Analysis of the Therapeutic Effect of Sodium Copper Chlorophyllin Tablet in Treating60Cases of Leukopenia

Objective： To evaluate the efficacy and safety of sodium copper chlorophyllin （trademarked as ＂Yebaike Tablet （叶拜克） which is abbreviated as YBK in treating leukopenia. Methods： One hundred and five patients with leukopenia caused by various factors were randomized into 3 groups. The 60 patients in the YBK group took orally YBK Tablets at the dose of 40 mg, three times per day, the 30 patients in the leucogen group were treated with Leucogen Tablets （利血生片） at the dose of 20 mg, three times per day, and the 15 patients in the placebo group were administered with vitamin C tablets 100 mg, three times per day. All the subjects were treated for 1 month. The change of peripheral leucocytes count after treatment and adverse drug reaction that occurred in patients were studied. Results： In the 60 patients treated with YBK, the treatment proved to be markedly effective in 34 cases, effective in 17 and ineffective in 9, the total effective rate being 85%, which was significantly higher than that in the placebo group （26.7%, P〈0.01） and similar to that in the leucogen group （83.3 %, P〉0.05）. No adverse reaction was found in the treatment course. Conclusion： YBK can be used in the treatment of leukopenia caused by various factors, satisfactory in efficacy and safe in use.

Extraction of Sodium Copper Chlorophyll in Food Samples Based on Cloud Point Extraction with a Nonionic Surfactant

A new method was developed for the determination of sodium copper chlorophyll(SCC) by cloud point extraction preconcentration and spectrophotometry, for which Triton X-114 was selected as a nonionic surfactant. Several factors affecting the extraction efficiency of SCC and its subsequent determination, including the p H of the sample solution, salt and surfactant concentrations, and equilibration temperature and time, were studied and optimized. The extraction efficiency approached 99.4%.The calibration graph under the optimum conditions was linear in the concentration range of 3–220 mg/L with correlation coefficients> 0.9997(n = 8). The limit of detection for the analytes was 0.6 mg/L(S/N = 3). The proposed method is inexpensive, simple, and accurate for the extraction and determination of SCC in food samples.

Effects of Sodium Copper Chlorophyllin on Mesenchymal Stem Cell Function in Aplastic Anemia Mice

Objective： To investigate the effects of sodium copper chlorophyllin （SCC） on the proliferation, differentiation and immunomodulatory function of mesenchymal stem cells （MSCs） from mice with aplastic anemia. Methods： A mouse model of aplastic anemia was established by exposure of BALB/c mice to sublethal doses of 5.0 Gy Co60 γ radiation, followed by transplantation of 2 × 108 lymph node cells from DBA/2 donor mice within 4 h after radiation. Aplastic anemic BALB/c mice were randomly divided into six groups： the treated groups, which received 25, 50, or 100 mg/kg/day SCC, respectively; a positive control group treated with cyclosporine A （CsA）; and an untreated model control group （model group）; while, the non-irradiated mice as the normal control group. SCC or CsA were administered by gastrogavage for 20 days, starting on day 4 after irradiation. Peripheral blood cells were counted and colony-forming fibroblasts （CFU-F） in the bone marrow were assayed. The ability of MSCs to form calcium nodes after culture in osteoinductive medium was also observed. The immunosuppressive effect of MSCs on T lymphocytes was analyzed by enzyme-linked immunosorbent assay and flow cytometry, to evaluate the efficacy of SCC in mice with aplastic anemia. Results： Peripheral blood white cell and platelet counts were increased by medium and high SCC doses, compared with the untreated control. CFU-Fs were also increased compared with the untreated control, and the numbers of calcium nodes in MSCs in osteoinductive medium were elevated in response to SCC treatment. The percentage of Forkhead box protein 3 （FOXP3^＋） T cells was increased in T celI-MSC cocultures, and the cytokine transforming growth factor 131 was up-regulated in SCC-treated groups. Conclusion： The results of this study suggest that SCC not only promotes the proliferation and differentiation of MSCs, but also improves their immunoregulatory capacity in mice with apiastic anemia.

