In view of application characteristics of Solid Thinking Evolve in product modeling design, and the practical design of cosmetics packaging, this paper introduced the unique Construction TreeTM, fast, convenient and e...In view of application characteristics of Solid Thinking Evolve in product modeling design, and the practical design of cosmetics packaging, this paper introduced the unique Construction TreeTM, fast, convenient and easy features of Solid Thinking Evolve, and its application prospects in product development.展开更多
In allusion to the deficient feature of product information in conceptualdesign, a framework of deficient information modeling for conceptual shape design is put forward,which includes qualitative shape modeling (a qu...In allusion to the deficient feature of product information in conceptualdesign, a framework of deficient information modeling for conceptual shape design is put forward,which includes qualitative shape modeling (a qualitative solid model), uncertain shape modeling (anuncertain relation model) and imprecise shape modeling (an imprecise region model). In theframework, the qualitative solid model is the core, which represents qualitatively (using symbols)the conceptual shapes of mechanical products. The uncertain relation model regarding domainrelations as objects and the imprecise region model regarding domains as objects are used to dealwith the uncertain and imprecise issues respectively, which arise from qualitative shape modeling orexist in product information itself.展开更多
Current formulation development strongly relies on trial-and-error experiments in the laboratory by pharmaceutical scientists,which is time-consuming,high cost and waste materials.This research aims to integrate vario...Current formulation development strongly relies on trial-and-error experiments in the laboratory by pharmaceutical scientists,which is time-consuming,high cost and waste materials.This research aims to integrate various computational tools,including machine learning,molecular dynamic simulation and physiologically based absorption modeling(PBAM),to enhance andrographolide(AG)/cyclodextrins(CDs)formulation design.The light GBM prediction model we built before was utilized to predict AG/CDs inclusion's binding free energy.AG/γ-CD inclusion complexes showed the strongest binding affinity,which was experimentally validated by the phase solubility study.The molecular dynamic simulation was used to investigate the inclusion mechanism between AG andγ-CD,which was experimentally characterized by DSC,FTIR and NMR techniques.PBAM was applied to simulate the in vivo behavior of the formulations,which were validated by cell and animal experiments.Cell experiments revealed that the presence of D-α-Tocopherol polyethylene glycol succinate(TPGS)significantly increased the intracellular uptake of AG in MDCKMDR1 cells and the absorptive transport of AG in MDCK-MDR1 monolayers.The relative bioavailability of the AG-CD-TPGS ternary system in rats was increased to 2.6-fold and 1.59-fold compared with crude AG and commercial dropping pills,respectively.In conclusion,this is the first time to integrate various computational tools to develop a new AG-CD-TPGS ternary formulation with significant improvement of aqueous solubility,dissolution rate and bioavailability.The integrated computational tool is a novel and robust methodology to facilitate pharmaceutical formulation design.展开更多
The general computer-aided design （CAD） software cannot meet the mould design requirement of the autoclave process for composites, because many parameters such as temperature and pressure should be considered in the...The general computer-aided design （CAD） software cannot meet the mould design requirement of the autoclave process for composites, because many parameters such as temperature and pressure should be considered in the mould design process, in addition to the material and geometry of the part. A framed-mould computer-aided design system （FMCAD） used in the autoclave moulding process is proposed in this paper. A function model of the software is presented, in which influence factors such as part structure, mould structure, and process parameters are considered; a design model of the software is established using object oriented （O-O） technology to integrate the stiffness calculation, temperature field calculation, and deformation field calculation of mould in the design, and in the design model, a hybrid model of mould based on calculation feature and form feature is presented to support those calculations. A prototype system is developed, in which a mould design process wizard is built to integrate the input information, calculation, analysis, data storage, display, and design results of mould design. Finally, three design examples are used to verify the prototype.展开更多
The selection of phase change material(PCM)plays an important role in developing high-efficient thermal energy storage(TES)processes.Ionic liquids(ILs)or organic salts are thermally stable,non-volatile,and non-flammab...The selection of phase change material(PCM)plays an important role in developing high-efficient thermal energy storage(TES)processes.Ionic liquids(ILs)or organic salts are thermally stable,non-volatile,and non-flammable.Importantly,researchers have proved that some ILs possess higher latent heat of fusion than conventional PCMs.Despite these attractive characteristics,yet surprisingly,little research has been performed to the systematic selection or structural design of ILs for TES.Besides,most of the existing work is only focused on the latent heat when selecting PCMs.However,one should note that other properties such as heat capacity and thermal conductivity could affect the TES performance as well.In this work,we propose a computer-aided molecular design(CAMD)based method to systematically design IL PCMs for a practical TES process.The effects of different IL properties are simultaneously captured in the IL property models and TES process models.Optimal ILs holding a best compromise of all the properties are identified through the solution of a formulated CAMD problem where the TES performance of the process is maximized.[MPyEtOH][TfO]is found to be the best material and excitingly,the identified top nine ILs all show a higher TES performance than the traditional PCM paraffin wax at 10 h thermal charging time.展开更多
