Velocity Form Calculations of Generalized Oscillator Strengths for 3s→ (3p, 4p, 5p, 6p) Dipole Transitions of Atomic Sodium in Debye Plasma

In this paper, the generalized oscillator strengths (GOSs) of excitations of atomic sodium from ground state to 2p63s0 (3p, 4p, 5p, 6p) states, immersed in Debye plasma, were calculated by using wavefunctions which were obtained numerically from the restricted Hartree-Fock (RHF) equation. This RHF equation employs the local density approach for exchange interactions including plasma Debye screening. Theoretical RHF and random phase approximation with exchange (RPAE) velocity calculations have shown that the GOSs for excitations to 3 s0(3 p,4 p,5 p,6 p)depend on the plasma Debye screening effects, as shown by the reduction in the GOS amplitude with decreasing Debye length λD. The agreement between the present RPAE V results for the transitions 3 s→3 s0(3 p,4 p,5 p)and the length calculations of Martínez-Flores was satisfactory. Correlation effects were found quite to be significant in the vicinity of the maxima of the GOS of the 3 s→3 s0(4 p,5 p,6 p)excitations by using the RPAE V approach. We note the poor influence of many electron correlations on the GOS of (3 s→3 p)transition with the same principal quantum number. Finally, we comment that the RPAE V calculations are useful in investigating electron correlation effects on the transition GOS of atomic sodium planted in Debye plasma. The present velocity results also reveal that the 3 s→3 s0(5p, 6p)transition GOSs tend to be delocalized due to more significant screening effects at Debye lengths λD=20and 30 a.u. for excited subshells 5p and 6p, respectively. We report here novel results of GOS for 3 s→3 s06ptransition obtained from different Debye lengths.

Studies on the Effects of Deltamethrin on Sodium Net Transport Through the in vivo Amphibian Skin

The action of micromolar concentrations of Deltamethrin on sodium net transport through the in vivo skin of the South American toad Bufo arenarum was studied. The effect of pure ethanolic insecticide solutions and commercial formulations when applied on the mucosal surface was assayed. Deltamethrin provoked a concentration-independent inhibition; the highest inhibition was found at the lowest concentrations. At highest concentrations of the insecticide the J Na was not altered

Protective effects of sodium ferulate in vascular endothelial function during cardiopulmonary bypass

Objective Cardiopulmonary bypass (CPB) and its related ischemia reperfusion injury may cause endothelial cell injury. To study the protective effects of sodium ferulate in vascular endothelial function during CPB by testing the changes of vascular endothelial cell(CEC) ,nitric oxide(NO) and endothelin-1 (ET-1) in children with congenital heart disease. Methods Sixty patients

Effects of Sodium Dodecyl Sulfate on a Single Cavitation Bubble

Dynamics of a single cavitation bubble in sodium dodecyl sulfate（SDS） aqueous solutions is investigated experimentally and theoretically. The bubble pulsation is measured by a phase-locked integrated imaging technique,and the ambient radius is obtained by fitting the numerical calculation based on the Rayleigh–Plesset bubble dynamics model to the experimental data. The results show that, under the same driving condition, the ambient radius of the cavitation bubble decreases correspondingly with the increase of SDS concentration within the critical micelle concentration, while the compression ratio of the radius increases, which indicates that the addition of SDS decreases the internal molecular number of the cavitation bubble and increases the power capability of the cavitation bubble. In addition, bubble oscillation increases the concentration of the surfactant molecules on the bubble wall, so that the effect of SDS on a single cavitation bubble is reduced when the SDS concentration is greater than 0.8 m M.

Protective effect of sodium valproate on motor neurons in the spinal cord following sciatic nerve injury in rats

