An extraction method of the component parameter values of an enhancement-mode InGaP/AIGaAs/In-GaAs PHEMT small signal equivalent circuit is presented,and these component parameter values are extracted by using the EEH...An extraction method of the component parameter values of an enhancement-mode InGaP/AIGaAs/In-GaAs PHEMT small signal equivalent circuit is presented,and these component parameter values are extracted by using the EEHEMT1 model of IC-CAP software. The extraction results are verified by ADS software,and the DC I-V curves and S parameters simulated by ADS are basically accordant with those of the test results. These results indicate that the EEHEMT1 model can be used for extracting the component parameters of an enhancement-mode PHEMT.展开更多
Recently, with increasing improvements in the penetration of wind power and photovoltaic power in the world, probabilistic small signal stability analysis(PSSSA) of a power system consisting of multiple types of renew...Recently, with increasing improvements in the penetration of wind power and photovoltaic power in the world, probabilistic small signal stability analysis(PSSSA) of a power system consisting of multiple types of renewable energy has become a key problem. To address this problem, this study proposes a probabilistic collocation method(PCM)-based PSSSA for a power system consisting of wind farms and photovoltaic farms. Compared with the conventional Monte Carlo method, the proposed method meets the accuracy and precision requirements and greatly reduces the computation; therefore, it is suitable for the PSSSA of this power system. Case studies are conducted based on a 4-machine 2-area and New England systems, respectively. The simulation results show that, by reducing synchronous generator output to improve the penetration of renewable energy, the probabilistic small signal stability(PSSS) of the system is enhanced. Conversely, by removing part of the synchronous generators to improve the penetration of renewable energy, the PSSS of the system may be either enhanced or deteriorated.展开更多
Small signal instability may cause severe accidents for power system if it can not be dear correctly and timely. How to maintain power system stable under small signal disturbance is a big challenge for power system o...Small signal instability may cause severe accidents for power system if it can not be dear correctly and timely. How to maintain power system stable under small signal disturbance is a big challenge for power system operators and dispatchers. Time delay existing in signal transmission process makes the problem more complex. Conventional eigenvalue analysis method neglects time delay influence and can not precisely describe power system dynamic behaviors. In this work, a modified small signal stability model considering time varying delay influence was constructed and a new time delay controller was proposed to stabilize power system under disturbance. By Lyapunov-Krasovskii function, the control law in the form of nonlinear matrix inequality (NLMI) was derived. Considering synthesis method limitation for time delay controller at present, both parameter adjustment method by using linear matrix inequality (LMI) solver and iteration searching method by solving nonlinear minimization problem were suggested to design the controller. Simulation tests were carried out on synchronous-machine infinite-bus power system. Satisfactory test results verify the correctness of the proposed model and the feasibility of the stabilization approach.展开更多
The increasing integration of wind power generation brings more uncertainty into the power system. Since the correlation may have a notable influence on the power system,the output powers of wind farms are generally c...The increasing integration of wind power generation brings more uncertainty into the power system. Since the correlation may have a notable influence on the power system,the output powers of wind farms are generally considered as correlated random variables in uncertainty analysis. In this paper, the C-vine pair copula theory is introduced to describe the complicated dependence of multidimensional wind power injection, and samples obeying this dependence structure are generated. Monte Carlo simulation is performed to analyze the small signal stability of a test system. The probabilistic stability under different correlation models and different operating conditions scenarios is investigated. The results indicate that the probabilistic small signal stability analysis adopting pair copula model is more accurate and stable than other dependence models under different conditions.展开更多
This paper presents an accurate small-signal model for multi-gate GaAs pHEMTs in switching-mode.The extraction method for the proposed model is developed.A 2-gate switch structure is fabricated on a commercial 0.5μm ...This paper presents an accurate small-signal model for multi-gate GaAs pHEMTs in switching-mode.The extraction method for the proposed model is developed.A 2-gate switch structure is fabricated on a commercial 0.5μm AlGaAs/GaAs pHEMT technology to verify the proposed model.Excellent agreement has been obtained between the measured and simulated results over a wide frequency range.展开更多
