ITERATIVE CONSTRUCTION OF FIXED POINTS FOR MULTIVALUED OPERATORS OF THE MONOTONE TYPE IN UNIFORMLY SMOOTH BANACH SPACES

The fixed points of set-valued operators satisfying a condition of monotonicitytype in s-uniformly smooth Banach spaces are approximated by recursive averagingprocess in the present paper.

ITERATIVE APPROXIMATION OF FIXED POINTS FOR MULTIVALUED OPERATORS OF THE MONOTONE TYPE IN UNIFORMLY SMOOTH BANACH SPACES

In this paper, let K be a nonempty subset of a uniformly smooth Banach space X, and T:K→2~k be a multivalued operator of the monotone type. The iterative sequence which converges strongly to the unique fixed point of T is given. Our results are the extension and improvements of the results obtained previously by several authors including Dunn, Chidume, Deng and Ding.

SIMILARITY TRANSFORMATION, THE STRUCTURE OF THE TRAVELING WAVES SOLUTION AND THE EXISTENCE OF A GLOBAL SMOOTH SOLUTION TO GENERALIZED KURAMOTO SIVASHINSKY TYPE EQUATIONS

The existence of a global smooth solution for the initial value problem of generalized Kuramoto-Sivashinsky type equations have been obtained. Similarty siolutions and the structure of the traveling waves solution for the generalized KS equations are discussed and analysed by using the qualitative theory of ODE and Lie's infinitesimal transformation respectively.

铁死亡诱导剂RAS合成致死分子3抑制病理性瘢痕成纤维细胞的纤维化

背景:病理性瘢痕主要表现为异常的细胞外基质积累和过度的成纤维细胞增殖,成纤维细胞过度增殖就会产生大量以胶原纤维为主的细胞外基质。因此深入探讨成纤维细胞纤维化在病理性瘢痕形成中的作用,将为揭示病理性瘢痕的机制和生物学治疗提供新思路。目的:探讨铁死亡诱导剂RAS合成致死分子3(RAS-selective lethal small molecule 3,RSL3)对人病理性瘢痕成纤维细胞纤维化的影响。方法:收集10例宁夏医科大学总医院烧伤整形美容科提供的病理性瘢痕组织和同一个体正常皮肤组织,提取人病理性瘢痕成纤维细胞和人正常皮肤成纤维细胞用于后续实验;苏木精-伊红染色观察病理性瘢痕组织和正常皮肤组织的形态;倒置显微镜观察病理性瘢痕成纤维细胞和正常皮肤成纤维细胞的外观形态;免疫荧光实验验证所提取的细胞是否为成纤维细胞;用不同浓度的RSL3(1,3,5,7,9,11,13μmol/L)干预细胞,CCK-8法检测RSL3作用于成纤维细胞的半数抑制浓度(IC_(50));设置对照组(不做处理)和RSL3干预组(用7μmol/L的RSL3干预细胞24 h),qRT-PCR和Western blot检测谷胱甘肽过氧化物酶4、Ⅰ型胶原蛋白、Ⅲ型胶原蛋白和α-平滑肌肌动蛋白的mRNA和蛋白的表达;检测细胞丙二醛浓度;划痕试验检测细胞划痕后24 h剩余划痕面积,并计算剩余划痕面积百分比。结果与结论:①与正常皮肤组相比,病理性瘢痕组的谷胱甘肽过氧化物酶4高表达(mRNA:t=3.252,P<0.01;蛋白:t=5.075,P<0.01);②与正常皮肤成纤维细胞组相比,病理性瘢痕成纤维细胞组的谷胱甘肽过氧化物酶4高表达(mRNA:t=10.32,P<0.01;蛋白:t=26.22,P<0.01);③与对照组相比,RSL3干预组谷胱甘肽过氧化物酶4表达减少(mRNA:t=2.798,P<0.05;蛋白:t=4.643,P<0.01),丙二醛浓度上升(t=2.917,P<0.05),Ⅰ型胶原蛋白(mRNA:t=15.84,P<0.01;蛋白:t=4.610,P<0.01)、Ⅲ型胶原蛋白(mRNA:t=28.86,P<0.01;蛋白:t=7.713,P<0.01)和α-平滑肌肌动蛋白(mRNA:t=2.671,P<0.05;蛋白:t=7.417,P<0.01)的表达减少,迁移能力减弱(t=14.06,P<0.01);④提示RSL3通过抑制谷胱甘肽过氧化物酶4的表达,进而抑制病理性瘢痕成纤维细胞的纤维化和迁移能力。