BACKGROUND: Sodium valproate (VPA) is used to be an effective anti-epileptic drug. VPA possesses the characteristics of penetrating rapidly through the blood-brain barrier (BBB) and increasing levels of Bcl-2 and growth cone-associated protein (GAP) 43 in spinal cord. OBJECTIVE: To observe the effect of VPA on Bcl-2 expression and motor neuronal apoptosis in spinal cord of rats following sciatic nerve transection. DESIGN: Randomized controlled experiment. SETTING: Department of Hand Surgery and Microsurgery, Wuhan Puai Hospital. MATERIALS: A total of 30 male healthy SD rats of clean grade and with the body mass of 180-220 g were provided by Experimental Animal Center of Medical College of Wuhan University. Sodium Valproate Tablets were purchases from Hengrui Pharmaceutical Factory, Jiangsu. METHODS: The experiment was performed in the Central Laboratory of Wuhan Puai Hospital and Medical College of Wuhan University from February to May 2006. Totally 30 rats were randomly divided into two groups: treatment group (n =15) and model group (n =15). Longitudinal incision along backside of right hind limbs of rats was made to expose sciatic nerves, which were sharply transected 1 cm distal to the inferior margin of piriform muscle after nerve liberation under operation microscope to establish sciatic nerve injury rat models. Sodium Valproate Tablets were pulverized and diluted into 50 g/L suspension with saline. On the day of operation, the rats in the treatment group received 6 mL/kg VPA suspension by gastric perfusion, once a day, whereas model group received 10 mL/kg saline by gastric perfusion, once a day. L4-6 spinal cords were obtained at days 1, 4, 7, 14 and 28 after operation, respectively. Terminal deoxyribonucleotidyl transferase (TdT)-mediated dUTP-biotin nick end labeling (TUNEL) technique and immunohistochemical method (SP method) were used to detect absorbance (A) of neurons with positive Bcl-2 expression. Apoptotic rate of cells (number of apoptotic cells/total number of cells×100%) was calculated. MAIN OUTCOME MEASURES: A value of neurons with positive Bcl-2 expression and apoptotic rate in spinal cord of rats in the two groups. RESULTS: A total of 30 SD rats were involved in the result analysis. ①expression of positive Bcl-2 neurons: A value of positive Bcl-2 neurons were 0.71±0.02, 0.86±0.04, 1.02±0.06 at days 4, 7 and 14, respectively after operation in the treatment group, which were obviously higher than those in the model group (0.62±0.03, 0.71±0.05, 0.89±0.04, t = 3.10-4.50, P < 0.05). ②apoptotic result of motor neurons: Apoptotic rate of motor neurons in spinal cord was (6.91±0.89)% and (15.12±2.34)% at days 7 and 14 in the treatment group, which was significantly lower than those in the model group [(9.45±1.61)%, (19.35±0.92)%, t = 2.39, 3.03. P < 0.05]. CONCLUSION: VPA can increase expression of Bcl-2 in spinal cord and reduce neuronal apoptosis in rats following sciatic nerve injury, and has protective effect on motor neuron in spinal cord of rats.

Neuroprotective Effects of Sodium Ferulate and Its Antidepressant-Like Effect Measured by Acute and Chronic Experimental Methods in Animal Models of Depression

Antidepressants with novel targets and without side effects are in great demand. Ferulic acid (FA) is a ubiquitous phenolic acid of low toxicity, and sodium ferulate (SF) is its sodium salt. Our previous studies have revealed that FA and SF show significant protective effect on excitotoxicity, we now test its potential neuroprotective and antidepressant-like effects. MTT assay and morphological analysis by fluorescence microscopy were adopted to measure the neuroprotective effects of SF;forced-swimming, tail-suspension, and chronic mild stress (CMS) tests were performed to assess its antidepressant-like activity. The results showed that SF had protection against H2O2-induced oxidative damage and dexamethasone (DXM)-induced neurotoxicity pheochromocytoma (PC12) cells. Acute administration of SF markedly decreased the duration of immobility during forced-swimming in rats and mice and tail-supension tests in mice. However, SF has no any effects on reserpine-induced hypothermia, 5-hydroxytryptophan-induced head-twitch response, and potentiation of noradrenaline toxicity in mice. Chronic administration of SF reversed the effects of CMS on consumption of food and sucrose solution, weight gain, and histopathology of hippocampus by light microscopy, and potently shortened the immobility time during forced-swimming test following CMS in rats. This study provides evidence that SF possesses obviously antidepressant-like activity, and the antidepressant-like effect may result from its neuroprotective effects.

