Game Analysis of Regulation for Online Prescription Drugs under Customer Feedback Mechanism

Objective To study the way to better regulate the online sales of prescription drugs,and to provide reference for the adjustment of relevant policies since the online sales of prescription drugs has become an inevitable trend.Methods A game model was constructed for the strategy choice of pharmaceutical e-commerce platform,customers and government departments based on differential game theory and Nash equilibrium game model to analyze the pure strategy Nash equilibrium,Nash equilibrium dominant strategy of each subject and the mixed strategy Nash equilibrium under different conditions.Besides,Matlab was used to carry out simulation analysis.Results and Conclusion The study shows that:(1)Improving the credibility of the government and reducing the cost of government regulation can not only make the pharmaceutical e-commerce platform operate with high quality,but also give greater play to government functions;(2)The greater the influence of social evaluation on pharmaceutical e-commerce platforms,the lower the cost of high-quality operation of pharmaceutical e-commerce platform,and the greater the probability of customer choosing real evaluation strategy;(3)The greater the customers’perception of potential risk,the greater the compensation,and the lower the cost of reporting.Then,the greater the probability that government departments will choose strict regulation.Finally,the model solution and simulation analysis are combined to provide countermeasures and suggestions for the safety regulation of online sales of prescription drugs.

APPLICATION OF MONTE-CARLO SIMULATED ANNEALING ON CONFORMATIONAL ANALYSIS

Monte-Carlo simulated annealing method (SA) was applied to the conformational analysis of flexible molecules such as peptides. The programs SAMM and SAPEP have been developed, using MM2 force field for organic molecules and ECEPP/2 force field for peptides respectively.

CFD Analysis of Spiral Flow Fields in Proton Exchange Membrane Fuel Cells

Proton exchange membrane fuel cells(PEMFCs)are largely used in various applications because of their pollution-free products and high energy conversion efficiency.In order to improve the related design,in the present work a new spiral flow field with a bypass is proposed.The reaction gas enters the flow field in the central path and diffuses in two directions through the flow channel and the bypass.The bypasses are arranged incrementally.The number of bypasses and the cross-section size of the bypasses are varied parametrically while a single-cell model of the PEMFC is used.The influence of the concentration of liquid water and oxygen in the cell on the performance of different flow fields is determined by means of Computational fluid dynamics(COMSOL Multiphysics software).Results show that when the bypass number is 48 and its cross-sectional area is 0.5 mm^(2),the cell exhibits the best performances.

Characteristic Analysis of Off-Axis Meta-Lens

Meta-lens are a new type of planar optical element that can flexibly manipulate the phase, polarization and amplitude of the beam, and are currently receiving a great deal of attention as they are easier to process and manufacture. Off-axis meta-lens are a special type of meta-lens with a certain degree of dispersion that can be used as a beam-splitting element, providing a unique and feasible way to realize micro-miniature instruments. We analyze the effects of different numerical apertures and off-axis angles on the spectral resolution, focusing efficiency and simulation results of off-axis meta-lens to provide ideas for subsequent research and application of off-axis meta-lens. A number of off-axis meta-lens with parameters NA = 0.408 α = 13°, NA = 0.18 α = 13° and NA = 0.408 α = 20° were simulated through Lumerical software. The results show that the off-axis angle is related to the resolution;the larger the angle, the better the spectral resolution but the lower the focusing efficiency;when the numerical aperture is smaller, the smaller the coverage of the phase distribution, which will lead to a larger deviation between simulation and theory. The designer needs to balance the numerical aperture, off-axis angle and other parameters reasonably according to the requirements in order to achieve the desired effect. The findings of this study have important reference values for the theoretical analysis of off-axis meta-lens and the design of parameters in practical applications. .