Repeating airgun sources are eco-friendly sources for monitoring the changes in the physical properties of subsurface mediums,but their signals decay quickly and are buried in the noises soon after traveling short dis...Repeating airgun sources are eco-friendly sources for monitoring the changes in the physical properties of subsurface mediums,but their signals decay quickly and are buried in the noises soon after traveling short distances.Stacking waveforms from different airgun shots recorded by a single seismic station(shot stacking)is the most popular technique to detect weak signals from noisy backgrounds,and has been widely used to process the data of Fixed Airgun Signal Transmission Stations(FASTS)in China.However,shot stacking sacrifices the time resolution in monitoring to recover a qualified airgun signal by stacking many shots at distance stations,and also suffers from persistent local noises.In this paper,we carried out several small-aperture seismic array experiments around the Binchuan FAST Station(BCFASTS)in Yunnan Province,China,and applied the array technique to improve airgun signal detection.The results show that seismic array processing combining with shot stacking can suppress seismic noises more efficiently,and provide better signal-to-noise ratio(SNR)and coherent airgun signals with less airgun shots.This work suggests that the array technique is a feasible and promising tool in FAST to increase the time resolution and reduce noise interference on routine monitoring.展开更多
The impacts of large-scale grid-connected wind farm on direct-driven permanent magnet synchronous generator(PMSG)type are discussed on the small signal stability performances of power systems.Firstly,a simplified prac...The impacts of large-scale grid-connected wind farm on direct-driven permanent magnet synchronous generator(PMSG)type are discussed on the small signal stability performances of power systems.Firstly,a simplified practical model of wind farm of PMSG type is derived for analyzing small signal stability.The rotor-fluxoriented control strategy is applied to the modelling of PMSG.Secondly,the framework of small signal stability analysis incorporating wind farm of PMSG type is built.Finally,the different simulation scenarios based on the IEEE 3-generator-9-bus test system as benchmark are designed to conduct the eigenvalue analysis and to assess the impacts of wind farm of PMSG type on power system small signal stability.Some conclusions are drawn with simulation results.展开更多
The conventional Duffing oscillator weak signal detection method, which is based on a strong reference signal, has inherent deficiencies. To address these issues, the characteristics of the Duffing oscillator's phase...The conventional Duffing oscillator weak signal detection method, which is based on a strong reference signal, has inherent deficiencies. To address these issues, the characteristics of the Duffing oscillator's phase trajectory in a small- scale periodic state are analyzed by introducing the theory of stopping oscillation system. Based on this approach, a novel Duffing oscillator weak wide-band signal detection method is proposed. In this novel method, the reference signal is discarded, and the to-be-detected signal is directly used as a driving force. By calculating the cosine function of a phase space angle, a single Duffing oscillator can be used for weak wide-band signal detection instead of an array of uncoupled Duffing oscillators. Simulation results indicate that, compared with the conventional Duffing oscillator detection method, this approach performs better in frequency detection intervals, and reduces the signal-to-noise ratio detection threshold, while improving the real-time performance of the system.展开更多
Hypertension is a primary risk factor for the progression of cognitive impairment caused by cerebral small vessel disease,the most common cerebrovascular disease.Howeve r,the causal relationship between hypertension a...Hypertension is a primary risk factor for the progression of cognitive impairment caused by cerebral small vessel disease,the most common cerebrovascular disease.Howeve r,the causal relationship between hypertension and cerebral small vessel disease remains unclear.Hypertension has substantial negative impacts on brain health and is recognized as a risk factor for cerebrovascular disease.Chronic hypertension and lifestyle factors are associated with risks for stro ke and dementia,and cerebral small vessel disease can cause dementia and stroke.Hypertension is the main driver of cerebral small vessel disease,which changes the structure and function of cerebral vessels via various mechanisms and leads to lacunar infarction,leukoaraiosis,white matter lesions,and intracerebral hemorrhage,ultimately res ulting in cognitive decline and demonstrating that the brain is the to rget organ of hypertension.This review updates our understanding of the pathogenesis of hypertensioninduced cerebral small vessel disease and the res ulting changes in brain structure and function and declines in cognitive ability.We also discuss drugs to treat cerebral small vessel disease and cognitive impairment.展开更多
Epidermal growth factor receptor(EGFR) controls a wide range of cellular processes, and aberrant EGFR signaling as a result of receptor overexpression and/or mutation occurs in many types of cancer. Tumor cells in non...Epidermal growth factor receptor(EGFR) controls a wide range of cellular processes, and aberrant EGFR signaling as a result of receptor overexpression and/or mutation occurs in many types of cancer. Tumor cells in non-small cell lung cancer(NSCLC) patients that harbor EGFR kinase domain mutations exhibit oncogene addiction to mutant EGFR, which confers high sensitivity to tyrosine kinase inhibitors(TKIs). As patients invariably develop resistance to TKIs, it is important to delineate the cell biological basis of mutant EGFR-induced cellular transformation since components of these pathways can serve as alternate therapeutic targets to preempt or overcome resistance. NSCLC-associated