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Socio-Demographic Characteristics and Risk Factors Contributing Pulmonary Tuberculosis Infection and Recent Transmission
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作者 S. M. Shahriar Rizvi Shirin Tarafder +3 位作者 S. M. Mostofa Kamal Shaheda Anwar Fatima Tuj Johora Shamim Hossain 《Journal of Tuberculosis Research》 2019年第4期228-237,共10页
Host factors, environmental factors, genetic diversity and distinct phylogeographic distribution of Mycobacterium tuberculosis (MTB) contribute to regional differences in drug resistance. Bangladesh remains among the ... Host factors, environmental factors, genetic diversity and distinct phylogeographic distribution of Mycobacterium tuberculosis (MTB) contribute to regional differences in drug resistance. Bangladesh remains among the top 20 high Multi drug resistant tuberculosis (MDR-TB) burden countries of the world. This cross sectional study was conducted to identify the socio demographic characteristics and the risk factors contributing Pulmonary tuberculosis (PTB) infection. These characteristics and risk factors were further investigated among the clustered isolates. Total 60 culture isolates consist of 40 RR and 20 rifampicin sensitive (RS) isolates were enrolled in this study. Laboratory works were done in National Tuberculosis Reference Laboratory (NTRL) and Department of Microbiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh. All 60 samples were confirmed as MTB by MPT 64 antigen detection. Two samples were excluded for possible cross contamination and two for failing to give PCR product for most of the locus. So, finally 56 samples were further analyzed for results. Four isolates were distributed within two clusters which were belonged to Beijing lineage. Socio demographic data and risk factors analysis of this study found significant male predominance (p = 0.04) with history of smoking (p = 0.01) and previous anti-TB treatment (p = 0.012) as the significant risk factors for RR TB. 展开更多
关键词 TUBERCULOSIS socio-demographic Beijing LINEAGE EPIDEMIOLOGY
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Profiling the Socio-Demographic Characteristics and Outcome of Preterm Delivery in Alex Ekwueme Federal University Teaching Hospital Abakaliki
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作者 Malachy Chizoba Onyema Vitus Okwuchukwu Obi +4 位作者 Johnbosco Ifunanya Nwafor Chinwe Wendy Oliobi Bridget Nkiruka Uche-Nwidagu Assumpta Nnenna Nweke Paschal Chijioke Okoye 《Open Journal of Obstetrics and Gynecology》 2019年第8期1168-1177,共10页
Background: Preterm delivery is a major cause of perinatal morbidity and mortality globally. In more than half of the cases, the exact cause is unknown and it is largely unpredictable. Certain maternal, social and dem... Background: Preterm delivery is a major cause of perinatal morbidity and mortality globally. In more than half of the cases, the exact cause is unknown and it is largely unpredictable. Certain maternal, social and demographic characteristics are risk factors and often help to predict and prognosticate the neonatal outcomes. Objective: This study was designed to determine the maternal socio-demographic characteristics and neonatal outcomes of patients managed for singleton preterm delivery in Alex Ekwueme Federal University Teaching Hospital, Abakaliki. Method: This was a 4-year retrospective analysis of patients managed for preterm birth from 1st January 2012 through 31st December 2015. Results: Over the study period there were a total number of 623 singleton preterm deliveries in the facility, while there were 9647 deliveries in the facility;the preterm birth rate was 6.5% or 65 per 1000 deliveries. The mean maternal age was 28.79 ± 5.33 while the mean parity was 1.89 ± 1.98. The mean gestational age and birth weight were 33.67 ± 2.62 and 2.30 ± 0.78 kg respectively. Apgar score in 1 minute was 6.89 ± 3.27, while in the 5th minute was 7.95 ± 3.42. Majority of the patients were multiparous and booked for antenatal care in the facility. Most of the preterm labour started spontaneously and were delivered vaginally. The caesarean section rate in this study was 35.5%. Fetal distress and preeclampsia/eclampsia were the commonest indications for caesarean section. The male to female ratio was 1.1:1. Nearly half of the neonates were born with normal birth weight and 427 (68.5%) were alive at discharge. However, 196 (31.5%) suffered early neonatal death due to prematurity. Maternal parity, booking status and fetal weight were significant determinants of fetal outcome with a p-value 0.05. Conclusion: Birth weight was the most important determinant of neonatal survival and the unbooked patient was an important determinant of poor outcome. Booking for antenatal care and ensuring optimal weight at delivery would go a long way at reducing the poor neonatal outcome associated with preterm delivery. 展开更多
关键词 PRETERM Delivery MATERNAL SOCIODEMOGRAPHIC characteristics NEONATE
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Effect of Socio-Demographic Characteristics on Kenyan Smallholder Dairy Farmers’ Adaptive Strategies to Climate Change Effects
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作者 Charles Okech Odhiambo Chlirukovian Bwire Wasike Harun Okello Ogindo 《Atmospheric and Climate Sciences》 2019年第4期583-599,共17页