Analysis of Damage Pattern of Road Bridge Landslide in Mountainous Area

Through on-site defect investigation,special inspection,and finite element simulation calculation of a high-speed upper-span(30+32+30)m prestressed concrete box girder bridge,the overall sliding force of the bridge on the right side of platform 0#is analyzed.In this situation,typical defects such as overall girder slippage,support dislocation,pier column deviation,and pier bottom side cracks have occurred in the overpass.At the same time,combined with simulation calculation analysis,it is interpreted that the 0#and 1#foundation has been damaged at a certain position below the ground line.The occurrence of broken piles has provided a reliable basis for the later reinforcement and maintenance of the bridge and ideas for emergency inspection and analysis of bridges damaged by the same type of landslides.

Simulation Analysis and Experimental Study of Defect Detection Underwater by ACFM Probe

This article studies the application of the alternating current field measurement （ACFM） method in defect detection for underwater structures. Numerical model of the ACFM system is built for structure surface defect detection in seawater environment. Finite element simulation is performed to investigate rules and characteristics of the electromagnetic signal distribution in the defected area. In respect of the simulation results, underwater artificial crack detection experiments are designed and conducted for the ACFM system. The experiment results show that the ACFM system can detect cracks in underwater structures and the detection accuracy is higher than 85%. This can meet the engineering requirement of underwater structure defect detection. The results in this article can be applied to establish technical foundation for the optimization and development of ACFM based underwater structure defects detection system.

Optimization Design and Performance Analysis of Vehicle Powertrain Mounting System

The design strategies for powertrain mounting systems play an important role in the reduction of vehicular vibration and noise. As stiffness and damping elements connecting the transmission system and vehicle body, the rubber mount exhibits better vibration isolation performance than the rigid connection. This paper presents a complete design process of the mounting system, including the vibration decoupling, vibration simulation analysis, topology optimization, and experimental verification. Based on the 6?degrees?of?freedom vibration coupling model of the powertrain mounting system, an optimization algorithm is used to extract the best design parameters of each mount, thus rendering the mounting system fully decoupled and the natural frequency well configured, and the optimal parameters are used to design the mounting system. Subsequently, vibration simulation analysis is applied to the mounting system, considering both transmission and road excitations. According to the results of finite element analysis, the topological structure of the metal frame of the front mount is optimized to improve the strength and dynamic characteristics of the mounting system. Finally, the vibration bench test is used to verify the availability of the optimization design with the analysis of acceleration response and vibration transmissibility of the mounting system. The results show that the vibration isolation performance of the mounting system can be improved effectively using the vibration optimal decoupling method, and the structural modification of the metal frame can well promote the dynamic characteristics of the mounting system.

Simulation analysis of regional surface mass anomalies inversion based on different types of constraints

Surface mass anomalies estimated by mass concentration(mascon)approach using Gravity Recovery and Climate Experiment(GRACE)observations with regularization constraints generally present higher spatial resolution than the spheric harmonic(SH)solutions.To analyze the influence of different types of constraints on the estimation of mascon solutions,we carried out a closed-loop simulation experiment to estimate surface mass anomalies over South America based on simulated GRACE intersatellite geopotential differences.Tikhonov regularization with spatial constraint(SC),uniform weighting constraint(UWC),and a prior information constraint(APC)were employed to stabilize the mascon solutions,and the corresponding optimal regularization parameters were determined based on the minimum residual root-mean-square(RMS)criterion.The results show that mascon solutions estimated under different types of constraints are consistent and equivalent when the optimal regularization parameters are selected.The spatial distributions and main characteristics of regional surface mass anomalies estimated by the three types of constraints agree well,and the values of residual RMS with different constraints are very close.But due to the smoothing effect of regularization,the signal strength of mascon solutions is a bit weaker than that of original true signal,especially in the regions with strong signals.In addition,due to the ill-conditioned problem is more serious for higher grid resolution,the relative contribution of the three types of constraints to the final mascon solutions would be stronger.The results show that the averages of relative contribution percentages of these constraints for 2°×2° mascon grids are 80%-90%,while the corresponding values for 4°×4° mascon grids are 30%-60%.However,based on the minimum residual RMS criterion,the accuracy of estimation results is not affected by the type of constraints and their relative contribution to the final mascon solutions.