短周期规则波浪在透水鱼礁型潜堤群上的传播特性

为探究系列以周期性分布的单排透水鱼礁型潜堤群对波浪传播变形以及波生湍流场的响应特性,通过水槽试验和数值模拟,对短周期规则波作用下不同间距布设的鱼礁型潜堤群波浪传播特性展开了研究。试验测定了短周期入射波况下无间距鱼礁型潜堤群的波面高度及其变化过程,波浪在发生浅水变形后波能耗散波高显著减小,但由于堤顶淹没水深较大波浪仍保持准对称性的正弦波形态向前传播。基于光滑粒子流体动力学(smoothed particle hydrodynamic,SPH)方法建立了验证后的二维无反射数值波浪水槽,模拟了间距比为0.5~3.0的鱼礁型潜堤群的波浪传播过程。数值结果表明:鱼礁型潜堤群的间距对波浪反射影响非常大,各工况下鱼礁型潜堤群的反射系数均大于0.75;透射系数总体上随着间距比的增大而减小。特别地,当间距比为2.5时,堤顶波高骤升,反射系数达到最大,透射系数几乎最小,这是由于波浪与鱼礁型潜堤群发生了同频共振的布拉格反射效应,此时迎浪堤上方的上涌流范围和流速也达到最大。

益气养阴疏肝法对糖尿病合并郁证患者脑神经递质的影响

目的探讨益气养阴疏肝法治疗糖尿病郁证患者的临床效果。方法选取2021年5月至2023年4月广州医科大学附属中医医院内分泌科收治的60例糖尿病合并郁证患者作为研究对象,按照随机数字表法分为对照组(30例)和试验组(30例)。对照组采用常规药物治疗,试验组在对照组的基础上给予益气养阴疏肝法治疗,比较两组患者治疗前后的理化指标、中医症候评分,抑郁量表评分及脑神经递质的变化情况。结果两组糖化血红蛋白比较,差异无统计学意义(P>0.05)。试验组中医症状评分的总有效率高于对照组,治疗后试验组的脑神经递质水平低于对照组,差异有统计学意义(P<0.05)。结论运用益气养阴疏肝法可以改善糖尿病合并郁证患者的临床症状,其作用机制可能与调节神经递质水平相关。

一种S型加减速组合的速度规划算法

针对传统NURBS曲线插补S型加减速的改进难以在加工柔性和加工效率上同时兼顾的问题,提出一种将多种S型加减速组合的速度规划算法。选取分别在加工柔性和加工效率上单独改进的两种S型加减速,并设计了一种兼顾柔性和效率的新改进S型加减速。在速度规划中,根据简化后的4种加减速形式,灵活组合这3种S型加减速,并采取合并曲线分段的速度平滑方式,减少了曲线段间的速度波动。仿真结果表明:该算法能在提高加工效率的同时满足加加速度的连续,最终实现加工柔性和加工效率的兼得。

低信噪比地震数据图像结构引导去噪方法与应用

地震噪声影响着复杂断裂结构与储层的刻画,有效压制噪声并保留地震资料中的结构信息,是解释性处理的关键。基于保边光滑原理,在地震数据处理中提出并引入图像结构引导滤波方法,实现自适应地保留断层、裂缝以及储层反射等关键信息并有效压制散射与随机噪声,提高地震数据信噪比。正演模拟数据的去噪试验结果表明,相比常规滤波方法,图像结构引导滤波方法具有更好的保边光滑特性;与构造导向滤波方法相比,该方法不需显式提取层位走向和倾角信息,具有较高的计算效率。实际三维资料的应用结果表明,该方法能有效压制不同类型噪声、提高信噪比和有效反射同相轴的连续性;处理后对应的相干属性可有效增强断裂、储层的分辨能力,更好地描述断裂系统的展布,有利于后续地震资料解释工作。