Novel copper redox-based cathode materials for room-temperature sodium-ion batteries

Layered oxides of P2-type Nao.68Cuo.34Mno.6602, P2-type Nao.68Cuo.34Mno.50Tio.1602, and O＇3-type NaCuo.67Sbo.3302 were synthesized and evaluated as cathode materials for room-temperature sodium-ion batteries. The first two materials can deliver a capacity of around 70 mAh/g. The Cu2＋ is oxidized to Cu3＋ during charging, and the Cu3＋ goes back to Cu2＋ upon discharging. This is the first demonstration of the highly reversible change of the redox couple of Cu2＋/Cu3＋ with high storage potential in secondary batteries.

Molybdenum removal from copper ore concentrate by sodium hypochlorite leaching

The removal of molybdenum from a copper ore concentrate by sodium hypochlorite leaching was investigated. The results show that leaching time,liquid to solid ratio,leaching temperature,agitation speed,and sodium hypochlorite and sodium hydroxide concentrations all have a significant effect on the removal of molybdenum.The optimum process operating parameters were found to be：time,4 h;sodium hydroxide concentration,10%;sodium hypochlorite concentration,8%;liquid to solid ratio,10：1;temperature,50℃;and, agitation speed,500 r/min.Under these conditions the extraction of molybdenum is greater than 99,9%and the extraction of copper is less than 0.01%.A shrinking particle model could be used to describe the leaching process.The apparent activation energy of the dissolution reaction was found to be approximately 8.8 kJ/mol.

Geochemical Studies of Sodium Enriched Met-avolcanite Series in the Area of Longbohe Copper Deposit, Yunnan Province, SW China: Nd, Sr and Pb Isotopic Characteristics and Chronology

The chronological data obtained by a variety of dating methods have confirmed that the sodium enriched metavolcanite series in the area of the Longbohe copper deposit at Jinping, Yunnan Province, was formed during the Proterozoic (its Pb-Pb isochron age=1595±75 Ma), corresponding to the Dahongshan Group sodium enriched metavolcanites. The Sm-Nd isochron age of 1336±46Ma should represent the time at which this series of volcanic rocks experienced spilitization in response to sodium metasomatism, equivalent to the time of sedimentation of the Ailaoshan Group and Yashan Group rocks. The Rb-Sr ages of the volcanic rocks and the Pb-Pb ages of copper ores have recorded the events of strong dynamic metamorphism and of strong reworking-metallogenesis of copper during the Jinningian period. Similarities in forming age, rock assemblage and isotopic characteristics between the sodium enriched metavolcanite series and the Dahongshan Group sodium enriched metavolcanite series have provided new clues to the exploration of the Dahongshan-type copper deposits in this area.

Application of Thermogravimetry to Study the Kinetics and Stability of Porphyrin Copper-sodium of Ephedra

Thermogravimetry was used to study the non-isothermal decomposition kinetics and the stability of porphyrin copper-sodium from ephedra. The kinetic equation for the second step can be expressed as . The kinetic compensation effect is found to be: InA=0. 2468E a ?8. 0513.Ea is 206. 61 kJ/mol. The results show that porphyrin copper-sodium has a high activation energy and good stability.