Climate change (CC) impedes smallholder dairy industry in Kenya. Consequently, farmers’ adaptation to CC effects would greatly determine their resilience, profitability, and sustainable contribution to the economy. S... Climate change (CC) impedes smallholder dairy industry in Kenya. Consequently, farmers’ adaptation to CC effects would greatly determine their resilience, profitability, and sustainable contribution to the economy. Socio-demography among other factors, determine smallholder farmers’ adaptive strategies to CC effects. This study sought to understand how smallholder dairy farmers in South Western Kenya adapt to climate changes and determine the relationship between famers’ adaptive strategies and their socio-demographics of sex, age, marital status, highest educational level, household size, and experience in dairying. Concurrent Fixed Mixed Methods were used to collect primary and secondary data. Reports and papers were reviewed for temperature and precipitation data, dairy population, production trends, and farmers’ socio-demographics. A survey questionnaire was administered to 367 smallholder dairy household heads with 10 years’ experience obtained through multi-stage sampling of respondents from 4 sub counties of Migori county. The data collected included the respondents’ socio-demographics, climate changes and adaptability to CC effects. Key informant interviews (KIIs) were conducted with heads of government departments of Livestock Production, Cooperative Development, Meteorology, Environment and Agriculture Sector Development Support Programme (ASDSP) in Migori County. Others included the leadership of Rongo Dairy Farmers’ Cooperative Society, Lichota Livestock Development Farm, and a Research Officer for Livestock Production Systems with Kenya Agriculture and Livestock Research Organization (KALRO). Focus group discussions (FGDs), on the other hand, were conducted with old men and women (aged 60 years and above), and farmer groups from Rongo Dairy Farmers Cooperative Society, Cham Gi Wadu Dairy and Multipurpose Cooperative Society, and East Sakwa Farmers’ Development Group. These were obtained purposively based on dairying experience. Descriptive statistics (percentages) were used to describe climate change effect on smallholder dairying and farmers’ adaptation. Percentages, minimum and maximum values, means, range, and standard deviations were used to describe respondents’ socio-demographics. Binary logistic regression analysis was used to determine the effect of farmers’ socio-demographics on their adaptive strategies to CC effects. Results indicated that individually, male farmers were more likely to adopt mixed crop and livestock farming (Odds = 3.97;p = 0.02) and experience an increasing trend in income earning from milk sales (Odds = 0.63;p = 0.04). Individually, older farmers were significantly more likely to establish own fodder (Odds = 0.96;p = 0.03), keep non-Friesians and their crosses (Odds = 0.97;p = 0.02), and experience increasing trends in income earned from milk sales (odds = 1.02;p = 0.02). Individually, household size significantly influenced establishment of own fodder (Odds = 0.69;p = 0.00) and jointly with the other 5 socio-demographic factors (Odds = 0.70;p = 0.00). With other socio-demographic factors, male farmers were more likely to rely mainly on household labour (Odds = 0.32;p = 0.05). Thus, gender, age and household size were found to have significant effects on smallholder dairy farmers’ adaptation to climate change effects in the study area. 展开更多
关键词 SMALLHOLDER DAIRY FARMERS SOUTHWESTERN Kenya CLIMATE Change Adaptation socio-demographic Factors Adaptive Strategies
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Socio-Demographic Factors, Clinical Characteristics and Maternal Prognosis of Hypertensive Disorders in Pregnancy at Panzi General Referral Hospital
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作者 Mushera Aganze Alain Musese Nguru Marie Constance +4 位作者 Julien Bwama Botalatala Mbozi Andrea Andre Nakalonge Raha Maroyi Kenny Olivier Nyakio 《Open Journal of Obstetrics and Gynecology》 CAS 2023年第5期860-873,共14页
Background: Hypertensive disease in pregnancy is an important cause of morbidity, long-term disability, and maternal and neonatal mortality. The aim is to determine the socio-demographic characteristics and maternal p... Background: Hypertensive disease in pregnancy is an important cause of morbidity, long-term disability, and maternal and neonatal mortality. The aim is to determine the socio-demographic characteristics and maternal prognosis of these women with Hypertension during pregnancy. Material and Method: We conducted a cross-sectional study, we interview patients and after discussion we transcripts in a database in Excel software before analysis with SPSS version 20.0 and Stata 14.0 The qualitative variables have been summarised by the Percentage and the quantitative variables will be summarised by Means and Standard Deviation. The associations of the variables were calculated by Pearson’s chi-square test with a significance level set at a p-value Result: The average age of the patients was 30.33 ± 7.020 years, 92.1% were married, 79.8% lived in urban areas, most of the patients were overweight (43%), 92.1% of them had monofetal pregnancies, 36% were multiparous, 34.2% had a previous history of preeclampsia in pregnancy and 14% were known to have hypertension. Pre-eclampsia was the most frequent form of hypertension in pregnancy with 73.68% of cases and represents 84.8% of severe forms of hypertension in pregnancy, 53.4% of the patients delivered vaginally. Eclampsia was the most frequent complication in our patients with 31.7% frequency and among the socio-demographic parameters, age and body mass index were significantly associated with maternal complications. Conclusion: Maternal age and body mass index are important socio-demographic factors associated with the occurrence of maternal complications in women with hypertensive disorders in pregnancy. 展开更多
