基于近似测量算法Sketch的高精度区块链异常检测机制

区块链存在网络动态性强和其管理困难等问题,使得区块链普遍存在DDoS攻击和账户接管等异常现象.现有区块链异常检测方法多从所有区块链账户中提取历史交易信息和交易频率等特征加以分析以甄别异常.然而,随着区块链数据规模的不断扩大,现有方法在提取特征时面临内存消耗高、检测精度低的挑战.为此,提出了一种高检测精度、低内存开销的区块链异常检测机制,该机制采用近似测量算法将区块链异常检测转化为异常交易账户检测,包括区块内异常账户和跨区块异常账户.对于区块内异常账户,即仅存在于单个区块内的异常账户,使用Sketch算法进行账户识别,精度高.而对于存在于多个区块且难以通过单个区块信息检测到的跨区块异常账户,则通过聚合和分析多区块信息进行账户的准确检测.使用包含88847个区块的真实区块链数据评估上述机制.实验结果表明,与现有代表性方法对比,所提出的机制将区块链异常检测的召回率最高提升了6.3倍,F1分数最高提升了4.4倍.因此,提出的高精度区块链异常检测机制对于规范区块链交易行为、维护系统安全性具有意义.

基于Count Sketch的预处理贪婪Kaczmarz方法

在贪婪Kaczmarz方法中,通过对系数矩阵进行正交三角分解引入右预处理子能够提高贪婪Kaczmarz方法的收敛速率。但在系数矩阵的行数远大于列数的情况下,正交三角分解的成本过高。为降低预处理的成本,通过引入Count Sketch变换,提出了基于Count Sketch的预处理贪婪Kaczmarz方法,并对新方法进行了收敛性分析。理论分析说明了新方法在系数矩阵条件数较大时比已有方法具有更好的收敛速率。数值实验验证了新方法的有效性。

IntervalSketch:面向数据流的间隔项近似统计方法

流式数据库在数据库中的占比逐渐增加,在流式数据库的数据流中提取所需信息是一项重要任务。文中研究了数据流的间隔项,并将其应用到了网络场景中。其中间隔项指在数据流中以固定时间间隔到达的元素对,这是第一项在数据流中定义和统计间隔项的工作。为了高效统计间隔项的top-K,提出了IntervalSketch。IntervalSketch首先基于模拟退火对数据流分块以加快统计速度,其次利用Sketch进行间隔项的存储,最后通过特征分组存储策略降低Sketch存储间隔项的空间开销,提升了统计间隔项的精度。IntervalSketch在两个真实数据集上进行了大量对比实验,实验结果表明,在同样内存的情况下,IntervalSketch明显优于基线方案,其中处理时间为基线方案的1/3~1/2,平均绝对误差、平均相对误差约为基线方案的1/3。

PeakSketch:检测网络流中的top-k流的无偏和通用草图

通过对现有Sketch结构的研究,提出一种新的Sketch结构:PeakSketch,本文将其应用于三种任务:检测top-k频繁流,检测top-k重变化流,检测top-k持久流,从理论上证明了PeakSketch可以提供无偏估计,并且给出了算法的误差界。实验结果表明,PeakSketch的各项性能优秀,在检测top-k频繁流任务中,PeakSketch的吞吐量显著提升,特别是在分配内存小于200 kB以下时,吞吐量最高提升可以达到50%,准确率最高提升一倍,PeakSketch也展现突出的性能。

基于多层Sketch的SDN网络流量测量技术研究

针对大流检测、突变流检测和基数估计等的网络流量测量对保障网络安全具有重要意义.但当前相关研究存在实时性不足、测量精度不高等问题.针对上述问题,设计了一种基于多层Sketch(multiple layer sketch, ML Sketch)的网络流量测量模型.首先,该模型采用自主设计的ML Sketch结构,使用分类存储结构提高了流量测量的精度.其次,在SDN(software defined network)环境下利用流量实时回放技术,模拟了流量的动态发生场景.最后,在SDN控制平面实现了对大流、突变流和基数估计类流量的实时动态检测.在UNSW-NB15上的实验结果表明,与传统Sketch结构相比,所设计的ML Sketch结构在F1_Score指标上最高提高4.81%,相关误差最高降低81.12%,验证了该模型的有效性.

