toextract visual features. Subsequently, the model establishes similarity representations between the textual featuresextracted by Text-CNN and visual features through similarity learning and reasoning. Finally, these features arefused to enhance the accuracy of fake news detection, and adversarial networks have been employed to investigatethe relationship between fake news and events. This paper validates the proposed model using publicly availablemultimodal datasets from Weibo and Twitter. Experimental results demonstrate that our proposed approachachieves superior performance on Twitter, with an accuracy of 86%, surpassing traditional unimodalmodalmodelsand existing multimodal models. In contrast, the overall better performance of our model on the Weibo datasetsurpasses the benchmark models across multiple metrics. The application of similarity reasoning and adversarialnetworks in multimodal fake news detection significantly enhances detection effectiveness in this paper. However,current research is limited to the fusion of only text and image modalities. Future research directions should aimto further integrate features fromadditionalmodalities to comprehensively represent themultifaceted informationof fake news.
文摘Text Summarization models facilitate biomedical clinicians and researchers in acquiring informative data from enormous domain-specific literature within less time and effort.Evaluating and selecting the most informative sentences from biomedical articles is always challenging.This study aims to develop a dual-mode biomedical text summarization model to achieve enhanced coverage and information.The research also includes checking the fitment of appropriate graph ranking techniques for improved performance of the summarization model.The input biomedical text is mapped as a graph where meaningful sentences are evaluated as the central node and the critical associations between them.The proposed framework utilizes the top k similarity technique in a combination of UMLS and a sampled probability-based clustering method which aids in unearthing relevant meanings of the biomedical domain-specific word vectors and finding the best possible associations between crucial sentences.The quality of the framework is assessed via different parameters like information retention,coverage,readability,cohesion,and ROUGE scores in clustering and non-clustering modes.The significant benefits of the suggested technique are capturing crucial biomedical information with increased coverage and reasonable memory consumption.The configurable settings of combined parameters reduce execution time,enhance memory utilization,and extract relevant information outperforming other biomedical baseline models.An improvement of 17%is achieved when the proposed model is checked against similar biomedical text summarizers.
文摘Neurodegeneration is attributable to metabolic disturbances in the various cell types responsible for this condition, in respect of glucose utilisation and dysfunctional mitochondrial oxidative mechanisms. The properties of neurotoxins and antagonists that limit their action are well documented in disease models, whereas effective therapy is very limited. Cell apoptosis, a general marker of neurodegeneration, is also of therapeutic interest in the treatment of cancer. cGMP nucleotide influences apoptosis and has a role in maintaining equilibrium within cell redox parameters. The chemical structure of cGMP provides a comparative template for demonstrating relative molecular similarity within the structures of natural and synthetic compounds influencing tumour cell apoptosis. The present study uses computational software to investigate molecular similarity within the structures of cGMP and compounds that modulate cell apoptosis in experimental models of diabetic peripheral neuropathy (DPN), Parkinson’s and multiple sclerosis. Differential molecular similarity demonstrated in neurotoxin and antagonist structures implicate metabolite impairment of cGMP signaling function as a common mechanism in the initial phases of these neurodegenerative conditions.
文摘Cholesterol and cholesterol oxides impact on the functional properties of cells, in respect of the intracellular and extracellular distribution of compounds across cell membranes, carcinogenesis and drug resistance. Abnormal levels of cholesterol oxides and steroids in cancerous tissues promote interest in steroid receptor cross-talk during cell-signalling and the steroid metabolome of cancer patients. The research literature links the cytotoxic properties of oxysterols to interference with the NO/cGMP pathway. cGMP participates in cell-signalling and has a molecular structure that relates to cancer-inducing and cancer-preventing agents. This study uses a molecular modelling approach to compare the structures of cholesterol oxides to cGMP. Cholesterol and cholesterol oxide structures fit to a cGMP structural template in several ways, some of which are replicated by corticosteroids and gonadal steroid hormones. The results of this study support the concept that cholesterol oxides modulate cell apoptosis and autophagy via the NO/cGMP pathway and in conjunction with steroid hormones participate in modulating regulation of cell function by cGMP.