关键词 Hypertensive Disorders Maternal Prognosis socio-demographic Factors Panzi General Referral Hospital
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Investigation of hydroxyl-terminated polybutadiene propellant breaking characteristics and mechanism impacted by submerged cavitation water jet 被引量:1
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作者 Wenjun Zhou Meng Zhao +3 位作者 Bo Liu Youzhi Ma Youzhi Zhang Xuanjun Wang 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第3期559-572,共14页
A submerged cavitation water jet(SCWJ)is an effective method to recycle solid propellant from obsolete solid engines by the breaking method.Solid propellant's breaking modes and mechanical process under SCWJ impac... A submerged cavitation water jet(SCWJ)is an effective method to recycle solid propellant from obsolete solid engines by the breaking method.Solid propellant's breaking modes and mechanical process under SCWJ impact are unclear.This study aims to understand those impact breaking mechanisms.The hydroxyl-terminated polybutadiene(HTPB)propellant was chosen as the research material,and a self-designed test system was used to conduct impact tests at four different working pressures.The high-speed camera characterized crack propagation,and the DIC method calculated strain change during the impact process.Besides,micro and macro fracture morphologies were characterized by scanning electron microscope(SEM)and computed tomography(CT)scanning.The results reveal that the compressive strain concentration region locates right below the nozzle,and the shear strain region distributes symmetrically with the jet axis,which increases to 4% at first 16th ms,the compressive strain rises to 2% and 6% in the axial and transverse direction,respectively.The two tensile cracks formed first at the compression strain concentrate region,and there generate many shear cracks around the tensile cracks,and those shear cracks that develop and aggregate cause the cracks to become wider and cut through the tensile cracks,forming the tensile-shear cracks and the impact parts eventually fail.The HTPB propellant forms a breaking hole shaped conical after impact 10 s.The mass loss increases by 17 times at maximum,with the working pressure increasing by three times.Meanwhile,the damage value of the breaking hole remaining on the surface increases by 7.8 times while 2.9 times in the depth of the breaking hole.The breaking efficiency is closely affected by working pressures.The failure modes of HTPB impacted by SCWJ are classified as tensile crack-dominated and tensile-shear crack-dominated damage mechanisms. 展开更多
关键词 Submerged cavitation water jet Hydroxyl-terminated polybutadiene propellant Breaking characteristics Failure modes
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Morphological and biochemical characteristics associated with autophagy in gastrointestinal diseases 被引量:1
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作者 Yi-Fan Chang Jia-Jing Li +4 位作者 Tao Liu Chong-Qing Wei Li-Wei Ma Vladimir N Nikolenko Wei-Long Chang 《World Journal of Gastroenterology》 SCIE CAS 2024年第11期1524-1532,共9页
Autophagy is a cellular catabolic process characterized by the formation of double-membrane autophagosomes.Transmission electron microscopy is the most rigorous method to clearly visualize autophagic engulfment and de... Autophagy is a cellular catabolic process characterized by the formation of double-membrane autophagosomes.Transmission electron microscopy is the most rigorous method to clearly visualize autophagic engulfment and degradation.A large number of studies have shown that autophagy is closely related to the digestion,secretion,and regeneration of gastrointestinal(GI)cells.However,the role of autophagy in GI diseases remains controversial.This article focuses on the morphological and biochemical characteristics of autophagy in GI diseases,in order to provide new ideas for their diagnosis and treatment. 展开更多
关键词 AUTOPHAGY Morphological study Biochemical characteristics Subcellular structure Transmission electron microscopy Gastrointestinal diseases
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Liquefaction susceptibility and deformation characteristics of saturated coral sandy soils subjected to cyclic loadings-a critical review 被引量:1
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作者 Chen Guoxing Qin You +3 位作者 Ma Weijia Liang Ke Wu Qi C.Hsein Juang 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2024年第1期261-296,共36页