Based upon characteristic movement features of the overlying strata in solid backfill mining and in-situ observations,an associated model representing a roadway support system has been developed.Based on the Winkler f...Based upon characteristic movement features of the overlying strata in solid backfill mining and in-situ observations,an associated model representing a roadway support system has been developed.Based on the Winkler foundation and beam model,the current study presents a static analysis of the model,thus permitting acquisition of a theoretical formula pertaining to roof convergence.Through use of working face 6304-1(Jisan Colliery) as the research setting,the association between roof convergence magnitude and both packwall strength and width have been elucidated.Based upon observed conditions at the working face,realistic packwall parameters have been formulated,with numerical simulation results and field application results indicating that design parameters garnered from the developed formula successfully adapted to local geological movement and deformation.Accordingly,roadway deformation was shown to be within the permissible range,thus satisfying mine production requirements.The proposed method in the current study may give a design basis for pack design in the context of SBM under similar conditions.展开更多
In this article, the mathematical foundations of the so called Criterion of Optimization by Compensation for designing commercial bottles with a straight section along its silhouette and with lateral surfaces of revol...In this article, the mathematical foundations of the so called Criterion of Optimization by Compensation for designing commercial bottles with a straight section along its silhouette and with lateral surfaces of revolution is presented. Such mathematical model uses as main tools, Lagrange polynomial interpolation and Newton’s Method for Nonlinear Systems being first necessary to formulate and demonstrate a theorem. It was redesigned and manufactured a bottle of a half-liter of Fanta soda of the well-known Coca Cola Company, which uses 18.86% more material that such criterion establishes. It was expected that the redesigned bottle use 4.91% more of material with respect to what is established by the Criterion of Optimization by Compensation. However, it was reported a 13% of mistake due to important limitations that must be overcome.展开更多
The landfill design is necessary to be implemented in various regions to protect public human health and the factors of environment. The suggested design of landfill was performed in the arid areas, where that Babylon...The landfill design is necessary to be implemented in various regions to protect public human health and the factors of environment. The suggested design of landfill was performed in the arid areas, where that Babylon Governorate, Iraq was selected as a case study. Babylon Governorate is located in the middle of Iraq. The suggested design for the selected sites for landfill in the arid areas was consisted of the base liner and final cover systems. The HELP 3.95D model was applied on both systems to check if there is any leakage by leachate from the suggested soil layers of landfill base on the water balance in Babylon Governorate for the years 2005-2016. The suggested design of final cover system was implemented based on weather parameters in the arid areas through storing water that coming from the surface within upper layers that have fine particles and over the top barrier without leakage into the waste body, thereby preventing leachate generation. This is allowing to the stored water to evaporate from the surface of soil or transpire through vegetation due to the high temperature during the most months in the study area. The results showed there was no percolation of leachate through the base liner system. The design of final cover system was acted to reduce the runoff on the surface and increase the actual evaporation.展开更多
A novel method to extract conic blending feature in reverse engineering is presented. Different from the methods to recover constant and variable radius blends from unorganized points, it contains not only novel segme...A novel method to extract conic blending feature in reverse engineering is presented. Different from the methods to recover constant and variable radius blends from unorganized points, it contains not only novel segmentation and feature recognition techniques, but also bias corrected technique to capture more reliable distribution of feature parameters along the spine curve. The segmentation depending on point classification separates the points in the conic blend region from the input point cloud. The available feature parameters of the cross-sectional curves are extracted with the processes of slicing point clouds with planes, conic curve fitting, and parameters estimation and compensation, The extracted parameters and its distribution laws are refined according to statistic theory such as regression analysis and hypothesis test. The proposed method can accurately capture the original design intentions and conveniently guide the reverse modeling process. Application examples are presented to verify the high precision and stability of the proposed method.展开更多
This paper creates 3D solid model and assembly of U RJ 92-6 oil tank and analyses its strength by integrated CAD/CAE/CAM software I-D EAS. Through integrated simulation in computer, design efficiency and quality of oi...This paper creates 3D solid model and assembly of U RJ 92-6 oil tank and analyses its strength by integrated CAD/CAE/CAM software I-D EAS. Through integrated simulation in computer, design efficiency and quality of oil tank is greatly improved. Adopting integrated CAD/CAE/CAM software to carry out integrated research to equ ipment and products, we will be able to take overall analysis in aspects of 3-D solid modeling, pre-assembly and strength, etc., to realize non-paper designi ng and parallel designing. Problems can be found and settled during designing, w hich will increase designing efficiency and one-time success rate and realize o ptimum designing for products.展开更多
文摘In view of application characteristics of Solid Thinking Evolve in product modeling design, and the practical design of cosmetics packaging, this paper introduced the unique Construction TreeTM, fast, convenient and easy features of Solid Thinking Evolve, and its application prospects in product development.