EGFR mutants are constitutively-active and induce ligandindependent transformation in nonmalignant cell lines. Emerging data suggest that a number of factors are critical for the mutant EGFR-dependent tumorigenicity, and bypassing the effects of TKIs on these pathways promotes drug resistance. For example, activation of downstream pathways such as Akt, Erk, STAT3 and Src is critical for mutant EGFR-mediated biological processes. It is now well-established that the potency and spatiotemporal features of cellular signaling by receptor tyrosine kinases such as EGFR, as well as the specific pathways activated, is determined by the nature of endocytic traffic pathways through which the active receptors traverse. Recent evidence indicates that NSCLCassociated mutant EGFRs exhibit altered endocytic trafficking and they exhibit reduced Cbl ubiquitin ligasemediated lysosomal downregulation. More recent work has shown that mutant EGFRs undergo ligand-independent traffic into the endocytic recycling compartment, a behavior that plays a key role in Src pathway activation and oncogenesis. These studies are beginning to delineate the close nexus between signaling and endocytic traffic of EGFR mutants as a key driver of oncogenicprocesses. Therefore, in this review, we will discuss the links between mutant EGFR signaling and endocytic properties, and introduce potential mechanisms by which altered endocytic properties of mutant EGFRs may alter signaling and vice versa as well as their implications for NSCLC therapy.展开更多
The harmonic stochastic resonance-enhanced signal detecting in Newman-Watts small-world neural network is studied using the Hodgkin-Huxley dynamical equation with noise. If the connection probability p, coupling stren...The harmonic stochastic resonance-enhanced signal detecting in Newman-Watts small-world neural network is studied using the Hodgkin-Huxley dynamical equation with noise. If the connection probability p, coupling strength gsyn and noise intensity D matches well, higher order resonance will be found and an optimal signal-to-noise ratio will be obtained. Then, the reasons are given to explain the mechanism of this appearance.展开更多
According to questions in the design of high quality small signal amplifier, this paper gave a new-type high performance small signal amplifier. The paper selected the operational amplifier of ICL Company and designed...According to questions in the design of high quality small signal amplifier, this paper gave a new-type high performance small signal amplifier. The paper selected the operational amplifier of ICL Company and designed a new-type circuit with simple, low cost and excellent performance,展开更多
This paper investigates the properties of traveling wave-beam interaction in a rectangular helix traveling-wave-tube (TWT) for a solid sheet electron beam. The "hot" dispersion equation is obtained by means of the...This paper investigates the properties of traveling wave-beam interaction in a rectangular helix traveling-wave-tube (TWT) for a solid sheet electron beam. The "hot" dispersion equation is obtained by means of the self-consistent field theory. The small signal analysis,which includes the effects of the beam parameters and slow-wave structure (SWS) parameters,is carried out by theoretical computation. The numerical results show that the bandwidth and the small-signal gain of the rectangular helix TWT increase as the beam current increases;and the beam voltage not obviously influences the small signal gain. Among different rectangular helix structures,the small-signal gain increases as the width of the rectangular helix SWS increases,however,the bandwidth decreases whether structure parameters a and L or ψ and L are fixed or not.In addition,a comparison of the small-signal gain of this structure with a conventional round helix is made.The presented analysis will be useful for the design of the TWT with a rectangular helix circuit.展开更多
This paper modeled a doubly fed induction generator (DFIG) - based offshore wind farm integrated through a voltage source converter –based high voltage direct current (VSC-HVDC) transmission system, which is collecte...This paper modeled a doubly fed induction generator (DFIG) - based offshore wind farm integrated through a voltage source converter –based high voltage direct current (VSC-HVDC) transmission system, which is collected with infinite bus for small signal stability analysis. The control system of HVDC system is considered for the stability analysis. The impact of the VSC control parameters on the network stability is studied. The lineared dynamic model is employed to do small signal stability analysis by the eigenvalue analysis. The locus of the eigenvalue, which is corresponding to the oscillation model is studied. Time domain simulations conducted in Matlab/Simulink are used to validate the small signal stability analysis.展开更多
The continuation power flow method combined with the Jacobi-Davidson method is presented to trace the critical eigenvalues for power system small signal stability analysis. The continuation power flow based on a predi...The continuation power flow method combined with the Jacobi-Davidson method is presented to trace the critical eigenvalues for power system small signal stability analysis. The continuation power flow based on a predictor- corrector technique is applied to evaluate a continuum of steady state power flow solutions as system parameters change;meanwhile, the critical eigenvalues are found by the Jacobi-Davidson method, and thereby the trajectories of the critical eigenvalues, Hopf bifurcation and saddle node bifurcation points can also be found by the proposed method. The numerical simulations are studied in the IEEE 30-bus test system.展开更多