Coral sandy soils widely exist in coral island reefs and seashores in tropical and subtropical regions.Due to the unique marine depositional environment of coral sandy soils,the engineering characteristics and respons... Coral sandy soils widely exist in coral island reefs and seashores in tropical and subtropical regions.Due to the unique marine depositional environment of coral sandy soils,the engineering characteristics and responses of these soils subjected to monotonic and cyclic loadings have been a subject of intense interest among the geotechnical and earthquake engineering communities.This paper critically reviews the progress of experimental investigations on the undrained behavior of coral sandy soils under monotonic and cyclic loadings over the last three decades.The focus of coverage includes the contractive-dilative behavior,the pattern of excess pore-water pressure(EPWP)generation and the liquefaction mechanism and liquefaction resistance,the small-strain shear modulus and strain-dependent shear modulus and damping,the cyclic softening feature,and the anisotropic characteristics of undrained responses of saturated coral sandy soils.In particular,the advances made in the past decades are reviewed from the following aspects:(1)the characterization of factors that impact the mechanism and patterns of EPWP build-up;(2)the identification of liquefaction triggering in terms of the apparent viscosity and the average flow coefficient;(3)the establishment of the invariable form of strain-based,stress-based,or energy-based EPWP ratio formulas and the unique relationship between the new proxy of liquefaction resistance and the number of cycles required to reach liquefaction;(4)the establishment of the invariable form of the predictive formulas of small strain modulus and strain-dependent shear modulus;and(5)the investigation on the effects of stress-induced anisotropy on liquefaction susceptibility and dynamic deformation characteristics.Insights gained through the critical review of these advances in the past decades offer a perspective for future research to further resolve the fundamental issues concerning the liquefaction mechanism and responses of coral sandy sites subjected to cyclic loadings associated with seismic events in marine environments. 展开更多
关键词 liquefaction susceptibility dynamic deformation characteristics coral sandy soil cyclic loading review and prospect
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Low-temperature characteristicsof rubbers and performance testsof type 120 emergencyvalve diaphragms 被引量:1
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作者 Ming Gao Anhui Pan +5 位作者 Yi Huang Jiaqi Wang Yan Zhang Xiao Xie Huanre Han Yinghua Jia 《Railway Sciences》 2024年第1期47-58,共12页
Purpose–The type 120 emergency valve is an essential braking component of railway freight trains,butcorresponding diaphragms consisting of natural rubber(NR)and chloroprene rubber(CR)exhibit insufficientaging resista... Purpose–The type 120 emergency valve is an essential braking component of railway freight trains,butcorresponding diaphragms consisting of natural rubber(NR)and chloroprene rubber(CR)exhibit insufficientaging resistance and low-temperature resistance,respectively.In order to develop type 120 emergency valverubber diaphragms with long-life and high-performance,low-temperatureresistant CR and NR were processed.Design/methodology/approach–The physical properties of the low-temperature-resistant CR and NRwere tested by low-temperature stretching,dynamic mechanical analysis,differential scanning calorimetryand thermogravimetric analysis.Single-valve and single-vehicle tests of type 120 emergency valves werecarried out for emergency diaphragms consisting of NR and CR.Findings–The low-temperature-resistant CR and NR exhibited excellent physical properties.The elasticityand low-temperature resistance of NR were superior to those of CR,whereas the mechanical properties of thetwo rubbers were similar in the temperature range of 0℃–150℃.The NR and CR emergency diaphragms metthe requirements of the single-valve test.In the low-temperature single-vehicle test,only the low-temperaturesensitivity test of the NR emergency diaphragm met the requirements.Originality/value–The innovation of this study is that it provides valuable data and experience for futuredevelopment of type 120 valve rubber diaphragms. 展开更多
关键词 Natural rubber Chloroprene rubber Low-temperature characteristic 120 emergency valve DIAPHRAGM
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Gravel hardness effect on compaction characteristics of gravelly soil
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作者 SHI Yunfang LI Shengang +1 位作者 JIANG Chen LIU Jinning 《Journal of Mountain Science》 SCIE CSCD 2024年第4期1432-1443,共12页
The compaction characteristics of gravelly soil are affected by gravel hardness.To investigate the evolution and influencing mechanism of different gravel hardness on the compaction characteristics of gravelly soil,he... The compaction characteristics of gravelly soil are affected by gravel hardness.To investigate the evolution and influencing mechanism of different gravel hardness on the compaction characteristics of gravelly soil,heavy compaction tests and crushing tests were conducted on gravelly soils with gravels originated from hard,soft and extremely soft rocks.According to orthogonal experiments and variance analysis,it was found that hardness has a significant impact on the maximum dry density of gravelly soil,followed by gravel content,and lastly,moisture content.For gravel compositions with an average saturated uniaxial compressive strength less than 60 MPa,the order of compacted maximum dry density is soft gravels>hard gravels>extremely soft gravels.Each type of gravelly soil has a threshold for gravel content,with 60%for hard and soft gravels and 50%for extremely soft gravels.Beyond these thresholds,the compacted dry density decreases significantly.There is a certain interaction between hardness,gravel content,and moisture content.Higher hardness increases the influence of gravel content,whereas lower hardness increases the influence of moisture content.Gravelly soils with the coarse aggregate(CA)between 0.7 and 0.8 typically achieve higher dry densities after compaction.In addition,the prediction equations for the particle breakage rate and CA ratio in the Bailey method were proposed to estimate the compaction performance of gravelly soil preliminarily.The results further revealed the compaction mechanism of different gravelly soils and can provide reference for subgrade filling construction. 展开更多
