In animal societies,some stressful events can lead to higher levels of physiological stress.Such stressors,like social rank,also predict an increased vulnerability to an array of diseases.However,the physiological rel...In animal societies,some stressful events can lead to higher levels of physiological stress.Such stressors,like social rank,also predict an increased vulnerability to an array of diseases.However,the physiological relationship between social rank and stress varies between different species,as well as within groups of a single species.For example,dominant individuals are more socially stressed at times,while at other times it is the subordinate ones who experience this stress.Together,these variations make it difficult to assess disease vulnerability as connected to social interactions.In order to learn more about how physiological rank relationships vary between groups of a single species,cortisol measurements from hair samples were used to evaluate the effects of dominance rank on long-term stress levels in despotic and less stringent female rhesus macaque hierarchal groups.In despotic groups,cortisol levels were found not to be correlated with social rank,but a negative correlation was found between social rank and cortisol levels in less stringent hierarchies.Low ranking monkeys in less stringent groups secreted elevated levels of cortisol compared to higher ranking animals.These data suggest that variations in the strictness of the dominance hierarchy are determining factors in rank related stress physiology.The further consideration of nonhuman primate social system diversity and the linear degree of their hierarchies may allow for the development of valid rank-related stress models that will help increase our understanding and guide the development of new therapeutics for diseases related to human socioeconomic status.展开更多
In animal societies, some stressful events can lead to higher levels of physiological stress. Such stressors, like social rank, also predict an increased vulnerability to an array of diseases. However, the physiologic...In animal societies, some stressful events can lead to higher levels of physiological stress. Such stressors, like social rank, also predict an increased vulnerability to an array of diseases. However, the physiological relationship between social rank and stress varies between different species, as well as within groups of a single species. For example, dominant individuals are more socially stressed at times, while at other times it is the subordinate ones who experience this stress. Together, these variations make it difficult to assess disease vulnerability as connected to social interactions. In order to learn more about how physiological rank relationships vary between groups of a single species, cortisol measurements from hair samples were used to evaluate the effects of dominance rank on long-term stress levels in despotic and less stringent female rhesus macaque hierarchal groups. In despotic groups, cortisol levels were found not to be correlated with social rank, but a negative correlation was found between social rank and cortisol levels in less stringent hierarchies. Low ranking monkeys in less stringent groups secreted elevated levels of cortisol compared to higher ranking animals. These data suggest that variations in the strictness of the dominance hierarchy are determining factors in rank related stress physiology. The further consideration of nonhuman primate social system diversity and the linear degree of their hierarchies may allow for the development of valid rank-related stress models that will help increase our understanding and guide the development of new therapeutics for diseases related to human socioeconomic status.展开更多
The primary objective of this pilot study was to evaluate the impact of social rank on the well-being of gestating sows housed in a free access stall-pen housing environment. At d 30 post-breeding, 32 multiparous cros...The primary objective of this pilot study was to evaluate the impact of social rank on the well-being of gestating sows housed in a free access stall-pen housing environment. At d 30 post-breeding, 32 multiparous crossbred sows in groups of 4 were allocated to a stall-pen housing environment. Blood samples were taken at gestational d 30 (before mixing) and d 31 (24-h post-mixing), and then again at d 89 and 110;whereas, sow behavior was recorded at gestational d 30, 66, 87, and 102. Social rank was determined based on aggressive encounters, dyadic fighting wins and losses, and displacements between sows by 48-h post-mixing. At d 31 (post-mixing), regardless of social rank, total WBC decreased and, lymphocyte counts increased, but % change was more significant among the subordinates than dominants. The same trend occurred with neutrophil chemotaxis increased more in subordinates, but ConA-induced lymphocyte proliferation increased more in dominants, whereas LPS-induced lymphocyte proliferation was reduced among dominants. Sow behavior was differentially affected by social rank and time-periods or gestational day, with subordinates spending more time sitting and drinking, especially during time-periods 1, 3, and 4. Dominants displayed more oral-nasal-facial behaviors during mid-gestation but more sham-chew during time-period 2, which included feeding time. Social rank also influenced the percentage of time sows spent in either the stall or pen area, with subordinates in stalls and dominants in pen. These data imply that social rank differentially influences physiology and behavior of dry sows housed in a free access stall-pen environment. More specifically, the location of the dominant sow, time of day, and activity may influence when and where the subordinates spend their time within this housing system.展开更多
