BACKGROUND Small cell lung cancer(SCLC)is a common and aggressive subtype of lung cancer.It is characterized by rapid growth and a high mortality rate.Approximately 10%of patients with SCLC present with brain metastas...BACKGROUND Small cell lung cancer(SCLC)is a common and aggressive subtype of lung cancer.It is characterized by rapid growth and a high mortality rate.Approximately 10%of patients with SCLC present with brain metastases at the time of diagnosis,which is associated with a median survival of 5 mo.This study aimed to summarize the effect of bevacizumab on the progression-free survival(PFS)and overall survival of patients with brain metastasis of SCLC.CASE SUMMARY A 62-year-old man was referred to our hospital in February 2023 because of dizziness and numbness of the right lower extremity without headache or fever for more than four weeks.The patient was diagnosed with limited-stage SCLC.He received 8 cycles of chemotherapy combined with maintenance bevacizumab therapy and achieved a PFS of over 7 mo.CONCLUSION The combination of bevacizumab and irinotecan effectively alleviated brain metastasis in SCLC and prolonged PFS.展开更多
针对低渗透油藏注入性差、洗油效率低,水驱无法有效提高采收率等问题,提出了一种低界面张力小分子驱油剂(LST溶液)提高低渗透油藏采收率新技术,评价了该驱油剂的界面活性、增黏性、乳化性、润湿性及其油藏环境适应性和驱油效果。结果表...针对低渗透油藏注入性差、洗油效率低,水驱无法有效提高采收率等问题,提出了一种低界面张力小分子驱油剂(LST溶液)提高低渗透油藏采收率新技术,评价了该驱油剂的界面活性、增黏性、乳化性、润湿性及其油藏环境适应性和驱油效果。结果表明,该驱油剂具有良好的界面活性和增黏性。在6788.23 mg/L的矿化水中,质量分数为0.4%时的LST溶液的油水界面张力为0.012 m N/m,且黏度与油藏原油黏度(3.4 m Pa·s)相近。LST溶液具有较好的油水乳化能力,可改善油藏水润湿性。在47.2℃、油水比为1∶1的条件下,LST乳状液的稳定时间为120 min。岩心经LST溶液处理后,水相接触角由57.0°降至12.5°,油相接触角由24.3°增至38.6°。LST溶液具有良好的静态抗吸附性能,经岩心3次吸附后,LST残液与原油间的界面张力仍能达到10^(-2)m N/m数量级,黏度达2.895 m Pa·s,乳状液静置10、120 min的析水率分别为38.6%、73.4%。LST溶液的耐盐性能较好。在矿化度为16570 mg/L的环境下,其油水界面张力低于7×10^(-2)m N/m、黏度为3.06 m Pa·s。LST溶液的驱油效果较好,可有效封堵高渗透孔道,启动低渗透孔道残余油。注入0.4 PV 0.4%LST溶液可使均质岩心(0.05μm^(2))的水驱驱油效率提高11.21百分点,非均质岩心(级差3~10)水驱后的综合采收率提高6.55百分点~19.41百分点。LST溶液可以实现低剂量或低成本有效提高水驱采收率,在低渗透非均质油藏化学驱提高采收率方面具有较好的应用前景。展开更多
基金Yu-Qing Xia Famous Old Chinese Medicine Heritage Workshop of“3+3”Project of Traditional Chinese Medicine Heritage in Beijing,Jing Zhong Yi Ke Zi(2021),No.73National Natural Science Foundation of China,No.81973640+1 种基金Nursery Program of Wangjing Hospital,Chinese Academy of Traditional Chinese Medicine,No.WJYY-YJKT-2022-05China Academy of Traditional Chinese Medicine Wangjing Hospital High-Level Chinese Medicine Hospital Construction Project Chinese Medicine Clinical Evidence-Based Research:The Evidence-Based Research of Electrothermal Acupuncture for Relieving Cancer-Related Fatigue in Patients With Malignant Tumor,No.WYYY-XZKT-2023-20.
文摘BACKGROUND Small cell lung cancer(SCLC)is a common and aggressive subtype of lung cancer.It is characterized by rapid growth and a high mortality rate.Approximately 10%of patients with SCLC present with brain metastases at the time of diagnosis,which is associated with a median survival of 5 mo.This study aimed to summarize the effect of bevacizumab on the progression-free survival(PFS)and overall survival of patients with brain metastasis of SCLC.CASE SUMMARY A 62-year-old man was referred to our hospital in February 2023 because of dizziness and numbness of the right lower extremity without headache or fever for more than four weeks.The patient was diagnosed with limited-stage SCLC.He received 8 cycles of chemotherapy combined with maintenance bevacizumab therapy and achieved a PFS of over 7 mo.CONCLUSION The combination of bevacizumab and irinotecan effectively alleviated brain metastasis in SCLC and prolonged PFS.
文摘针对低渗透油藏注入性差、洗油效率低,水驱无法有效提高采收率等问题,提出了一种低界面张力小分子驱油剂(LST溶液)提高低渗透油藏采收率新技术,评价了该驱油剂的界面活性、增黏性、乳化性、润湿性及其油藏环境适应性和驱油效果。结果表明,该驱油剂具有良好的界面活性和增黏性。在6788.23 mg/L的矿化水中,质量分数为0.4%时的LST溶液的油水界面张力为0.012 m N/m,且黏度与油藏原油黏度(3.4 m Pa·s)相近。LST溶液具有较好的油水乳化能力,可改善油藏水润湿性。在47.2℃、油水比为1∶1的条件下,LST乳状液的稳定时间为120 min。岩心经LST溶液处理后,水相接触角由57.0°降至12.5°,油相接触角由24.3°增至38.6°。LST溶液具有良好的静态抗吸附性能,经岩心3次吸附后,LST残液与原油间的界面张力仍能达到10^(-2)m N/m数量级,黏度达2.895 m Pa·s,乳状液静置10、120 min的析水率分别为38.6%、73.4%。LST溶液的耐盐性能较好。在矿化度为16570 mg/L的环境下,其油水界面张力低于7×10^(-2)m N/m、黏度为3.06 m Pa·s。LST溶液的驱油效果较好,可有效封堵高渗透孔道,启动低渗透孔道残余油。注入0.4 PV 0.4%LST溶液可使均质岩心(0.05μm^(2))的水驱驱油效率提高11.21百分点,非均质岩心(级差3~10)水驱后的综合采收率提高6.55百分点~19.41百分点。LST溶液可以实现低剂量或低成本有效提高水驱采收率,在低渗透非均质油藏化学驱提高采收率方面具有较好的应用前景。