By using the output inductors and body capacitances without adding any component compared with hard switching synchronous rectifier,the topology of a soft switched synchronous rectifier with phase-shifted full bridge ...By using the output inductors and body capacitances without adding any component compared with hard switching synchronous rectifier,the topology of a soft switched synchronous rectifier with phase-shifted full bridge zero voltage switching DC/DC converter is proposed. The converter efficiency is maximized due to soft switching of the full bridge MOSFETs and the synchronous MOSFETs, and also the low conduction loss of synchronous MOSFET. The operation principles of the circuit are analyzed in detail and the small-signal model is derived, also the converter dynamic characteristics are analyzed. Frequency responses of transfer functions under different values of transformer primary leakage inductance are discussed. The experimental results were obtained from a 400 V input and 100 A/12 V output DC/DC converter operating at 100 kHz. The results show that the converter efficiency is 2% higher in rated power than traditional diode rectifier.展开更多
The voltage source converter based high voltage direct current(VSC-HVDC)system is based on voltage source converter,and its control system is more complex.Also affected by the fast control of power electronics,oscilla...The voltage source converter based high voltage direct current(VSC-HVDC)system is based on voltage source converter,and its control system is more complex.Also affected by the fast control of power electronics,oscillation phenomenon in wide frequency domain may occur.To address the problem of small signal stability of the VSCHVDC system,a converter control strategy is designed to improve its small signal stability,and the risk of system oscillation is reduced by attaching a damping controller and optimizing the control parameters.Based on the modeling of the VSC-HVDC system,the general architecture of the inner and outer loop control of the VSCHVDC converter is established;and the damping controllers for DC control and AC control are designed in the phase-locked loop and the inner and outer loop control parts respectively;the state-space statemodel of the control system is established to analyze its performance.And the electromagnetic transient simulation model is built on the PSCAD/EMTDC simulation platform to verify the accuracy of the small signal model.The influence of the parameters of each control part on the stability of the system is summarized.The main control parts affecting stability are optimized for the phenomenon of oscillation due to changes in operation mode occurring on the AC side due to faults and other reasons,which effectively eliminates system oscillation and improves system small signal stability,providing a certain reference for engineering design.展开更多
This paper presents a method of tuning governor control parameters of an isolated hydropower generator considering the primary frequency performance and small-signal stability. First, generators that can be operated i...This paper presents a method of tuning governor control parameters of an isolated hydropower generator considering the primary frequency performance and small-signal stability. First, generators that can be operated in isolated state are identified. Second, different schemes are proposed for generator mode switching from on-grid to off-grid state through comparison and mechanism analysis. Third, the time domain model and frequency domain model of the isolated generator governor are constructed to respectively estimate the primary frequency performance and small signal stability. Parameter sets that satisfy the primary frequency performance and small signal stability are acquired as optimal values of governor control parameters. Finally, the measurement-based parameters of the governor are identified and validated using simulations to demonstrate the feasibility and effectiveness of the method.展开更多
An accurate and broad-band method for hetero-junction bipolar transistors(HBT) small-signal model parameters-extraction is presented in this paper. An equivalent circuit forthe HBT under a forward-bias condition is pr...An accurate and broad-band method for hetero-junction bipolar transistors(HBT) small-signal model parameters-extraction is presented in this paper. An equivalent circuit forthe HBT under a forward-bias condition is proposed for extraction of accessresistance and parasiticinductance. This method differs from previous ones by extracting the c-quivalent circuit parameterswithout using special test structure or global numerical optimization techniques. The mainadvantage of this method is that a unique and physically meaningful set of intrinsic parameters isextracted from impedance and admittance representation of the measured S-pa-rameters in thefrequency range of 1-12 GHz under different bias conditions. The method yields a deviation of lessthan 5% between measured and modeled S-parameters.展开更多
文摘An extraction method of the component parameter values of an enhancement-mode InGaP/AIGaAs/In-GaAs PHEMT small signal equivalent circuit is presented,and these component parameter values are extracted by using the EEHEMT1 model of IC-CAP software. The extraction results are verified by ADS software,and the DC I-V curves and S parameters simulated by ADS are basically accordant with those of the test results. These results indicate that the EEHEMT1 model can be used for extracting the component parameters of an enhancement-mode PHEMT.
