Obesity is recognized as the second highest risk factor for cancer. The pathogenic mechanisms underlying tobaccorelated cancers are well characterized and efective programs have led to a decline in smoking and related...Obesity is recognized as the second highest risk factor for cancer. The pathogenic mechanisms underlying tobaccorelated cancers are well characterized and efective programs have led to a decline in smoking and related cancers, but there is a global epidemic of obesity without a clear understanding of how obesity causes cancer. Obesity is heterogeneous, and approximately 25% of obese individuals remain healthy(metabolically healthy obese, MHO), so which fat deposition(subcutaneous versus visceral, adipose versus ectopic) is "malignant"? What is the mechanism of carcinogenesis? Is it by metabolic dysregulation or chronic inflammation? Through which chemokines/genes/signaling pathways does adipose tissue influence carcinogenesis? Can selective inhibition of these pathways uncouple obesity from cancers? Do all obesity related cancers(ORCs) share a molecular signature? Are there common(overlapping) genetic loci that make individuals susceptible to obesity, metabolic syndrome, and cancers? Can we identify precursor lesions of ORCs and will early intervention of high risk individuals alter the natural history? It appears unlikely that the obesity epidemic will be controlled anytime soon; answers to these questions will help to reduce the adverse efect of obesity on human condition.展开更多
The Nanjing International Symposium of New Frontiers in Cancer Research will be held on Nov 9-10, 2007. The purpose of this symposium is to stimulate a dialogue among basic and clinical cancer researchers between Chin...The Nanjing International Symposium of New Frontiers in Cancer Research will be held on Nov 9-10, 2007. The purpose of this symposium is to stimulate a dialogue among basic and clinical cancer researchers between China and other countries to speed up translation of new findings in basic cancer biology into disease prevention, diagnosis, and treatment. We hope to use this conference as a forum to create a unique opportunity for exchange in current discoveries, fostering multidisciplinary collaborations, and identification of future opportunities in cancer treatment and patient care. There will be four sessions in this symposium：展开更多
THURSDAY,March 18 Pre-Conference Workshops"lntroduction to current issues in acupunclure research""ConsideratiOns for developing COllaboration research between AOM COlleges and conventionaI medicalinsti...THURSDAY,March 18 Pre-Conference Workshops"lntroduction to current issues in acupunclure research""ConsideratiOns for developing COllaboration research between AOM COlleges and conventionaI medicalinstitutions"展开更多
Scientific research provides essential information for conservation of threatened species.Data deficiency due to insufficient research impedes the design of conservation plans,and research bias may mistakenly direct l...Scientific research provides essential information for conservation of threatened species.Data deficiency due to insufficient research impedes the design of conservation plans,and research bias may mistakenly direct limited resources to low biodiversity regions or less threatened species.Here,we conducted a systematic review of published papers,grants,and graduate student training on carnivorans in China to identify species bias and research gaps.Furthermore,we collected intrinsic and extrinsic features of carnivorans,and identified features that impact research intensity using generalized linear models.We found that the amount of research on carnivorans increased markedly after 2000,but species bias existed.Bears and big cats received the greatest research attention,while most small-and medium-sized carnivorans received little attention,thus showing the 80-20 phenomenon.Species with a higher level of endemism and protection under Chinese law received more consideration.As an animal conservation icon in China,the giant panda(Ailuropoda melanoleuca)attracted more than 50%of overall carnivoran research resources.However,the giant panda also showed spillover effects,i.e.,post-doctoral graduates who studied the giant panda shifted their research focus to other species after graduation,which may help improve research on other species.Thus,to improve and strengthen Carnivora research and conservation,we suggest investing greater effort in species of less concern,training of more graduate students,and reinforcing academic exchange.If such actions are not taken,many carnivoran species will continue being data deficient and threatened.展开更多
The present study was conducted to explore ways of JIVET research on Texel sheep,and to provide technical support for the improvement of the JIVET technology system for research on Texel sheep.Superovulation was condu...The present study was conducted to explore ways of JIVET research on Texel sheep,and to provide technical support for the improvement of the JIVET technology system for research on Texel sheep.Superovulation was conducted on 4-8-week old Texel sheep,and in-vivo ovum collection,in-vitro oocyte maturation and fertilization,and fertilized-embryo culture and transplantation were adopted to perform JIVET research on Texel sheep.The results showed that 296 available oocytes were obtained at an average of 74 oocytes per sheep;205 fertilized eggs were obtained at the 2-4 cell stage at an average of 51.25 eggs per sheep and a cleavage rate of 69.26%;and 66 of the fertilized eggs were transplanted to 11 receptor sheep.Six sheep were conceived at a conception rate of 54.55%,and 11 lambs were born.These results indicated that the present test could be used as a method for the study of JIVET technique on Texel sheep.展开更多
文摘Obesity is recognized as the second highest risk factor for cancer. The pathogenic mechanisms underlying tobaccorelated cancers are well characterized and efective programs have led to a decline in smoking and related cancers, but there is a global epidemic of obesity without a clear understanding of how obesity causes cancer. Obesity is heterogeneous, and approximately 25% of obese individuals remain healthy(metabolically healthy obese, MHO), so which fat deposition(subcutaneous versus visceral, adipose versus ectopic) is "malignant"? What is the mechanism of carcinogenesis? Is it by metabolic dysregulation or chronic inflammation? Through which chemokines/genes/signaling pathways does adipose tissue influence carcinogenesis? Can selective inhibition of these pathways uncouple obesity from cancers? Do all obesity related cancers(ORCs) share a molecular signature? Are there common(overlapping) genetic loci that make individuals susceptible to obesity, metabolic syndrome, and cancers? Can we identify precursor lesions of ORCs and will early intervention of high risk individuals alter the natural history? It appears unlikely that the obesity epidemic will be controlled anytime soon; answers to these questions will help to reduce the adverse efect of obesity on human condition.