Sketch软件在UI设计中的应用研究

随着移动智能设备的普及和各类App的迭代发展,用户对产品的用户界面(User Interface,UI)期望越来越高。为了追求良好的设计效果,越来越多的计算机图像处理软件被运用到UI设计行业。作为一款专门为数字产品的设计而生的软件,目前,Sketch已经基本替代Photoshop,被广泛地应用于UI设计领域。基于此,文章从Sketch软件在UI设计中的实际应用角度出发,介绍了UI设计与Sketch软件的基本内容,分析了Sketch软件在设计应用中的主要优势和一般步骤。

基于高职应用型人才培养的教学研究——以SketchUp草图大师课程为例

该文以SketchUp草图大师课程为例,阐述了教学改革中高职应用型人才培养的必要性和可行性,分析了现阶段高职院校课程教学中存在的问题,并针对存在的问题提出了具体的解决措施。在此基础上,从学生能力培养、课堂教学质量提升以及教学团队建设等方面探索了课程改革效果,并总结课程改革的实施过程。

A novel molybdenite depressant for efficient selective flotation separation of chalcopyrite and molybdenite

A novel small molecule depressant(M-DEP)was used to separate chalcopyrite and molybdenite via flotation.The results showed that M-DEP had an excellent selective depression on molybdenite,while had little effect on the flotation of chalcopyrite.The adsorption capacity of M-DEP on the surface of molybdenite was greater than that on chalcopyrite surface.The adsorption of M-DEP reduced the floatability of molybdenite and had less effect on the floatability of chalcopyrite,which was due to its different adsorption modes on the surface of the two minerals.Furthermore,the interaction between chalcopyrite and M-DEP was mainly chemical interaction,and almost all of the adsorbed M-DEP molecules were removed and replaced by sodium butyl xanthate(SBX).By contrast,hydrophobic interaction was the main way in which M-DEP was adsorbed on the molybdenite surface with little chemical interaction,which was less interfered by SBX addition.Therefore,M-DEP had a super selective depression on molybdenite.The study provided a novel depressant and approach for the deep separation of chalcopyrite and molybdenite via flotation.

Functional analysis of the novel mitochondrial tRNA^(Trp)and tRNA^(Ser(AGY))variants associated with type 2 diabetes mellitus

BACKGROUND Mutations in mitochondrial tRNA(mt-tRNA)genes that result in mitochondrial dysfunction play important roles in type 2 diabetes mellitus(T2DM).We previously reported a large Chinese pedigree with maternally inherited T2DM that harbors novel mt-tRNA^(Trp)A5514G and tRNA^(Ser(AGY))C12237T variants,however,the effects of these mt-tRNA variants on T2DM progression are largely unknown.AIM To assess the potential pathogenicity of T2DM-associated m.A5514G and m.C12237T variants at genetic,molecular,and biochemical levels.METHODS Cytoplasmic hybrid(cybrid)cells carrying both m.A5514G and m.C12237T variants,and healthy control cells without these mitochondrial DNA(mtDNA)variants were generated using trans-mitochondrial technology.Mitochondrial features,including mt-tRNA steady-state level,levels of adenosine triphosphate(ATP),mitochondrial membrane potential(MMP),reactive oxygen species(ROS),mtDNA copy number,nicotinamide adenine dinucleotide(NAD+)/NADH ratio,enzymatic activities of respiratory chain complexes(RCCs),8-hydroxy-deoxyguanine(8-OhdG),malondialdehyde(MDA),and superoxide dismutase(SOD)were examined in cell lines with and without these mt-tRNA variants.RESULTS Compared with control cells,the m.A5514G variant caused an approximately 35%reduction in the steady-state level of mt-tRNA^(Trp)(P<0.0001);however,the m.C12237T variant did not affect the mt-tRNA^(Ser(AGY))steady-state level(P=0.5849).Biochemical analysis revealed that cells with both m.A5514G and m.C12237T variants exhibited more severe mitochondrial dysfunctions and elevated oxidative stress than control cells:ATP,MMP,NAD+/NADH ratio,enzyme activities of RCCs and SOD levels were markedly decreased in mutant cells(P<0.05 for all measures).By contrast,the levels of ROS,8-OhdG and MDA were significantly increased(P<0.05 for all measures),but mtDNA copy number was not affected by m.A5514G and m.C12237T variants(P=0.5942).CONCLUSION The m.A5514G variant impaired mt-tRNA^(Trp)metabolism,which subsequently caused mitochondrial dysfunction.The m.C12237T variant did not alter the steady-state level of mt-tRNA^(Ser(AGY)),indicating that it may be a modifier of the m.A5514G variant.The m.A5514G variant may exacerbate the pathogenesis and progression of T2DM in this Chinese pedigree.