关键词 Gravelly soil HARDNESS Compaction characteristics Crushing characteristics Particle breakage rate Bailey method
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Molecular Epidemiology and Clinical Characteristics of Hand, Foot and Mouth Disease in North Sichuan Region, China, 2018-2023: A Descriptive Study
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作者 Zhe Xu Zheng Zhao +6 位作者 Linming Fan Manyu Liang Jinglu Chen Jia Zeng Ping Shi Xi’en Gu Zhengdong Li 《Advances in Microbiology》 CAS 2024年第6期317-332,共16页
Background: Hand, foot and mouth disease (HFMD) remains an important public health problem in China. Many studies on the epidemiological characteristics of HFMD have been reported, but studies in North Sichuan region ... Background: Hand, foot and mouth disease (HFMD) remains an important public health problem in China. Many studies on the epidemiological characteristics of HFMD have been reported, but studies in North Sichuan region have been neglected. Methods: HFMD-related enterovirus infected cases were clinically confirmed and underwent real-time RT-PCR (rRT-PCR) from May 2018 to October 2023 in Guangyuan Central Hospital. Results: During 2018-2023, other EV (437 cases, 81.08%) was the most predominant serotype followed by CV-A16 (94 cases, 17.44%), EV-A71 (8 cases, 1.48%) was the least predominant serotype. Peak infections occurred in July and October. There were no significant differences in gender, age and serotypes. HFMD was concentrated in children under 47 months of age, with the highest incidence in children aged 12 - 23 months and the highest proportion of other EV infections in the whole age group. COVID-19 did not cause significant changes in gender, age and serotype. Overall, there was a significant increase in the proportion of children aged 12 - 23 months infected with CV-A16, and an increase in the proportion of children aged over 36 months infected with other EVs. Conclusions: The incidence of HFMD caused by EV-A71 has decreased significantly, and other EVs have become the main pathogens of HFMD in North Sichuan region in recent years. In the prevention and control of CV-A16, more attention should be paid to children aged 12 - 23 months and the dominant serotype should be closely monitored. Our study highlights the importance of developing of new diagnostic reagents and vaccines for the prevention and control of enterovirus infection. This study for the first time provides insights into district interventions to local conditions. 展开更多
关键词 ENTEROVIRUS HFMD EPIDEMIOLOGY Clinical characteristics
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Sleep quality and characteristics of older adults with acute cardiovascular disease
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作者 Haroon Munir Michael Goldfarb 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2024年第3期369-373,共5页
Sleep plays a vital role in restoring the physical and mental health of people with cardiovascular disease.However,the hospital setting is not a conducive environment for sleep.Sleep interruptions by members of the ca... Sleep plays a vital role in restoring the physical and mental health of people with cardiovascular disease.However,the hospital setting is not a conducive environment for sleep.Sleep interruptions by members of the care team,including vital sign checks,medication delivery,and blood draws for laboratory investigations,are routinely done in many hospitals.Frequent interruptions by staff and noise by other patients have been cited as barriers to restorative sleep in the hospital. 展开更多
关键词 SLEEP ROUTINE characteristics
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Some of the Chemical and Physical Characteristics of the Graff River in Kut City, Iraq
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作者 Salih Mahdi Ali Imad Kazem Ali 《Open Journal of Modern Hydrology》 CAS 2024年第1期56-67,共12页
Some of the chemical and physical water qualities of the Graff River in the city of Kut were studied, and for two sites of the river, One was at the Crimea site, the other in the Jihad district, and for the period fro... Some of the chemical and physical water qualities of the Graff River in the city of Kut were studied, and for two sites of the river, One was at the Crimea site, the other in the Jihad district, and for the period from October/2018 to March/2019, Seven variables of river water have been analyzed: temperature PH, electrical conductivity, TDS, turbidity, alkaline, and chloride. The results showed that most of the chemical and physical water properties of the river were in normal proportions and did not rise, except for the turbidity, which was at a very high level, and that the pH values were close to the basal side. The results of the statistical analysis revealed positive significant relationships between the pH and (chloride and TDS). On the other hand, between electrical conductivity and both previous variables as well. And a negative significant connection between temperature and alkaline. 展开更多
关键词 Graff River Kut City Iraq Chemical characteristics Physical characteristics
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The Influence of Acid on the RockMechanical Characteristics of Deep Shale in theWujiaping Formation
