Background Idiopathic choroidal neovascularization （ICNV） affects young patients and thus may have a significant impact on vision and life quality over a patient＇s lifespan. This study was designed to compare the v...Background Idiopathic choroidal neovascularization （ICNV） affects young patients and thus may have a significant impact on vision and life quality over a patient＇s lifespan. This study was designed to compare the visual outcome and retinal pigment epithelium （RPE） damage after photodynamic therapy （PDT） with small laser spot and PDT with standard laser spot for idiopathic choroidal neovascularization （ICNV）. Methods This was a randomized controlled study. Fifty-two patients with ICNV were enrolled and randomly divided into a study group （small laser spot PDT, n=27） and a control group （standard laser spot PDT, n=25）. Best corrected visual acuity （BCVA）, optic coherence tomography （OCT） and fluorescein angiography （FA） findings were the main measurements. The patients were followed up 1 week, 1, 3, 6, 9 months and 1 year after PDT. Results BCVA improvement was statistically significantly higher in the study group than the control group at 6-month （（25.53±15.01） letters vs. （14.71±11.66） letters, P=-0.025） and 9-month follow-ups （（27.53±17.78） letters vs. （15.59±12.21） letters, P=0.039）. At 3- and 6-month follow-ups, the quadrants of RPE damage between the two groups varied significantly （P 〈0.001 and P=0.023, respectively）. In each follow-up, the number of cases with decreased or unchanged leakage of choroidal neovascularization by FA and reduced subretinal fluid by OCT did not vary significantly between the two groups. Ten cases （37.0%） in the study group and eight cases （32.0%） in the control group suffered from recurrent CNV （P=-0.703）. Conclusions Better visual improvements, less RPE damage, a similar recurrent rate of CNV and change of subretinal fluid were observed in the small laser spot PDT group than in the standard laser spot PDT group for ICNV.展开更多
目的:探究30%超分子水杨酸联合小光斑点阵CO_(2)激光治疗轻中度寻常痤疮的有效性和安全性。方法:选取2022年11月-2023年6月就诊于吉林大学中日联谊医院30例面部轻、中度寻常痤疮患者,以患者面部矢状线为界,按照随机数表将患者的双侧面...目的:探究30%超分子水杨酸联合小光斑点阵CO_(2)激光治疗轻中度寻常痤疮的有效性和安全性。方法:选取2022年11月-2023年6月就诊于吉林大学中日联谊医院30例面部轻、中度寻常痤疮患者,以患者面部矢状线为界,按照随机数表将患者的双侧面部随机分为对照侧和观察侧。对照侧(n=30),给予30%超分子水杨酸治疗(每4周治疗1次);观察侧(n=30),给予小光斑点阵CO_(2)激光治疗后即刻30%超分子水杨酸治疗(每4周治疗1次)。通过拍照、皮肤检测仪、皮损计数和痤疮综合分级系统(The global acne grading system,GAGS)评分等评估治疗的有效性;通过皮损清除率判定临床疗效,同时观察不良反应以评估安全性。治疗结束后12周对患者进行随访,评估复发情况。结果:治疗12周后,患者观察侧的临床疗效优于对照侧(P<0.05);观察侧的皮损清除效果明显优于对照侧(P<0.001);观察侧的GAGS评分改善程度明显优于对照侧(P<0.001)。治疗期间两侧均未出现严重不良反应。结论:30%超分子水杨酸联合小光斑点阵CO_(2)激光疗法对清除轻中度痤疮皮损优于30%超分子水杨酸单一治疗,具有见效快、安全性高、操作简单、患者满意度高等优点,且不增加患者相关不良反应。展开更多
基金This study was supported by grants from National Basic Research Program of China （973 Program, No. 2011CB510200）, an education grant from Novartis China, Beijing Novel Program （No. 2009B04） and National Natural Science Foundation of China （No. 30901639）.
文摘Background Idiopathic choroidal neovascularization （ICNV） affects young patients and thus may have a significant impact on vision and life quality over a patient＇s lifespan. This study was designed to compare the visual outcome and retinal pigment epithelium （RPE） damage after photodynamic therapy （PDT） with small laser spot and PDT with standard laser spot for idiopathic choroidal neovascularization （ICNV）. Methods This was a randomized controlled study. Fifty-two patients with ICNV were enrolled and randomly divided into a study group （small laser spot PDT, n=27） and a control group （standard laser spot PDT, n=25）. Best corrected visual acuity （BCVA）, optic coherence tomography （OCT） and fluorescein angiography （FA） findings were the main measurements. The patients were followed up 1 week, 1, 3, 6, 9 months and 1 year after PDT. Results BCVA improvement was statistically significantly higher in the study group than the control group at 6-month （（25.53±15.01） letters vs. （14.71±11.66） letters, P=-0.025） and 9-month follow-ups （（27.53±17.78） letters vs. （15.59±12.21） letters, P=0.039）. At 3- and 6-month follow-ups, the quadrants of RPE damage between the two groups varied significantly （P 〈0.001 and P=0.023, respectively）. In each follow-up, the number of cases with decreased or unchanged leakage of choroidal neovascularization by FA and reduced subretinal fluid by OCT did not vary significantly between the two groups. Ten cases （37.0%） in the study group and eight cases （32.0%） in the control group suffered from recurrent CNV （P=-0.703）. Conclusions Better visual improvements, less RPE damage, a similar recurrent rate of CNV and change of subretinal fluid were observed in the small laser spot PDT group than in the standard laser spot PDT group for ICNV.
文摘目的:探究30%超分子水杨酸联合小光斑点阵CO_(2)激光治疗轻中度寻常痤疮的有效性和安全性。方法:选取2022年11月-2023年6月就诊于吉林大学中日联谊医院30例面部轻、中度寻常痤疮患者,以患者面部矢状线为界,按照随机数表将患者的双侧面部随机分为对照侧和观察侧。对照侧(n=30),给予30%超分子水杨酸治疗(每4周治疗1次);观察侧(n=30),给予小光斑点阵CO_(2)激光治疗后即刻30%超分子水杨酸治疗(每4周治疗1次)。通过拍照、皮肤检测仪、皮损计数和痤疮综合分级系统(The global acne grading system,GAGS)评分等评估治疗的有效性;通过皮损清除率判定临床疗效,同时观察不良反应以评估安全性。治疗结束后12周对患者进行随访,评估复发情况。结果:治疗12周后,患者观察侧的临床疗效优于对照侧(P<0.05);观察侧的皮损清除效果明显优于对照侧(P<0.001);观察侧的GAGS评分改善程度明显优于对照侧(P<0.001)。治疗期间两侧均未出现严重不良反应。结论:30%超分子水杨酸联合小光斑点阵CO_(2)激光疗法对清除轻中度痤疮皮损优于30%超分子水杨酸单一治疗,具有见效快、安全性高、操作简单、患者满意度高等优点,且不增加患者相关不良反应。