已有的社会化协同排序推荐算法的研究只是简单地融入用户的社交网络信息,没有考虑用户之间社会化信任网络的传递性;同时,该推荐算法的性能面临数据高度稀疏性问题的挑战.为了进一步解决这些问题,在传统的协同排序推荐算法(ListRank,List...已有的社会化协同排序推荐算法的研究只是简单地融入用户的社交网络信息,没有考虑用户之间社会化信任网络的传递性;同时,该推荐算法的性能面临数据高度稀疏性问题的挑战.为了进一步解决这些问题,在传统的协同排序推荐算法(ListRank,List-wise Learning to Rank)和最新的社会化协同过滤算法(TrustMF,Social Collaborative Filtering by Trust)的基础上,提出了一种新的社会化协同排序推荐算法(TLRank),融合均高度稀疏的用户的显式评分数据和社会化信任网络数据,以进一步增强协同排序推荐算法的性能.实验结果表明:在各个评价指标下,TLRank算法的性能均优于几个经典的协同排序推荐算法,且复杂度低、运算时间与评分点个数线性相关;TLRank算法的推荐精度高、可扩展性好,适合处理大数据,可广泛运用于互联网信息推荐领域.展开更多
Psychedelic is one of psychoac⁃tive drug substances which leads to abnormali⁃ties in thinking,mood and sensory perception via the subtype of 5-HT receptor(5-HT2A receptor).Psychedelic is known to cause schizophrenia-l...Psychedelic is one of psychoac⁃tive drug substances which leads to abnormali⁃ties in thinking,mood and sensory perception via the subtype of 5-HT receptor(5-HT2A receptor).Psychedelic is known to cause schizophrenia-like symptoms or worsen schizophrenia.Mean⁃while it causes abnormalities in neural synchroni⁃zation and oscillations.In recent years,with the prevalence of various new psychedelic drugs and the rising population of young addicts,the clinical effects of psychedelic have been highly concerned.Adolescence is an important period for the formation of neuroplasticity,and it is an important stage in the functional development and maturation of the central nervous system.However,it is currently unclear about the endur⁃ing effects of juvenile exposure to psychedelic on social behavior,and neural network function.OBJECTIVE The chronic exposure model of psy⁃chedelic(2CC-NBOMe,2CC)in rats was used to reveal the enduring effects on social behavior and neural network function in adulthood,which is intended to provide important reference infor⁃mation about the potential enduring effects and clinical applicability of psychedelic.METHODS Repeated exposure of normal saline in adoles⁃cence group(0.1 mL·kg-1,for 14 d),repeated exposure of 2CC group(0.1 mg·kg-1,for 14 d).The duration of adolescent administration was 35-48 d after birth.Adulthood means 9 weeks after birth.Behavioral and somatic neuroelectro⁃physiological experiments were performed 9-12 weeks after birth in the adolescent drug exposure group.RESULTS Psychedelic-exposed animals during adolescence showed a significant decline in social rank and an increase in social willingness.Coherence of theta waves(6-10 Hz)from the hippocampal CA1 to the orbital frontal cortex(Orb)was significantly reduced in the psy⁃chedelic-exposed animals compared to the con⁃trol animals.During the social task,the coher⁃ence of theta waves between CA1 and Orb was significantly reduced in the control animals,but not in the psychedelic-exposed animals.CON⁃CLUSION The altered social function caused by chronic psychedelic exposure during adoles⁃cence is associated with abnormal CA1-Orb theta wave coherence.展开更多
Recently, the community analysis has seen enormous research advancements in the field of social networks. A large amount of the current studies put forward different models and algorithms about most influential people...Recently, the community analysis has seen enormous research advancements in the field of social networks. A large amount of the current studies put forward different models and algorithms about most influential people. However, there is little work to shed light on how to rank communities while considering their levels that are determined by the quality of their published contents. In this paper, we propose solution for measuring the influence of communities and ranking them by considering joint weight composed of internal and external influence of communities. To address this issue, we design a novel algorithm called Com Rank: a modification of Page Rank, which considers the joint weight in order to identify impact of each community and ranking them. We use real-world data trace in citation network and perform extensive experiments to evaluate our proposed algorithm. The comparative results depict significant improvements by our algorithm in community ranking due to the inclusion of proposed weighting feature.展开更多
