Control Effect of Slow-release, Long-acting and Multi-functional New Pesticides on Sugarcane Borders and Woolly Aphids

In order to select the long-acting,low toxic,low-risk and multi-functional new pesticides for the control of sugarcane borders and woolly aphids and precise and efficient application technology,the control effect of 10% monosultap · thiamethoxam granular formulation and 1% Bt · clothianidin granular formulation on sugarcane borders and woolly aphids were studied.The results showed that 10% monosultap·thiamethoxam GR and 1% Bt·clothianidin GR had good control effects on sugarcane borders and woolly aphids.They were ideal slow-release,long-acting,low toxic and multi-functional new pesticides used to control sugarcane borders and woolly aphids.They could be used alternately with other pesticides to delay the emergence and development of pest resistance to pesticides.The best dosage of the two pesticides in the field was 45 kg/hm^2.They could be mixed with fertilizer( 1200-1800 kg/hm^2),scattered in sugarcane ditches or at the base of sugarcane plants,and covered with soil or film from January to July.The control effect on dead heart seedlings damaged by borers could be up to above 79.2%,and the control effect on sugarcane woolly aphids could reach more than 98.8%.In comparison with the control group,the actual yield and sugar content of sugarcane increased by above 41 555 kg/hm^2 and 6.5% respectively.The application of slow-release,long-acting,strong systemic and multi-functional new agents with fertilizer around roots is convenient,precise and efficient,labor-saving,time-saving and environmentally friendly,and is worthy of being widely applied in sugarcane areas.

Imaging tumor hypoxia:Blood-borne delivery of imaging agents is fundamentally different in hypoxia subtypes

Dedicated to the memory of Professor Briton Chance on the ccasion of his 100th birthday(July24 th,2013),and remembering mary erciting discussions on the orygenation of breast cancer,ontumor hyporia in general and imaging of the orygenation status of malignant tumors.Hypoxic tissue subvolumes are a hallmark feat ure of solid malignant tumors,relevant for cancertherapy and patient outcome because they increase both the intrinsic aggressiveness of tumor cells and their resist ance to several commonly used anticancer strategies.Pathogenetic mech-anisms leading to hypoxia are diverse,may coexist within the same tumor and are commonlygrouped according to the duration of their ffects.Chronic hypoxia is mainly caused by difusionlimitations resulting from enlarged intercapilary distances and adverse difusion geometriesand--to a lsser extent--by hypoxemia,compromised perfusion or long-lasting microregionalfow stops.Conversely,acute hypoxia preferentilly results from transient disruptions in per.fusion.While each of these features of the tumor microenvironment can contribute to a criticalreduction of oxy gen availability,the delivery of imaging agents(as well as nutrients and anti-cancer agents)may be compromised or remain unaffected,Thus,a critial appraisal of the ffectsof the various mechanisms leading to hypoxia with regard to the blood-bome delivery of imagingagents is necessary to judge their ability to correctly represent the hypoxic phenotype of solidmalignancies.

The state-of-the-art of atmospheric pressure plasma for transdermal drug delivery

Plasma-enhanced transdermal drug delivery(TDD) presents advantages over traditional methods,including painless application, minimal skin damage, and rapid recovery of permeability. To harness its clinical potential, factors related to plasma’s unique properties, such as reactive species and electric fields, must be carefully considered.This review provides a concise summary of conventional TDD methods and subsequently offers a comprehensive examination of the current state-of-the-art in plasma-enhanced TDD. This includes an analysis of the impact of plasma on HaCaT human keratinocyte cells, ex vivo/in vivo studies, and clinical research on plasma-assisted TDD. Moreover, the review explores the effects of plasma on skin physical characteristics such as microhole formation, transepidermal water loss(TEWL), molecular structure of the stratum corneum(SC), and skin resistance. Additionally, it discusses the involvement of various reactive agents in plasma-enhanced TDD, encompassing electric fields,charged particles, UV/VUV radiation, heat, and reactive species. Lastly, the review briefly addresses the temporal behavior of the skin after plasma treatment, safety considerations, and potential risks associated with plasma-enhanced TDD.