基金National Natural Science Foundation of China (No.59990470)
文摘In allusion to the deficient feature of product information in conceptualdesign, a framework of deficient information modeling for conceptual shape design is put forward,which includes qualitative shape modeling (a qualitative solid model), uncertain shape modeling (anuncertain relation model) and imprecise shape modeling (an imprecise region model). In theframework, the qualitative solid model is the core, which represents qualitatively (using symbols)the conceptual shapes of mechanical products. The uncertain relation model regarding domainrelations as objects and the imprecise region model regarding domains as objects are used to dealwith the uncertain and imprecise issues respectively, which arise from qualitative shape modeling orexist in product information itself.
基金financially supported by the FDCT Project 0029/2018/A1the University of Macao Research Grants(MYRG2019-00041-ICMS)performed in part at the High-Performance Computing Cluster(HPCC)which is supported by Information and Communication Technology Office(ICTO)of the University of Macao。
文摘Current formulation development strongly relies on trial-and-error experiments in the laboratory by pharmaceutical scientists,which is time-consuming,high cost and waste materials.This research aims to integrate various computational tools,including machine learning,molecular dynamic simulation and physiologically based absorption modeling(PBAM),to enhance andrographolide(AG)/cyclodextrins(CDs)formulation design.The light GBM prediction model we built before was utilized to predict AG/CDs inclusion's binding free energy.AG/γ-CD inclusion complexes showed the strongest binding affinity,which was experimentally validated by the phase solubility study.The molecular dynamic simulation was used to investigate the inclusion mechanism between AG andγ-CD,which was experimentally characterized by DSC,FTIR and NMR techniques.PBAM was applied to simulate the in vivo behavior of the formulations,which were validated by cell and animal experiments.Cell experiments revealed that the presence of D-α-Tocopherol polyethylene glycol succinate(TPGS)significantly increased the intracellular uptake of AG in MDCKMDR1 cells and the absorptive transport of AG in MDCK-MDR1 monolayers.The relative bioavailability of the AG-CD-TPGS ternary system in rats was increased to 2.6-fold and 1.59-fold compared with crude AG and commercial dropping pills,respectively.In conclusion,this is the first time to integrate various computational tools to develop a new AG-CD-TPGS ternary formulation with significant improvement of aqueous solubility,dissolution rate and bioavailability.The integrated computational tool is a novel and robust methodology to facilitate pharmaceutical formulation design.
文摘The general computer-aided design （CAD） software cannot meet the mould design requirement of the autoclave process for composites, because many parameters such as temperature and pressure should be considered in the mould design process, in addition to the material and geometry of the part. A framed-mould computer-aided design system （FMCAD） used in the autoclave moulding process is proposed in this paper. A function model of the software is presented, in which influence factors such as part structure, mould structure, and process parameters are considered; a design model of the software is established using object oriented （O-O） technology to integrate the stiffness calculation, temperature field calculation, and deformation field calculation of mould in the design, and in the design model, a hybrid model of mould based on calculation feature and form feature is presented to support those calculations. A prototype system is developed, in which a mould design process wizard is built to integrate the input information, calculation, analysis, data storage, display, and design results of mould design. Finally, three design examples are used to verify the prototype.
基金the financial support from Max Planck Society,Germany,for the Computer-Aided Material and Process Design(CAMPD)project
文摘The selection of phase change material(PCM)plays an important role in developing high-efficient thermal energy storage(TES)processes.Ionic liquids(ILs)or organic salts are thermally stable,non-volatile,and non-flammable.Importantly,researchers have proved that some ILs possess higher latent heat of fusion than conventional PCMs.Despite these attractive characteristics,yet surprisingly,little research has been performed to the systematic selection or structural design of ILs for TES.Besides,most of the existing work is only focused on the latent heat when selecting PCMs.However,one should note that other properties such as heat capacity and thermal conductivity could affect the TES performance as well.In this work,we propose a computer-aided molecular design(CAMD)based method to systematically design IL PCMs for a practical TES process.The effects of different IL properties are simultaneously captured in the IL property models and TES process models.Optimal ILs holding a best compromise of all the properties are identified through the solution of a formulated CAMD problem where the TES performance of the process is maximized.[MPyEtOH][TfO]is found to be the best material and excitingly,the identified top nine ILs all show a higher TES performance than the traditional PCM paraffin wax at 10 h thermal charging time.