文摘The Nanjing International Symposium of New Frontiers in Cancer Research will be held on Nov 9-10, 2007. The purpose of this symposium is to stimulate a dialogue among basic and clinical cancer researchers between China and other countries to speed up translation of new findings in basic cancer biology into disease prevention, diagnosis, and treatment. We hope to use this conference as a forum to create a unique opportunity for exchange in current discoveries, fostering multidisciplinary collaborations, and identification of future opportunities in cancer treatment and patient care. There will be four sessions in this symposium：
文摘THURSDAY,March 18 Pre-Conference Workshops"lntroduction to current issues in acupunclure research""ConsideratiOns for developing COllaboration research between AOM COlleges and conventionaI medicalinstitutions"
基金This study was supported by the National Natural Science Foundation of China(31900372,31822049)。
文摘Scientific research provides essential information for conservation of threatened species.Data deficiency due to insufficient research impedes the design of conservation plans,and research bias may mistakenly direct limited resources to low biodiversity regions or less threatened species.Here,we conducted a systematic review of published papers,grants,and graduate student training on carnivorans in China to identify species bias and research gaps.Furthermore,we collected intrinsic and extrinsic features of carnivorans,and identified features that impact research intensity using generalized linear models.We found that the amount of research on carnivorans increased markedly after 2000,but species bias existed.Bears and big cats received the greatest research attention,while most small-and medium-sized carnivorans received little attention,thus showing the 80-20 phenomenon.Species with a higher level of endemism and protection under Chinese law received more consideration.As an animal conservation icon in China,the giant panda(Ailuropoda melanoleuca)attracted more than 50%of overall carnivoran research resources.However,the giant panda also showed spillover effects,i.e.,post-doctoral graduates who studied the giant panda shifted their research focus to other species after graduation,which may help improve research on other species.Thus,to improve and strengthen Carnivora research and conservation,we suggest investing greater effort in species of less concern,training of more graduate students,and reinforcing academic exchange.If such actions are not taken,many carnivoran species will continue being data deficient and threatened.
基金the Science and Technology Project of Shanxi Province(20120311024-1)Special Fund for the Construction of National Wool Sheep Industrial Technology Research System(CARS-39-24)+1 种基金Shanxi Provincial Science and Technology Innovation Team Fund(201705D131028-20)Shanxi Financial Fund for Agriculture(NYGX2015-03)。
文摘The present study was conducted to explore ways of JIVET research on Texel sheep,and to provide technical support for the improvement of the JIVET technology system for research on Texel sheep.Superovulation was conducted on 4-8-week old Texel sheep,and in-vivo ovum collection,in-vitro oocyte maturation and fertilization,and fertilized-embryo culture and transplantation were adopted to perform JIVET research on Texel sheep.The results showed that 296 available oocytes were obtained at an average of 74 oocytes per sheep;205 fertilized eggs were obtained at the 2-4 cell stage at an average of 51.25 eggs per sheep and a cleavage rate of 69.26%;and 66 of the fertilized eggs were transplanted to 11 receptor sheep.Six sheep were conceived at a conception rate of 54.55%,and 11 lambs were born.These results indicated that the present test could be used as a method for the study of JIVET technique on Texel sheep.