Due to the increasing number of wireless mobile devices,the possibility of mobile communications without infrastructure becomes a reality.The Decentralized Mobile Social Network(DMSN) is a paradigm where nodes can mov...Due to the increasing number of wireless mobile devices,the possibility of mobile communications without infrastructure becomes a reality.The Decentralized Mobile Social Network(DMSN) is a paradigm where nodes can move freely and organize themselves arbitrarily.Routing in these environments is difficult for the reason of the rapid changes of the social relationship graph's topology.Meanwhile,the social ties among nodes change overtime.Therefore,an efficient data forwarding mechanism should be considered over the temporal weighted relationship graph.In this paper,an Advanced routing Protocol based on Parameters Optimization in the Weighted mobile social network(APPOW) is proposed to improve the delivery success ratio and reduce the cost of exchanging information.APPOW combines the normalized relative weights of three local social metrics,i.e.,LinkRank,similarity and contact strength,to select the next relay node.The weights of the three metrics are derived by pair-wise learning algorithm.The result shows that APPOW outperforms the state-ofthe-art SimBet Routing in delivering message and significantly reduces the average hops.Additionally,the delivery performance of APPOW is close to Epidemic Routing but without message duplications.展开更多
Introduction: The Liebowitz Social Anxiety Scale (LSAS), used to assess the severity of social anxiety disorder (SAD), requires considerable effort and time to complete. The aims of this study were: 1) to investigate ...Introduction: The Liebowitz Social Anxiety Scale (LSAS), used to assess the severity of social anxiety disorder (SAD), requires considerable effort and time to complete. The aims of this study were: 1) to investigate whether a visual analogue scale (VAS) could be linear with the LSAS and substitute for the LSAS, 2) to relate such a VAS instrument to patient demographics. Methods: Fifty SAD patients were assessed using the LSAS and VAS instruments completed by both patients and doctors at the same session. We then drew distributions and calculated the Spearman’s ρ and κ coefficient values (divided at the median for each scale) between patient and doctor assessments. Next, each pair among the scores for the LSAS, the patient VAS and the doctor VAS was compared using Wilcoxon rank sum tests according to patient life profile data. Results: Scatter plots of pairs of scores were obtained. Spearman’s ρ was 0.661 between the LSAS and the patient VAS, 0.461 between the LSAS and the doctor VAS, and 0.494 between VAS scores of patients and doctors. The κ coefficients were 0.501 between the LSAS and patient VAS, 0.251 between the LSAS and doctor VAS, and 0.425 between patient VAS and doctor VAS (for all six, p < 0.001). The Wilcoxon rank sum tests indicated a significant difference between the groups with/ without “employment” (LSAS, patient/doctor VAS), with/without “graduation from junior college/university” (doctor VAS) (p < 0.05) and with/without marital history (the age of first consultation) (p < 0.01). Conclusions: A patient VAS may substitute for the LSAS and offer the versatility necessary to capture patient states and life profiles.展开更多
基金This study was funded by the National Science Foundation of China(NSFC 31271167,and 31070963)the 973 program(2007CB947703 and 2011CB707800)the Key Program of the Chinese Academy of Sciences,China(KSCX2-EW-R-13)。
文摘In animal societies,some stressful events can lead to higher levels of physiological stress.Such stressors,like social rank,also predict an increased vulnerability to an array of diseases.However,the physiological relationship between social rank and stress varies between different species,as well as within groups of a single species.For example,dominant individuals are more socially stressed at times,while at other times it is the subordinate ones who experience this stress.Together,these variations make it difficult to assess disease vulnerability as connected to social interactions.In order to learn more about how physiological rank relationships vary between groups of a single species,cortisol measurements from hair samples were used to evaluate the effects of dominance rank on long-term stress levels in despotic and less stringent female rhesus macaque hierarchal groups.In despotic groups,cortisol levels were found not to be correlated with social rank,but a negative correlation was found between social rank and cortisol levels in less stringent hierarchies.Low ranking monkeys in less stringent groups secreted elevated levels of cortisol compared to higher ranking animals.These data suggest that variations in the strictness of the dominance hierarchy are determining factors in rank related stress physiology.The further consideration of nonhuman primate social system diversity and the linear degree of their hierarchies may allow for the development of valid rank-related stress models that will help increase our understanding and guide the development of new therapeutics for diseases related to human socioeconomic status.