Fatty acid binding protein 5 is a novel therapeutic target for hepatocellular carcinoma

BACKGROUND Hepatocellular carcinoma(HCC)is an aggressive subtype of liver cancer and is one of the most common cancers with high mortality worldwide.Reprogrammed lipid metabolism plays crucial roles in HCC cancer cell survival,growth,and evolution.Emerging evidence suggests the importance of fatty acid binding proteins(FABPs)in contribution to cancer progression and metastasis;however,how these FABPs are dysregulated in cancer cells,especially in HCC,and the roles of FABPs in cancer progression have not been well defined.AIM To understand the genetic alterations and expression of FABPs and their associated cancer hallmarks and oncogenes in contributing to cancer malignancies.METHODS We used The Cancer Genome Atlas datasets of pan cancer and liver hepatocellular carcinoma(LIHC)as well as patient cohorts with other cancer types in this study.We investigated genetic alterations of FABPs in various cancer types.mRNA expression was used to determine if FABPs are abnormally expressed in tumor tissues compared to non-tumor controls and to investigate whether their expression correlates with patient clinical outcome,enriched cancer hallmarks and oncogenes previously reported for patients with HCC.We determined the protein levels of FABP5 and its correlated genes in two HCC cell lines and assessed the potential of FABP5 inhibition in treating HCC cells.RESULTS We discovered that a gene cluster including five FABP family members(FABP4,FABP5,FABP8,FABP9 and FABP12)is frequently co-amplified in cancer.Amplification,in fact,is the most common genetic alteration for FABPs,leading to overexpression of FABPs.FABP5 showed the greatest differential mRNA expression comparing tumor with non-tumor tissues.High FABP5 expression correlates well with worse patient outcomes(P<0.05).FABP5 expression highly correlates with enrichment of G2M checkpoint(r=0.33,P=1.1e-10),TP53 signaling pathway(r=0.22,P=1.7e-5)and many genes in the gene sets such as CDK1(r=0.56,P=0),CDK4(r=0.49,P=0),and TP53(r=0.22,P=1.6e-5).Furthermore,FABP5 also correlates well with two co-expressed oncogenes PLK1 and BIRC5 in pan cancer especially in LIHC patients(r=0.58,P=0;r=0.58,P=0;respectively).FABP5high Huh7 cells also expressed higher protein levels of p53,BIRC5,CDK1,CDK2,and CDK4 than FABP5low HepG2 cells.FABP5 inhibition more potently inhibited the tumor cell growth in Huh7 cells than in HepG2 cells.CONCLUSION We discovered that FABP5 gene is frequently amplified in cancer,especially in HCC,leading to its significant elevated expression in HCC.Its high expression correlates well with worse patient outcome,enriched cancer hallmarks and oncogenes in HCC.FABP5 inhibition impaired the cell viability of FABP5high Huh7 cells.All these support that FABP5 is a novel therapeutic target for treating FABP5high HCC.

Analyzing the Adaptation of Rebecca from the Novel to the Film in Light of the Black-and-White

Classical Chinese aesthetics is based on Chinese philosophy.The characteristic of classical Chinese aesthetics regards“artistic conception”as one of the basic aesthetic categories.Chinese art speaks highly of the charm of the black-and-white.During the adaptation,there is the same beauty in the black-and-white photography and the“color without color”of Chinese paintings.The“artistic conception”is similar between them from the aesthetic perspective.Therefore,the unique“artistic conception”of the novel should be mastered,if the adapter aims to retain the“soul”of it.In other words,film adaptation not only considers“similarity in form”,but also draws much attention to“similarity in spirit”.The latter is the essence of film adaptation.

Prevention and Nursing of Adverse Reactions of Novel Coronavirus Inactivated Vaccine (Vero Cells)

Objective:To discuss and analyze the causes of adverse reactions caused by the inactivated novel coronavirus vaccine(Vero cells),and to propose methods of prevention and care.Methods:A questionnaire was used to randomly select 229 adults who were vaccinated with the inactivated novel coronavirus vaccine(Vero cells)at Xi’an People’s Hospital(Xi’an Fourth Hospital).The adverse reactions were statistically analyzed.Results:Among the 229 adults vaccinated with the inactivated novel coronavirus vaccine(Vero cells),30 experienced vaccination reactions.The main reaction was local induration at the inoculation site,and dizziness was the primary systemic symptom.Conclusion:To reduce the incidence of adverse reactions to the inactivated novel coronavirus vaccine(Vero cells),it is necessary to effectively evaluate the health status of adults before vaccination,select the correct vaccination site,and strictly implement the rules of 3-inspections,7-checks,and 1-verification.Standardizing the operation process and providing thorough health education after vaccination can effectively reduce the occurrence of adverse reactions.

