Objective:To assess the efficacy of triclabendazole(TCBZ) in porcine cysticercosis.Methods:Eighteen naturally infected cysticercotic pigs were divided into 3 groups of 6 individuals each.The first group was treated or...Objective:To assess the efficacy of triclabendazole(TCBZ) in porcine cysticercosis.Methods:Eighteen naturally infected cysticercotic pigs were divided into 3 groups of 6 individuals each.The first group was treated orally with TCBZ at a single dose of 30 mg/kg of body weight,the second group was treated orally with oxfendazole at a single dose of 30 mg/kg of body weight and the third group received a placebo(control group).All animals were kept under the same management conditions.The pigs were euthanized 17 wk post-treatment and the number of surviving cysts in muscles was assessed and compared between groups.Results:All pigs treated with oxfendazole had only degenerated cysts in their carcasses.In contrast,TCBZ had very little effect against the parasitic cysts.Cysts from pigs in the TCBZ group looked apparently normal after treatment.However,histological evaluation showed a mild to moderate degree of inflammation.Conclusions:TCBZ is not an efficacious drug against Taenia solium cysticercosis in swine using a single dose.展开更多
[ Objective ] In order to observe the morphological structure of Taenia solium and improve the dyeing method of Taenia solium. [ Method ] Taenia soli- um was stained by hematoxylin-eosin （HE） staining method and obs...[ Objective ] In order to observe the morphological structure of Taenia solium and improve the dyeing method of Taenia solium. [ Method ] Taenia soli- um was stained by hematoxylin-eosin （HE） staining method and observed under microscope. Taenia solium specimens with clear structure and bright color were made. [ Results] Male reproductive system and excretory system of Taenia solium segment could be observed under the optical microscope, structures of uterus and eggs in Taenia solium gravid proglottid could also be observed. [ Conclusion] Aiming at providing a reference for the identification of Taenia solium and the diagnosis of the tapeworm disease.展开更多
T. solium cysticercosis is a tropical neglected disease with a high impact on public health and agriculture. To better understand the socio-economical drivers of this disease, this study was carried out with the goal ...T. solium cysticercosis is a tropical neglected disease with a high impact on public health and agriculture. To better understand the socio-economical drivers of this disease, this study was carried out with the goal to analyze knowledge, attitudes and practices of populations of the Boucle du Mouhoun region in connection with the life cycle of T. solium. We carried out a knowledge-attitudes-practices (KAP) survey with 320 people in four villages. More than half of the interviewees (60.3%) have already seen pig’s carcasses with the parasite cysts. Only two people know that the infestation is associated with the consumption of human faeces. In addition, 32.2% think that they can get sick by ingesting infested meat. Wells water is consumed by 62.8% of people and 75.1% of wells do not carry curbs. Moreover, 84.1% of concessions had latrines but 52.2% of the people practice open defecation. Pig meat is consumed by 80.6% of people and 30.9% have already consumed meat with cysts. This study shows that the transmission routes of porcine cysticercosis are not known and that the populations adopt attitudes and practices which allow the perpetuation of teniasis/cysticercosis in these villages.展开更多
For decades, Taenia solium cysticercosis (TSC) has remained an important constraint for public health and economic well being of the predisposed communities. Despite the fact that the disease is easily preventable, hu...For decades, Taenia solium cysticercosis (TSC) has remained an important constraint for public health and economic well being of the predisposed communities. Despite the fact that the disease is easily preventable, humans remain foci for transmission. They harbour the mature form of the parasite (Taenia solium) which may be curable at this stage and also easily prevented from contaminating pig feeds and environment with eggs of the parasite to break the cycle. Researchers, knowledgeable communities and international organisations such as the World Health Organisation work hard to make the disease a history. Nevertheless, persistence of the disease in endemic regions such as sub Saharan Africa is kept on increasing. While TSC in human may serve as a silent killer as it can go unnoticed for years, the immanent social cultural settings and lifestyles of the communities in endemic areas form the main concern on the epidemiology of the disease. Unless lifestyles change in endemic regions, front line research might rarely find its way into applications in an area of huge societal and economic impact, the TSC epidemiology. Sincerely, transmission of TSC is favoured by poor sanitation and hygiene which is motivated by lifestyle and poverty. What is perhaps missing is the knowledge on “why is the communities involved ease indiscriminately while almost every member of the community in endemic areas knows that indiscriminate defecation may harm their health? What social drivers are behind this motive (bush defecation)? How best can the disease be controlled and monitored? This review recommends for developing and implementing an interdisciplinary OneHealth community-based control mechanism and monitoring (surveillance) programme as standpoints towards eliminating TSC in sub-Saharan Africa and the rest endemic regions.展开更多
