Numerical Analysis and Experimental Verification of the Behaviour of Solid Inclusions in Induction Crucible Furnaces

The paper refers to the dynamics of solid inclusion in the turbulent flow of liquid metal in induction furnaces. The numerical analysis is carried out adopting LES-based Euler-Lagrange approach in the limit of dilute conditions.The admixing of carbon particles in induction crucible furnace from the open surface of a melt is simulated.The behaviour of the particles in the bulk of the flow is illustrated as well as compared with the industrial observation of the open surface of the alloy.The paper also contains the description of the novel experimental technique,which is proposed for the verification of the numerical model.The experiment deals with ferromagnetic particles in the flow of Wood's metal in the small induction crucible furnace.This experiment confirms the satisfactory agreement with the numerical results.

APPLICATION OF A NEW FAST MULTIPOLE BEM FOR SIMULATION OF 2D ELASTIC SOLID WITH LARGE NUMBER OF INCLUSIONS

A fast multipole method(FMM)is applied for BEM to reduce both the operation and memory requirement in dealing with very large scale problems.In this paper,a new version of fast multipole BEM for 2D elastostatics is presented and used for simulation of 2D elastic solid with a large number of randomly distributed inclusions combined with a similar subregion approach.Generalized minimum residual method(GMRES)is used as an iterative solver to solve the equation system formed by BEM iteratively.The numerical results show that the scheme presented is applicable to certain large scale problems.

A Mathematical Model to Study the Effect of Pore Sizes Distribution on Densification Process in Ceramic Compacts

In this research the effect of pore size distribution on densification process during sintering of ceramic compacts is studied by assuming a Gaussian distribution of the pore sizes and depending on a mathematical model that was developed in a previous research in describing the densification process.

Drug-polymer inclusion complex as a new pharmaceutical solid form

The solid forms of drugs play a central role in controlling their physicochemical properties and consequently the bioavailability. Multiple types of drug solid forms have been developed to achieve the desirable pharmaceutical profiles, but new solid forms will provide more options for the solid-state property optimization and hence are highly desirable. This review focuses on a new pharmaceutical solid form, drug-polymer inclusion complexes （ICs）, and summarizes their structural features, structure- property relationships, as well as potential pharmaceutical applications

Crystalline inclusion complexes formed between the drug diflunisal and block copolymers

The solid form of drugs plays a central role in optimizing the physicochemical properties of drugs,and new solid forms will provide more options to achieve the desirable pharmaceutical profiles of drugs.Recently,certain drugs have been found to form crystalline inclusion complexes（ICs） with multiple types of linear polymers,representing a new subcategory of pharmaceutical solids.In this study,we used diflunisal（DIF） as the model drug host and extended the guest of drug/polymer ICs from homopolymers to block copolymers of poly（ethylene glycol）（PEG） and poly（s-caprolactone）（PCL）.The block length in the guest copolymers showed a significant influence on the formation,thermal stability and dissolution behavior of the DIF ICs.Though the PEG block could hardly be included alone,it could indeed be included in the DIF ICs when the PCL block was long enough.The increase of the PCL block length produced IC crystals with improved thermal stability.The dissolution profiles of DIF/block copolymer ICs exhibited gradually decreased aqueous solubility and dissolution rate with the increasing PCL block length.These results demonstrate the possibility of using drug/polymer ICs to modulate the desired pharmaceutical profiles of drugs in a predictable and controllable manner.