基金supported by the National Natural Science Foundation of China (NSFC) (No. 51577075)
文摘Recently, with increasing improvements in the penetration of wind power and photovoltaic power in the world, probabilistic small signal stability analysis(PSSSA) of a power system consisting of multiple types of renewable energy has become a key problem. To address this problem, this study proposes a probabilistic collocation method(PCM)-based PSSSA for a power system consisting of wind farms and photovoltaic farms. Compared with the conventional Monte Carlo method, the proposed method meets the accuracy and precision requirements and greatly reduces the computation; therefore, it is suitable for the PSSSA of this power system. Case studies are conducted based on a 4-machine 2-area and New England systems, respectively. The simulation results show that, by reducing synchronous generator output to improve the penetration of renewable energy, the probabilistic small signal stability(PSSS) of the system is enhanced. Conversely, by removing part of the synchronous generators to improve the penetration of renewable energy, the PSSS of the system may be either enhanced or deteriorated.
基金Project(51007042)supported by the National Natural Science Foundation of China
文摘Small signal instability may cause severe accidents for power system if it can not be dear correctly and timely. How to maintain power system stable under small signal disturbance is a big challenge for power system operators and dispatchers. Time delay existing in signal transmission process makes the problem more complex. Conventional eigenvalue analysis method neglects time delay influence and can not precisely describe power system dynamic behaviors. In this work, a modified small signal stability model considering time varying delay influence was constructed and a new time delay controller was proposed to stabilize power system under disturbance. By Lyapunov-Krasovskii function, the control law in the form of nonlinear matrix inequality (NLMI) was derived. Considering synthesis method limitation for time delay controller at present, both parameter adjustment method by using linear matrix inequality (LMI) solver and iteration searching method by solving nonlinear minimization problem were suggested to design the controller. Simulation tests were carried out on synchronous-machine infinite-bus power system. Satisfactory test results verify the correctness of the proposed model and the feasibility of the stabilization approach.
基金supported by the National Natural Science Foundation of China(51307107,51477098,51877133)SRFDP(20130073120034)State Grid Corporation of China Science and Technology Project(Hybrid AC/DC Power Grid Planning and Optimization Study Under the Framework of GEI)。
文摘The increasing integration of wind power generation brings more uncertainty into the power system. Since the correlation may have a notable influence on the power system,the output powers of wind farms are generally considered as correlated random variables in uncertainty analysis. In this paper, the C-vine pair copula theory is introduced to describe the complicated dependence of multidimensional wind power injection, and samples obeying this dependence structure are generated. Monte Carlo simulation is performed to analyze the small signal stability of a test system. The probabilistic stability under different correlation models and different operating conditions scenarios is investigated. The results indicate that the probabilistic small signal stability analysis adopting pair copula model is more accurate and stable than other dependence models under different conditions.
文摘This paper presents an accurate small-signal model for multi-gate GaAs pHEMTs in switching-mode.The extraction method for the proposed model is developed.A 2-gate switch structure is fabricated on a commercial 0.5μm AlGaAs/GaAs pHEMT technology to verify the proposed model.Excellent agreement has been obtained between the measured and simulated results over a wide frequency range.
基金jointly sponsored by National Natural Science Foundation of China(41574050,41674058)
文摘Repeating airgun sources are eco-friendly sources for monitoring the changes in the physical properties of subsurface mediums,but their signals decay quickly and are buried in the noises soon after traveling short distances.Stacking waveforms from different airgun shots recorded by a single seismic station(shot stacking)is the most popular technique to detect weak signals from noisy backgrounds,and has been widely used to process the data of Fixed Airgun Signal Transmission Stations(FASTS)in China.However,shot stacking sacrifices the time resolution in monitoring to recover a qualified airgun signal by stacking many shots at distance stations,and also suffers from persistent local noises.In this paper,we carried out several small-aperture seismic array experiments around the Binchuan FAST Station(BCFASTS)in Yunnan Province,China,and applied the array technique to improve airgun signal detection.The results show that seismic array processing combining with shot stacking can suppress seismic noises more efficiently,and provide better signal-to-noise ratio(SNR)and coherent airgun signals with less airgun shots.This work suggests that the array technique is a feasible and promising tool in FAST to increase the time resolution and reduce noise interference on routine monitoring.