基金the National Natural Science Foundation of China(Nos.51988101 and 42007262).
文摘3D printing is widely adopted to quickly produce rock mass models with complex structures in batches,improving the consistency and repeatability of physical modeling.It is necessary to regulate the mechanical properties of 3D-printed specimens to make them proportionally similar to natural rocks.This study investigates mechanical properties of 3D-printed rock analogues prepared by furan resin-bonded silica sand particles.The mechanical property regulation of 3D-printed specimens is realized through quantifying its similarity to sandstone,so that analogous deformation characteristics and failure mode are acquired.Considering similarity conversion,uniaxial compressive strength,cohesion and stress–strain relationship curve of 3D-printed specimen are similar to those of sandstone.In the study ranges,the strength of 3D-printed specimen is positively correlated with the additive content,negatively correlated with the sand particle size,and first increases then decreases with the increase of curing temperature.The regulation scheme with optimal similarity quantification index,that is the sand type of 70/140,additive content of 2.5‰and curing temperature of 81.6℃,is determined for preparing 3D-printed sandstone analogues and models.The effectiveness of mechanical property regulation is proved through uniaxial compression contrast tests.This study provides a reference for preparing rock-like specimens and engineering models using 3D printing technology.
基金supported by the National Natural Science Foundation of China(62033010)Qing Lan Project of Jiangsu Province(R2023Q07)。
文摘For accurately identifying the distribution charac-teristic of Gaussian-like noises in unmanned aerial vehicle(UAV)state estimation,this paper proposes a non-parametric scheme based on curve similarity matching.In the framework of the pro-posed scheme,a Parzen window(kernel density estimation,KDE)method on sliding window technology is applied for roughly esti-mating the sample probability density,a precise data probability density function(PDF)model is constructed with the least square method on K-fold cross validation,and the testing result based on evaluation method is obtained based on some data characteristic analyses of curve shape,abruptness and symmetry.Some com-parison simulations with classical methods and UAV flight exper-iment shows that the proposed scheme has higher recognition accuracy than classical methods for some kinds of Gaussian-like data,which provides better reference for the design of Kalman filter(KF)in complex water environment.
文摘Ontologies have been used for several years in life sciences to formally represent concepts and reason about knowledge bases in domains such as the semantic web, information retrieval and artificial intelligence. The exploration of these domains for the correspondence of semantic content requires calculation of the measure of semantic similarity between concepts. Semantic similarity is a measure on a set of documents, based on the similarity of their meanings, which refers to the similarity between two concepts belonging to one or more ontologies. The similarity between concepts is also a quantitative measure of information, calculated based on the properties of concepts and their relationships. This study proposes a method for finding similarity between concepts in two different ontologies based on feature, information content and structure. More specifically, this means proposing a hybrid method using two existing measures to find the similarity between two concepts from different ontologies based on information content and the set of common superconcepts, which represents the set of common parent concepts. We simulated our method on datasets. The results show that our measure provides similarity values that are better than those reported in the literature.
基金supported by the National Natural Science Foundation of China(Nos.42174063,92155307,41976046)Guangdong Provincial Key Laboratory of Geophysical High-resolution Imaging Technology under(No.2022B1212010002)Project for introduced Talents Team of Southern Marine Science and Engineering Guangdong(Guangzhou)(No.GML2019ZD0203)。
文摘Existing lithospheric velocity models exhibit similar structures typically associated with the first-order tectonic features,with dissimilarities due to different data and methods used in model generation.The quantification of model structural similarity can help in interpreting the geophysical properties of Earth's interior and establishing unified models crucial in natural hazard assessment and resource exploration.Here we employ the complex wavelet structural similarity index measure(CW-SSIM)active in computer image processing to analyze the structural similarity of four lithospheric velocity models of Chinese mainland published in the past decade.We take advantage of this method in its multiscale definition and insensitivity to slight geometrical distortion like translation and scaling,which is particularly crucial in the structural similarity analysis of velocity models accounting for uncertainty and resolution.Our results show that the CW-SSIM values vary in different model pairs,horizontal locations,and depths.While variations in the inter-model CW-SSIM are partly owing to different databases in the model generation,the difference of tomography methods may significantly impact the similar structural features of models,such as the low similarities between the full-wave based FWEA18 and other three models in northeastern China.We finally suggest potential solutions for the next generation of tomographic modeling in different areas according to corresponding structural similarities of existing models.