Protective effects of panax notoginseng saponin on dextran sulfate sodium-induced colitis in rats through phosphoinositide-3-kinase protein kinase B signaling pathway inhibition

BACKGROUND Intestinal inflammation is a common digestive tract disease, which is usually treated with hormone medicines. Hormone medicines are effective to some extent, but long-term use of them may bring about many complications.AIM To explore the protective effects of panax notoginseng saponin(PNS) against dextran sulfate sodium(DSS)-induced intestinal inflammatory injury through phosphoinositide-3-kinase protein kinase B(PI3K/AKT) signaling pathway inhibition in rats.METHODS Colitis rat models were generated via DSS induction, and rats were divided into control(no modeling), DSS, DSS + PNS 50 mg/k, and DSS + PNS 100 mg/kg groups. Then, the intestinal injury, oxidative stress parameters, inflammatory indices, tight junction proteins, apoptosis, macrophage polarization, and TLR4/AKT signaling pathway in colon tissues from rats in each of the groups were detected. The PI3 K/AKT signaling pathway in the colon tissue of rats was blocked using the PI3K/AKT signaling pathway inhibitor, LY294002.RESULTS Compared with rats in the control group, rats in the DSS group showed significantly shortened colon lengths, and significantly increased disease activity indices, oxidative stress reactions and inflammatory indices, as well as significantly decreased expression of tight junction-associated proteins. In addition, the DSS group showed significantly increased apoptotic cell numbers,and showed significantly increased M1 macrophages in spleen and colon tissues.They also showed significantly decreased M2 macrophages in colon tissues, as well as activation of the PI3K/AKT signaling pathway(all P < 0.05). Compared with rats in the DSS group, rats in the DSS + PNS group showed significantly lengthened colon lengths, decreased disease activity indices, and significantly alleviated oxidative stress reactions and inflammatory responses. In addition, this group showed significantly increased expression of tight junction-associated proteins, significantly decreased apoptotic cell numbers, and significantly decreased M1 macrophages in spleen and colon tissues. This group further showed significantly increased M2 macrophages in colon tissues, and significantly suppressed activation of the PI3K/AKT signaling pathway, as well as a dose dependency(all P < 0.05). When the PI3K/AKT signaling pathway was inhibited, the apoptosis rate of colon tissue cells in the DSS + LY294002 group was significantly lower than that of the DSS group(P < 0.05).CONCLUSION PNS can protect rats against DSS-induced intestinal inflammatory injury by inhibiting the PI3K/AKT signaling pathway, and therefore may be potentially used in the future as a drug for colitis.

Thermodynamic Analysis of the Performance of a Single-Effect Absorption Refrigeration System Using the Ammonia/Sodium Thiocyanate Couple

This paper aims at presenting analysis of the thermodynamic of the performance of an absorption refrigeration system of the single-effect ammonia/sodium thiocyanate couple. Since the generator is the starting point for the operation of system, one of the most important point to be addressed in this work is to determine the generator’s temperatures at which the system can accept the best quantities and qualities of energy. A mathematical model has been developed to study the performance of the system. Equations obtained from the thermodynamic properties of the ammonia/sodium thiocyanate couple were implemented in Matlab. The analysis consists of determining the effects of the generator’s temperature on the energy performance of the system. The computerized performance parameters are the coefficient of performance and the energy efficiency. Results indicate that the coefficient of performance increases with the temperature of the generator. Moreover, these remarks are not observed on the exergetic efficiency, because the latter increases until its maximum value 0.43, in order to decrease until its final value 0.35. In addition, the maximum value of the coefficient of performance tends towards 0.7 with increasing generator temperature. The system admits better operation when the generator temperatures are between 80&deg;C and 90&deg;C. The determination of this temperature interval by simulation can be use as a variable setting point in controlling the real system.

Fabrication of the Sodium Ions Extended Gate Field Effect Transistor by Using the Entrapment Method

The sodium ion is necessary in physiological function and an important element in blood of human body,because the concentration of the sodium ion in the blood directly affects the functions of some organs or pathological feature,how to detect it is an important affair.In this paper,we measure the concentration of sodium ions by the extended gate field effect transistor (EGFET).We use three different substrates RuO_x/p-Si,ITO glass,SnO_2/ITO to fabricate EGFET,and we choose the optimum structure.The fabrication of device needed to use the entrapment method.

