Evaluation of Entrance Skin Dose from Paediatric Diagnostic X-Ray Examination

As children are prone to be more radiosensitive than adults, it is imperative to assess the Entrance Skin Doses (ESDs) for patients being examined by X-rays, in order to ensure the optimization of dose while considering a number of other fickles. The ESD received by 50 paediatrics (aged 1-13 years) undergoing 8 types of X-ray examinations were measured at Federal Teaching Hospital, Ido-Ekiti, Ekiti, Nigeria, within a period of February 2019 to March 2020 using thermoluminescent dosimeters. The mean ± SD of ESDs were 0.85 ± 0.32, 2.04 ± 0.75, 0.60 ± 0.07, 0.62 ± 0.22, 0.57 ± 0.24, 1.75 ± 0.76, 0.93 ± 0.31 and 0.63 ± 0.06 mGy for Chest, Skull, Hand, Forearm, Knee, Abdomen, Leg and Feet, respectively. The mean ESDs were found to be within the recommended reference dose in all examinations, except for the Chest examination which was higher. The data obtained in this study will serve as existing data in Nigeria for future research works, as it would assist in optimizing dose to patients, especially the paediatrics.

The impact of intensity modulated radiotherapy on the skin dose for deep seated tumors

Objective: The purpose of this study was to investigate the impact of intensity modulated radiotherapy (IMRT) on surface doses for brain, abdomen and pelvis deep located tumors treated with 6 MV photon and to evaluate the skin dose calculation accuracy of the XIO 4.04 treatment planning system. Methods: More investigations for the influences of IMRT on skin doses would increase its applications for many treatment sites. Measuring skin doses in real treatment situations would reduce the uncertainty of skin dose prediction. In this work a pediatric human phantom was covered by a layer of 1 mm bolus at three treatment sites and thermoluminescent dosimeter (TLD) chips were inserted into the bolus at each treatment site before CT scan. Two different treatment plans [three-dimensional conformal radiation therapy (3DCRT) and IMRT] for each treatment sites were performed on XIO 4.04 treatment planning system using superposition algorism. Results: The results showed that the surface doses for 3DCRT were higher than the surface doses in IMRT by 1.6%, 2.5% and 3.2% for brain, abdomen and pelvis sites respectively. There was good agreement between measured and calculated surface doses, where the calculated surface dose was 15.5% for brain tumor calculated with 3DCRT whereas the measured surface dose was 12.1%. For abdomen site the calculated surface dose for IMRT treatment plan was 16.5% whereas the measured surface dose was 12.6%. Conclusion: The skin dose in IMRT for deep seated tumors is lower than that in 3DCRT which is another advantage for the IMRT. The TLD readings showed that the difference between the calculated and measured point dose is negligible. The superposition calculation algorism of the XIO 4.04 treatment planning system modeled the superficial dose well.

Measurement of Electron Return Effect and Skin Dose Reduction by a Bolus in an Anthropomorphic Physical Phantom under a Magnetic Resonance Guided Linear Accelerator (MR-LINAC) System

Background: Magnetic resonance image-guided radiation therapy (MR-IGRT) promises more precise and effective radiation treatments compared to conventional IGRT by using real-time on-board MR imaging. Under the influence of a magnetic field, however, secondary electrons exiting a surface can be forced in a circular path and re-enter the medium, resulting in dose increase at a beam-exit surface, called the electron return effect (ERE). The purpose of the study is to compare the exit skin dose computed by Monte Carlo dose calculation with measurements using an adult anthropomorphic phantom and to measure the effect of skin dose reduction by adding 1 cm-thick bolus. Method: The plan was compared with measurements using an adult anthropomorphic phantom combined with radiochromic films and thermoluminescent dosimeters. We also measured the skin dose reduction by adding 1 cm-thick bolus on the frontal surface of the phantom. Results: We found that 1 cm-thick bolus reduced the skin dose by up to 20% both in measurements and calculations. The plan was found to overestimate the measured skin dose by about 10% and there was no significant difference in the bolus effect between the breast skin and the skin (without breast attachment) doses. Conclusion: In conclusion, we confirmed the ERE effect on the anthropomorphic phantom under the magnetic field and the exit skin dose reduction by adding a bolus. Skin dose measurements using anthropomorphic phantom may be helpful to evaluate more realistic skin dose and the bolus effect in the magnetic field.