移动Agent通信技术的研究与分析

该文研究和分析了移动Agent系统中常见的四个通信技术问题。这四个问题分别是:移动Agent的命名,移动Agent的定位,移动Agent的消息处理及移动Agent通信可靠性。

工程化间充质干细胞来源外泌体在靶向递送抗肿瘤药物中的应用与问题

背景:间充质干细胞来源外泌体具有免疫原性低且肿瘤归巢能力强等优点,在靶向递送药物方面备受关注。但外泌体在到达靶细胞前易被体内循环迅速清除,此外,由于外泌体表面性质和摄取机制复杂,其靶向性并不十分明显,需要一定的工程化策略提高递送效率。目的:通过综述间充质干细胞来源外泌体工程化修饰的不同策略,了解提高外泌体递送效率的相关机制、临床前应用和面临的问题,为进一步临床应用提供理论依据。方法:检索中国知网、维普、万方、PubMed数据库从建库至2024年的相关文献,检索词为“间充质干细胞,外泌体,工程化外泌体,靶向递送,抗肿瘤药物”和“mesenchymal stem cells,exosomes,engineered exosomes,targeted delivery,antineoplastic agents”,筛选工程化间充质干细胞来源外泌体靶向递送抗肿瘤药物的文献,共计纳入85篇文献进行综述分析。结果与结论:(1)间充质干细胞来源外泌体的工程化修饰复杂多样,可通过显著增强外泌体对器官或组织靶向能力,增加血液循环中停留时间,以及降低外泌体中促肿瘤分子的表达,以此达到提高外泌体递送效率的效果;(2)间充质干细胞外泌体在目前的抗肿瘤治疗研究中递送传统和新型药物具有巨大前景;(3)当前仍然存在一些安全问题不能将其转化在临床中,未来的研究将进一步改进和深入研究递送机制,有望开发出更为高效和安全的治疗策略。

基于Multi-Agent的面向交货期的生产协同模型应用研究

在分析企业准时交货的影响因素和企业内部订单处理流程的基础上,针对制造型企业在准时交货中存在的问题,提出了面向交货期的生产协同模型.根据订单处理和车间调度的复杂性,并结合Multi-Agent的自主性、协调性等特点,探讨了面向交货期的生产协同系统的框架结构与多代理的功能分类,建立了基于Multi-Agent的面向交货期的生产协同物理模型.最后用一个案例分析了所建立的生产协同模型在企业中的应用,缩短了交货期,证实了所建模型的可行性.

移动Agent通信技术的研究与分析

本文研究和分析了移动Agent系统中常见的四个通信技术问题。这四个问题分别是:移动Agent的命名,移动Agent的定位,移动Agent的消息处理及移动Agent通信可靠性。

Stem cells as delivery vehicles for regenerative medicinechallenges and perspectives

The use of stem cells as carriers for therapeutic agents is an appealing modality for targeting tissues or organs of interest. Combined delivery of cells together with various information molecules as therapeutic agents has the potential to enhance, modulate or even initiate local or systemic repair processes, increasing stem cell efficiency for regenerative medicine applications. Stem-cell-mediated delivery of genes, proteins or small molecules takes advantage of the innate capability of stem cells to migrate and home to injury sites. As the native migratory properties are affected by in vitro expansion, the existent methods for enhancing stem cell targeting capabilities(modified culture methods, genetic modification, cell surface engineering) are described. The role of various nanoparticles in eq-uipping stem cells with therapeutic small molecules is revised together with their class-specific advantages and shortcomings. Modalities to circumvent common challenges when designing a stem-cell-mediated targeted delivery system are described as well as future prospects in using this approach for regenerative medicine applications.

Film forming systems for topical and transdermal drug delivery

Skin is considered as an important route of administration of drugs for both local and systemic effects. The effectiveness of topical therapy depends on the physicochemical properties of the drug and adherence of the patient to the treatment regimen as well as the system’s ability to adhere to skin during the therapy so as to promote drug penetration through the skin barrier.Conventional formulations for topical and dermatological administration of drugs have certain limitations like poor adherence to skin, poor permeability and compromised patient compliance.For the treatment of diseases of body tissues and wounds, the drug has to be maintained at the site of treatment for an effective period of time. Topical film forming systems are such developing drug delivery systems meant for topical application to the skin, which adhere to the body, forming a thin transparent film and provide delivery of the active ingredients to the body tissue. These are intended for skin application as emollient or protective and for local action or transdermal penetration of medicament for systemic action. The transparency is an appreciable feature of this polymeric system which greatly influences the patient acceptance.In the current discussion, the film forming systems are described as a promising choice for topical and transdermal drug delivery. Further the various types of film forming systems (sprays/solutions, gels and emulsions) along with their evaluation parameters have also been reviewed.

