Based on the effects of skim components on ammonium removal as well as the current processing technology, a new process-intensified technology of removing ammonia from skim by air stripping on rotating packed bed was ...Based on the effects of skim components on ammonium removal as well as the current processing technology, a new process-intensified technology of removing ammonia from skim by air stripping on rotating packed bed was proposed. The experiments were conducted on a wave-thread packed Rotating Packed Bed(RPB) under atmospheric pressure, suggesting that, in terms of order of importance, the ammonium concentration of feed-stock(x_w), the average ultra-gravity factor(β), feed-stock flux(L), and gas flux(G) had significant impact on ammonium removal rate(η) and the ammonium concentration of products(x_D). In the experiment, mass-transfer coefficient in gas phase(k_ya_e) increases with the increase of β, G/L, and L. The ammonium concentration of products decreases with the increase of β, G/L and the increase of L. The ammonium concentration of products would be as low as ~0.10% and the ammonia removal rate would be 63.21% when skim temperature was 25 °C, x_w0.28%, β 133.2, and G/L 15.0 m^3·L^(-1). Experiment results indicated that the proposed technology for removing ammonium from skim on a rotating packed bed would be a new process-intensified technique compared with traditional aeration process and centrifugal atomization method.展开更多
A FAST (fluorescence of advanced Maillard products and Soluble Tryptophan) method for identification of recon- stituted milk made from skim milk powder in the fresh milk was developed. Considering milk and skim milk p...A FAST (fluorescence of advanced Maillard products and Soluble Tryptophan) method for identification of recon- stituted milk made from skim milk powder in the fresh milk was developed. Considering milk and skim milk powders variations from different seasons and countries, milk was collected from different dairy farms in different seasons and skim milk powders were collected from different countries to measure the Tryptophan (Trp), advanced Maillard products (AMP) fluorescence values. The results showed that there were differences (P<0.01) between raw and reconstituted milk. The plot of values in each mixed level of raw and reconstituted milk had a correlation coefficient >0.97. The FAST method is a simple, rapid, low-cost and sensitive method enabling the detection of 5% reconstituted milk in fresh milk. The measurement of the Trp, AMP fluorescence values and calculation of the FAST index is a suitable method for large-scale monitoring of fresh milk samples.展开更多
[Objective] The aim of this study was to investigate the decolorization ef- fects of activated carbon and macroporous resin on Periplaneta americana L. skimmed cream and compare the advantages and disadvantages of the...[Objective] The aim of this study was to investigate the decolorization ef- fects of activated carbon and macroporous resin on Periplaneta americana L. skimmed cream and compare the advantages and disadvantages of the two decolorization technologies. [Method] Periplaneta americana L. skimmed cream was decolored with activated carbon and macroporous resin, and freeze-dried to collect solid decolorization products. By investigating the yield, decolorization rate, protein retention rate and decolorization operation process, the advantages and disadvantages of the two decolorization technologies were compared. [Result] Both activated carbon and macroporous resin can be used for decolorization. To be specific, macroporous resin-decolorization is superior in the yield and protein retention rate, while activated carbon-decolorization is superior in decolorization rate and decolorization operation process. [Conclusion] Macroporous resin-decolorization can be used if protein is the main ingredient required in the experiment, while activated carbon-decolorization can be used if protein is not the main ingredient required.展开更多
In order to make the slag from desulphurization and slag skimming(SDSS)to be comprehensively recycled and utilized,a combined process of beneficiation and building materials preparation was proposed to recover iron fr...In order to make the slag from desulphurization and slag skimming(SDSS)to be comprehensively recycled and utilized,a combined process of beneficiation and building materials preparation was proposed to recover iron from SDSS,meanwhile to apply the remaining slag tailings as cement admixture.From this process,three iron-rich products were recovered in stages by clean gravity-magnetic separation,slag tailings were left.Slag powder was prepared by ultrafine grinding of slag tailings.The stability,setting time and cement