Investigation of Well-Balanced kV X-Ray Imaging Conditions between Skin Dose and Image Noise for Dynamic Tumor Tracking Irradiation

Purpose: The purposes of this study were to estimate accumulated kV X-ray imaging dose throughout dynamic tumor tracking (DTT) irradiation by Vero 4DRT system and to address an analytical skin dose formula for well-balanced kV X-ray imaging conditions between skin dose and image noise. Method: First, skin dose was measured using kV X-ray tube, chamber, and water-equivalent phantoms. Next, imaging dose for six patients in DTT treatment was computed using log files. Subsequently, scattered dose ratio was calculated by amount of ionization in front of flat panel detector (FPD) for fields with size of maximum and the chamber for 0 - 200 mm-thickness phantoms and tube voltage of 60, 80, 100, 120 kV, respectively. Furthermore, image noise was computed from FPD images. Results: The skin dose was greater by a factor of 1.4 - 1.6 than those in Synergy XVI system. The image noise in FPD, ?was expressed as N = 0.045×(1/QFPDen)0.479, where QFPDen denotes amount of ionization in front of FPD. Then, skin dose, D (N, t, v) was formulated as (0.045/N)(1/0.479)/QFPDen/mAs (t, v) ×D/mAs (v), where QFPDen/mAs (t, v) and D/mAs (v) denote amount of ionization in front of FPD and skin dose per mAs, respectively. Using the formulae, it has been demonstrated that skin dose with 120 kV has become lower than any other tube voltage in this study. Conclusion: Using skin doses for the phantom, the skin dose throughout DTT irradiation was estimated as 0.50 Gy. Furthermore, skin dose by kV X-ray imaging was described as a function of image noise, phantom thickness, and tube voltage, suggesting image noise may be reduced with higher X-ray tube voltage in this phantom study.

Patient Peak Skin Dose and Dose Area Product from Interventional Cardiology Procedures

Information about the peak skin dose and Dose Area product (DAP) from percutaneous transluminal coronary angioplasty (PTCA) and coronary angiography (CA) was collected from three catheter application rooms. The range of maximum photon energy was 50 - 125 kVp and the fluoroscopy time was 0.6 - 52 seconds. Values of up to 143 Gy·cm2 for DAP and 0.752 mGy for cumulative dose (CD) were found in CA procedures. Otherwise the DAP and CD for PTCA were found to be 143 Gy·cm2 and 2.287 mGy respectively in 3rd Quartile. The relation between the fluoroscopy time and the DAP is also considered. Objectives: The objective of this study is to obtain information about patient peak skin doses (PSD), dose area product (DAP), Fluoroscopy Time (FT) and Cumulative Dose (CD) from PTCA and CA which is the most predominant with respect to high skin doses in addition to other procedures. The aim of this study is also to assess the radiation dose received by patients undergoing interventional radiology procedures, by identifying the procedures that deliver the highest doses. This study is also helpful to establish the reference dose level for adult patients undergoing interventional procedure, and to provide recommendations on how to reduce dose on selected procedures that have been identified to deliver patient dose values near the ICRP (International Commission on Radiological Protection) threshold values.

Radiation Doses in Diagnostic Radiology and Method for Dose Reduction

Objective: The current research study aims to calculate entrance surface air kerma for skull, chest, cervical spine, lumbar spine, and pelvic X-ray examinations in interior posterior and posterior interior positions and generate a method for chest dose reduction to decrease radiation risk. Materials and Methods: The indirect dose measurement was used in the current research. The X-ray tube output was measured using RAD-CHECK Plus ionization chamber and the indirect entrance surface air kerma was calculated via applying physical acquisition parameters such as a focus on skin distance, tube current times exposure time (mAs), and applied tube voltage (kV), and applying a mathematical model. Results: The main findings were obtained from comparing the radiation doses with the reference levels of International organizations such as the American College of Radiology and the International Atomic Energy Authority. The mean entrance skin dose for the skull (AP), skull (PA), skull (LAT), cervical spine (PA), cervical spine (LAT), lumbar spine (AP), lumbar spine (LAT), pelvis (AP), and pelvis (LAT) of adult X-ray examinations was within the diagnostic reference dose level values obtained by ACR (2018) except for the ESD for chest (AP) which was 0.88 mGy. Conclusions: The results of the study concluded that by adjusting the applied tube voltage, kV, and tube current product time, mAs decreased the radiation dose to the chest X-ray by 58%.