基金Partial support from the Fogarty International Center/NIH(training grants D43 TW008273-03 and D43 TW001140) is acknowledgedsupported by the Fogarty International Center/NIH(D43 TW008273-03)supported by a Wellcome Trust Senior International Research Fellowship in Public Health and Tropical Medicine
文摘Objective:To assess the efficacy of triclabendazole(TCBZ) in porcine cysticercosis.Methods:Eighteen naturally infected cysticercotic pigs were divided into 3 groups of 6 individuals each.The first group was treated orally with TCBZ at a single dose of 30 mg/kg of body weight,the second group was treated orally with oxfendazole at a single dose of 30 mg/kg of body weight and the third group received a placebo(control group).All animals were kept under the same management conditions.The pigs were euthanized 17 wk post-treatment and the number of surviving cysts in muscles was assessed and compared between groups.Results:All pigs treated with oxfendazole had only degenerated cysts in their carcasses.In contrast,TCBZ had very little effect against the parasitic cysts.Cysts from pigs in the TCBZ group looked apparently normal after treatment.However,histological evaluation showed a mild to moderate degree of inflammation.Conclusions:TCBZ is not an efficacious drug against Taenia solium cysticercosis in swine using a single dose.
文摘[ Objective ] In order to observe the morphological structure of Taenia solium and improve the dyeing method of Taenia solium. [ Method ] Taenia soli- um was stained by hematoxylin-eosin （HE） staining method and observed under microscope. Taenia solium specimens with clear structure and bright color were made. [ Results] Male reproductive system and excretory system of Taenia solium segment could be observed under the optical microscope, structures of uterus and eggs in Taenia solium gravid proglottid could also be observed. [ Conclusion] Aiming at providing a reference for the identification of Taenia solium and the diagnosis of the tapeworm disease.
文摘T. solium cysticercosis is a tropical neglected disease with a high impact on public health and agriculture. To better understand the socio-economical drivers of this disease, this study was carried out with the goal to analyze knowledge, attitudes and practices of populations of the Boucle du Mouhoun region in connection with the life cycle of T. solium. We carried out a knowledge-attitudes-practices (KAP) survey with 320 people in four villages. More than half of the interviewees (60.3%) have already seen pig’s carcasses with the parasite cysts. Only two people know that the infestation is associated with the consumption of human faeces. In addition, 32.2% think that they can get sick by ingesting infested meat. Wells water is consumed by 62.8% of people and 75.1% of wells do not carry curbs. Moreover, 84.1% of concessions had latrines but 52.2% of the people practice open defecation. Pig meat is consumed by 80.6% of people and 30.9% have already consumed meat with cysts. This study shows that the transmission routes of porcine cysticercosis are not known and that the populations adopt attitudes and practices which allow the perpetuation of teniasis/cysticercosis in these villages.
文摘For decades, Taenia solium cysticercosis (TSC) has remained an important constraint for public health and economic well being of the predisposed communities. Despite the fact that the disease is easily preventable, humans remain foci for transmission. They harbour the mature form of the parasite (Taenia solium) which may be curable at this stage and also easily prevented from contaminating pig feeds and environment with eggs of the parasite to break the cycle. Researchers, knowledgeable communities and international organisations such as the World Health Organisation work hard to make the disease a history. Nevertheless, persistence of the disease in endemic regions such as sub Saharan Africa is kept on increasing. While TSC in human may serve as a silent killer as it can go unnoticed for years, the immanent social cultural settings and lifestyles of the communities in endemic areas form the main concern on the epidemiology of the disease. Unless lifestyles change in endemic regions, front line research might rarely find its way into applications in an area of huge societal and economic impact, the TSC epidemiology. Sincerely, transmission of TSC is favoured by poor sanitation and hygiene which is motivated by lifestyle and poverty. What is perhaps missing is the knowledge on “why is the communities involved ease indiscriminately while almost every member of the community in endemic areas knows that indiscriminate defecation may harm their health? What social drivers are behind this motive (bush defecation)? How best can the disease be controlled and monitored? This review recommends for developing and implementing an interdisciplinary OneHealth community-based control mechanism and monitoring (surveillance) programme as standpoints towards eliminating TSC in sub-Saharan Africa and the rest endemic regions.