Cu(Ⅱ)催化NaOCl氧化碘帕醇的效果和过程解析

本文研究Cu(Ⅱ)催化NaOCl氧化非离子型碘代X射线造影剂—碘帕醇(IPM),对IPM降解过程中Cu的回收和形态进行解析,考察Cu(Ⅱ)、NaOCl浓度和卤素离子对IPM降解效果及碘代消毒副产物-碘仿的生成影响;采用XRD、XPS分析Cu(Ⅱ)反应后的产物晶型和形态变化,结合循环伏安曲线和计时电流表征Cu(Ⅲ)的生成,推测Cu(Ⅱ)催化NaOCl氧化IPM的机理.利用HPLC/MS/MS分析中间产物,推测IPM的降解路径.结果表明,与Co(Ⅱ)、Fe(Ⅱ)、Mn(Ⅱ)相比,Cu(Ⅱ)显著提高了NaOCl的分解率和IPM的氧化效果,25℃、pH=6.71,500r/min,NaOCl和Cu(Ⅱ)浓度分别为0.5和0.05mmol/L,60min,8.0mg/L IPM的降解率达到77.51%;HO·、活性氯自由基和Cu(Ⅲ)都有助于Cu(Ⅱ)/NaOCl氧化IPM,且Cu(Ⅲ)的贡献随pH值升高而增大.NaOCl浓度在0.1~2.5mmol/L范围增加,IPM降解率增加;Cu(Ⅱ)浓度在0.005~0.5mmol/L存在适宜值.HPLC/MS/MS共检测出13种产物,IPM的降解途径主要包括:侧链酰胺键水解和氧化,碘取代、羟基加成.Cl^(−)、Br^(−)和I^(−)(1~5mmol/L)在影响IPM氧化效果的同时,Br^(-)显著促进了CHI_(3)的生成,生成量达到48.28μg/L.

Experimental and Quantum Chemical Studies of the Inhibition of Copper with Sodium Dodecyl Sulphate (SDS) in Acidic Medium

This work investigates the inhibitive properties of sodium dodecyl sulphate (SDS) on the corrosion of copper (Cu) in nitric acid using gasometric methods. The inhibition efficiency increases with time and concentration of SDS. The corrosion rate of copper decreases as concentration of SDS increases. Adsorption of the SDS on the surface obeyed the Langmuir adsorption isotherm. The high negative values of the kinetic parameter B suggest that the inhibitor’s effectiveness increases with temperature. The equilibrium constant and the free energy of adsorption of SDS to copper are negative and large. This observation implies that the adsorption mechanism maybe chemisorption. The quantum chemical calculation of copper dodecyl sulphate shows that the energy change in the HOMO-LUMO energy of the moiety is positive and small. This observation implies that the SDS is an efficient inhibitor. The high dipole moment obtained implies that corrosion inhibition of Cu is enhanced by adsorption of SDS and this observation correlates with the observed experimental inhibition efficiency.

某难选高次生铜硫化铜矿石选矿试验研究及现场技术改造

通过对某高次生铜硫化铜矿矿石的工艺矿物学分析以及矿石特性的研究,确定了合适的浮选流程,并进行了不同条件的选矿试验。试验结果表明:通过使用高效捕收剂酯-305、添加适量的Na 2 S活化铜、采用中矿集中返回再磨工艺,可取得了较好的技术指标。在试验的基础上现场实施了简单的流程改造,对于含Cu 0.92%的原矿经过磨矿分级以及两次粗选浮选后、浮选粗精矿再经过两次精选,获得了Cu品位22.16%的铜精矿产品,同时Cu总回收率达到了92.72%,取得了较好的分选指标。

刚果(金)某铜钴矿浸出新工艺

这是一篇冶金工程领域的文章。刚果(金)某铜钴矿为氧化矿,铜钴含量分别为Cu 3.43%和Co 0.42%。本文采用浸出液五级循环浸出工艺浸出铜和钴,在硫酸用量为矿石质量的7.4%、亚硫酸钠用量为理论量的1.68倍、磨矿粒度-74μm 75%、浸出温度45℃、浸出液固体积质量比2/1~3/1、单级浸出时间4 h的实验条件下,铜浸出率96.85%、钴浸出率95.67%。该工艺在确保铜钴浸出率的情况下,比一级浸出降低硫酸用量6 kg/t、浸出过程总溶液量减少约1/4,降低了酸耗、减少了后续钴沉淀和铜萃取处理液量。