Evaluation of Entrance Skin Radiation Exposure Dose for Pediatrics Examined by Digital Radiography at Asser Central Hospital-KSA

Assessment of entrance skin doses for patients in Digital radiography examinations should be made as a means for the optimization of the radiation protection of the patients. We measured the entrance skin dose (ESD) received by 50 pediatrics undergoing 12 types of diagnostic X-ray examination at Radiology Department of Asser Central Hospital-KSA. The entrance skin dose ESD was determined via measurements parameters: focus to skin distance (FSD), tube current (mAs) and tube voltage (kV) in arithmetical equation. The mean ± SD for ESDs were found to be 0.16 ± 0.03, 0.21 ± 0.01, 0.63 ± 0.26, 0.55 ± 0.09, 0.15 ± 0.05, 0.27 ± 0.06, 0.41 ± 0.19, 0.46 ± 0.18, 0.46 ± 0.12, 0.20 ± 0.02, 0.39 ± 0.01, 0.29 ± 0.03, for PA chest, foot, AP pelvis, PA skull, PA hand, AP arm, ankle, AP shoulder, abdomen, forearm, AP femur, AP elbow consequently. Our study is considered as an attempt to evaluate the ESDs received by digital radiographic x-ray machine for children aged between 2 - 15 years old, taking in our considerations number of other variables. The mean ESD values obtained are found to be within the standard reference. The data obtained may add to the available information in national records for general use. It may provide guidance on where efforts on dose reduction will need to be directed to fulfill the requirements of the optimization process and serve as a reference for future researches.

^238U and^232Th concentrations measured in different medical drugs by using solid-state nuclear track detectors and resulting radiation doses to the skin of patients

Urban populations in Morocco receive free medical drugs as prescribed by doctors in district health centres.To explore the exposure pathway of ^(238)U and^(232)Th and their decay products on the skin of patients,these radionuclides were measured in various medical drugs by using solid-state nuclear track detectors(SSNTDs).The measured concentrations range of ^(238)U and ^(232)Th in the medical drug samples of interest vary from(4.3±0.3) to(11.1±0.7) mBq 1^(-1) and(0.49±0.03) to(1.3±0.1)mBq 1^(-1),respectively.A new dosimetric model,based on the concept of specific alpha-dose and alpha-particle residual energy,was developed for evaluating radiation doses to skin following the application of different medical drugs by patients.The maximum total equivalent effective dose to skin due to the ^(238)U and ^(232)Th series from cutaneous application of different medical drugs by patients was found to be 2.8 mSv year^(-1) cm^(-2).

Commissioning and Optimization of a Total Skin Electron Therapy Technique Using a High Dose Rate Electron Facility

Total skin electron therapy (TSET) is used for the treatment of Mycosis Fungoides. Several tech-niques have been developed, in order to achieve homogeneous dose distribution over the complete body surface. To implement a TSET technique, one has to optimize a variety of parameters. Monte Carlo simulation of TSET can facilitate this optimization. The aim of this study was to commission and optimize a TSET technique using the 4 and 6 MeV electron and the high dose rate facility on the Elekta Precise accelerator. The EGS4nrc/BEAMnrc Monte Carlo code was used. The beam data were calculated and measured at two different scoring planes for a single beam. The Model was validated by comparing the simulation with measurements. Two different vertical angles were used to obtain a uniform dose. The angle was optimized for best dose uniformity. The Rando phantom is placed on a rotating platform and rotates 60 degrees apart to facilitate the six patient position orientations. The doses delivered in a phantom by complete treatment were measured with Kodak EDR2 films and TLDs. The dose distribution varied among various scanning directions by 2 - 3 mm and 3 - 4 mm for 4 and 6 MeV respectively. The composite percentage depth dose of all six dual fields for the 4 and 6 MeV yielded an R80 of ~4 mm and ~6 mm, respectively. Dose uniformity was ±6% for 4 MeV and ±5% for 6 MeV. The bremsstrahlung contamination was 0.9% - 1.3%. Good agreements were found with published literature and inline with international protocols.