Ameliorating effects of Raphanus sativus leaves on sodium arsenite-induced perturbation of blood indices in Swiss albino mice

Objective: To evaluate the ameliorating effects of Raphanus sativus leaves(RSL)against sodium arsenite(Sa)-induced adverse effects through mice experiments.Methods: Swiss albino mice were divided into four equal groups: control, Sa, RSL,RSL + Sa. Sa(10 mg/kg body weight/day), and powder form of RSL(50 mg/kg body weight/day) were provided as food supplement orallty. Blood indices were measured using commercially available kits through colorimetric methods.Results: It was observed that lactate dehydrogenase, alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase activities were significantly(P < 0.05)higher in Sa-treated mice than those in the control group. RSL significantly reduced Sainduced elevation of the activities of these enzymes in serum significantly(P < 0.05).Serum butyrylcholinesterase activity and high density lipoproteins cholesterol levels in Satreated mice were significantly(P < 0.05) lower than the control group, and the food supplementation of RSL could significantly(P < 0.05) prevent the reduction of Sa-mediated serum butyryl cholinesterase activity and high density lipoproteins cholesterol levels. RSL could also reduce the Sa-induced elevation of serum urea level significantly(P < 0.05).Conclusions: Results of this study suggest the protective or ameliorating effects of RSL on Sa-induced perturbation of blood indices are related to the hepatic, cardiovascular and kidney dysfunction. Therefore, RSL may be useful to reduce arsenic toxicity in human in the future.

Neurogenesis-enhancing effect of sodium ferulate and its role in repair following stress-induced neuronal damage

Ferulic acid (FA) is a ubiquitous phenolic acid of low toxicity, and sodium ferulate (SF) is its sodium salt. Our previous studies have revealed that FA shows neuroprotective effect and significant antidepressant- like effect. The aim of this study was to investigate its potential neurogenesis-enhancing effect and its role in repair following stress-induced neuronal damage. MTT assay was performed to measure the effect of SF on the growth of rat pheochromocytoma (PC12) cells;morphological and immunocytochemical meth- ods were used for assessing its differentiation-induc- ing action. Chronic mild stress (CMS) tests were per- formed to establish rat model of depression. The histopathology of animal brains was studied to ana- lyze CMS-induced morphological changes and the effect of SF on the repair of CMS-induced brain in- jury. The expressions of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) and the proliferation of neural stem cell/neural progenitor cells were assessed in the hippocampi of chronic mild stress (CMS)-induced depression-like model rats by immunohistochemistry and bromodeoxyuridine (BrdU)- incorporation assays, respectively. Our in vitro tests showed that SF promoted the proliferation of PC12 cells in the concentration range of 5 - 320 μM, and induced PC12 cells to differentiate to more mature cells with the morphological characteristics and mo- lecular marker of neuronal-like cells. In vivo tests showed that SF up-regulated the expressions of NGF and BDNF, and induced the proliferation of neural stem cell/neural progenitor cells in the hippocampi of CMS-induced depression-like model rats. This study provides evidences that SF shows neurogenesis-en- hancing effect, and its antidepressant-like effect of SF may be related directly and closely to its above-men- tioned effect.

复方氨基丁酸维E联合丙戊酸钠对癫痫患儿认知功能及血清α-Syn、HSP70水平的影响

目的研究复方氨基丁酸维E联合丙戊酸钠对癫痫患儿认知功能及血清α-突触核蛋白(α-Syn)、热休克蛋白70(HSP70)水平的影响。方法选取周口市中心医院收治的116例癫痫患儿,根据治疗方案分为联合组和对照组,各58例。对照组接受丙戊酸钠治疗,联合组接受复方氨基丁酸维E联合丙戊酸钠治疗。比较两组临床疗效、治疗前、治疗3、6个月后癫痫持续发作时间及发作频率、韦氏儿童智力量表第四版(WISC-Ⅳ)及简易精神状态检测量表(MMSE)评分、血清相关因子[α-Syn、神经元特异性烯醇化酶(NSE)、HSP70、脑源性神经营养因子(BDNF)]水平、不良反应发生率。结果联合组临床总有效率高于对照组(P<0.05)。治疗3、6个月后,联合组癫痫发作频率少于对照组,持续发作时间短于对照组(P<0.05);WISC-Ⅳ、MMSE评分高于对照组(P<0.05);血清HSP70、α-Syn、NSE水平低于对照组,BDNF水平高于对照组(P<0.05)。两组间不良反应总发生率差异无统计学意义(P>0.05)。结论采用复方氨基丁酸维E与丙戊酸钠联合治疗可有效改善癫痫患儿认知功能及神经功能,降低癫痫持续发作时间及发作频率,增强疗效,安全性良好。