The Application of Newmark’s Metaphor Theory in Novel Translation--A Case Study of“the Jade King:History of a Chinese Muslim Family”

This paper examines the metaphorical part of“The Jade King:History of a Chinese Muslim Family”,Hoda’s novel,under the guidance of Newmark’s theory of metaphor.Newmark proposes six categories of metaphors,namely Dead Metaphor,ClichéMetaphor,Stock or Standard Metaphor,Adapted Metaphor,Recent Metaphor,Original Metaphor;and seven strategies of metaphor translation,including reproducing the same image in the target language,replacing the image in the source language with a standard target language image,translation of metaphor by simile,translation of metaphor(or simile)by simile plus sense,conversion of metaphor to sense,deletion and same metaphor combined with sense.They can provide a strong theoretical support for analyzing the expressions of metaphors in novels and their translation methods.By deeply analyzing the expressions of metaphor and its translation methods in novels,it not only helps to understand the metaphorical meaning and cultural connotation of the original works,but also helps to explore the cultural differences and challenges faced by English and Chinese bilingualism in the process of metaphor translation,thereby significantly improving the translation level and promoting the development of translation research.

Text-to-Sketch Synthesis via Adversarial Network

In the past,sketches were a standard technique used for recognizing offenders and have remained a valuable tool for law enforcement and social security purposes.However,relying on eyewitness observations can lead to discrepancies in the depictions of the sketch,depending on the experience and skills of the sketch artist.With the emergence of modern technologies such as Generative Adversarial Networks(GANs),generating images using verbal and textual cues is now possible,resulting in more accurate sketch depictions.In this study,we propose an adversarial network that generates human facial sketches using such cues provided by an observer.Additionally,we have introduced an Inverse Gamma Correction Technique to improve the training and enhance the quality of the generated sketches.To evaluate the effectiveness of our proposed method,we conducted experiments and analyzed the results using the inception score and Frechet Inception Distance metrics.Our proposed method achieved an overall inception score of 1.438±0.049 and a Frechet Inception Distance of 65.29,outperforming other state-of-the-art techniques.

基于Sketch Engine检索工具的日语近义词辨析——以「積む」「蓄える」「重ねる」为例

基于在线语料库检索工具Sketch Engine,利用其目标语料库Japanese Web 2011(jaTenTen11)中的Word Sketch Difference(词汇素描差异)功能与Concordance(词语索引)功能,考察了近义词「積む」「蓄える」「重ねる」的词语搭配规律及语义特征。主要考察了这三个动词所搭配的宾格名词的显著性并通过分布图直观地呈现了其分布情况。另外,还通过词汇素描差异对比,对「積む」与「蓄える」,「積む」与「重ねる」进行了辨析。该研究方法将改变传统的近义词辨析方法,利用大型语料库的数据优势来阐释问题,研究结果更客观、直观,更具说服力,不仅可应用于日语教学,也可以利用语料库推进学生开展数据驱动学习及自主学习实践。

精细化工项目上Sketch Up三维配管的应用研究

近年来,我国工业经济持续稳定发展,各行业领域在产品生产过程中进一步消耗和开发资源,其中工业生产污染物排放问题对自然生态环境造成了一定影响,甚至威胁人民群众的生命健康,对此如何有效提升工业领域生产效率,降低工业生产能耗,有效维护自然生态环境越发受到社会各界的广泛关注。精细化工产业在进行化工灌区工艺设计和设备安装时需要积极应用三维建模技术,Sketch Up软件以其独特优势在精细化工项目中进行广泛应用。基于此,文章主要针对精细化工项目上Sketch Up三维配管进行应用研究。

Clinical and genetic characteristics of retinoblastoma patients in a single center with four novel RB1 variants