mortar strength of the slag tailings cements(STC)which were mixed with Portland cement and slag powder were studied respectively.The results showed that a proper overall performance still could be obtained at the slag powder content of 30%.Chemical composition analysis,X-ray diffraction(XRD)analysis,metallographic microscope and scanning electron microscope(SEM)analysis were employed to assess the characteristics of the SDSS and the products obtained from the whole process.The results indicated that the three iron-rich products could be used as a raw material for steelmaking and ironmaking and the relatively large amount of calcium silicate(C_(2)S)and tricalcium silicate(C_(3)S)in the slag tailings make the addition of slag powder into the Portland cement feasible.展开更多
This paper has proposed a new modelling and simulating technique for the echo of the semi-active radar seeker against the sea skimming target. The echo modelling is based on the electromagnetic scattering mechanisms. ...This paper has proposed a new modelling and simulating technique for the echo of the semi-active radar seeker against the sea skimming target. The echo modelling is based on the electromagnetic scattering mechanisms. A modified Four-path model based on the radar detection scene is used to describe the multipath scattering between the target and rough sea surface. A Facet-based Small Slope Approximation (FBSSA) method is employed to calculate the scattering from the sea surface. The Physical Optics (PO) and the Equivalent Edge Current (EEC) Method is used to calculate the target scattering. In the echo simulations. The results present the original echo and the echo processed by the signal processing procedures, where the clutter and multipath effect can be observed.展开更多
Celtis is a Cannabaceae genus of 60e70 species of trees,or rarely shrubs,commonly known as hackberries.This woody genus consists of very valuable forest plants that provide important wildlife habitat for birds and mam...Celtis is a Cannabaceae genus of 60e70 species of trees,or rarely shrubs,commonly known as hackberries.This woody genus consists of very valuable forest plants that provide important wildlife habitat for birds and mammals.Although previous studies have identified its phylogenetic position,interspecific relationships within Celtis remain unclear.In this study,we generated genome skimming data from five Celtis species to analyze phylogenetic relationships within the genus and develop genome resources.The plastomes of Celtis ranged in length from 158,989 bp to 159,082 bp,with a typical angiosperm quadripartite structure,and encoded a total of 132 genes with 20 duplicated in the IRs.Comparative analyses showed that plastome content and structure were relatively conserved.Whole plastomes showed no signs of gene loss,translocations,inversions,or genome rearrangement.Six plastid hotspot regions(trnH-psbA,psbA-trnK,trnG-trnR,psbC-trnS,cemA-petA and rps8-rpl14),4097 polymorphic nuclear SSRs,as well as 62 low or single-copy gene fragments were identified within Celtis.Moreover,the phylogenetic relationships based on the complete plastome sequences strongly endorse the placement of C.biondii as sister to the((((C.koraiensis,C.sinensis),C.tetrandra),C.julianae),C.cerasifera)clade.These findings and the genetic resources developed here will be conducive to further studies on the genus Celtis involving phylogeny,population genetics,and conservation biology.展开更多
This paper deals with some aspects of the air entrainment process along the chute of spillway and study of pressure fluctuations. The experimental study has been carried out using stepped spillway model located in the...This paper deals with some aspects of the air entrainment process along the chute of spillway and study of pressure fluctuations. The experimental study has been carried out using stepped spillway model located in the campus of Government College of Engineering, Amravati (India). It is observed that air concentration is increasing with discharge as well as with number of step. Air concentration is increasing along the length of spillway. It is also observed that the bottom mean air concentration increases with step height in the upstream reach of stepped spillway, which is prone to cavitation. The pressure profiles exhibit a wavy pattern down the stepped chute and pressure on each step increases with ratio of critical depth to step height (yc/h).展开更多