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作者 Hao Zhang Yan Zhang +2 位作者 Wei Liu Ximin Zhang Xiang Liu 《Energy Engineering》 EI 2024年第1期27-42,共16页
The microscopic characteristics and mechanical properties of rocks change after the action of acid on deep shale,which affects the fracturing effect.Accordingly,we designed and conducted indoor experiments related to ... The microscopic characteristics and mechanical properties of rocks change after the action of acid on deep shale,which affects the fracturing effect.Accordingly,we designed and conducted indoor experiments related to the changes in macro and microscopic characteristics after the interaction of acid with the shale of Wujiaping Formation,based on which the characteristic law of fracture volume modification after acid fracturing was studied using numerical simulation.The results demonstrate that the pores and fractures are enlarged and the structure is significantly loosened after the acid immersion.And a 15%concentration of hydrochloric acid can effectively dissolve shale.Furthermore,the degree of acid-etching reaction is highly variable because of the different carbonate content,which reveals the strong inhomogeneity of the shale system in the Wujiaping Group reservoir section.After the acid interacted with the shale rock samples,the triaxial compressive strength,elastic modulus,and Poisson’s ratio of shale decreased.Moreover,the evaluation of the effect after acid fracturing simulated by fracturing software revealed that the smaller the value of elastic modulus in shale-based reservoirs,the more favorable the fracture volume modification.This discovery not only provides a theoretical basis for the expansion and extension patterns of acid-fracturing in carbonaceous shale formations but also offers research methods and theoretical insights for the fundamental exploration of other deep-seated oil and gas resources. 展开更多
关键词 SHALE acid fracturing macro characteristics microscopic characteristics mechanical properties
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Comprehensive understanding of glioblastoma molecular phenotypes:classification,characteristics,and transition
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作者 Can Xu Pengyu Hou +7 位作者 Xiang Li Menglin Xiao Ziqi Zhang Ziru Li Jianglong Xu Guoming Liu Yanli Tan Chuan Fang 《Cancer Biology & Medicine》 SCIE CAS CSCD 2024年第5期363-381,共19页
Among central nervous system-associated malignancies,glioblastoma(GBM)is the most common and has the highest mortality rate.The high heterogeneity of GBM cell types and the complex tumor microenvironment frequently le... Among central nervous system-associated malignancies,glioblastoma(GBM)is the most common and has the highest mortality rate.The high heterogeneity of GBM cell types and the complex tumor microenvironment frequently lead to tumor recurrence and sudden relapse in patients treated with temozolomide.In precision medicine,research on GBM treatment is increasingly focusing on molecular subtyping to precisely characterize the cellular and molecular heterogeneity,as well as the refractory nature of GBM toward therapy.Deep understanding of the different molecular expression patterns of GBM subtypes is critical.Researchers have recently proposed tetra fractional or tripartite methods for detecting GBM molecular subtypes.The various molecular subtypes of GBM show significant differences in gene expression patterns and biological behaviors.These subtypes also exhibit high plasticity in their regulatory pathways,oncogene expression,tumor microenvironment alterations,and differential responses to standard therapy.Herein,we summarize the current molecular typing scheme of GBM and the major molecular/genetic characteristics of each subtype.Furthermore,we review the mesenchymal transition mechanisms of GBM under various regulators. 展开更多
关键词 GLIOBLASTOMA molecular phenotype CLASSIFICATION characteristIC mesenchymal transition
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Research on the influences of motion characteristics of jetting projectile charge under water
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作者 Xing Chen Yong-gang Lu 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第3期411-425,共15页
Shaped charge warhead is important for enhancing the damage performance of underwater weapons.This paper used finite element analysis software and based on JPC water penetration experiments to examine the influence of... Shaped charge warhead is important for enhancing the damage performance of underwater weapons.This paper used finite element analysis software and based on JPC water penetration experiments to examine the influence of liner parameters(wall thickness,material),charge aspect ratio,and stand-off distance on the movement characteristics of JPC in water.The findings reveal that the head diameter of the JPC increases and experiences significant erosion after entering the water,the effective length of the JPC in water undergoes two distinct phases:a growth phase and a decrease phase,with the velocity of the JPC decaying exponentially.Increasing the liner thickness,stand-off distance and the charge aspect ratio can improve the erosion resistance and the velocity retention capacity of the JPC.The optimal ranges for liner thickness and stand-off distance are 0.0363D_(k) to 0.0545D_(k)(D_(k) is the charge diameter),the stand-off distance should be within 1.0D_(k).After the charge aspect ratio higher than 1.25,the charge structure exerts minimal influence the movement characteristics of the JPC in water.Material density plays a crucial role in the velocity decay pattern of the JPC during penetration.JPC with higher densities exhibit superior velocity retention capabilities in water,with the velocity decay pattern converging if the densities are similar.Consequently,copper,tantalum and tungsten liners are deemed appropriate for underwater shaped charge warhead.Finally,the results will provide an important reference for the design of underwater shaped charge warhead. 展开更多