基金supported by Research Project of Science and Technology from Shenzhen Government of China(No.JC200903180528A)
文摘The impacts of large-scale grid-connected wind farm on direct-driven permanent magnet synchronous generator(PMSG)type are discussed on the small signal stability performances of power systems.Firstly,a simplified practical model of wind farm of PMSG type is derived for analyzing small signal stability.The rotor-fluxoriented control strategy is applied to the modelling of PMSG.Secondly,the framework of small signal stability analysis incorporating wind farm of PMSG type is built.Finally,the different simulation scenarios based on the IEEE 3-generator-9-bus test system as benchmark are designed to conduct the eigenvalue analysis and to assess the impacts of wind farm of PMSG type on power system small signal stability.Some conclusions are drawn with simulation results.
基金Project supported by the National Natural Science Foundation of China(Grant No.61673066)
文摘The conventional Duffing oscillator weak signal detection method, which is based on a strong reference signal, has inherent deficiencies. To address these issues, the characteristics of the Duffing oscillator's phase trajectory in a small- scale periodic state are analyzed by introducing the theory of stopping oscillation system. Based on this approach, a novel Duffing oscillator weak wide-band signal detection method is proposed. In this novel method, the reference signal is discarded, and the to-be-detected signal is directly used as a driving force. By calculating the cosine function of a phase space angle, a single Duffing oscillator can be used for weak wide-band signal detection instead of an array of uncoupled Duffing oscillators. Simulation results indicate that, compared with the conventional Duffing oscillator detection method, this approach performs better in frequency detection intervals, and reduces the signal-to-noise ratio detection threshold, while improving the real-time performance of the system.
基金supported by the National Natural Science Foundation of China,Nos.82274611 (to LZ),82104419 (to DM)Capital Science and Technology Leading Talent Training Project,No.Z1 91100006119017 (to LZ)+3 种基金Beijing Hospitals Authority Ascent Plan,No.DFL20190803 (to LZ)Cultivation Fund of Hospital Management Center in Beijing,No.PZ2022006 (to DM)R&D Program of Beijing Municipal Education Commission,No.KM202210025017 (to DM)Beijing Gold-Bridge Project,No.ZZ20145 (to DM)。
文摘Hypertension is a primary risk factor for the progression of cognitive impairment caused by cerebral small vessel disease,the most common cerebrovascular disease.Howeve r,the causal relationship between hypertension and cerebral small vessel disease remains unclear.Hypertension has substantial negative impacts on brain health and is recognized as a risk factor for cerebrovascular disease.Chronic hypertension and lifestyle factors are associated with risks for stro ke and dementia,and cerebral small vessel disease can cause dementia and stroke.Hypertension is the main driver of cerebral small vessel disease,which changes the structure and function of cerebral vessels via various mechanisms and leads to lacunar infarction,leukoaraiosis,white matter lesions,and intracerebral hemorrhage,ultimately res ulting in cognitive decline and demonstrating that the brain is the to rget organ of hypertension.This review updates our understanding of the pathogenesis of hypertensioninduced cerebral small vessel disease and the res ulting changes in brain structure and function and declines in cognitive ability.We also discuss drugs to treat cerebral small vessel disease and cognitive impairment.