Stability analysis of backflling in subsiding area and optimization of the stoping sequence

In underground mining by sublevel caving method, the deformation and damage of the surface induced by subsidence are the major challenging issues. The dynamic and soft backflling body increases the safety risks in the subsiding area. In this paper, taking Zhangfushan iron mine as an example, the ore body and the general layout are focused on the safety of backflling of mined-out area. Then, we use the ANSYS software to construct a three-dimensional(3D) model for the mining area in the Zhangfushan iron mine. According to the simulation results of the initial mining stages, the ore body is stoped step by step as suggested in the design. The stability of the backflling is back analyzed based on the monitored displacements, considering the stress distribution to optimize the stoping sequence. The simulations show that a reasonable stoping sequence can minimize the concentration of high compressive stress and ensure the safety of stoping of the ore body.

Experimental and Simulation Analysis of Two-Tone and Three-Tone Photodetector Linearity Characterizing Systems

Two measurement techniques are investigated to characterize photodetector linearity. A model for the two-tone and three-tone photodetector systems is developed to thoroughly investigate the influences of setup components on the measurement results. We demonstrate that small bias shifts from the quadrature point of the modulator will induce deviation into measurement results of the two-tone system, and the simulation results correspond well to experimental and calculation results.

Simulation Analysis Module of High-speed Rail Bearings Based on Secondary Development in ADAMS

This paper develops a strong secondary development based on ADAMS feature which creates high-speed rail bearings for simulation analysis module. This thesis is in the case of non-circular pattern instructions of how to achieve rapid roller modeling, with analysis of functions and parameters required for the design of the simulation module of the high-speed rail bearing, as well as the design of dialog boxes, the environment and file structure. The specific modules is based on the secondary development language provided by ADAMS ! View. Through the menus, dialog boxes which input parameters, it can achieve high iron bearing automatic modeling, dynamic analysis and post-processing to simplify the analysis of high-speed rail bearing operations, as well as improving the high-speed rail bearing development efficiency.

Population Viability Analysis of Gloydius shedaoensis from Northeastern China:A Contribution to the Assessment of the Conservation and Management Status of an Endangered Species

Shedao pit-vipers(Gloydius shedaoensis) on Snake Island in the Liaoning Province, China, are among the most imperiled species in China. The isolated and unique populations are crucial in the recovery of this endangered species by providing a way for conservation and management. Research based on the ecological simulation tools can evaluate alternative mitigation strategies in terms of their benefits to the populations, which are vital for informed decision-making. In this paper, using the program VORTEX 9.42, we developed a population viability analysis(PVA) for the Shedao pit-viper to:(1) address the extinction likelihood of the population;(2) simulate population dynamics under various environment events, and(3) evaluate the efficacy of current protection and management strategies. Overall, we found the population to be susceptible to the factors of catastrophic events, mortality and environment capacity. The population is recovering slowly at present on account of improvement of habitat and greater food availability. Under the current conditions, the probability of extinction in 100 years is approximately zero. These data coincide with the evidence that the wild population may be arriving at K. Our results strengthen the view that protection and management can create a pronounced effect on populations of this endangered species.

A Mathematical Model of Real-Time Simulation and the Convergence Analysis on Real-Time Runge-Kutta Algorithms

In this paper, a mathematical model of real-time simulation is given, and the problem of convergence on real-time Runge-Kutta algorithms is analysed. At last a theorem on the relation between the order of compensation and the convergent order of real-time algorithm is proved.

Kinematics Analysis and Singularity Avoidance of a Parallel Mechanism with Kinematic Redundancy

The kinematic redundancy is considered as a way to improve the performance of the parallel mechanism.In this paper,the kinematics performance of a three degree-of-freedom parallel mechanism with kinematic redundancy(3-DOF PM-KR)and the influence of redundant parts on the PM-KR are analyzed.Firstly,the kinematics model of the PM-KR is established.The inverse solutions,the Jacobian matrix,and the workspace of the PM-KR are solved.Secondly,the influence of redundancy on the PM-KR is analyzed.Since there exists kinematic redundancy,the PM-KR possesses fault-tolerant performance.By locking one actuating joint or two actuating joints simultaneously,the fault-tolerant workspace is obtained.When the position of the redundant part is changed,the workspace and singularity will be changed.The results show that kinematic redundancy can be used to avoid singularity.Finally,the simulations are performed to prove the theoretical analysis.