Intervening Effect of Sodium Aescinate on Pulmonary Fibrosis in Rats with Acute Lung Injury

[Objectives] The aim was to investigate the intervening effect of sodium aescinate on pulmonary fibrosis in rats with acute lung injury( ALI). [Methods] The rats were randomly divided into normal group,model group and sodium aescinate group. The rat model of ALI was induced by administration of oleic acid. The rats in the sodium aescinate group were intravenously injected with sodium aescinate according to the amount of 4 mg/kg for 14 consecutive d. Then,11 rats were selected randomly from each group and slaughtered on Day 1 and Day 14,respectively after last administration. The body mass index,arterial partial pressure of oxygen( PaO_2),oxygenation index( PaO_2/FiO_2),lung index,wet/dry mass ratio of lung,serum IL-1β,TNF-α,PC Ⅲ and TGF-β1 levels of the rats were analyzed. [Results]No significant differences were found in body mass index,lung index or lung wet/dry mass ratio among different groups. Compared with the model group,the PaO_2 and PaO_2/FiO_2 ratio increased significantly( P < 0. 05),the serum IL-1β,TNF-α,PC Ⅲ and TGF-β1 levels declined significantly( P <0. 05),the lung histopathological damage was reduced,and the semi-quantitative histological score( IQA) of damaged lung tissue decreased significantly( P < 0. 01). [Conclusions]Sodium aescinate can reduce the levels of inflammatory factors in rats with ALI,with certain intervening on pulmonary effect.

癫痫患者CYP2C19基因多态性与丙戊酸钠血药浓度、疗效的相关性研究

目的研究癫痫患者CYP2C19基因多态性与丙戊酸钠血药浓度、疗效的相关性。方法选取2022年8月至2023年7月乌鲁木齐市第四人民医院收治的115例癫痫患者作为研究对象,采用实时荧光聚合酶链反应(PCR)技术检测所有患者的CYP2C19基因型,同时给予丙戊酸钠治疗,将患者按CYP2C19基因型别分为强代谢型(*1/*1)47例、中间代谢型(*1/*2,*1/*3)50例和弱代谢型(*2/*2,*3/*3,*2/*3)18例,比较CYP2C19代谢型对血药浓度的影响;并根据丙戊酸钠治疗效果分为疗效良好组(n=85)和疗效不佳组(n=30),比较两组患者的一般资料,采用Logistic多因素回归分析影响丙戊酸钠治疗效果的因素。结果癫痫患者CYP2C19基因分型分布频率符合Hardy-Weinberg平衡定律检验;CYP2C19弱代谢型的丙戊酸钠血药浓度为(3.80±1.02)μg/mL,明显高于强代谢的(2.67±0.34)μg/mL和中间代谢型的(2.73±0.36)μg/mL,差异均有统计学意义(P<0.05),而强代谢型和中间代谢型的丙戊酸钠血药浓度比较差异无统计学意义(P>0.05);经单因素分析结果显示,月发病频率≥4次、继发性病因为热性惊厥、丙戊酸钠血药浓度<50μg/mL、服药依从性差、CYP2C19基因型为弱代谢型与丙戊酸钠治疗效果有关(P<0.05);经Logistic多因素回归分析结果显示,月发病频率≥4次、继发性病因为热性惊厥、丙戊酸钠血药浓度<50μg/mL、服药依从性差、CYP2C19基因型为弱代谢型均为影响丙戊酸钠治疗效果的独立危险因素(P<0.05)。结论癫痫患者的CYP2C19基因具有多态性,且与丙戊酸钠血药浓度及疗效具有相关性。因此,在采用丙戊酸钠治疗癫痫患者时,可检测CYP2C19基因分型,以指导癫痫患者的临床个体化治疗。