关键词 JPC Movement characteristics Underwater penetration Numerical simulation
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Study of Pyrolysis Characteristics and Kinetic Analysis of Shenmu Coal at a High Heating Rate Using TG-FTIR
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作者 An Xiaoxi Zhang Yanpeng +2 位作者 Shang Yanchao Tian Yuanyu Qiao Yingyun 《China Petroleum Processing & Petrochemical Technology》 SCIE CAS CSCD 2024年第1期47-55,共9页
Coal pyrolysis is a fundamental reaction in the thermal processing and utilization of coal.Investigating the behavior and kinetics of coal pyrolysis is crucial for optimizing,designing,and developing a composite riser... Coal pyrolysis is a fundamental reaction in the thermal processing and utilization of coal.Investigating the behavior and kinetics of coal pyrolysis is crucial for optimizing,designing,and developing a composite riser for the staged pyrolysis gasification process of pulverized coal.In this study,the non-isothermal pyrolysis behavior and kinetics of coal were examined at different heating rates(30,50,100,300,500,700,and 900℃/min)using thermogravimetry(TG)coupled with Fourier-transform infrared spectroscopy.Analysis of the TG/derivative TG(TG/DTG)curves indicated that coal pyrolysis mainly occurred between 300℃ and 700℃.Higher heating rates led to more volatiles being released from the coal,and a higher temperature was required to achieve rapid pyrolysis.Kinetic analysis showed that both the model-free methods(Friedman,Flynn-Wall-Ozawa,and Kissinger-Akahira-Sunose)and the model-based method(Coats-Redfern)effectively describe the coal pyrolysis process.The change in the Ea values between the two kinetic models was consistent throughout the pyrolysis process,and the most probable mechanism was the F2 model(secondary chemical reaction).In addition,the heating rate did not change the overall reaction order of the pyrolysis process;however,a higher heating rate resulted in a decrease in the Ea value during the initial pyrolysis stage. 展开更多
关键词 coal pyrolysis TG-FTIR characteristic parameters DYNAMICS
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Development characteristics and controlling factors of fractures in lacustrine shale and their geological significance for evaluating shale oil sweet spots in the third member of the Shahejie Formation in the Qikou Sag, Bohai Bay Basin
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作者 Xu Zeng Tao Yang +5 位作者 Jian-Wei Feng Cong-Sheng Bian Ming Guan Wei Liu Bing-Cheng Guo Jin Dong 《Petroleum Science》 SCIE EI CAS CSCD 2024年第2期791-805,共15页
Natural fractures are critical for shale oil and gas enrichment and development. Due to the extremely high heterogeneity of shale, the factors controlling the formation of internal fractures, especially horizontal fra... Natural fractures are critical for shale oil and gas enrichment and development. Due to the extremely high heterogeneity of shale, the factors controlling the formation of internal fractures, especially horizontal fractures, remain controversial. In this study, we integrate thin section analysis and microcomputed tomography(CT) data from several lacustrine shale samples from the third member(Es3) of the Shahejie Formation, Qikou Sag, Bohai Bay Basin, to assess the fractures in detail. The goal is to reveal the development characteristics, controlling factors, and geological significance for evaluating sweet spots in a shale oil play. The fractures in the Es3contain high-angle structural and horizontal bed-parallel fractures that are mostly shear and extensional. Various factors influence fracture development,including lithofacies, mineral composition, organic matter content, and the number of laminae. Structural fractures occur predominantly in siltstone, whereas bed-parallel fractures are abundant in laminated shale and layered mudstone. A higher quartz content results in higher shale brittleness, causing fractures, whereas the transformation between clay minerals contributes to the development of bedparallel fractures. Excess pore pressure due to hydrocarbon generation and expulsion during thermal advance can cause the formation of bed-parallel fractures. The density of the bed-parallel and structural fractures increases with the lamina density, and the bed-parallel fractures are more sensitive to the number of laminae. The fractures are critical storage spaces and flow conduits and are indicative of sweet spots. The laminated shale in the Es3with a high organic matter content contains natural fractures and is an organic-rich, liquid-rich, self-sourced shale play. Conversely, the siltstone, massive mudstone, and argillaceous carbonate lithofacies contain lower amounts of organic matter and do not have bed-parallel fractures. However, good reservoirs can form in these areas when structural fractures are present and the source, and storage spaces are separated. 展开更多
关键词 FRACTURES Development characteristics Controlling factors Shale oil Sweet spot
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Comparison of Combustion Characteristics of Tars Produced with Tobacco Stem Biomass Gasification