铜钼分离过程中辉钼矿的多方式分散效果研究

针对辉钼矿在浮选矿浆中易团聚并包裹黄铜矿,导致铜钼浮选分离困难的问题,通过光学显微镜和聚焦光束反射测量仪研究了超声波分散、机械搅拌和添加分散剂六偏磷酸钠3种方式对辉钼矿分散行为的影响;采用红外光谱、扫描电子显微镜、Zeta电位并结合浮选溶液化学技术对分散机理进行了研究。结果表明,3种分散方式都可起到分散辉钼矿团聚体的作用,其中以添加六偏磷酸钠的效果最好;加入400 mg/L六偏磷酸钠,不但能够有效降低辉钼矿团聚体的尺寸、减少其数量,还能降低辉钼矿团聚体内黄铜矿含量,使人工混合矿浮选钼精矿的铜含量由3.86%降低至2.73%;六偏磷酸钠在辉钼矿表面吸附并产生空间位阻排斥力,电离出的阴离子增大了颗粒间的静电斥力,致使辉钼矿表现出较好的分散行为。

氧化浸出法从黑铜泥中分离回收铜砷试验研究

研究了采用氧化浸出法从黑铜泥中综合回收铜砷,考察了酸度、双氧水用量、温度、浸出时间、液固体积质量比对铜和砷浸出率的影响。结果表明:在酸度200 g/L、双氧水用量30%、温度80℃、浸出时间2.0 h、液固体积质量比9∶1条件下,铜、砷浸出率达99.53%和98.24%;氧化酸浸液按n(NaHS)/n(Cu)=1.1加入硫氢化钠进行沉铜,铜砷分离后液中铜质量浓度低于0.01 g/L,砷质量浓度大于40 g/L,铜砷得到有效分离;富砷液通入二氧化硫还原,可得到三氧化二砷和还原后液,还原后液可返回氧化浸出。

顶空进样-气相色谱法测定着色剂叶绿素铜钠盐中溶剂残留量

建立顶空进样-气相色谱测定着色剂叶绿素铜钠盐中溶剂残留量的分析方法。对平衡温度、分流比及色谱柱型号等参数进行考察,氢火焰离子化检测器(Flame Ionization Detector,FID)检测,内标法定量。结果表明,通过CD-624毛细管色谱柱分离,平衡温度设为80℃时效果最优,6种残留溶剂可实现完全分离,线性关系良好,r均大于0.999,加标回收率为84.50%~98.83%,相对标准偏差(n=6)均低于10%。该方法简单、快速、准确,可满足着色剂叶绿素铜钠盐中溶剂残留量的检测。

某堆存铜渣中回收铜金属的选矿试验研究及生产应用

对某堆存铜渣开展了工艺矿物学及选矿试验研究,并确定了回收其中铜金属的选矿工艺流程及参数。在原矿含铜0.81%条件下,以Z-200为捕收剂、2#油为起泡剂,磨矿细度为-0.038 mm粒级占85%,采用快速浮选产出高品位铜精矿,再经一粗两扫两精优先浮选得到低品位铜精矿产品,可获得铜品位26.40%的高品位精矿和铜品位3.58%的低品位精矿,总铜精矿铜品位13.03%、铜回收率76.47%。该回收工艺已成功应用于工程化生产实践,实现了堆存铜渣中铜金属的回收利用。

添加剂HP在复合添加剂中对电解铜箔组织性能的影响

电解铜箔具有工艺简单、导电导热等力学性能较好的特点,目前已经成为了现代电子行业重要的基础原材料。本研究采用直流电沉积法,以一定量的醇硫基丙烷磺酸钠(HP)、聚乙二醇(PEG)、聚二硫二丙烷磺酸钠(SPS)、糖精钠(BSI)和胶原蛋白作为复合添加剂,研究了不同HP浓度对铜箔表面微观形貌、抗拉强度以及其他物理性能的影响。结果表明:HP在合适的浓度范围内,可以在组合添加剂中与其他添加剂发生协同作用提高(200)和(220)晶面的择优取向,从而有效地细化晶粒,降低粗糙度。当HP在组合添加剂中的浓度为6 mg·L^(−1)时,制备的铜箔其抗拉强度和延伸率分别达到了634.1 MPa和4.1%。