Global Existence of Smooth Solutions of Compressible Bipolar Euler-Maxwell Equations

The bipolar compressible Euler-Maxwell equations as a fluid dynamic model arising from plasma physics to describe the dynamics of the compressible electrons and ions is investigated. This work is concerned with three-dimensional Euler-Maxwell equations with smooth periodic solutions. With the help of the symmetry operator techniques and energy method, the global smooth solution with small amplitude is constructed around a constant equilibrium solution with asymptotic stability property.

干姜吴茱萸水煎液对大鼠结肠平滑肌细胞L型Ca^(2+)通道的影响

目的:探讨干姜吴茱萸水煎液对大鼠结肠平滑肌收缩及平滑肌细胞L型Ca^(2+)通道的影响机制。方法:采用0、0.01、0.1、1、10 g/L干姜吴茱萸(1∶1)水煎液依次作用于正常结肠平滑肌,10 g/L水煎液及L型Ca^(2+)通道激动剂BAY-K-8644依次作用于氯化乙酰胆碱(Ach)诱导后的正常平滑肌,检测平滑肌收缩张力、频率和振幅;全细胞膜片钳记录L型钙电流;Western blot检测各组细胞中L-型电压依赖钙离子通道α1C亚基(α1c)和钙调蛋白(CaM)蛋白表达情况。结果:1、10 g/L水煎液组能显著降低离体结肠平滑肌的收缩张力(P<0.05),对频率及振幅并无显著影响(P>0.05);与0 g/L水煎液组相比,Ach促进平滑肌收缩张力、频率和振幅显著增加(P<0.05);与Ach组相比,10 g/L水煎液显著降低平滑肌的收缩张力、频率和振幅(P<0.05);与10 g/L水煎液组相比,BAY-K-8644显著增加平滑肌的收缩张力、频率和振幅(P<0.05);与0 g/L水煎液组相比,Ach可显著增加ICa-L峰值电流密度(P<0.05);与Ach组相比,10 g/L水煎液显著降低ICa-L峰值电流密度(P<0.05);与10 g/L水煎液组相比,BAY-K-8644可显著增加ICa-L峰值电流密度(P<0.05);与对照组相比,Ach组结肠平滑肌细胞Ca^(2+)相对荧光强度峰值、α1c、CaM表达显著增加(P<0.05);Ach组相比,10 g/L组Ca^(2+)相对荧光强度峰值、α1c和CaM表达水平显著降低(P<0.05);与10 g/L组相比,BAYK-8644组Ca^(2+)相对荧光强度峰值、α1c、CaM表达显著增加(P<0.05)。结论:干姜吴茱萸水煎液可抑制大鼠结肠平滑肌收缩,并阻滞L型Ca^(2+)通道。

Interference of Y-27632 on the signal transduction of transforming growth factor beta type 1 in ocular Tenon capsule fibroblasts

AIM: To investigate the interfering effect of Y-27632, a ROCK-I selective inhibitor, on the signal transduction pathway of transforming growth factor-beta 1 (TGF-beta 1) in ocular Tenon capsule fibroblasts (OTFS) in vitro. METHODS: After OTFS from passages 4 to 6 47 vitro were induced by TGF-beta 1 and then treated by Y-27632, the changes of the OTFS cell cycles were analyzed via flow cytometry, and the proteins expression of the alpha -smooth muscular actin (alpha -SMA), connective tissue growth factor (CTGF), collagen I were calculated by Western blot. After OTFS treated by the different concentrations of Y-27632, the expression levels of the alpha -SMA, CTGF and collagen I mRNA were assayed by RT-PCR. RESULTS: Y-27632 had no markedly effect on the OTFS cell cycles. After treated by TGF-beta 1, OTFS in G1 period significantly increased. The cell cycles distribution by both TGF-beta 1 and Y-27632 had no remarkable difference from that in control group. Y-27632 significantly inhibited the proteins expressions of both alpha -SMA and CTGF, while to some extent inhibited that of collagen I. TGF-beta 1 significantly promoted the proteins expressions of alpha -SMA, CTGF and collagen I. After OTFS treated by both TGF-beta 1 and Y-27632, of alpha -SMA, the protein expression was similar with that in control group (P=0.066>0.05), but the protein expression of CTGF or collagen I, respectively, was significantly different from that in control group (P=0.000<0.01). The differences of expressions of the alpha -SMA, CTGF and collagen I mRNA in 30, 150, 750 mu mol/L Y-27632 group were statistically significant, compared with those in control group, respectively (alpha -SMA, P=0.002, 0.000, 0.000; CTGF, P=0.014, 0.002, 0.001; collagen I,P=0.003, 0.002, 0.000). CONCLUSION: Blocking the Rho/ROCK signaling pathway by using of Y-27632 could inhibit the cellular proliferation and the expression of both CTGF and alpha -SMA whatever OTFS induced by TGF-beta 1 or not. Y-27632 suppressed the expression of collagen I mRNA without induction.