Monaco计划系统中鼻咽癌患者颈部皮肤受量的剂量学研究

目的探索在Monaco计划系统中制定鼻咽癌放疗计划时,如何降低鼻咽癌患者颈部皮肤受照剂量。方法随机选取我院已完成治疗的中晚期鼻咽癌患者计划15例,将放疗靶区上下各1 cm范围内由系统自动生成的皮肤(Skin1)内缩3 mm形成新的皮肤轮廓(Skin2),并由二者通过减法运算得到一个厚度为3 mm的皮肤层环形结构(Skin3)。在Monaco计划系统中按处方要求重新制定放疗计划时,增加Parallel函数对该环形结构进行体积剂量的调控,并对两组计划的数据进行对比分析。结果两组计划的原发部位PGTVnx D_(95)、颈部淋巴结PGTVnd D_(95),高危淋巴引流区PCTV1 D_(95)的靶区剂量分布以及危及器官受照剂量相比较,差异均无统计学意义(P>0.05);两组预防照射区PCTV2 D_(95)和机器输出跳数(MU)相比较,差异有统计学意义(P<0.05),单独调控后机器的输出(MU)会增加6.15%;两组PCTV2的剂量分布适形度指数(CI)和皮肤受照剂量差异有统计学意义(P<0.05),单独调控后PCTV2 CI增加6.41%且皮肤受量下降明显,其中Skin3V 50下降71.56%。结论在Monaco计划系统中对鼻咽癌患者颈部皮肤进行剂量调控,虽然会在一定程度上引起机器输出的增加,但是会对靶区剂量分布进行再调整,剂量约束更加优化,皮肤受量也能得到很好的调控,这对于降低患者皮肤受量提高放疗质量能够起到相应的促进作用。

Influence of quality assurance on patients dose reduction in some hospitals

The radiation dose received by patients undergoing chest radiography was included. 200 patients who attended these investigations in 10 hospitals in Iran were randomly selected from all ages groups and both female and male. Critically ill patients were excluded. This paper presents the work, which was implemented on 200 patients and evaluated using the entrance skin dose （ESD） in the posterior anterior （PA） chest projection measured directly at the center of the X-ray field. In addition, the machine room, and dark room .parameters, as well as work practices and repeat rates were studied. The quality control （QC） parameters and the ESD before and after QC were evaluated utilizing an anthropomorphic phantom to define the optimal exposure condition at all hospitals. This research shows that after using the QC parameters and after optimization of the exposure conditions, the ESD was decreased by 42% on average. Also the qua/ity of the radiographs generally increased. The reported method is easily implemented in any clinical situation where optimization of chest radiography is needed.

DETERMINATION OF SUPERFICAL ABSORBED DOSE FROMEXTERNAL EXPOSURE OF WEAKLY PENETRATING RADEATIONS

The methods of determining the superficial absorbed dose distributions in a water phantom by means of the experiments and available theories have been reported. The distributions of beta dose were measured by an extrapolation ionization chamber at definite depthes corresponding to some superficial organs and tissues such as the radiosensitive layer of the skin, cornea, sclera, anterior chamber and lens of eyeball.The ratios among superficial absorbed dose D (0.07) and average absorbed doses at the depthes 1,2,3,4,5 and 6 mm are also obtained with Cross's methods. They can be used for confining the deterministic effects of some superficial tissues and organs such as the skin and the components of eyeball for weakly penetrating radiations.

Dosimetric Effects of Thermoplastic Immobilizing Devices on Surface Dose

Thermoplastic immobilizing masks have dosimetric effects on the patient’s skin dose. The thermoplastic percentage depth dose (PDD), equivalent thickness of water for the masks and surface doses were determined. The surface dose factors due to the thermoplastic mask was found to be 1.7949, 1.9456, 2.0563, 2.1967, 2.3827, 2.5459 and 2.6565 for field sizes of 5 × 5, 8 × 8, 10 × 10, 12 × 12, 15 × 15, 18 × 18 and 20 × 20 cm2 respectively which shifted the percentage depth dose curve to lower values. The physical thermoplastic thickness was measured to be between 2.30 and 1.80 mm, and the equivalent thicknesses of water, de, were determined to be between 1.2 and 1.00 mm. This meant that, as the mask thickness decreased, its water equivalent thickness also decreased. The presence of the mask material increased the skin dose to a factor of 1%. The thermoplastic mask factor was also found to be 0.99.