Inner ear barriers to nanomedicine-augmented drug delivery and imaging

There are several challenges to inner ear drug delivery and imaging due to the existence of tight biological barriers to the target structure and the dense bone surrounding it. Advances in imaging and nanomedicine may provide knowledge for overcoming the existing limitations to both the diagnosis and treatment of inner ear diseases. Novel techniques have improved the efficacy of drug delivery and targeting to the inner ear, as well as the quality and accuracy of imaging this structure. In this review, we will describe the pathways and biological barriers of the inner ear regarding drug delivery, the beneficial applications and limitations of the imaging techniques available for inner ear research, the behavior of engineered nanomaterials in inner ear applications, and future perspectives for nanomedicine-based inner ear imaging.

Ultrasound-mediated transdermal drug delivery of fluorescent nanoparticles and hyaluronic acid into porcine skin in vitro

Transdermal drug delivery （TDD） can effectively bypass the first-pass effect. In this paper, ultrasound-facilitated TDD on fresh porcine skin was studied under various acoustic parameters, including frequency, amplitude, and exposure time. The delivery of yellow-green fluorescent nanoparticles and high molecular weight hyaluronic acid （HA） in the skin samples was observed by laser confocal microscopy and ultraviolet spectrometry, respectively. The results showed that, with the application of ultrasound exposures, the permeability of the skin to these markers （e.g., their penetration depth and concentration） could be raised above its passive diffusion permeability. Moreover, ultrasound-facilitated TDD was also tested with/without the presence of ultrasound contrast agents （UCAs）. When the ultrasound was applied without UCAs, low ultrasound frequency will give a better drug delivery effect than high frequency, but the penetration depth was less likely to exceed 200 p.m. However, with the help of the ultrasound-induced microbubble cavitation effect, both the penetration depth and concentration in the skin were significantly enhanced even more. The best ultrasound-facilitated TDD could be achieved with a drug penetration depth of over 600 p.m, and the penetration concentrations of fluorescent nanoparticles and HA increased up to about 4-5 folds. In order to get better understanding of ultrasound-facilitated TDD, scanning electron microscopy was used to examine the surface morphology of skin samples, which showed that the skin structure changed greatly under the treatment of ultrasound and UCA. The present work suggests that, for TDD applications （e.g., nanoparticle drug carriers, transdermal patches and cosmetics）, protocols and methods presented in this paper are potentially useful.

Near-Infrared Light-Responsive Nitric Oxide Delivery Platform for Enhanced Radioimmunotherapy

Radiotherapy(RT)is a widely used way for cancer treatment.However,the efficiency of RT may come with various challenges such as low specificity,limitation by resistance,high dose and so on.Nitric oxide(NO)is known a very effective radiosensitizer of hypoxic tumor.However,NO cannot circulate in body with high concentration.Herein,an NIR light-responsive NO delivery system is developed for controlled and precisely release of NO to hypoxic tumors during radiotherapy.Tert-Butyl nitrite,which is an efficient NO source,is coupled to Ag2S quantum dots(QDs).NO could be generated and released from the Ag2S QDs effectively under the NIR irradiation due to the thermal effect.In addition,Ag is also a type of heavy metal that can benefit the RT therapy.We demonstrate that Ag2S NO delivery platforms remarkably maximize radiotherapy effects to inhibit tumor growth in CT26 tumor model.Furthermore,immunosuppressive tumor microenvironment is improved by our NO delivery system,significantly enhancing the anti-PD-L1 immune checkpoint blockade therapy.100% survival rate is achieved by the radio-immune combined therapy strategy based on the Ag2S NO delivery platforms.Our results suggest the promise of Ag2S NO delivery platforms for multifunctional cancer radioimmunotherapy.

煤矿安全信息系统的分布式Agent探析

本文根据煤矿安全信息系统的重要性及自身的特点,引入基于分布式Agent智能理论的控制方法,将Agent的自治性,面向目标性,应激性和社会性等特点应用于煤矿安全生产系统,在此基础上对基于Agent理论的煤矿安全信息系统的模型进行了研究。提出了分布式Agent煤矿安全信息管理系统的总体结构.该系统的应用使煤矿安全信息系统的智能化和自动化得到了很大的提高。

Nanoemulsion for delivery of anticancer drugs

Cancer refers to a collection of diseases that have abnormal cell growth as their hallmark.This inability of cytotoxic agents to distinguish between rapidly dividing healthy cells and rapidly multiplying cancerous cells produces the most notorious adverse effects of cytotoxic anticancer agents.As an essential tool in nanotechnology,nanoemulsions have therapeutic and clinical applications.Currently,nanoemulsions are considered to be one of the most feasible nano-carriers for delivering lipophilic antineoplastic agents with targeted delivery.In addition to solving water-solubilization issues,these formulations deliver specific targeting to cancer cells and might even be developed to overcome multi-drug resistance.Nanoemulsions overcome the problems associated with conventional drug delivery systems,such as low bioavailability and noncompliance.A review of nanoemulsion in cancer therapeutics is presented here to shed light on the current position of this technology.