Determinants of airway hyperresponsiveness—Balance of tonic and phasic contractility of airway smooth muscles of lobular bronchioles

Airway hyperresponsiveness (AHR) is a characteristic feature of asthma, and generally correlates with severity of asthma. Understanding the protection mechanism against excessive airway narrowing and how it breaks down is fundamental to solving the problem of asthma. In this paper we have proposed a stochastic modeling the airway smooth muscle bundle for reproducing AHR such as an increased sensitivity of the airways to an inhaled constrictor agonist, a steeper slope of the dose-response curve, and a greater maximal response to agonist. A large number N of contractile muscle cells was assumed to repeat themselves in between contraction and relaxation asynchronously. Dynamic equilibrium of statistic physics was applied to the system of ASM bundle. Thus, the relation of dose to response of a piece of ASM bundle was described by Φ=tanh(βH) , where β was Boltzman factor and H represented energy of contraction induced by constrictor agents. Each of adjacent pair contractile cells was assumed to have Ising-type of antimagnetic interactions of preference energy J (for the condition of contraction-relaxation) between them. A motion equation for a piece of ASM bundle was described by Φ=N(H-zJΦ , which explained existence of combined tonic and phasic contractions. Based on observations of Venegas et al. [4], airway responsiveness was assumed to be assessable by total volume of the ventilation defects (TVD) of 13NN PET-CT images. Interactions via propagation of Ca ion waves between ASM bundles would cause percolation probability by PΦ=(1+tanh(βH))2/4 along the tree, then the relation of dose βH to TVD was described by TVD=PΦ[1-(1-PΦ)3/PΦ3]-TVD0. TVD0 represented the protection mechanism against excessive airway narrowing, which was determined by the ratio of amplitudes between tonic and phasic contractions, thus the balance of amplitudes between tonic and phasic contractions of peripheral lobular smooth muscles would be the determinant of AHR.

Hydrogen sulfide-induced enhancement of gastric fundus smooth muscle tone is mediated by voltagedependent potassium and calcium channels in mice

AIM:To investigate the effect of hydrogen sulfide(H2S)on smooth muscle motility in the gastric fundus.METHODS:The expression of cystathionineβ-synthase(CBS)and cystathionineγ-lyase(CSE)in cultured smooth muscle cells from the gastric fundus was examined by the immunocytochemistry technique.The tension of the gastric fundus smooth muscle was recorded by an isometric force transducer under the condition of isometric contraction with each end of the smooth muscle strip tied with a silk thread.Intracellular recording was used to identify whether hydrogen sulfide affects the resting membrane potential of the gastric fundus in vitro.Cells were freshly separated from the gastric fundus of mice using a variety of enzyme digestion methods and whole-cell patch-clamp technique was used to find the effects of hydrogen sulfide on voltage-dependent potassium channel and calcium channel.Calcium imaging with fura-3AM loading was used to investigate the mechanism by which hydrogen sulfide regulates gastric fundus motility in cultured smooth muscle cells.RESULTS:We found that both CBS and CSE were expressed in the cul tured smooth muscle cel ls from the gastric fundus and that H2S increased the smooth muscle tension of the gastric fundus in mice at low concentrations.In addition,nicardipine and aminooxyacetic acid(AOAA),a CBS inhibitor,reduced the tension,whereas Nω-nitro-L-arginine methyl ester,a nonspecific nitric oxide synthase,increased the tension.The AOAA-induced relaxation was significantly recovered by H2S,and the Na HS-induced increase in tonic contraction was blocked by 5 mmol/L4-aminopyridine and 1μmol/L nicardipine.Na HS significantly depolarized the membrane potential and inhibited the voltage-dependent potassium currents.Moreover,Na HS increased L-type Ca2+currents and caused an elevation in intracellular calcium([Ca2+]i).CONCLUSION:These findings suggest that H2S may be an excitatory modulator in the gastric fundus in mice.The excitatory effect is mediated by voltagedependent potassium and L-type calcium channels.