As a widely used flood energy dissipator, the stepped spillway can significantly dissipate the kinetic or hydraulic energy due to the air-entrainment in skimming flow over the steps. The free-surface aeration involves...As a widely used flood energy dissipator, the stepped spillway can significantly dissipate the kinetic or hydraulic energy due to the air-entrainment in skimming flow over the steps. The free-surface aeration involves the sharp deformation of the free surface and the complex turbulent shear flows. In this study, the volume of fluid (VOF), mixture, and Eulerian methods are utilized to simulate the air-entrainment by coupling with the Reynolds-averaged Navier-Stokes/large eddy simulation (RANS/LES) turbulence models. The free surface deformation, air volume fraction, pressure, and velocity are compared for the three different numerical methods. Only the Eulerian+RANS method fails to capture the free-surface aeration. The air volume fraction predicted by the VOF+LES method best matches the experimental measurement, while the mixture+LES method predicts the inception point of the air entrainment more accurately.展开更多
For a long time, fermented dairy products have been consumed for human’s nutrition and health. Recently, consumption of whole dairy products, such as full fat yoghurt, has declined due to the awareness of probable ha...For a long time, fermented dairy products have been consumed for human’s nutrition and health. Recently, consumption of whole dairy products, such as full fat yoghurt, has declined due to the awareness of probable harmful effects of fat on consumers’ health, resulting change of market interest in favor of low or non fat dairy products. It is a challenge for food scientists to produce a suitable fat substitute providing the functionality of the missing fat. The present investigation was carried out to examine the effect of 0 to 50% renneted skim milk (RSM) as a fat mimetic upon the physico-chemical, physical, rheological and sensory characteristics of nonfat yoghurt in comparison to control samples (full fat and skim yoghurt). By increasing RSM content, the chemical characteristics (titratable acidity, pH as well as the content of fat and total protein) of yoghurts did not alter except decrease of total solid in sample with 50% RSM. The yoghurts with more content of RSM exhibited higher b*and a* values, while the highest L* value, viscosity, water holding capacity (WHC), firmness and lowest syneresis were found in sample containing 30% RSM. It seems that new interaction in gel network of yoghurts containing RSM, exhibited greater ability to bind water than control skim yoghurt. In addition, probably new bridges between milk proteins (interacting partially hydrolyzed casein with casein) can increase the number of bounds between protein particles leading to lower syneresis. However, excessive RSM content (higher than 30%) did not increase the L* value, viscosity and WHC of samples probably because of too much aggregation of casein. Sensory results revealed that sample containing 30% RSM was exactly alike to full fat yoghurt in terms of overall sensory attributes. New formulation of palatable skim yoghurt was developed using 3% RSM successfully.展开更多
This paper illustrates the similarity and dissimilarity between two basic reading skills- skimming and scanning from different ways.It advises readers to understand and make full use of them in their everyday reading....This paper illustrates the similarity and dissimilarity between two basic reading skills- skimming and scanning from different ways.It advises readers to understand and make full use of them in their everyday reading.They will make reading easier and help improve reading comprehension to a certain extent.展开更多
Limited enzymatic hydrolysis of skim milk by trypsin was investigated in this paper, and it was found that the degree of hydrolysis (DH) of milk proteins had a relationship of DH -1 =a+bt -1 with the time(t) o...Limited enzymatic hydrolysis of skim milk by trypsin was investigated in this paper, and it was found that the degree of hydrolysis (DH) of milk proteins had a relationship of DH -1 =a+bt -1 with the time(t) of hydrolysis at low enzyme concentrations, some properties of the protein such as NSI in PI or TCA were changed obviously. It was suggested that most milk proteins would be degraded into peptides by trypsin .展开更多