基金financial support from the Fundamental Research Funds for the Central Universities(China University of Mining and Technology)under Grant 2014ZDPY02Qing Lan Project
文摘Based upon characteristic movement features of the overlying strata in solid backfill mining and in-situ observations,an associated model representing a roadway support system has been developed.Based on the Winkler foundation and beam model,the current study presents a static analysis of the model,thus permitting acquisition of a theoretical formula pertaining to roof convergence.Through use of working face 6304-1(Jisan Colliery) as the research setting,the association between roof convergence magnitude and both packwall strength and width have been elucidated.Based upon observed conditions at the working face,realistic packwall parameters have been formulated,with numerical simulation results and field application results indicating that design parameters garnered from the developed formula successfully adapted to local geological movement and deformation.Accordingly,roadway deformation was shown to be within the permissible range,thus satisfying mine production requirements.The proposed method in the current study may give a design basis for pack design in the context of SBM under similar conditions.
文摘In this article, the mathematical foundations of the so called Criterion of Optimization by Compensation for designing commercial bottles with a straight section along its silhouette and with lateral surfaces of revolution is presented. Such mathematical model uses as main tools, Lagrange polynomial interpolation and Newton’s Method for Nonlinear Systems being first necessary to formulate and demonstrate a theorem. It was redesigned and manufactured a bottle of a half-liter of Fanta soda of the well-known Coca Cola Company, which uses 18.86% more material that such criterion establishes. It was expected that the redesigned bottle use 4.91% more of material with respect to what is established by the Criterion of Optimization by Compensation. However, it was reported a 13% of mistake due to important limitations that must be overcome.
文摘The landfill design is necessary to be implemented in various regions to protect public human health and the factors of environment. The suggested design of landfill was performed in the arid areas, where that Babylon Governorate, Iraq was selected as a case study. Babylon Governorate is located in the middle of Iraq. The suggested design for the selected sites for landfill in the arid areas was consisted of the base liner and final cover systems. The HELP 3.95D model was applied on both systems to check if there is any leakage by leachate from the suggested soil layers of landfill base on the water balance in Babylon Governorate for the years 2005-2016. The suggested design of final cover system was implemented based on weather parameters in the arid areas through storing water that coming from the surface within upper layers that have fine particles and over the top barrier without leakage into the waste body, thereby preventing leachate generation. This is allowing to the stored water to evaporate from the surface of soil or transpire through vegetation due to the high temperature during the most months in the study area. The results showed there was no percolation of leachate through the base liner system. The design of final cover system was acted to reduce the runoff on the surface and increase the actual evaporation.
基金This project is supported by General Electric Company and National Advanced Technology Project of China(No.863-511-942-018).
文摘A novel method to extract conic blending feature in reverse engineering is presented. Different from the methods to recover constant and variable radius blends from unorganized points, it contains not only novel segmentation and feature recognition techniques, but also bias corrected technique to capture more reliable distribution of feature parameters along the spine curve. The segmentation depending on point classification separates the points in the conic blend region from the input point cloud. The available feature parameters of the cross-sectional curves are extracted with the processes of slicing point clouds with planes, conic curve fitting, and parameters estimation and compensation, The extracted parameters and its distribution laws are refined according to statistic theory such as regression analysis and hypothesis test. The proposed method can accurately capture the original design intentions and conveniently guide the reverse modeling process. Application examples are presented to verify the high precision and stability of the proposed method.
文摘This paper creates 3D solid model and assembly of U RJ 92-6 oil tank and analyses its strength by integrated CAD/CAE/CAM software I-D EAS. Through integrated simulation in computer, design efficiency and quality of oil tank is greatly improved. Adopting integrated CAD/CAE/CAM software to carry out integrated research to equ ipment and products, we will be able to take overall analysis in aspects of 3-D solid modeling, pre-assembly and strength, etc., to realize non-paper designi ng and parallel designing. Problems can be found and settled during designing, w hich will increase designing efficiency and one-time success rate and realize o ptimum designing for products.