基金funded by the National Science Foundation of China (NSFC 31271167, and 31070963)the 973 program (2007CB947703 and 2011CB707800)the Key Program of the Chinese Academy of Sciences, China (KSCX2-EW-R-13)
文摘In animal societies, some stressful events can lead to higher levels of physiological stress. Such stressors, like social rank, also predict an increased vulnerability to an array of diseases. However, the physiological relationship between social rank and stress varies between different species, as well as within groups of a single species. For example, dominant individuals are more socially stressed at times, while at other times it is the subordinate ones who experience this stress. Together, these variations make it difficult to assess disease vulnerability as connected to social interactions. In order to learn more about how physiological rank relationships vary between groups of a single species, cortisol measurements from hair samples were used to evaluate the effects of dominance rank on long-term stress levels in despotic and less stringent female rhesus macaque hierarchal groups. In despotic groups, cortisol levels were found not to be correlated with social rank, but a negative correlation was found between social rank and cortisol levels in less stringent hierarchies. Low ranking monkeys in less stringent groups secreted elevated levels of cortisol compared to higher ranking animals. These data suggest that variations in the strictness of the dominance hierarchy are determining factors in rank related stress physiology. The further consideration of nonhuman primate social system diversity and the linear degree of their hierarchies may allow for the development of valid rank-related stress models that will help increase our understanding and guide the development of new therapeutics for diseases related to human socioeconomic status.
文摘The primary objective of this pilot study was to evaluate the impact of social rank on the well-being of gestating sows housed in a free access stall-pen housing environment. At d 30 post-breeding, 32 multiparous crossbred sows in groups of 4 were allocated to a stall-pen housing environment. Blood samples were taken at gestational d 30 (before mixing) and d 31 (24-h post-mixing), and then again at d 89 and 110;whereas, sow behavior was recorded at gestational d 30, 66, 87, and 102. Social rank was determined based on aggressive encounters, dyadic fighting wins and losses, and displacements between sows by 48-h post-mixing. At d 31 (post-mixing), regardless of social rank, total WBC decreased and, lymphocyte counts increased, but % change was more significant among the subordinates than dominants. The same trend occurred with neutrophil chemotaxis increased more in subordinates, but ConA-induced lymphocyte proliferation increased more in dominants, whereas LPS-induced lymphocyte proliferation was reduced among dominants. Sow behavior was differentially affected by social rank and time-periods or gestational day, with subordinates spending more time sitting and drinking, especially during time-periods 1, 3, and 4. Dominants displayed more oral-nasal-facial behaviors during mid-gestation but more sham-chew during time-period 2, which included feeding time. Social rank also influenced the percentage of time sows spent in either the stall or pen area, with subordinates in stalls and dominants in pen. These data imply that social rank differentially influences physiology and behavior of dry sows housed in a free access stall-pen environment. More specifically, the location of the dominant sow, time of day, and activity may influence when and where the subordinates spend their time within this housing system.
文摘已有的社会化协同排序推荐算法的研究只是简单地融入用户的社交网络信息,没有考虑用户之间社会化信任网络的传递性;同时,该推荐算法的性能面临数据高度稀疏性问题的挑战.为了进一步解决这些问题,在传统的协同排序推荐算法(ListRank,List-wise Learning to Rank)和最新的社会化协同过滤算法(TrustMF,Social Collaborative Filtering by Trust)的基础上,提出了一种新的社会化协同排序推荐算法(TLRank),融合均高度稀疏的用户的显式评分数据和社会化信任网络数据,以进一步增强协同排序推荐算法的性能.实验结果表明:在各个评价指标下,TLRank算法的性能均优于几个经典的协同排序推荐算法,且复杂度低、运算时间与评分点个数线性相关;TLRank算法的推荐精度高、可扩展性好,适合处理大数据,可广泛运用于互联网信息推荐领域.
文摘Psychedelic is one of psychoac⁃tive drug substances which leads to abnormali⁃ties in thinking,mood and sensory perception via the subtype of 5-HT receptor(5-HT2A receptor).Psychedelic is known to cause schizophrenia-like symptoms or worsen schizophrenia.Mean⁃while it causes abnormalities in neural synchroni⁃zation and oscillations.In recent years,with the prevalence of various new psychedelic drugs and the rising population of young addicts,the clinical effects of psychedelic have been highly concerned.Adolescence is an important period for the formation of neuroplasticity,and it is an important stage in the functional development and maturation of the central nervous system.However,it is currently unclear about the endur⁃ing effects of juvenile exposure to psychedelic on social behavior,and neural network function.OBJECTIVE The chronic exposure model of psy⁃chedelic(2CC-NBOMe,2CC)in rats was used to reveal the enduring effects on social behavior and neural network function in adulthood,which is intended to provide important reference infor⁃mation about the potential enduring effects and clinical applicability of psychedelic.METHODS Repeated exposure of normal saline in adoles⁃cence group(0.1 mL·kg-1,for 14 d),repeated exposure of 2CC group(0.1 mg·kg-1,for 14 d).The duration of adolescent administration was 35-48 d after birth.Adulthood means 9 weeks after birth.Behavioral and somatic neuroelectro⁃physiological experiments were performed 9-12 weeks after birth in the adolescent drug exposure group.RESULTS Psychedelic-exposed animals during adolescence showed a significant decline in social rank and an increase in social willingness.Coherence of theta waves(6-10 Hz)from the hippocampal CA1 to the orbital frontal cortex(Orb)was significantly reduced in the psy⁃chedelic-exposed animals compared to the con⁃trol animals.During the social task,the coher⁃ence of theta waves between CA1 and Orb was significantly reduced in the control animals,but not in the psychedelic-exposed animals.CON⁃CLUSION The altered social function caused by chronic psychedelic exposure during adoles⁃cence is associated with abnormal CA1-Orb theta wave coherence.