Atorvastatin has low aqueous solubility resulting in low oral bioavailability(12%)and thus presents a challenge in formulating a suitable dosage form.To improve the aqueous solubility,a solid dispersion formulation of...Atorvastatin has low aqueous solubility resulting in low oral bioavailability(12%)and thus presents a challenge in formulating a suitable dosage form.To improve the aqueous solubility,a solid dispersion formulation of atorvasta tin was prepared by lyophilization utilising skimmed milk as a carrier.Six different formulations were prepared with varying ratios of drug and carrier and the corresponding physical mixtures were also prepared.The formation of a solid dispersion formulation was confirmed by differential scanning ca lorimetry and X-ray diffraction studies.The optimum drug-to-carrier ratio of 1:9 en hanced solubility nearly 33-fold as compared to pure drug.In vitro drug release studies exhibited a cumulative release of 83.69% as compared to 22.7% for the pure drug.Additionally,scanning electron microscopy studies suggested the conversion of crystalline atorvastatin to an amorphous form.In a Triton-induced hyperlipidemia model,a 3-fold increase in the lipid lowering potential was obtained with the reformulated drug as compared to pure drug.These results suggest that solid dispersion of atorvastatin using skimmed milk as carrier is a promising approach for oral delivery of atorvastatin.展开更多
Numerical simulation of stepped channel flow was conducted using turbulence models based on the VOF technique. Stepped channel flow is a complicated air-water two-phase flow with free surface, which can be divided int...Numerical simulation of stepped channel flow was conducted using turbulence models based on the VOF technique. Stepped channel flow is a complicated air-water two-phase flow with free surface, which can be divided into three flow regimes: skimming flow, nappe flow and transition flow. The characteristics of skimming flow over mild stepped channel was investigated, including friction factors, air concentration profiles velocity field, clear-water and bulked depths, static pressure, etc. Smooth channel flow was also simulated to compare the hydraulic characteristics of the stepped channel flow with the smooth one. Comparisons between the computed and the measured were made. Furthermore, comparison of the computed air concentration with Straub and Anderson's data was also performed. The Fluent 6.1 software was employed to conduct this numerical simulation work.展开更多
Genome skimming has dramatically extended DNA barcoding from short DNA fragments to next generation barcodes in plants.However,conserved DNA barcoding markers,including complete plastid genome and nuclear ribosomal DN...Genome skimming has dramatically extended DNA barcoding from short DNA fragments to next generation barcodes in plants.However,conserved DNA barcoding markers,including complete plastid genome and nuclear ribosomal DNA(nrDNA)sequences,are inadequate for accurate species identification.Skmer,a recently proposed approach that estimates genetic distances among species based on unassembled genome skims,has been proposed to effectively improve species discrimination rate.In this study,we used Skmer to identify species based on genomic skims of 47 individuals representing 10 out of 13 species of Schima(Theaceae)from China.The unassembled reads identified six species,with a species identification rate of 60%,twice as high as previous efforts that used plastid genomes(27.27%).In addition,Skmer was able to identify Schima species with only 0.5sequencing depth,as six species were well-supported with unassembled data sizes as small as 0.5 Gb.These findings demonstrate the potential for Skmer approach in species identification,where nuclear genomic data plays a crucial role.For taxonomically difficult taxa such as Schima,which have diverged recently and have low levels of genetic variation,Skmer is a promising alternative to next generation barcodes.展开更多
基金Supported by the Opening Project Fund of Key Laboratory of Danzhou Investigation&Experiment Station of Tropical Crops,Ministry of Agriculture(RRI-KLOF201701)
文摘Based on the effects of skim components on ammonium removal as well as the current processing technology, a new process-intensified technology of removing ammonia from skim by air stripping on rotating packed bed was proposed. The experiments were conducted on a wave-thread packed Rotating Packed Bed(RPB) under atmospheric pressure, suggesting that, in terms of order of importance, the ammonium concentration of feed-stock(x_w), the average ultra-gravity factor(β), feed-stock flux(L), and gas flux(G) had significant impact on ammonium removal rate(η) and the ammonium concentration of products(x_D). In the experiment, mass-transfer coefficient in gas phase(k_ya_e) increases with the increase of β, G/L, and L. The ammonium concentration of products decreases with the increase of β, G/L and the increase of L. The ammonium concentration of products would be as low as ~0.10% and the ammonia removal rate would be 63.21% when skim temperature was 25 °C, x_w0.28%, β 133.2, and G/L 15.0 m^3·L^(-1). Experiment results indicated that the proposed technology for removing ammonium from skim on a rotating packed bed would be a new process-intensified technique compared with traditional aeration process and centrifugal atomization method.