文摘Following the publication,concerns have been raised about a number of figures in this article.An unexpected area of similarity was identified in terms of the cellular data,where the results from differently performed experiments were intended to have been shown,although the areas immediately surrounding this area featured comparatively different distributions of cells.In addition,the western blots in this article were presented with atypical,unusually shaped and possibly anomalous protein bands in many cases.The authors were contacted and invited to comment on the concerns raised and to provide the original,unmodified figures,but did not respond.The Editors-in-Chief therefore no longer have confidence in the integrity of the data in this article and decided to retract this article.
文摘The scientific community faces the challenge of measuring progress toward biodiversity targets and indices have been traditionally used.However,recent inventories in secondary tropical mountain forests using traditional biodiversity indices have yielded results that are indistinct with primary ones.This shows the need to develop complementary indices that goes beyond species count but integrates the distribution and conservation status of the species.This study developed endemicity and conservation importance index for tropical forest that incorporated the distribution and conservation status of the species.These indices were applied to Mt.Natoo,a remnant primary mossy forest in Buguias,Benguet,Philippines,that resulted to endemicity index of 81.07 and conservation importance index of 42.90.Comparing these with secondary forest sites with comparable Shannon-Wiener,Simpson,Evenness and Margalef’s indices,our endemicity and conservation indices clearly differentiates primary forest(our study site)with higher values from secondary forests with much lower values.Thus,we are proposing these indices for a direct but scientifically-informed identification of specific sites for conservation and protection in tropical forests.Additionally,our study documented a total of 168 vascular plant species(79 endemic and 12 locally threatened species)in Mt.Nato-o.Majority are of tropical elements for both generic and species levels with some temperate elements that could be attributed to the site's high elevation and semi-temperate climate.These are important baseline information for conservation plans and monitoring of tropical mossy forests.
文摘Following the publication,concerns have been raised about a number of figures in this article.An unexpected area of similarity was identified in terms of the cellular data,where the results from differently performed experiments were intended to have been shown,although the areas immediately surrounding this area featured comparatively different distributions of cells.In addition,the western blots in this article were presented with atypical,unusually shaped and possibly anomalous protein bands in many cases.
文摘Following the publication,concerns have been raised about a number of figures in this article.An unexpected area of similarity was identified in terms of the cellular data,where the results from differently performed experiments were intended to have been shown,although the areas immediately surrounding this area featured comparatively different distributions of cells.In addition,the western blots in this article were presented with atypical,unusually shaped and possibly anomalous protein bands in many cases.
文摘Following the publication,concerns have been raised about a number of figures in this article.An unexpected area of similarity was identified in terms of the cellular data,where the results from differently performed experiments were intended to have been shown,although the areas immediately surrounding this area featured comparatively different distributions of cells.In addition,the western blots in this article were presented with atypical,unusually shaped and possibly anomalous protein bands in many cases.
文摘Following the publication,concerns have been raised about a number of figures in this article.An unexpected area of similarity was identified in terms of the cellular data,where the results from differently performed experiments were intended to have been shown,although the areas immediately surrounding this area featured comparatively different distributions of cells.In addition,the western blots in this article were presented with atypical,unusually shaped and possibly anomalous protein bands in many cases.
文摘Following the publication,concerns have been raised about a number of figures in this article.An unexpected area of similarity was identified in terms of the cellular data,where the results from differently performed experiments were intended to have been shown,although the areas immediately surrounding this area featured comparatively different distributions of cells.In addition,the western blots in this article were presented with atypical,unusually shaped and possibly anomalous protein bands in many cases.
基金support from the National Key Research and Development Program of China(No.2018YFD0900704)the National Natural Science Foundation of China(No.31972796).