AIM:To assess the clinical and genetic characteristics of children diagnosed with retinoblastoma(RB)at Gazi University Faculty of Medicine’s Department of Pediatric Oncology.METHODS:All cases diagnosed with RB and received treatment and follow-up in the Ophthalmology and Pediatric Oncology Department,October 2016 to May 2021 were evaluated retrospectively.The RB1 gene was analyzed by next-generation sequencing(NGS)technique in DNAs obtained from peripheral blood samples of the patients.RESULTS:This study included 53 cases with 67 RBaffected eyes during the study period.The mean age was 24.6(median:18.5,range:3–151)mo.There were 15(22.3%)Group D eyes and 39(58.2%)Group E eyes.The RB1 gene was sequenced by the NGS method in 19 patients.Heterozygous RB1:NM_000321.3:c.54_76del(p.Glu19AlafsTer4)variant was detected in a 15-month-old female with bilateral RB.Heterozygous RB1:NM_000321.3:c.1814+3A>T variant was detected in a 5.5-month-old male with bilateral RB.The intronic RB1:NM_000321.3:c.1332+4A>G variant was detected in patient 14,a 13-month-old male with unilateral RB.The RB1:NM_000321.3:c.575_576del(p.Lys192SerfsTer10)variant was found in an 18-month-old female with an allele frequency of 37%.These variants have not been reported in the literature and mutation databases.CONCLUSION:Four novel variants are described and one of them is found in two different patients.This data is crucial for assessing prognosis.It serves as a guide for estimating the long-term risk of secondary malignancy as well as the short-term risk of developing additional malignancies in the same eye and the other eye.

基于Sketch Engine检索工具的日语近义词辨析--以「探す」「探る」「見付ける」为例

本文基于在线语料库检索工具Sketch Engine,以Japanese Web 2011(jaTenTen11)为检索语料库,利用其词语索引(Concordance)功能、词汇素描(Word Sketch)功能、词汇素描差异(Word Sketch Difference)功能,考察了日语中的「探す」「探る」「見付ける」这三个近义动词的搭配特点、规律,以及语义趋向(Semantic Preference),并对搭配词的分布情况进行了可视化呈现。教师利用Sketch Engine工具不仅可以进行近义词辨析研究,还可以应用于词汇教学及翻转课堂实践,学习者也可以利用此方法提高词汇学习效率,从而提升语言技能。

基于Sketch Engine和WordNet“雨”的概念隐喻研究

雨是人们经常接触到的一种天气现象。人们通过各种不同的生活经历和历史、文化的积累,赋予它越来越深刻的意义。基于BNC语料库,本文借助Sketch Engine和WordNet收集所有与“雨”有关的表达式,并运用概念隐喻理论系统地分析英语中有关“雨”的隐喻表达。得出以下发现:1) “雨”作名词时的隐喻表达明显多于其作为动词时的表达。2) 9个“雨”的名词隐喻表达式的成因与体认有关,人们在特定的文化模式下形成了独特的认知。

A Novel Approach for Optimum Conjunctive Use Management of Groundwater and Surface Water Resources under Uncertainty

Uncertainty in determining optimum conjunctive water use lies not only on variability of hydrological cycle and climate but also on lack of adequate data and perfect knowledge about groundwater-surface water system interactions, errors in historic data and inherent variability of system parameters both in space and time. Simulation-optimization models are used for conjunctive water use management under uncertain conditions. However, direct application of such approach whereby all realizations are considered at every-iteration of the optimization process leads to a highly computational time-consuming optimization problem as the number of realizations increases. Hence, this study proposes a novel approach—a Retrospective Optimization Approximation (ROA) approach. In this approach, a simulation model was used to determine aquifer system responses (draw-downs) which were assembled as response matrices and incorporated in the optimization model (procedure) as coefficients in the constraints. The sample optimization sub-problems generated, were solved and analyzed through ROA-Active-Set procedure implemented under MATLAB code. The ROA-Active Set procedure solves and evaluates a sequence of sample path optimization sub-problems in an increasing number of realizations. The methodology was applied to a real-world conjunctive water use management problem found in Great Letaba River basin, South Africa. In the River basin, surface water source contributes 87% of the existing un-optimized total conjunctive water use withdrawal rate (6512.04 m3/day) and the remaining 13% is contributed by groundwater source. Through ROA approach, results indicate that the optimum percentages contribution of the surface and subsurface sources to the total water demand are 58% and 42% respectively. This implies that the existing percentage contribution can be increased or reduced by ±29% that is groundwater source can be increased by 29% while the surface water source contribution can be reduced by 29%. This reveals that the existing conjunctive water use practice is unsustainable wherein surface water system is overstressed while groundwater system is under-utilized. Through k-means sampling technique ROA-Active Set procedure was able to attain a converged maximum expected total optimum conjunctive water use withdrawal rate of 4.35 × 104 m3/day within a relatively few numbers of iterations (6 to 8 iterations) in about 2.30 Hrs. In conclusion, results demonstrated that ROA approach is capable of managing real-world regional aquifers sustainable conjunctive water use practice under hydro-geological uncertainty conditions.