基金Project (No. 2002BA518A06) supported by the Hi-Tech Researchand Development Program (863) of China
文摘A FAST (fluorescence of advanced Maillard products and Soluble Tryptophan) method for identification of recon- stituted milk made from skim milk powder in the fresh milk was developed. Considering milk and skim milk powders variations from different seasons and countries, milk was collected from different dairy farms in different seasons and skim milk powders were collected from different countries to measure the Tryptophan (Trp), advanced Maillard products (AMP) fluorescence values. The results showed that there were differences (P<0.01) between raw and reconstituted milk. The plot of values in each mixed level of raw and reconstituted milk had a correlation coefficient >0.97. The FAST method is a simple, rapid, low-cost and sensitive method enabling the detection of 5% reconstituted milk in fresh milk. The measurement of the Trp, AMP fluorescence values and calculation of the FAST index is a suitable method for large-scale monitoring of fresh milk samples.
基金Supported by National Natural Science Foundation of China(30560181)~~
文摘[Objective] The aim of this study was to investigate the decolorization ef- fects of activated carbon and macroporous resin on Periplaneta americana L. skimmed cream and compare the advantages and disadvantages of the two decolorization technologies. [Method] Periplaneta americana L. skimmed cream was decolored with activated carbon and macroporous resin, and freeze-dried to collect solid decolorization products. By investigating the yield, decolorization rate, protein retention rate and decolorization operation process, the advantages and disadvantages of the two decolorization technologies were compared. [Result] Both activated carbon and macroporous resin can be used for decolorization. To be specific, macroporous resin-decolorization is superior in the yield and protein retention rate, while activated carbon-decolorization is superior in decolorization rate and decolorization operation process. [Conclusion] Macroporous resin-decolorization can be used if protein is the main ingredient required in the experiment, while activated carbon-decolorization can be used if protein is not the main ingredient required.
基金The authors gratefully acknowledge the National Key Research and Development Program of China(No.2018YFC1901902)the Liao Ning Revitalization Talents Program(No.XLYC1907162).
文摘In order to make the slag from desulphurization and slag skimming(SDSS)to be comprehensively recycled and utilized,a combined process of beneficiation and building materials preparation was proposed to recover iron from SDSS,meanwhile to apply the remaining slag tailings as cement admixture.From this process,three iron-rich products were recovered in stages by clean gravity-magnetic separation,slag tailings were left.Slag powder was prepared by ultrafine grinding of slag tailings.The stability,setting time and cement mortar strength of the slag tailings cements(STC)which were mixed with Portland cement and slag powder were studied respectively.The results showed that a proper overall performance still could be obtained at the slag powder content of 30%.Chemical composition analysis,X-ray diffraction(XRD)analysis,metallographic microscope and scanning electron microscope(SEM)analysis were employed to assess the characteristics of the SDSS and the products obtained from the whole process.The results indicated that the three iron-rich products could be used as a raw material for steelmaking and ironmaking and the relatively large amount of calcium silicate(C_(2)S)and tricalcium silicate(C_(3)S)in the slag tailings make the addition of slag powder into the Portland cement feasible.
文摘This paper has proposed a new modelling and simulating technique for the echo of the semi-active radar seeker against the sea skimming target. The echo modelling is based on the electromagnetic scattering mechanisms. A modified Four-path model based on the radar detection scene is used to describe the multipath scattering between the target and rough sea surface. A Facet-based Small Slope Approximation (FBSSA) method is employed to calculate the scattering from the sea surface. The Physical Optics (PO) and the Equivalent Edge Current (EEC) Method is used to calculate the target scattering. In the echo simulations. The results present the original echo and the echo processed by the signal processing procedures, where the clutter and multipath effect can be observed.
基金supported by the National Natural Science Foundation of China(Grant Nos.31900188,31970225)Natural Science Foundation of Zhejiang Province(Grant No.LY19C030007).