基金Supported by the NIH grant to Band H,No.CA99163,CA87986,CA105489 and CA116552a Department of Defense grant to Band H,No.W81WH-11-1-0167+4 种基金the NIH grant to Band V,No.CA96844 and CA144027Department of Defense grant to Band V,No.W81XWH-07-1-0351 and W81XWH-11-1-0171the Nebraska Department of Health and Human Services LB-506 grant to Band H,No.2014-01the NCI Core Support Grant to the UNMC Buffett Cancer CenterBielecki TA was a predoctoral trainee under the NCI Institutional Cancer Biology Training Grant,No.CA009476
文摘Epidermal growth factor receptor(EGFR) controls a wide range of cellular processes, and aberrant EGFR signaling as a result of receptor overexpression and/or mutation occurs in many types of cancer. Tumor cells in non-small cell lung cancer(NSCLC) patients that harbor EGFR kinase domain mutations exhibit oncogene addiction to mutant EGFR, which confers high sensitivity to tyrosine kinase inhibitors(TKIs). As patients invariably develop resistance to TKIs, it is important to delineate the cell biological basis of mutant EGFR-induced cellular transformation since components of these pathways can serve as alternate therapeutic targets to preempt or overcome resistance. NSCLC-associated EGFR mutants are constitutively-active and induce ligandindependent transformation in nonmalignant cell lines. Emerging data suggest that a number of factors are critical for the mutant EGFR-dependent tumorigenicity, and bypassing the effects of TKIs on these pathways promotes drug resistance. For example, activation of downstream pathways such as Akt, Erk, STAT3 and Src is critical for mutant EGFR-mediated biological processes. It is now well-established that the potency and spatiotemporal features of cellular signaling by receptor tyrosine kinases such as EGFR, as well as the specific pathways activated, is determined by the nature of endocytic traffic pathways through which the active receptors traverse. Recent evidence indicates that NSCLCassociated mutant EGFRs exhibit altered endocytic trafficking and they exhibit reduced Cbl ubiquitin ligasemediated lysosomal downregulation. More recent work has shown that mutant EGFRs undergo ligand-independent traffic into the endocytic recycling compartment, a behavior that plays a key role in Src pathway activation and oncogenesis. These studies are beginning to delineate the close nexus between signaling and endocytic traffic of EGFR mutants as a key driver of oncogenicprocesses. Therefore, in this review, we will discuss the links between mutant EGFR signaling and endocytic properties, and introduce potential mechanisms by which altered endocytic properties of mutant EGFRs may alter signaling and vice versa as well as their implications for NSCLC therapy.
基金Project supported by the Natural Science Foundation of Jiangsu Province,China (Grant No. 06KJB140110)the Project of Xuzhou Normal Uiniversity,China (Grant Nos. 08XLB06 and 07PYL02)
文摘The harmonic stochastic resonance-enhanced signal detecting in Newman-Watts small-world neural network is studied using the Hodgkin-Huxley dynamical equation with noise. If the connection probability p, coupling strength gsyn and noise intensity D matches well, higher order resonance will be found and an optimal signal-to-noise ratio will be obtained. Then, the reasons are given to explain the mechanism of this appearance.
文摘According to questions in the design of high quality small signal amplifier, this paper gave a new-type high performance small signal amplifier. The paper selected the operational amplifier of ICL Company and designed a new-type circuit with simple, low cost and excellent performance,
基金Project supported in part by the National Natural Science Foundation of China (Grant No 60532010)the Talent Fund of Chinese Education Administration
文摘This paper investigates the properties of traveling wave-beam interaction in a rectangular helix traveling-wave-tube (TWT) for a solid sheet electron beam. The "hot" dispersion equation is obtained by means of the self-consistent field theory. The small signal analysis,which includes the effects of the beam parameters and slow-wave structure (SWS) parameters,is carried out by theoretical computation. The numerical results show that the bandwidth and the small-signal gain of the rectangular helix TWT increase as the beam current increases;and the beam voltage not obviously influences the small signal gain. Among different rectangular helix structures,the small-signal gain increases as the width of the rectangular helix SWS increases,however,the bandwidth decreases whether structure parameters a and L or ψ and L are fixed or not.In addition,a comparison of the small-signal gain of this structure with a conventional round helix is made.The presented analysis will be useful for the design of the TWT with a rectangular helix circuit.
文摘This paper modeled a doubly fed induction generator (DFIG) - based offshore wind farm integrated through a voltage source converter –based high voltage direct current (VSC-HVDC) transmission system, which is collected with infinite bus for small signal stability analysis. The control system of HVDC system is considered for the stability analysis. The impact of the VSC control parameters on the network stability is studied. The lineared dynamic model is employed to do small signal stability analysis by the eigenvalue analysis. The locus of the eigenvalue, which is corresponding to the oscillation model is studied. Time domain simulations conducted in Matlab/Simulink are used to validate the small signal stability analysis.