Stechkin-Marchaud Type Inequalities in Lp for Linear Combination of Bernstein-Durrmeyer Operators

In this paper, we use the equivalence relation between K-functional and modulus of smoothness, and give the Stechkin-Marchaud-type inequalities for linear combination of Bernstein-Durrmeyer operators . Moreover, we obtain the inverse result of approximation for linear combination of Bernstein-Durrmeyer operators with . Meanwhile we unify and extend some previous results.

特高压干式平波电抗器地震反应分析

特高压干式平波电抗器广泛应用在电力工程中,具有适应性好、方便运输、安装灵活等特点,能够抵抗恶劣天气的影响,长期在户外条件下运行。干式平波电抗器质量大、尺寸大、重心高,具有较高的地震易损性,是变电站直流输电工程中重要塔式设备,有必要对其抗震设计和评估进行深入研究。以典型布置的干式平波电抗器为研究对象,采用振型分解反应谱法进行地震反应分析,为实际工程中特高压干式平波电抗器的抗震设计评估及薄弱环节提供参考。

糖尿病肾病与其他类型肾病患者肾组织中Smad1蛋白表达的比较

目的比较糖尿病患者及其他类型肾病患者肾组织中Smad1蛋白表达量的差异,以及与相应尿Smad1蛋白含量的关系。方法收集通过肾活检确诊的糖尿病肾病患者(DN组9例)及其他类型肾病患者,包括局灶性肾小球硬化性肾病(FSGS组5例)、IgA肾病(IgA组12例)、微小病变型肾病(MNP组10例)的尿液及肾活检组织。ELISA以及免疫组化、免疫荧光等方法检测尿Smad1蛋白含量、肾活检组织Smad1蛋白的表达情况以及可受Smad1调节的胶原蛋白4(Col4)、α-平滑肌肌球蛋白(α-SMA)的表达情况。结果DN组及其他3种肾病的患者均检测到尿中有Smad1蛋白的排泄,均高于健康人群(47例)(P<0.05)。4组肾病患者的肾活检组织不同区域(包括肾小球与肾小管区域)均有Smad1蛋白的表达,而DN组肾小管区域的Smad1蛋白的表达含量高于其他3组的水平(P<0.05)。4组肾病患者肾活检组织中不同区域均有Col4、α-SMA蛋白与Smad1蛋白共同表达。结论不同肾病肾组织的不同区域都有Smad1蛋白表达的上调,与肾损伤有关。

基于空间激光通信的离轴盘式无线光滑环设计

针对传统的滑环存在通信宽带不足、接触磨损寿命低的问题,设计了一种基于空间激光通信的离轴盘式无线光滑环,并完成了样机研制。该光滑环采用光学追迹仿真技术,将4个红外发射器均匀等间距地布置在光滑环的4个角,使接收端旋转时能连续稳定地接收到光功率。光学仿真和性能测试结果表明:在传输距离为20~200 mm时,离轴盘式无线光滑环的接收功率为-28.3~-29.2 dBm,满足探测器灵敏度(约-30 dBm)的要求;在0~500 r/min旋转环境下,其误码率会随着传输距离的增加而增大,但整体误码率均小于10-6。

基于SPH的新型人工块体TB-CUBE设计优化和水动力特性数值模拟

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