小剂量红霉素联合孟鲁司特钠与布地奈德吸入剂治疗儿童难治性哮喘的临床效果

目的:研究小剂量红霉素联合孟鲁司特钠与布地奈德吸入剂治疗儿童难治性哮喘的临床效果。方法:选取2016年1月—2022年12月太仓市第一人民医院收治的82例难治性哮喘患儿,将患儿随机分为对照组(n=40)和观察组(n=42),其中对照组应用孟鲁司特钠口服与布地奈德吸入剂联合方案治疗,观察组在此基础上联合小剂量红霉素治疗,连续治疗30 d。比较两组临床疗效、症状缓解时间、治疗前后肺功能指标及炎症和免疫标志物。结果:与对照组比较,观察组治疗总有效率更高,差异有统计学意义(P<0.05)。与对照组比较,观察组咳嗽和喘息缓解时间更短,差异有统计学意义(P<0.05)。两组治疗前肺功能比较,差异无统计学意义(P>0.05),治疗后,两组肺功能均有改善,且观察组的用力肺活量(FVC)、第1秒用力呼气容积(FEV_(1))、最大呼气流量(PEF)、用力呼气75%肺活量的瞬间流速(FEF_(75))及最大呼气中期流速(MMEF)水平更高,差异有统计学意义(P<0.05)。两组治疗前嗜酸性粒细胞、免疫球蛋白G(IgG)及免疫球蛋白E(IgE)水平比较,差异无统计学意义(P>0.05);治疗后,两组嗜酸性粒细胞、IgG及IgE水平均低于治疗前,观察组低于对照组,差异有统计学意义(P<0.05)。结论:应用小剂量红霉素联合孟鲁司特钠与布地奈德吸入剂治疗儿童难治性哮喘可以显著提高临床疗效,提高患儿肺功能指标,降低炎症和免疫标志物。

Saudi Consensus on the Usage of Sodium-Glucose Cotransporter-2 Inhibitors on the Management of Chronic Kidney Diseases

According to recent epidemiological data, chronic kidney diseases (CKDs) affect approximately 10% of the global population. Like many countries, CKD is a significant public health issue in Saudi Arabia. The prevalence of CKD in Saudi Arabia is estimated to be around 4.5% of the adult population, with a higher prevalence in older age groups. Sodium-glucose cotransporter-2 inhibitors (SGLT2is) are a class of oral medications used to treat type 2 diabetes mellitus (T2DM). In addition to their glucose-lowering effects, SGLT2i have been shown to have beneficial effects on kidney function in patients with or without T2DM. Therefore, a Saudi task force gathered to develop an explicit, evidence-based consensus on SGLT2i use in CKD Saudi patients. A panel of 14 experts made up a task force. An initial concept proposal was obtained. The proposal was divided into several topics discussed on 24 May 2023. A literature review was carried out. The literature search was completed on 3rd June 2023. A drafted report was distributed to the entire panel. Approval of the recommendations required consensus, defined as a majority approval (i.e. above 75%). The recommendations were revised to accommodate any differences of opinion until a consensus was reached. Recommendations were finally formulated on 21st June 2023. Subsequently, the panel reviewed and discussed the supporting rationale of the revised recommendations. This article presents these practical recommendations.

非剥脱点阵激光联合透明质酸钠复合溶液注射治疗颈部老化疗效观察

目的:观察非剥脱点阵激光联合透明质酸钠复合溶液注射治疗颈部老化的临床疗效。方法:选取2020年7月-2022年7月于笔者医院就诊的30例颈部老化女性就医者,按随机数字表法分为对照组和联合组各15例。对照组给予1 565 nm M22-ResurFx非剥脱点阵激光治疗;联合组给予1 565 nm M22-ResurFx非剥脱点阵激光联合透明质酸钠复合溶液注射治疗。对照组激光治疗3次;联合组激光及透明质酸钠复合溶液联合治疗3次,收集每次治疗前、后照片,评估治疗前、后就医者颈部老化的改善程度和治疗后不良反应。结果:联合组改善率为66.67%,明显高于对照组的20.00%(P<0.05);联合组就医者满意率为80.00%,高于对照组的53.33%;联合组颈部老化分级明显优于对照组(P<0.05)。激光治疗后治疗区域均即刻出现红斑及风团,3~5 d消退,无结痂及出血发生。两组均未有其他严重不良反应发生。结论:非剥脱点阵激光联合透明质酸钠复合溶液注射治疗颈部老化疗效好,患者满意度高,值得临床推广应用。