文摘The continuation power flow method combined with the Jacobi-Davidson method is presented to trace the critical eigenvalues for power system small signal stability analysis. The continuation power flow based on a predictor- corrector technique is applied to evaluate a continuum of steady state power flow solutions as system parameters change;meanwhile, the critical eigenvalues are found by the Jacobi-Davidson method, and thereby the trajectories of the critical eigenvalues, Hopf bifurcation and saddle node bifurcation points can also be found by the proposed method. The numerical simulations are studied in the IEEE 30-bus test system.
文摘By using the output inductors and body capacitances without adding any component compared with hard switching synchronous rectifier,the topology of a soft switched synchronous rectifier with phase-shifted full bridge zero voltage switching DC/DC converter is proposed. The converter efficiency is maximized due to soft switching of the full bridge MOSFETs and the synchronous MOSFETs, and also the low conduction loss of synchronous MOSFET. The operation principles of the circuit are analyzed in detail and the small-signal model is derived, also the converter dynamic characteristics are analyzed. Frequency responses of transfer functions under different values of transformer primary leakage inductance are discussed. The experimental results were obtained from a 400 V input and 100 A/12 V output DC/DC converter operating at 100 kHz. The results show that the converter efficiency is 2% higher in rated power than traditional diode rectifier.
基金supported by Research on the Oscillation Mechanism and Suppression Strategy of Yu-E MMC-HVDC Equipment and System(2021Yudian Technology 33#).
文摘The voltage source converter based high voltage direct current(VSC-HVDC)system is based on voltage source converter,and its control system is more complex.Also affected by the fast control of power electronics,oscillation phenomenon in wide frequency domain may occur.To address the problem of small signal stability of the VSCHVDC system,a converter control strategy is designed to improve its small signal stability,and the risk of system oscillation is reduced by attaching a damping controller and optimizing the control parameters.Based on the modeling of the VSC-HVDC system,the general architecture of the inner and outer loop control of the VSCHVDC converter is established;and the damping controllers for DC control and AC control are designed in the phase-locked loop and the inner and outer loop control parts respectively;the state-space statemodel of the control system is established to analyze its performance.And the electromagnetic transient simulation model is built on the PSCAD/EMTDC simulation platform to verify the accuracy of the small signal model.The influence of the parameters of each control part on the stability of the system is summarized.The main control parts affecting stability are optimized for the phenomenon of oscillation due to changes in operation mode occurring on the AC side due to faults and other reasons,which effectively eliminates system oscillation and improves system small signal stability,providing a certain reference for engineering design.
基金supported by the Fujian Provincial Government Project (Title: Research on whole process evaluation of dynamic stability and control strategy in condition of grid connection of ultra-high voltage and large scale penetration of nuclear power.No.2015H0023)the State Grid Science & Technology Project (Title: Research on the improvement on stability of primary frequency of generator in account of the tolerance of equipment.No.52130417002P)the Key project of State Grid Fujian Electric Power Company,Ltd (research on key technologies of primary frequency power oscillation mechanism analysis and inhibition measures in large-scale unit in Fujian power grid.No.52130417000J)
文摘This paper presents a method of tuning governor control parameters of an isolated hydropower generator considering the primary frequency performance and small-signal stability. First, generators that can be operated in isolated state are identified. Second, different schemes are proposed for generator mode switching from on-grid to off-grid state through comparison and mechanism analysis. Third, the time domain model and frequency domain model of the isolated generator governor are constructed to respectively estimate the primary frequency performance and small signal stability. Parameter sets that satisfy the primary frequency performance and small signal stability are acquired as optimal values of governor control parameters. Finally, the measurement-based parameters of the governor are identified and validated using simulations to demonstrate the feasibility and effectiveness of the method.
基金Supported by the National Natural Science Foun dation of China(60444004) and the AM Foundation of Shanghai Mu nicipal Science and Technology Commission of China (0109)
文摘An accurate and broad-band method for hetero-junction bipolar transistors(HBT) small-signal model parameters-extraction is presented in this paper. An equivalent circuit forthe HBT under a forward-bias condition is proposed for extraction of accessresistance and parasiticinductance. This method differs from previous ones by extracting the c-quivalent circuit parameterswithout using special test structure or global numerical optimization techniques. The mainadvantage of this method is that a unique and physically meaningful set of intrinsic parameters isextracted from impedance and admittance representation of the measured S-pa-rameters in thefrequency range of 1-12 GHz under different bias conditions. The method yields a deviation of lessthan 5% between measured and modeled S-parameters.