To choose the optimum construction method of metro tunneling, we conducted research with numerical simulation on strata consolidation subsidence by dewatering, dynamic dewatering, and non-dewatering construction metho...To choose the optimum construction method of metro tunneling, we conducted research with numerical simulation on strata consolidation subsidence by dewatering, dynamic dewatering, and non-dewatering construction method, taking the integrated effects of fluid-solid coupling and tunneling mechanics into account. We obtained the curved surfaces of ground surface subsidence and strata consolidation subsidence. The results show that the quantity of ground surface subsidence is 31 mm for the non-dewatering method, 39 mm for the dynamic dewatering method, and 105 mm for the dewatering method. Their ratio is 1：1.3：3.4; and the percentages of strata consolidation subsidence to whole ground surface subsidence of each construction method is 27% （no-dewatering）, 50% （dynamic dewatering）, and 79% （dewatering）. It is obvious that the non-dewatering construction method is the most effective method to control the strata consolidation subsidence induced by metro tunneling in saturated soft clay strata, and it has been successfully applied to the construction of the Shenzben metro line 1.展开更多
Objective: This work compares the occlusive effect and the penetration enhancement ability of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC), through in vitro skin. Methods: SLN and NLC were p...Objective: This work compares the occlusive effect and the penetration enhancement ability of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC), through in vitro skin. Methods: SLN and NLC were prepared by high shear homogenization and characterized by size, polydispersity index, zeta potential, morphology and physical stability. Occlusive effect was assessed by an in vitro test and by measuring TEWL using pig skin. Skin treated with the lipid carriers was visualized by SEM. A penetration test through skin, followed by tape stripping, was carried out using Nile red as a marker. Results: SLN (200 ± 6 nm) and NLC (192 ± 11 nm) were obtained. An occlusion factor of 36% - 39% was observed for both systems, while a reduction in TEWL of 34.3% ± 14.8% and 26.2% ± 6.5% was seen after treatment with SLN and NLC, respectively. SEM images showed a film formed by the lipid carriers, responsible for the occlusion observed. No differences were found between the occlusive effect produced by SLN and NLC in both tests. NLC allowed the penetration of a greater amount of Nile red than SLN: 4.7 ± 1.3 μg and 1.7 ± 0.4 μg, respectively. Conclusion: Both carriers form a film on the skin, providing an occlusive effect with no differences between these two systems. The penetration of a marker (Nile red) into the stratum corneum was quite higher for NLC than for SLN, suggesting an influence of the composition of these particles on their penetration enhancing ability.展开更多
For an all solid-state Marx modulator applied in dielectric barrier discharges（DBDs）,hard switching results in a very low efficiency.In this paper,a series resonant soft switching circuit,which series an inductance ...For an all solid-state Marx modulator applied in dielectric barrier discharges（DBDs）,hard switching results in a very low efficiency.In this paper,a series resonant soft switching circuit,which series an inductance with DBD capacitor,is proposed to reduce the power loss.The power loss of the all circuit status with hard switching was analyzed,and the maximum power loss occurred during discharging at the rising and falling edges.The power loss of the series resonant soft switching circuit was also presented.A comparative analysis of the two circuits determined that the soft switching circuit greatly reduced power loss.The experimental results also demonstrated that the soft switching circuit improved the power transmission efficiency of an all solid-state Marx modulator for DBDs by up to 3 times.展开更多
文摘To choose the optimum construction method of metro tunneling, we conducted research with numerical simulation on strata consolidation subsidence by dewatering, dynamic dewatering, and non-dewatering construction method, taking the integrated effects of fluid-solid coupling and tunneling mechanics into account. We obtained the curved surfaces of ground surface subsidence and strata consolidation subsidence. The results show that the quantity of ground surface subsidence is 31 mm for the non-dewatering method, 39 mm for the dynamic dewatering method, and 105 mm for the dewatering method. Their ratio is 1：1.3：3.4; and the percentages of strata consolidation subsidence to whole ground surface subsidence of each construction method is 27% （no-dewatering）, 50% （dynamic dewatering）, and 79% （dewatering）. It is obvious that the non-dewatering construction method is the most effective method to control the strata consolidation subsidence induced by metro tunneling in saturated soft clay strata, and it has been successfully applied to the construction of the Shenzben metro line 1.
文摘Objective: This work compares the occlusive effect and the penetration enhancement ability of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC), through in vitro skin. Methods: SLN and NLC were prepared by high shear homogenization and characterized by size, polydispersity index, zeta potential, morphology and physical stability. Occlusive effect was assessed by an in vitro test and by measuring TEWL using pig skin. Skin treated with the lipid carriers was visualized by SEM. A penetration test through skin, followed by tape stripping, was carried out using Nile red as a marker. Results: SLN (200 ± 6 nm) and NLC (192 ± 11 nm) were obtained. An occlusion factor of 36% - 39% was observed for both systems, while a reduction in TEWL of 34.3% ± 14.8% and 26.2% ± 6.5% was seen after treatment with SLN and NLC, respectively. SEM images showed a film formed by the lipid carriers, responsible for the occlusion observed. No differences were found between the occlusive effect produced by SLN and NLC in both tests. NLC allowed the penetration of a greater amount of Nile red than SLN: 4.7 ± 1.3 μg and 1.7 ± 0.4 μg, respectively. Conclusion: Both carriers form a film on the skin, providing an occlusive effect with no differences between these two systems. The penetration of a marker (Nile red) into the stratum corneum was quite higher for NLC than for SLN, suggesting an influence of the composition of these particles on their penetration enhancing ability.
基金supported by the Engineering Research Center of Advanced Lighting Technology Ministry of Education
文摘For an all solid-state Marx modulator applied in dielectric barrier discharges（DBDs）,hard switching results in a very low efficiency.In this paper,a series resonant soft switching circuit,which series an inductance with DBD capacitor,is proposed to reduce the power loss.The power loss of the all circuit status with hard switching was analyzed,and the maximum power loss occurred during discharging at the rising and falling edges.The power loss of the series resonant soft switching circuit was also presented.A comparative analysis of the two circuits determined that the soft switching circuit greatly reduced power loss.The experimental results also demonstrated that the soft switching circuit improved the power transmission efficiency of an all solid-state Marx modulator for DBDs by up to 3 times.