文摘Celtis is a Cannabaceae genus of 60e70 species of trees,or rarely shrubs,commonly known as hackberries.This woody genus consists of very valuable forest plants that provide important wildlife habitat for birds and mammals.Although previous studies have identified its phylogenetic position,interspecific relationships within Celtis remain unclear.In this study,we generated genome skimming data from five Celtis species to analyze phylogenetic relationships within the genus and develop genome resources.The plastomes of Celtis ranged in length from 158,989 bp to 159,082 bp,with a typical angiosperm quadripartite structure,and encoded a total of 132 genes with 20 duplicated in the IRs.Comparative analyses showed that plastome content and structure were relatively conserved.Whole plastomes showed no signs of gene loss,translocations,inversions,or genome rearrangement.Six plastid hotspot regions(trnH-psbA,psbA-trnK,trnG-trnR,psbC-trnS,cemA-petA and rps8-rpl14),4097 polymorphic nuclear SSRs,as well as 62 low or single-copy gene fragments were identified within Celtis.Moreover,the phylogenetic relationships based on the complete plastome sequences strongly endorse the placement of C.biondii as sister to the((((C.koraiensis,C.sinensis),C.tetrandra),C.julianae),C.cerasifera)clade.These findings and the genetic resources developed here will be conducive to further studies on the genus Celtis involving phylogeny,population genetics,and conservation biology.
文摘This paper deals with some aspects of the air entrainment process along the chute of spillway and study of pressure fluctuations. The experimental study has been carried out using stepped spillway model located in the campus of Government College of Engineering, Amravati (India). It is observed that air concentration is increasing with discharge as well as with number of step. Air concentration is increasing along the length of spillway. It is also observed that the bottom mean air concentration increases with step height in the upstream reach of stepped spillway, which is prone to cavitation. The pressure profiles exhibit a wavy pattern down the stepped chute and pressure on each step increases with ratio of critical depth to step height (yc/h).
基金supported by the Guangdong Special Research Fund of Public Welfare and Capacity Building(2015A020216008)the Special Program for Applied Research on Super Computation of the NSFC-Guangdong Joint Fund(the second phase)
文摘As a widely used flood energy dissipator, the stepped spillway can significantly dissipate the kinetic or hydraulic energy due to the air-entrainment in skimming flow over the steps. The free-surface aeration involves the sharp deformation of the free surface and the complex turbulent shear flows. In this study, the volume of fluid (VOF), mixture, and Eulerian methods are utilized to simulate the air-entrainment by coupling with the Reynolds-averaged Navier-Stokes/large eddy simulation (RANS/LES) turbulence models. The free surface deformation, air volume fraction, pressure, and velocity are compared for the three different numerical methods. Only the Eulerian+RANS method fails to capture the free-surface aeration. The air volume fraction predicted by the VOF+LES method best matches the experimental measurement, while the mixture+LES method predicts the inception point of the air entrainment more accurately.
文摘For a long time, fermented dairy products have been consumed for human’s nutrition and health. Recently, consumption of whole dairy products, such as full fat yoghurt, has declined due to the awareness of probable harmful effects of fat on consumers’ health, resulting change of market interest in favor of low or non fat dairy products. It is a challenge for food scientists to produce a suitable fat substitute providing the functionality of the missing fat. The present investigation was carried out to examine the effect of 0 to 50% renneted skim milk (RSM) as a fat mimetic upon the physico-chemical, physical, rheological and sensory characteristics of nonfat yoghurt in comparison to control samples (full fat and skim yoghurt). By increasing RSM content, the chemical characteristics (titratable acidity, pH as well as the content of fat and total protein) of yoghurts did not alter except decrease of total solid in sample with 50% RSM. The yoghurts with more content of RSM exhibited higher b*and a* values, while the highest L* value, viscosity, water holding capacity (WHC), firmness and lowest syneresis were found in sample containing 30% RSM. It seems that new interaction in gel network of yoghurts containing RSM, exhibited greater ability to bind water than control skim yoghurt. In addition, probably new bridges between milk proteins (interacting partially hydrolyzed casein with casein) can increase the number of bounds between protein particles leading to lower syneresis. However, excessive RSM content (higher than 30%) did not increase the L* value, viscosity and WHC of samples probably because of too much aggregation of casein. Sensory results revealed that sample containing 30% RSM was exactly alike to full fat yoghurt in terms of overall sensory attributes. New formulation of palatable skim yoghurt was developed using 3% RSM successfully.