基于MTSP问题的公共图书馆智慧配送服务

随着“互联网+”思维和图书馆服务模式与水平的发展,纸质资源的物流配送成为图书馆借阅平台的最后环节。如何在智慧图书馆智能服务平台中降低图书馆的配送成本、均衡配送员的工作量、提升配送效率是智慧服务的研究方向。在智能计算研究中,解决TSP旅行商问题常采用蚁群算法,因为蚁群算法能利用信息正反馈和启发式信息诱导,从而找出多目标遍历的最优解。针对图书馆馆际与社区物流配送的多旅行商MTSP问题,使用混合蚁群优化算法来实现图书纸质资源最后配送路径最优化处理,可以更好地实现配送效率的综合提升。图书馆高效率优质服务可以更好地提升阅读质量。

基质组成对抗肿瘤药物白藜芦醇可溶性微针成型及其穿透性的影响

目的评估微针基质组成对白藜芦醇可溶性微针(Res-DMNs)成型性及穿透性能的影响,以提高抗肿瘤药物白藜芦醇的经皮递送效率。方法采用多步减压扩散法制备Res-DMNs,以成膜性、平整度、气泡数和含针率为考察指标,对聚乙烯醇(PVA)不同聚合度的单一基质材料(PVA-0488、PVA-0588、PVA-1788)以及PVA与聚乙烯吡咯烷酮(PVP-K30)混合体系进行成型性评价,以确定最佳混合比例,并对制得的可溶性微针的形貌、溶解性能、机械性能、体外穿刺性能和离体皮肤穿刺效率进行全面评价。结果采用PVA-0588与PVP-K30混合基质(2∶1,体积比)制备的Res-DMNs,其含针率可达90%以上,针长约为720μm,针尖距离约800μm;在刺入皮肤后10 min内,微针几乎完全溶解;通过固定皮肤组织测量,Res-DMNs的刺入深度平均为(535.23±87.24)μm,且刺入率达到92.4%。结论可溶性微针的成型性和穿透性能是其临床应用成功的关键,本研究确定了适宜的基质材料组成,为保证Res-DMNs治疗效果提供了基础。

Applied Ecotechnical Research on Lbao Slow-Release Water-Fertilizer-Nutrition Agent

L黚ao slow-release water-fertilizer-nutrition agent (LSWA) is a new and proven highly effective soil additive. This nutrient absorbent polymer dramatically conserves water and reduces fertilizer usage while significantly increasing plant and crop yield. There are numerous benefits that LSWA is engineered to produce, and moreover, with every new application new benefits are discovered. The versatility of this additive will undoubtedly lead to some new applications. LSWA crystals in the soil absorb hundreds of times their mass in water and then, upon demand, release the stored moisture regardless of the soil condition. Unlike previously used polymers, LSWA has great absorbability even under soil pressure, and maintains its absorbability in the presence of fertilizers and other water soluble additives. It is completely non-toxic, and has a lengthy effective period of seven to ten years. LSWA is extremely cost effective due to its low initial cost, the dramatic reduction in the number of watering cycles, the decrease of fertilizer usage and the increase in crop yield, as well as allowing utilization of previously unusable land. When LSWA crystals are added into the soil, irrigation schedule times can be reduced by more than 50%, and fertilizer usage reduced by up to 33%. In this paper, some basic researches on the basic properties of the soil additive are reported. Some applications are described by reference to a number of case studies. Finally, specific recommendations are given for the application rates and methods for a range of crops and soil conditions.

一个移动智能体位置管理与可靠通信的算法

对于移动智能体应用环境下的可靠通信问题,已有的支撑系统和相关研究或不能满足要求或存在缺陷提出了一个面向移动智能体位置管理与可靠通信的新算法,它保证在智能体的移动行为不可预测的情况下,可靠的完成消息传递,并承诺消息传递的exactly-once语义.

肺靶向米托蒽醌明胶微球的研究

采用二步法制备米托蒽醌明胶微球，球径范围为５．１～２５．０μｍ的占总数８７．３６％，体外释药与原药相比ｔ１／２延长４倍，ＤＴＡ曲线上的特征吸热峰为１３３℃，经３７℃，ＲＨ７５％考察３月，几乎无变化。经小鼠体内分布试验表明具有明显的肺靶向性，靶向效率增加３～３５倍，肺中药代动力学行为可用一室开放模型描述，平均滞留时间延长１０ｈ。