物相调控对铌酸钠纳米棒压电-弱可见光协同催化的优化作用

半导体材料能够吸收光能产生电子空穴对,利用光催化实现环境废物降解,然而其催化效率受环境光条件和天气等因素严重制约。因此,有必要研发能够利用环境中的水波能和光能协同作用的催化剂,以有效提升水相环境的污染物降解效率。无铅钙钛矿结构的铌酸钠具有适宜的能隙和压电性能,因此具备实现光-压电协同催化的潜力。通过水热法合成并调控了铌酸钠纳米棒的物相结构,探究了其对光-压电协同催化中的性能增强机制。虽然两种物相的铌酸钠光催化效率差异较小,但相较NaNbO_(3),Na_(7)(H_(3)O)Nb_(6)O_(19)14(H_(2)O)表现出更高的压电性能,因此在压电光催化过程中能够更好地促进光生电子空穴对的分离,从而大幅提升了水中四环素的降解效率。进一步对材料物相调控方法、催化机理等开展研究,揭示了空穴和羟基自由基在催化过程中起到关键作用,研究结果能够为高效光-压电协同催化剂的设计、开发和优化提供参考。

达肝素钠注射液和依诺肝素钠注射液用于骨科手术后预防静脉血栓栓塞症的成本效果分析

目的分析达肝素钠注射液和依诺肝素钠注射液在骨科手术后患者中预防静脉血栓栓塞症(VTE)的成本效果,为临床用药决策提供经济学依据。方法回顾性分析2021年7月~2022年12月成都市新都区人民医院收治的106例骨科手术患者的病历资料,根据不同的术后干预方法分为观察组和对照组,每组53例。观察组行达肝素钠注射液预防骨科手术后VTE的发生,对照组则采用依诺肝素钠注射液进行预防,对两组患者用药的成本效果进行分析。结果达肝素钠注射液和依诺肝素钠注射液的成本分别为481.32元和616.42元,预防有效率分别为98.11%和94.34%,两者有效性和安全性的差异无统计学意义(P>0.05),但两者的成本效果比分别为490.59和653.40。结论在骨科手术后,采用达肝素钠注射液和依诺肝素钠注射液预防VTE发生的疗效相当,均具备较高应用价值;但在药物治疗成本上,达肝素钠注射液则更具经济优势。

达格列净联合常规抗心衰药物治疗慢性心力衰竭患者的临床效果观察

目的 探讨达格列净片联合常规抗心力衰竭(心衰)药物(呋塞米、螺内酯、美托洛尔缓释片、沙库巴曲缬沙坦钠)在慢性心力衰竭患者中的临床疗效。方法 84例慢性心力衰竭患者为研究对象,采用简单化随机法分为对照组和观察组,每组42例。对照组患者采用常规抗心力衰竭药物呋塞米、螺内酯、美托洛尔缓释片、沙库巴曲缬沙坦钠进行治疗,观察组在对照组基础上联用达格列净片进行治疗。比较两组患者的临床疗效、心功能指标[左室射血分数(LVEF)和左室舒张末期内径(LVEDD)]、炎性指标[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]及不良反应发生率。结果 与对照组(81.0%)比较,观察组患者临床总有效率(97.6%)明显更高(P<0.05)。治疗后,观察组患者LVEF(49.62±4.81)%明显高于对照组的(40.53±4.55)%, LVEDD(52.19±2.09)mm明显低于对照组的(63.68±2.33)mm,差异均具有统计学意义(P<0.05)。治疗后,观察组患者血清IL-6、TNF-α水平分别为(33.32±4.31)、(12.27±2.09)ng/L,明显低于对照组的(56.92±5.38)、(35.85±4.63)ng/L(P<0.05)。与对照组(7.1%)比较,观察组患者的不良反应发生率(4.8%)无明显差异(P>0.05)。结论 慢性心力衰竭患者经常规抗心力衰竭药物与达格列净片联合治疗临床疗效显著,心功能指标和机体内炎性反应得到有效改善,且联合用药安全性良好,值得临床推广。