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作者 Bo Chen Mingjun Wang +4 位作者 Bo Liu Chunping Lu Guohai Jia Yong Chao Chao Zhong 《Journal of Renewable Materials》 EI CAS 2024年第1期119-129,共11页
In order to study the combustion characteristics of tar in biomass gasifier inner wall and gasification gas,“tobacco stem semi-tar inside furnace”,“tobacco stem tar inside furnace”and“tobacco stem tar out-of-furn... In order to study the combustion characteristics of tar in biomass gasifier inner wall and gasification gas,“tobacco stem semi-tar inside furnace”,“tobacco stem tar inside furnace”and“tobacco stem tar out-of-furnace”were subjected to thermogravimetric experiments,and the combustion characteristics and kinetic characteristics were analyzed.The result shows that“tobacco stem semi-tar inside furnace”has the highest value and“tobacco stem tar out-of-furnace”is has the lowest value on ignition characteristics,combustion characteristics and combustible stability;“tobacco stem semi-tar inside furnace”has the lowest value and“tobacco stem tar outside furnace”has the highest value on burnout characteristics;“tobacco stem tar outside furnace”has the highest value and“tobacco stem tar inside furnace”has the lowest value on integrated combustion characteristics. 展开更多
关键词 Tobacco stem TAR GASIFIER combustion characteristics
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The effect of Ti and Zr content on the structure,mechanics and energy-release characteristics of Ti—Zr—Ta alloys
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作者 Jia-yu Meng Jing-zhi He +4 位作者 Bin Zhang Jin Chen Shun Li Dun Niu Yu Tang 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第1期343-350,共8页
Energetic structural materials(ESMs)are a new type of structural materials with bearing and damage characteristics.In this work the microstructure,mechanical properties and energy release characteristics of multi-elem... Energetic structural materials(ESMs)are a new type of structural materials with bearing and damage characteristics.In this work the microstructure,mechanical properties and energy release characteristics of multi-element Ti-Zr-Ta alloys with good casting performance were studied.The microstructure of the Ti_(x)ZrTa alloys gradually change from BCC+HCP to single BCC structure with the increase of Ti.While the Ti_(2)Zr_(y)Ta alloys was still uniform and single BCC structure with the increase of Zr.The evolution of microstructure and composition then greatly affect the mechanical properties and energy-release characteristics of Ti-Zr-Ta alloys.The synergistic effect of dual phase structure increases the fracture strain of Ti_(x)ZrTa(x=0.2,0.5)with the Ti content decreases,while the fracture strain of Ti_(x)ZrTa(x=2.0,3.0,4.0)gradually increase with the Ti content increases caused by the annihilation of the obstacles for dislocation movement.And as Zr content increases,the fracture strain of Ti_(2)Zr_(y)Ta alloys decrease,then the oxidation reaction rate and fragmentation degree gradually increase.The higher oxidation rate and the lager exposed oxidation area jointly leads the higher releasing energy efficiency of Ti_(x)ZrTa alloys with low Ti content and Ti_(2)Zr_(y)Ta alloys with high Zr content. 展开更多
关键词 Energetic structural materials Ti-Zr-Ta Multi-element alloy Energy release characteristics
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Dynamic response mechanism and precursor characteristics of gneiss rockburst under different initial burial depths
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作者 LIU Dongqiao SUN Jie +4 位作者 MENG Wen HE Manchao ZHANG Chongyuan LI Ran CAO Binghao 《Journal of Mountain Science》 SCIE CSCD 2024年第3期1004-1018,共15页
To investigate the influence mechanism of geostress on rockburst characteristics,three groups of gneiss rockburst experiments were conducted under different initial geostress conditions.A high-speed photography system... To investigate the influence mechanism of geostress on rockburst characteristics,three groups of gneiss rockburst experiments were conducted under different initial geostress conditions.A high-speed photography system and acoustic emission(AE)monitoring system were used to monitor the entire rockburst process in real time.The experimental results show that when the initial burial depth increases from 928 m to 1320 m,the proportion of large fracture scale in rockburst increases by 154.54%,and the AE energy increases by 565.63%,reflecting that the degree and severity of rockburst increase with the increase of burial depth.And then,two mechanisms are proposed to explain this effect,including(i)the increase of initial geostress improves the energy storage capacity of gneiss,and then,the excess energy which can be converted into kinetic energy of debris ejection increases,consequently,a more pronounced violent ejection phenomenon is observed at rockburst;(ii)the increase of initial geostress causes more sufficient plate cracks of gneiss after unloading ofσh,which provides a basis for more severe ejection of rockburst.What’s more,a precursor with clear physical meaning for rockburst is proposed under the framework of dynamic response process of crack evolution.Finally,potential value in long term rockburst warning of the precursor obtained in this study is shown via the comparison of conventional precursor. 展开更多
关键词 Traffic Engineering Gneiss Rockburst Crack propagation Excess energy Precursor characteristic
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