文摘This paper illustrates the similarity and dissimilarity between two basic reading skills- skimming and scanning from different ways.It advises readers to understand and make full use of them in their everyday reading.They will make reading easier and help improve reading comprehension to a certain extent.
文摘Limited enzymatic hydrolysis of skim milk by trypsin was investigated in this paper, and it was found that the degree of hydrolysis (DH) of milk proteins had a relationship of DH -1 =a+bt -1 with the time(t) of hydrolysis at low enzyme concentrations, some properties of the protein such as NSI in PI or TCA were changed obviously. It was suggested that most milk proteins would be degraded into peptides by trypsin .
文摘Atorvastatin has low aqueous solubility resulting in low oral bioavailability(12%)and thus presents a challenge in formulating a suitable dosage form.To improve the aqueous solubility,a solid dispersion formulation of atorvasta tin was prepared by lyophilization utilising skimmed milk as a carrier.Six different formulations were prepared with varying ratios of drug and carrier and the corresponding physical mixtures were also prepared.The formation of a solid dispersion formulation was confirmed by differential scanning ca lorimetry and X-ray diffraction studies.The optimum drug-to-carrier ratio of 1:9 en hanced solubility nearly 33-fold as compared to pure drug.In vitro drug release studies exhibited a cumulative release of 83.69% as compared to 22.7% for the pure drug.Additionally,scanning electron microscopy studies suggested the conversion of crystalline atorvastatin to an amorphous form.In a Triton-induced hyperlipidemia model,a 3-fold increase in the lipid lowering potential was obtained with the reformulated drug as compared to pure drug.These results suggest that solid dispersion of atorvastatin using skimmed milk as carrier is a promising approach for oral delivery of atorvastatin.
文摘Numerical simulation of stepped channel flow was conducted using turbulence models based on the VOF technique. Stepped channel flow is a complicated air-water two-phase flow with free surface, which can be divided into three flow regimes: skimming flow, nappe flow and transition flow. The characteristics of skimming flow over mild stepped channel was investigated, including friction factors, air concentration profiles velocity field, clear-water and bulked depths, static pressure, etc. Smooth channel flow was also simulated to compare the hydraulic characteristics of the stepped channel flow with the smooth one. Comparisons between the computed and the measured were made. Furthermore, comparison of the computed air concentration with Straub and Anderson's data was also performed. The Fluent 6.1 software was employed to conduct this numerical simulation work.
基金supported by National Natural Science Foundation of China(No.32070369)the Youth Innovation Promotion Association CAS of China(No.2021393)+1 种基金the Yunnan Revitalization Talent Support Program“Young Talent”Project,the Applied Fundamental Research Foundation of Yunnan Province(202301AT070308)the Fund of Yunnan Key Laboratory of Plant Reproductive Adaptation and Evolutionary Ecology(YNPRAEC-2023006).
文摘Genome skimming has dramatically extended DNA barcoding from short DNA fragments to next generation barcodes in plants.However,conserved DNA barcoding markers,including complete plastid genome and nuclear ribosomal DNA(nrDNA)sequences,are inadequate for accurate species identification.Skmer,a recently proposed approach that estimates genetic distances among species based on unassembled genome skims,has been proposed to effectively improve species discrimination rate.In this study,we used Skmer to identify species based on genomic skims of 47 individuals representing 10 out of 13 species of Schima(Theaceae)from China.The unassembled reads identified six species,with a species identification rate of 60%,twice as high as previous efforts that used plastid genomes(27.27%).In addition,Skmer was able to identify Schima species with only 0.5sequencing depth,as six species were well-supported with unassembled data sizes as small as 0.5 Gb.These findings demonstrate the potential for Skmer approach in species identification,where nuclear genomic data plays a crucial role.For taxonomically difficult taxa such as Schima,which have diverged recently and have low levels of genetic variation,Skmer is a promising alternative to next generation barcodes.