云南某高含镁铜矿浮选试验研究

针对云南某高含镁铜矿,开展了化学多元素和元素赋存状态分析,查明该高含镁铜矿主要物相组成,并通过原矿解离情况分析,得出最佳磨矿细度为-0.074 mm占80%。后进行磨矿细度、石灰用量、硫化钠用量、捕收剂种类及用量试验研究,确定最佳试验条件,在该条件下开展闭路试验可获得铜品位为23.47%,铜回收率为90.32%,镁品位为7.53%,镁回收率为0.79%的铜精矿。在此基础上使用腐植酸钠将精矿镁品位降低至4.95%,满足生产要求。

添加剂对5μm电解铜箔性能及形貌的影响

电解铜箔因其具有强度高、延展性良好等优势被广泛应用于新能源领域,目前对于5μm电解铜箔性能的影响因素研究较少。本文采用单一变量法考察了PEG、HVP和HP等添加剂对Cu电沉积的影响,通过正交试验探究PEG、HVP和HP复合添加剂对5μm电解铜箔性能的影响,并对比了不同添加剂对5μm电解铜箔外观形貌的影响,得到如下结论:PEG和HVP具有增强极化的作用,且随着浓度的增加极化作用增强,HP具有去极化的作用,且随着浓度的增加去极化作用增强;通过正交试验得出的最优复合添加剂的浓度为PEG 0.36 g/L、HVP 0.12 g/L、HP 0.05 g/L,在此条件下得到的较佳性能为抗拉强度485.17 MPa、延伸率3.72%、粗糙度1.31;相比于单一添加剂,最优配比复合添加剂下的复合镀层表面更加均匀平整,且颗粒细小。

海藻酸钠-硫化钠在铜钼混合精矿浮选分离中的抑制研究

针对铜钼分离过程中硫化钠用量过大的环保压力,以及抑制剂选择性差导致钼精矿指标达不到产品要求的问题,采用浮选试验、动电位测量、吸附量测定等方法,进行了海藻酸钠-硫化钠组合抑制剂分离铜钼的试验研究。浮选结果表明,以海藻酸钠+硫化钠为组合抑制剂,水玻璃和氟硅酸钠为调整剂、煤油为捕收剂,采用硫化钠+活性炭+再磨+硫化钠工艺对某铜钼混合精矿进行脱药处理后,1粗1扫4精闭路浮选工艺,可以获得钼品位为44.60%、钼回收率为94.84%的合格钼精矿。与单一硫化钠抑制剂方案相比,组合抑制剂工艺的硫化钠用量降低了约41%,取得了较好的环境和经济效益。动电位和吸附量分析表明,海藻酸钠与黄铜矿之间的亲和力强于辉钼矿,对黄铜矿浮选表现出较好的选择性抑制效果,是组合抑制剂提升分离效果的原因。

高砷铜精矿硫化钠-氢氧化钠碱浸除砷

云南某高砷铜精矿铜品位为13.46%,含砷质量分数为5.17%,主要矿物为黄铜矿、黄铁矿、毒砂、含砷黄锡矿、锡石和镁铝硅酸盐。在硫化钠-氢氧化钠碱性体系下浸出高砷铜精矿的砷,系统研究工艺参数条件如氢氧化钠浓度、硫化钠用量、浸出温度、转速、液固比、浸出时间等对砷脱除率的影响。结果表明,上述工艺参数条件均对砷的碱浸脱除率影响较大,最佳浸出工艺条件为:氢氧化钠浓度5 mol/L、硫化钠浓度为50 g/L、浸出温度90℃、转速为1000 r/min、液固比为10∶1、浸出时间为3 h,在此最佳条件下可最终获得砷去除率为60.55%的技术指标。采用EMPA-EDS对碱浸渣进一步分析发现,采用硫化钠-氢氧化钠碱性体系浸出可完全溶解高砷铜精矿中的毒砂,浸出渣中主要含砷矿物为含锌硫砷铜矿和砷黝铜矿;浸出过程形成的氢氧化铁以及脱水后生成的氧化铁覆盖在含砷矿物表面,阻碍了碱性浸出剂与矿物的充分接触,影响了浸出过程传质效果。