Simulation and analysis of vehicle stability based on ADAMS/CAR differential brake

To improve the braking safety of automobiles, the author studied the effect of differential brake on the stabilities. To analyze the mechanical characteristics of differential brake, automotive subsystem models were built by applying ADAMS/CAR, and automotive mechanics simulation model was built by setting the main subsystems such as body, engine and brake. The simulation model studied the distribution mode of three kinds of differential brake, and beeline braking stability and turning braking stability were simulated. It shows that differential brake can amend turning shortage of automobile brake and improve its braking stability, but the effect of automobile mass on its braking stability is great. So the distribution mode of braking force and the effect of mass change should be considered while differential brake is applied.

Simulation and experimental analysis of melt pool evolution in laser engineered net shaping

In this work,the evolution of melt pool under single-point and single-line printing in the laser engineered net shaping(LENS)process is analyzed.Firstly,the basic structure of the melt pool model of the LENS process is established and the necessary assumptions are made.Then,the establishment process of the multi-physical field model of the melt pool is introduced in detail.It is concluded that the simulation model results are highly consistent with the online measurement experiment results in terms of melt pool profile,space temperature gradient,and time temperature gradient.Meanwhile,some parameters,such as the 3D morphology and surface fluid field of the melt pool,which are not obtained in the online measurement experiment,are analyzed.Finally,the influence of changing the scanning speed on the profile,peak temperature,and temperature gradient of the single-line melt pool is also analyzed,and the following conclusions are obtained:With the increase in scanning speed,the profile of the melt pool gradually becomes slender;The relationship between peak temperature and scanning speed is approximately linear in a certain speed range;The space temperature gradient at the tail of the melt pool under different scanning speeds hardly changes with the scanning speed,and the time temperature gradient at the tail of the melt pool is in direct proportion to the scanning speed.

Analysis of cooperation equilibrium of participants in power battery recycling chains considering information barrier

In the era of large-scale retirement of power batteries,there are information barriers and high recovery costs in their recycling.In view of this,in this study we constructed a tripartite evolutionary game model of the cooperation between power battery production and recycling enterprises and government participation.We analyzed the strategic choice of the three parties in the process of power battery recycling and simulated the influence of participants'willingness and information barriers on the strategic choices of the parties.The results showed that power battery production and recycling enterprises,and the government are affected by each other's willingness to participate at different degrees.The willingness of power battery manufacturers and recycling enterprises to cooperate with each other decreased with increases in information barriers.By analyzing the impact of information barrier on power battery recycling,some suggestions are put forward to provide decision-making reference for promoting the sustainable development of power battery industry.

Thermal Analysis Simulation of Germanium Zone Refining Process Assuming a Constant Radio-Frequency Heating Source

Three-dimensional thermal a nalysis simulation of a horizontal zone refining system is conducted for germanimn semiconductor materials. The considered geometry includes a g＇ral）hite boat filled with germanium placed in a cylindrical quartz tube. A flow of Ar and H2 gas mixture is purged througll the tube. A narrow section of the, boat is assmned to be exposed to a constant heat rate produced b v an rf coil located outside the quartz tube. The results of this analysis provide essential information about various parameters such as the shape of tile molten zone, required power and temperature gradient in the system.

Simulative analysis for deep seabed mining lifting systems

Computer simulation was used for hydraulic lifting systems. Based on theoryof multiphase flows and their applications on the lifting systems, mathematical models for pumplifting and air lifting were built and simulative analysis programs for them were developedrespectively. Corresponding lifting behaviors and system parameters were analyzed and optimum matchof the parameters for future pilot mining tests and commercial mining production was predicted.