度普利尤单抗结合小剂量激素对大疱性类天疱疮患者皮损瘙痒症状及新发水疱数量的影响

目的 观察大疱性类天疱疮(BP)患者采用度普利尤单抗结合小剂量激素治疗对皮损瘙痒症状及新发水疱数量的影响。方法 选取2020年6月至2023年6月本院收治的BP患者70例,根据治疗方案不同分为观察组和对照组,各35例。观察组采用度普利尤单抗结合小剂量激素治疗,对照组采用小剂量激素治疗,对比两组治疗效果。结果 观察组皮损开始愈合时间与瘙痒症状开始缓解时间短于对照组;治疗2周、4周后,观察组新发水疱数量少于对照组,BP疾病面积指数(BPDAI)、瘙痒数字评定量表(NRS)低于对照组(P <0.05)。两组不良反应发生率对比差异无统计学意义(P> 0.05)。结论 对大疱性类天疱疮患者实施度普利尤单抗结合小剂量激素治疗,可快速缓解皮损瘙痒症状,减少新发水疱数量,具有良好的安全性。

Clinical and Dosimetric Implications of Air Gaps between Bolus and Skin Surface during Radiation Therapy

Purpose: The main objective of the study was to evaluate the effect of air gaps of 0 - 5.0 cm between bolus and skin for 1.0 cm Superflab bolus on surface dose (DSurf) and depth of maximum dose (dmax) in solid water and Rando? phantoms. Methods: In this work, the effects of bolus to surface distance on DSurf and variation in dmax were analyzed in a solid water phantom and in an anthropomorphic Rando? phantom for different field sizes, using Gafchromic? EBT films and farmer chamber. Results: For field sizes of 5 × 5 cm2 the DSurf is significantly affected by increasing air gaps greater than 5 mm. For field sizes larger than 10 × 10 cm2, DSurf is nearly the same for air gaps of 0 - 5.0 cm. For small fields and 6 MV photon beam, dmax increases with increasing air gap, while for 10 MV beam and smaller field sizes (i.e. 5 × 5 and 10 × 10 cm2) the dmax first decreases and then increases with the air gaps. For both 3DCRT and IMRT plans on Rando?, DSurf reduction is more prominent with increasing air gaps. Conclusion: For field sizes larger than 10 × 10 cm2 DSurf is largely unaffected by air gaps. However, smaller air gap results in shallower dmax for both 6 MV and 10 MV photon beams at all fields sizes. Special consideration should be taken to reduce air gaps between bolus and skin for field sizes smaller than 10 × 10 cm2 or when surface contour variations are greater or when the bolus covers small area and at the border of the field.

Patient dose considerations in computed tomography examinations

Ionizing radiation is extensively used in medicine and its contribution to both diagnosis and therapy is undisputable.However,the use of ionizing radiation also involves a certain risk since it may cause damage to tissues and organs and trigger carcinogenesis.Computed tomography(CT) is currently one of the major contributors to the collective population radiation dose both because it is a relatively high dose examination and an increasing number of people are subjected to CT examinations many times during their lifetime.The evolution of CT scanner technology has greatly increased the clinical applications of CT and its availability throughout the world and made it a routine rather than a specialized examination.With the modern multislice CT scanners,fast volume scanning of the whole human body within less than 1 min is now feasible.Two dimensional images of superb quality can be reconstructed in every possible plane with respect to the patient axis(e.g.axial,sagital and coronal).Furthermore,three-dimensional images of all anatomic structures and organs can be produced with only minimal additional effort(e.g.skeleton,tracheobronchial tree,gastrointestinal system and cardiovascular system).All these applications,which are diagnostically valuable,also involve a significant radiation risk.Therefore,all medical professionals involved with CT,either as referring or examining medical doctors must be aware of the risks involved before they decide to prescribe or perform CT examinations.Ultimately,the final decision concerning justification for a prescribed CT examination lies upon the radiologist.In this paper,we summarize the basic information concerning the detrimental effects of ionizing radiation,as well as the CT dosimetry background.Furthermore,after a brief summary of the evolution of CT scanning,the current CT scanner technology and its special features with respect to patient doses are given in detail.Some numerical data is also given in order to comprehend the magnitude of the potential radiation risk involved in comparison with risk from exposure to natural background radiation levels.