基金supported in part by the following funding agencies of China:National Natural Science Foundation under Grant 61170274, 61602050 and U1534201
文摘Recently, the community analysis has seen enormous research advancements in the field of social networks. A large amount of the current studies put forward different models and algorithms about most influential people. However, there is little work to shed light on how to rank communities while considering their levels that are determined by the quality of their published contents. In this paper, we propose solution for measuring the influence of communities and ranking them by considering joint weight composed of internal and external influence of communities. To address this issue, we design a novel algorithm called Com Rank: a modification of Page Rank, which considers the joint weight in order to identify impact of each community and ranking them. We use real-world data trace in citation network and perform extensive experiments to evaluate our proposed algorithm. The comparative results depict significant improvements by our algorithm in community ranking due to the inclusion of proposed weighting feature.
基金supported by NSFC (Grant No. 61172074, 61471028, 61371069, and 61272505)Fundamental Research Funds for the Central Universities under Grant No. 2015JBM016+1 种基金the Research Fund for the Doctoral Program of Higher Education of China under Grant No.20130009110015the financial support from China Scholarship Council
文摘Due to the increasing number of wireless mobile devices,the possibility of mobile communications without infrastructure becomes a reality.The Decentralized Mobile Social Network(DMSN) is a paradigm where nodes can move freely and organize themselves arbitrarily.Routing in these environments is difficult for the reason of the rapid changes of the social relationship graph's topology.Meanwhile,the social ties among nodes change overtime.Therefore,an efficient data forwarding mechanism should be considered over the temporal weighted relationship graph.In this paper,an Advanced routing Protocol based on Parameters Optimization in the Weighted mobile social network(APPOW) is proposed to improve the delivery success ratio and reduce the cost of exchanging information.APPOW combines the normalized relative weights of three local social metrics,i.e.,LinkRank,similarity and contact strength,to select the next relay node.The weights of the three metrics are derived by pair-wise learning algorithm.The result shows that APPOW outperforms the state-ofthe-art SimBet Routing in delivering message and significantly reduces the average hops.Additionally,the delivery performance of APPOW is close to Epidemic Routing but without message duplications.
文摘Introduction: The Liebowitz Social Anxiety Scale (LSAS), used to assess the severity of social anxiety disorder (SAD), requires considerable effort and time to complete. The aims of this study were: 1) to investigate whether a visual analogue scale (VAS) could be linear with the LSAS and substitute for the LSAS, 2) to relate such a VAS instrument to patient demographics. Methods: Fifty SAD patients were assessed using the LSAS and VAS instruments completed by both patients and doctors at the same session. We then drew distributions and calculated the Spearman’s ρ and κ coefficient values (divided at the median for each scale) between patient and doctor assessments. Next, each pair among the scores for the LSAS, the patient VAS and the doctor VAS was compared using Wilcoxon rank sum tests according to patient life profile data. Results: Scatter plots of pairs of scores were obtained. Spearman’s ρ was 0.661 between the LSAS and the patient VAS, 0.461 between the LSAS and the doctor VAS, and 0.494 between VAS scores of patients and doctors. The κ coefficients were 0.501 between the LSAS and patient VAS, 0.251 between the LSAS and doctor VAS, and 0.425 between patient VAS and doctor VAS (for all six, p < 0.001). The Wilcoxon rank sum tests indicated a significant difference between the groups with/ without “employment” (LSAS, patient/doctor VAS), with/without “graduation from junior college/university” (doctor VAS) (p < 0.05) and with/without marital history (the age of first consultation) (p < 0.01). Conclusions: A patient VAS may substitute for the LSAS and offer the versatility necessary to capture patient states and life profiles.