文摘The settling flux of biodeposition affects the environmental quality of cage culture areas and determines their environmental carrying capacity.Simple and effective simulation of the settling flux of biodeposition is extremely important for determining the spatial distribution of biodeposition.Theoretically,biodeposition in cage culture areas without specific emission rules can be simplified as point source pollution.Fluent is a fluid simulation software that can simulate the dispersion of particulate matter simply and efficiently.Based on the simplification of pollution sources and bays,the settling flux of biodeposition can be easily and effectively simulated by Fluent fluid software.In the present work,the feasibility of this method was evaluated by simulation of the settling flux of biodeposition in Maniao Bay,Hainan Province,China,and 20 sampling sites were selected for determining the settling fluxes.At sampling sites P1,P2,P3,P4,P5,Z1,Z2,Z3,Z4,A1,A2,A3,A4,B1,B2,C1,C2,C3 and C4,the measured settling fluxes of biodeposition were 26.02,15.78,10.77,58.16,6.57,72.17,12.37,12.11,106.64,150.96,22.59,11.41,18.03,7.90,19.23,7.06,11.84,5.19 and 2.57 g d^(−1)m^(−2),respectively.The simulated settling fluxes of biodeposition at the corresponding sites were 16.03,23.98,8.87,46.90,4.52,104.77,16.03,8.35,180.83,213.06,39.10,17.47,20.98,9.78,23.25,7.84,15.90,6.06 and 1.65 g d^(−1)m^(−2),respectively.There was a positive correlation between the simulated settling fluxes and measured ones(R=0.94,P=2.22×10^(−9)<0.05),which implies that the spatial differentiation of biodeposition flux was well simulated.Moreover,the posterior difference ratio of the simulation was 0.38,and the small error probability was 0.94,which means that the simulated results reached an acceptable level from the perspective of relative error.Thus,if nonpoint source pollution is simplified to point source pollution and open waters are simplified based on similarity theory,the setting flux of biodeposition in the open waters can be simply and effectively simulated by the fluid simulation software Fluent.
文摘Following the publication,concerns have been raised about a number of figures in this article.An unexpected area of similarity was identified in terms of the cellular data,where the results from differently performed experiments were intended to have been shown,although the areas immediately surrounding this area featured comparatively different distributions of cells.In addition,the western blots in this article were presented with atypical,unusually shaped and possibly anomalous protein bands in many cases.
基金Supported by the National Natural Science Foundation of China(U22B6004)Scientific Research and Technological Development Project of RIPED(2022yjcq03)Technology Research Project of PetroChina Changqing Oilfield Company(KJZX2023-01)。
文摘Based on the production curves,changes in hydrocarbon composition and quantities over time,and production systems from key trial production wells in lacustrine shale oil areas in China,fine fraction cutting experiments and molecular dynamics numerical simulations were conducted to investigate the effects of changes in shale oil composition on macroscopic fluidity.The concept of“component flow”for shale oil was proposed,and the formation mechanism and conditions of component flow were discussed.The research reveals findings in four aspects.First,a miscible state of light,medium and heavy hydrocarbons form within micropores/nanopores of underground shale according to similarity and intermiscibility principles,which make components with poor fluidity suspended as molecular aggregates in light and medium hydrocarbon solvents,such as heavy hydrocarbons,thereby decreasing shale oil viscosity and enhancing fluidity and outflows.Second,small-molecule aromatic hydrocarbons act as carriers for component flow,and the higher the content of gaseous and light hydrocarbons,the more conducive it is to inhibit the formation of larger aggregates of heavy components such as resin and asphalt,thus increasing their plastic deformation ability and bringing about better component flow efficiency.Third,higher formation temperatures reduce the viscosity of heavy hydrocarbon components,such as wax,thereby improving their fluidity.Fourth,preservation conditions,formation energy,and production system play important roles in controlling the content of light hydrocarbon components,outflow rate,and forming stable“component flow”,which are crucial factors for the optimal compatibility and maximum flow rate of multi-component hydrocarbons in shale oil.The component flow of underground shale oil is significant for improving single-well production and the cumulative ultimate recovery of shale oil.