发泡胶对鼻咽癌调强放疗计划的剂量学影响

目的 探讨发泡胶对鼻咽癌调强放射治疗计划的剂量学影响。方法 首先测量发泡胶不同厚度对中心点剂量的影响。然后选取11例使用头颈肩热塑膜联合发泡胶进行体位固定的早期鼻咽癌患者,对每例患者勾画两种外轮廓,一种勾画人体正常皮肤外轮廓,另一种将发泡胶也勾画进人体外轮廓。分别设计两种不同皮肤外轮廓的调强计划,比较两种计划的靶区剂量、危及器官剂量和皮肤剂量。结果 将发泡胶加入外轮廓后,降低了鼻咽癌放疗计划的靶区剂量和危及器官的剂量,靶区最大剂量降低了0.56%~0.78%,靶区平均剂量分别降低了0.63%~0.90%。脊髓、视交叉、视神经等危及器官的最大剂量降低了0.2%~1.1%。颈后皮肤平均剂量增加0.8~6.0 Gy。结论 发泡胶的应用降低了鼻咽癌调强计划的靶区剂量和危及器官剂量,增加了皮肤剂量。

空气间隙、射线过滤模式、计算模型和光束倾角在不同补偿膜厚度条件下对皮肤剂量的影响

目的基于联影uRT-TPS建模,探讨空气间隙、射线过滤模式、计算模型和光束倾角在不同补偿膜厚度条件下对皮肤剂量的影响。方法利用固体水层板,通过改变空气间隙大小(0、2、4和6 mm)、补偿膜厚度(0、5、10、15和20 mm)分别构建17种模体模型,在uRT-TPS中通过改变射线过滤模式、计算模型(MC和Convolution)和光束倾角(0°~80°)这3类变量对这17种模体模型设计248个治疗计划,在满足所有计划靶区层平均剂量达到1000cGy的条件下,获得皮肤层平均剂量(Da或Dt)和皮肤层剂量增强因子(div)。结果补偿膜厚度在0~10 mm范围内,Dt随厚度增加而增加。补偿膜为5 mm时,4 mm空间间隙的Dt最大,0 mm空间间隙的div最小。无补偿膜时,FFF模式下的Da值高于FF模式,且FF和MC条件下的Da值偏高。有补偿膜时,FF和MC条件下的div偏低。div随光束倾角增大而增大,且FF模式下的div值随补偿膜的增加而降低,而FFF模式下的div值随补偿膜的增加而增加。结论在表浅肿瘤放射治疗中,皮肤剂量受到补偿膜厚度、空间间隙、射线过滤模式、计算模型和光束倾角5类因素的综合影响,临床实践应结合需求灵活调整,尽可能降低皮肤剂量。

医用射线抗护喷剂联合德莫林乳膏治疗乳腺癌患者放射性皮肤损伤疗效观察

目的探讨医用射线抗护喷剂联合德莫林乳膏治疗乳腺癌患者术后放射性皮肤损伤的疗效。方法选择2019年1月至2021年6月焦作煤业(集团)有限责任公司中央医院收治的女性乳腺癌患者113例为研究对象,根据治疗方法将患者分为对照组(n=56)和观察组(n=57)。2组患者均接受放射治疗,对照组患者于放射治疗前1 d及放射治疗后将德莫林乳膏均匀涂抹于照射区域及区域外2 cm内,每日1次,连续使用2周。观察组在对照组患者治疗方案的基础上,于放射治疗前1 d及放射治疗后在患侧乳腺、腋窝、锁骨上区皮肤喷涂医用射线防护喷剂,各部位早晚各喷涂1次,0.02 mL·cm^(-2),连续喷涂2周。药物治疗2周后,分别记录2组放射治疗≤2周和>2周患者急性放射性皮炎的发生情况,并计算总发生率。于放射治疗2周后,依据急性放射性损伤程度分级观察并评估患者皮肤损伤发生情况。记录2组患者发生Ⅱ级及以上皮肤损伤的累积剂量。结果药物治疗2周后,观察组患者的急性放射性皮炎发生率显著低于对照组(χ^(2)=7.983,P<0.05)。放射治疗≤2周,观察组患者的急性放射性皮炎发生率显著低于对照组(χ^(2)=5.423,P<0.05);放射治疗>2周,2组患者的急性放射性皮炎发生率比较差异无统计学意义(χ^(2)=0.444,P>0.05)。药物治疗2周后,观察组患者的皮肤损伤程度分级显著优于对照组(Z=3.129,P<0.05)。对照组和观察组患者中发生Ⅱ级及以上皮肤损伤患者的累积剂量分别为(4318.87±323.72)、(4929.87±324.61)cGY;观察组患者中发生Ⅱ级及以上皮肤损伤患者的累积剂量显著高于对照组(P<0.05)。结论医用射线抗护喷剂联合德莫林乳膏应用于接受放射治疗的乳腺癌患者,能有效降低患者急性放射性皮炎发生率及皮肤损伤程度,提高发生Ⅱ级及以上放射性皮肤损伤的累积剂量。